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Drug-induced erythema multiforme

MedGen UID:
658407
•Concept ID:
C0574715
•
Disease or Syndrome
SNOMED CT: Drug-induced erythema multiforme (297942002)

Professional guidelines

PubMed

Clinical features, outcomes and treatment in children with drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis.
Liotti L, Caimmi S, Bottau P, Bernardini R, Cardinale F, Saretta F, Mori F, Crisafulli G, Franceschini F, Caffarelli C
Acta Biomed 2019 Jan 29;90(3-S):52-60. doi: 10.23750/abm.v90i3-S.8165. PMID: 30830062Free PMC Article
HLA and pharmacogenetics of drug hypersensitivity.
Pavlos R, Mallal S, Phillips E
Pharmacogenomics 2012 Aug;13(11):1285-306. doi: 10.2217/pgs.12.108. PMID: 22920398
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent clinical studies

Etiology

Reality of drug-induced erythema multiforme: A French pharmacovigilance study.
Demouche S, Bettuzzi T, Sbidian E, Laugier Castellan D, Osmont MN, Ingen-Housz-Oro S, Lebrun-Vignes B
Therapie 2023 Nov-Dec;78(6):711-719. Epub 2023 Mar 10 doi: 10.1016/j.therap.2023.03.004. PMID: 37024401

Diagnosis

Reality of drug-induced erythema multiforme: A French pharmacovigilance study.
Demouche S, Bettuzzi T, Sbidian E, Laugier Castellan D, Osmont MN, Ingen-Housz-Oro S, Lebrun-Vignes B
Therapie 2023 Nov-Dec;78(6):711-719. Epub 2023 Mar 10 doi: 10.1016/j.therap.2023.03.004. PMID: 37024401
Drug induced oral erythema multiforme: Case report.
Asif SM, Shamsudeen SM, Assiri KI, Muburak HMA, Kaleem SM, Khan AA, Shariff M
Medicine (Baltimore) 2021 Apr 30;100(17):e22387. doi: 10.1097/MD.0000000000022387. PMID: 33907086Free PMC Article
Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy.
Nomura H, Takahashi H, Suzuki S, Kurihara Y, Chubachi S, Kawada I, Yasuda H, Betsuyaku T, Amagai M, Funakoshi T
J Dermatol 2017 Jul;44(7):818-821. Epub 2017 Mar 11 doi: 10.1111/1346-8138.13810. PMID: 28295542
Erythema multiforme due to clonazepam - supportive evidence from the macrophage migration inhibition factor test.
Amichai B, Grunwald MH
Clin Exp Dermatol 1998 Sep;23(5):206-7. doi: 10.1046/j.1365-2230.1998.00358.x. PMID: 10233601

Therapy

Drug induced oral erythema multiforme: Case report.
Asif SM, Shamsudeen SM, Assiri KI, Muburak HMA, Kaleem SM, Khan AA, Shariff M
Medicine (Baltimore) 2021 Apr 30;100(17):e22387. doi: 10.1097/MD.0000000000022387. PMID: 33907086Free PMC Article
Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy.
Nomura H, Takahashi H, Suzuki S, Kurihara Y, Chubachi S, Kawada I, Yasuda H, Betsuyaku T, Amagai M, Funakoshi T
J Dermatol 2017 Jul;44(7):818-821. Epub 2017 Mar 11 doi: 10.1111/1346-8138.13810. PMID: 28295542
Increased adherence to keratinocytes of peripheral blood mononuclear leucocytes of a patient with drug-induced erythema multiforme.
Bruynzeel I, Van der Raaij EM, Boorsma DM, De Haan P, Willemze R
Br J Dermatol 1993 Jul;129(1):45-9. doi: 10.1111/j.1365-2133.1993.tb03310.x. PMID: 8369210
Drug-induced, photosensitive, erythema multiforme-like eruption: possible role for cell adhesion molecules in a flare induced by Rhus dermatitis.
Shiohara T, Chiba M, Tanaka Y, Nagashima M
J Am Acad Dermatol 1990 Apr;22(4):647-50. doi: 10.1016/0190-9622(90)70090-5. PMID: 1969427
Drug-induced erythema multiforme: a possible immunologic pathogenesis.
Delafuente JC
Drug Intell Clin Pharm 1985 Feb;19(2):114-7. doi: 10.1177/106002808501900206. PMID: 3971857

Prognosis

Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy.
Nomura H, Takahashi H, Suzuki S, Kurihara Y, Chubachi S, Kawada I, Yasuda H, Betsuyaku T, Amagai M, Funakoshi T
J Dermatol 2017 Jul;44(7):818-821. Epub 2017 Mar 11 doi: 10.1111/1346-8138.13810. PMID: 28295542

Clinical prediction guides

Reality of drug-induced erythema multiforme: A French pharmacovigilance study.
Demouche S, Bettuzzi T, Sbidian E, Laugier Castellan D, Osmont MN, Ingen-Housz-Oro S, Lebrun-Vignes B
Therapie 2023 Nov-Dec;78(6):711-719. Epub 2023 Mar 10 doi: 10.1016/j.therap.2023.03.004. PMID: 37024401
Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy.
Nomura H, Takahashi H, Suzuki S, Kurihara Y, Chubachi S, Kawada I, Yasuda H, Betsuyaku T, Amagai M, Funakoshi T
J Dermatol 2017 Jul;44(7):818-821. Epub 2017 Mar 11 doi: 10.1111/1346-8138.13810. PMID: 28295542
Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine.
Friedmann PS, Strickland I, Pirmohamed M, Park BK
Arch Dermatol 1994 May;130(5):598-604. PMID: 8179341
Increased adherence to keratinocytes of peripheral blood mononuclear leucocytes of a patient with drug-induced erythema multiforme.
Bruynzeel I, Van der Raaij EM, Boorsma DM, De Haan P, Willemze R
Br J Dermatol 1993 Jul;129(1):45-9. doi: 10.1111/j.1365-2133.1993.tb03310.x. PMID: 8369210

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