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Cutaneous macular amyloidosis

MedGen UID:
639717
•Concept ID:
C0546393
•
Disease or Syndrome
Synonyms: Macular amyloidosis; Macular cutaneous amyloidosis
SNOMED CT: Macular cutaneous amyloidosis (111032003)
 
HPO: HP:0032347

Definition

A type of cutaneous amyloidosis that is characterized by hyperpigmented patches with indefinite margins composed of grayish brown macules, often with a reticulated or rippled appearance. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous macular amyloidosis

Conditions with this feature

Corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome
MedGen UID:
815206
•Concept ID:
C3808876
•
Neoplastic Process
Multiple self-healing palmoplantar carcinoma (MSPC) is characterized by recurrent keratoacanthomas in palmoplantar skin as well as in conjunctival and corneal epithelia. In addition, patients experience a high susceptibility to malignant squamous cell carcinoma (summary by Zhong et al., 2016).
See: Condition Record
Corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome

Professional guidelines

PubMed

Comparing the efficacy of pulsed dye laser, Q-Switched Nd-YAG, CO2, and combined CO(2) and Q-Switched Nd-YAG lasers for the treatment of cutaneous macular amyloidosis.
Radmanesh M, Ghanatir F, Radmanesh R
J Dermatolog Treat 2021 Mar;32(2):258-260. Epub 2019 Aug 25 doi: 10.1080/09546634.2019.1654071. PMID: 31415215

Recent clinical studies

Etiology

Efficacy of topical gabapentin in women with primary macular amyloidosis: A side-by-side triple-blinded randomized clinical trial.
Abtahi-Naeini B, Hemati E, Faghihi G, Shahmoradi Z, Paknazar F, Rastegarnasab F, Varshosaz J, Hadian M, Akbari M, Sabzghabaee AM
J Cosmet Dermatol 2024 May;23(5):1677-1684. Epub 2024 Jan 30 doi: 10.1111/jocd.16180. PMID: 38291677
The therapeutic effects of 1540-nm nonablative fractional erbium laser on macular amyloidosis: a randomized clinical trial.
Nahidi Y, Delghandi SR, Kiafar B, Saki A
J Dermatolog Treat 2021 May;32(3):340-344. Epub 2019 Aug 29 doi: 10.1080/09546634.2019.1655136. PMID: 31411528
Comparative study of fractional CO(2) laser and fractional CO(2) laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis.
Sobhi RM, Sharaoui I, El Nabarawy EA, El Nemr Esmail RS, Hegazy RA, Aref DHF
Lasers Med Sci 2018 May;33(4):909-916. Epub 2018 Feb 26 doi: 10.1007/s10103-018-2457-1. PMID: 29480422

Diagnosis

Efficacy of topical gabapentin in women with primary macular amyloidosis: A side-by-side triple-blinded randomized clinical trial.
Abtahi-Naeini B, Hemati E, Faghihi G, Shahmoradi Z, Paknazar F, Rastegarnasab F, Varshosaz J, Hadian M, Akbari M, Sabzghabaee AM
J Cosmet Dermatol 2024 May;23(5):1677-1684. Epub 2024 Jan 30 doi: 10.1111/jocd.16180. PMID: 38291677
Primary diffuse macular amyloidosis.
Kanchanapoomi M, Rosenstein R, Shvartsbeyn M, Meehan SA, Dolly N, Femia A
Dermatol Online J 2015 Dec 16;21(12) PMID: 26990346

Therapy

Efficacy of topical gabapentin in women with primary macular amyloidosis: A side-by-side triple-blinded randomized clinical trial.
Abtahi-Naeini B, Hemati E, Faghihi G, Shahmoradi Z, Paknazar F, Rastegarnasab F, Varshosaz J, Hadian M, Akbari M, Sabzghabaee AM
J Cosmet Dermatol 2024 May;23(5):1677-1684. Epub 2024 Jan 30 doi: 10.1111/jocd.16180. PMID: 38291677
Comparing the efficacy of pulsed dye laser, Q-Switched Nd-YAG, CO2, and combined CO(2) and Q-Switched Nd-YAG lasers for the treatment of cutaneous macular amyloidosis.
Radmanesh M, Ghanatir F, Radmanesh R
J Dermatolog Treat 2021 Mar;32(2):258-260. Epub 2019 Aug 25 doi: 10.1080/09546634.2019.1654071. PMID: 31415215
The therapeutic effects of 1540-nm nonablative fractional erbium laser on macular amyloidosis: a randomized clinical trial.
Nahidi Y, Delghandi SR, Kiafar B, Saki A
J Dermatolog Treat 2021 May;32(3):340-344. Epub 2019 Aug 29 doi: 10.1080/09546634.2019.1655136. PMID: 31411528
Comparative study of fractional CO(2) laser and fractional CO(2) laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis.
Sobhi RM, Sharaoui I, El Nabarawy EA, El Nemr Esmail RS, Hegazy RA, Aref DHF
Lasers Med Sci 2018 May;33(4):909-916. Epub 2018 Feb 26 doi: 10.1007/s10103-018-2457-1. PMID: 29480422

Clinical prediction guides

Efficacy of topical gabapentin in women with primary macular amyloidosis: A side-by-side triple-blinded randomized clinical trial.
Abtahi-Naeini B, Hemati E, Faghihi G, Shahmoradi Z, Paknazar F, Rastegarnasab F, Varshosaz J, Hadian M, Akbari M, Sabzghabaee AM
J Cosmet Dermatol 2024 May;23(5):1677-1684. Epub 2024 Jan 30 doi: 10.1111/jocd.16180. PMID: 38291677
The therapeutic effects of 1540-nm nonablative fractional erbium laser on macular amyloidosis: a randomized clinical trial.
Nahidi Y, Delghandi SR, Kiafar B, Saki A
J Dermatolog Treat 2021 May;32(3):340-344. Epub 2019 Aug 29 doi: 10.1080/09546634.2019.1655136. PMID: 31411528
Comparative study of fractional CO(2) laser and fractional CO(2) laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis.
Sobhi RM, Sharaoui I, El Nabarawy EA, El Nemr Esmail RS, Hegazy RA, Aref DHF
Lasers Med Sci 2018 May;33(4):909-916. Epub 2018 Feb 26 doi: 10.1007/s10103-018-2457-1. PMID: 29480422

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