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Amyloid Tumor

MedGen UID:
107462
•Concept ID:
C0544840
•
Neoplastic Process
Synonyms: Amyloid tumor; Localized AL Amyloidosis; Nodular Amyloidosis; Tumoral Amyloidosis
SNOMED CT: Amyloid tumor (37279009)

Definition

A rare tumor composed of acellular amyloid material. It rarely progresses to systemic amyloidosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmyloid Tumor

Professional guidelines

PubMed

Diagnosis and Treatment of AL Amyloidosis.
Palladini G, Milani P
Drugs 2023 Feb;83(3):203-216. Epub 2023 Jan 18 doi: 10.1007/s40265-022-01830-z. PMID: 36652193
Chronic inflammatory demyelinating polyradiculoneuropathy-Diagnostic pitfalls and treatment approach.
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Management of Intracerebral Hemorrhage: JACC Focus Seminar.
Schrag M, Kirshner H
J Am Coll Cardiol 2020 Apr 21;75(15):1819-1831. doi: 10.1016/j.jacc.2019.10.066. PMID: 32299594

Recent clinical studies

Etiology

Giant exophytic tumor of the leg: A case report of amyloidoma with literature review.
Civriz AH, Vural Ç, Turan G, Yaşar EK
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):810-813. doi: 10.4103/IJPM.IJPM_800_20. PMID: 34673611
Efficacy of anakinra in a patient with systemic amyloidosis presenting as amyloidoma.
Nalcacioglu H, Ozkaya O, Genc G, Ayyildiz S, Kefeli M, Elli M, Aydin O, Ceyhan Bilgici M
Int J Rheum Dis 2018 Feb;21(2):552-559. Epub 2017 Dec 13 doi: 10.1111/1756-185X.13250. PMID: 29239128
Oral soft tissue alterations in patients with neurofibromatosis.
Jouhilahti EM, Visnapuu V, Soukka T, Aho H, Peltonen S, Happonen RP, Peltonen J
Clin Oral Investig 2012 Apr;16(2):551-8. Epub 2011 Feb 8 doi: 10.1007/s00784-011-0519-x. PMID: 21301902
Soft-tissue amyloidoma of the extremities: a case report and review of literature.
Maheshwari AV, Muro-Cacho CA, Kransdorf MJ, Temple HT
Skeletal Radiol 2009 Mar;38(3):287-92. Epub 2008 Dec 3 doi: 10.1007/s00256-008-0621-6. PMID: 19050870
Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part XII: appendix.
Bisceglia M, Spagnolo D, Galliani C, Fisher C, Suster S, Kazakov DV, Cooper K, Michal M
Pathologica 2006 Aug;98(4):239-98. PMID: 17175794

Diagnosis

Orbital amyloid tumor associated with myasthenia gravis.
Tresserra F, López-Fortuny M, Martínez-Lanao MA, D'Antin JC, Fernandez M, Barraquer RI
Rev Esp Patol 2022 Sep;55 Suppl 1:S7-S10. Epub 2020 Jul 25 doi: 10.1016/j.patol.2020.06.007. PMID: 36075668
Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part XII: appendix.
Bisceglia M, Spagnolo D, Galliani C, Fisher C, Suster S, Kazakov DV, Cooper K, Michal M
Pathologica 2006 Aug;98(4):239-98. PMID: 17175794
Lacrimal gland amyloidosis.
Cheng JY, Fong KS, Cheah ES, Choo CT
Ophthalmic Plast Reconstr Surg 2006 Jul-Aug;22(4):306-8. doi: 10.1097/01.iop.0000222354.44000.eb. PMID: 16855510
Clinical and computed tomographic characteristics of amyloid tumor of the lacrimal gland.
Massry GG, Harrison W, Hornblass A
Ophthalmology 1996 Aug;103(8):1233-6. doi: 10.1016/s0161-6420(96)30517-4. PMID: 8764792
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations.
Silverman JF, Dabbs DJ, Norris HT, Pories WJ, Legier J, Kay S
Am J Surg Pathol 1986 Aug;10(8):539-45. doi: 10.1097/00000478-198608000-00003. PMID: 3526931

Therapy

Progression of dialysis-related amyloidoma towards pathologic fracture.
Baal JD, Horvai AE, Link TM
Skeletal Radiol 2019 Feb;48(2):301-306. Epub 2018 Jun 26 doi: 10.1007/s00256-018-3009-2. PMID: 29946879
SMASH-U versus H-ATOMIC: A Head-to-Head Comparison for the Etiologic Classification of Intracerebral Hemorrhage.
Martí-Fàbregas J, Prats-Sánchez L, Guisado-Alonso D, Martínez-Domeño A, Delgado-Mederos R, Camps-Renom P
J Stroke Cerebrovasc Dis 2018 Sep;27(9):2375-2380. Epub 2018 May 18 doi: 10.1016/j.jstrokecerebrovasdis.2018.04.026. PMID: 29779884
Efficacy of anakinra in a patient with systemic amyloidosis presenting as amyloidoma.
Nalcacioglu H, Ozkaya O, Genc G, Ayyildiz S, Kefeli M, Elli M, Aydin O, Ceyhan Bilgici M
Int J Rheum Dis 2018 Feb;21(2):552-559. Epub 2017 Dec 13 doi: 10.1111/1756-185X.13250. PMID: 29239128
Genital beta2-microglobulin amyloidoma in a long-term dialysis patient.
Okuda I, Ubara Y, Takaichi K, Kitajima I, Motoi N, Hara S, Kokubo T
Am J Kidney Dis 2006 Sep;48(3):e35-9. doi: 10.1053/j.ajkd.2006.05.009. PMID: 16931206
Specific imaging of dialysis-related amyloid deposits using 131I-beta-2-microglobulin.
Floege J, Nonnast-Daniel B, Gielow P, Brandis A, Spindler E, Hundeshagen H, Koch KM, Shaldon S
Nephron 1989;51(3):444-7. doi: 10.1159/000185351. PMID: 2645537

Prognosis

SMASH-U versus H-ATOMIC: A Head-to-Head Comparison for the Etiologic Classification of Intracerebral Hemorrhage.
Martí-Fàbregas J, Prats-Sánchez L, Guisado-Alonso D, Martínez-Domeño A, Delgado-Mederos R, Camps-Renom P
J Stroke Cerebrovasc Dis 2018 Sep;27(9):2375-2380. Epub 2018 May 18 doi: 10.1016/j.jstrokecerebrovasdis.2018.04.026. PMID: 29779884
Soft-tissue amyloidoma of the extremities: a case report and review of literature.
Maheshwari AV, Muro-Cacho CA, Kransdorf MJ, Temple HT
Skeletal Radiol 2009 Mar;38(3):287-92. Epub 2008 Dec 3 doi: 10.1007/s00256-008-0621-6. PMID: 19050870
Primary localized amyloidosis of the urinary bladder. A case report.
Anavi BL, Poriazova EG, Staikova ND, Staikov DS
Folia Med (Plovdiv) 2001;43(3):47-52. PMID: 11930833
Calcifying amyloidoma of the breast.
Symonds DA, Eichelberger MF, Sager GL
South Med J 1995 Nov;88(11):1169-72. doi: 10.1097/00007611-199511000-00021. PMID: 7481996
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations.
Silverman JF, Dabbs DJ, Norris HT, Pories WJ, Legier J, Kay S
Am J Surg Pathol 1986 Aug;10(8):539-45. doi: 10.1097/00000478-198608000-00003. PMID: 3526931

Clinical prediction guides

SMASH-U versus H-ATOMIC: A Head-to-Head Comparison for the Etiologic Classification of Intracerebral Hemorrhage.
Martí-Fàbregas J, Prats-Sánchez L, Guisado-Alonso D, Martínez-Domeño A, Delgado-Mederos R, Camps-Renom P
J Stroke Cerebrovasc Dis 2018 Sep;27(9):2375-2380. Epub 2018 May 18 doi: 10.1016/j.jstrokecerebrovasdis.2018.04.026. PMID: 29779884
Lacrimal gland amyloidosis.
Cheng JY, Fong KS, Cheah ES, Choo CT
Ophthalmic Plast Reconstr Surg 2006 Jul-Aug;22(4):306-8. doi: 10.1097/01.iop.0000222354.44000.eb. PMID: 16855510
Primary localized nodular tongue amyloidosis associated with Sjögren's syndrome.
Haraguchi H, Ohashi K, Yamada M, Hasegawa M, Maeda S, Komatsuzaki A
ORL J Otorhinolaryngol Relat Spec 1997 Jan-Feb;59(1):60-3. doi: 10.1159/000276907. PMID: 9104752
Localized primary amyloid tumor of the thyroid developing in the course of Hashimoto's thyroiditis.
Moriuchi A, Yokoyama S, Kashima K, Andoh T, Nakayama I, Noguchi S
Acta Pathol Jpn 1992 Mar;42(3):210-6. doi: 10.1111/j.1440-1827.1992.tb01673.x. PMID: 1570743
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations.
Silverman JF, Dabbs DJ, Norris HT, Pories WJ, Legier J, Kay S
Am J Surg Pathol 1986 Aug;10(8):539-45. doi: 10.1097/00000478-198608000-00003. PMID: 3526931

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