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Chandler syndrome

MedGen UID:
107777
•Concept ID:
C0544008
•
Disease or Syndrome
Synonym: Chandler's syndrome
SNOMED CT: Chandler syndrome (392481002)
 
Monarch Initiative: MONDO:0020369
Orphanet: ORPHA98979

Definition

A rare disorder of the eye in which the endothelium lining the interior of the cornea proliferates causing unusually high pressure in the eye, distortion of the iris and corneal edema. [from SNOMEDCT_US]

Professional guidelines

PubMed

Diagnosis and Management of Iridocorneal Endothelial Syndrome.
Sacchetti M, Mantelli F, Marenco M, Macchi I, Ambrosio O, Rama P
Biomed Res Int 2015;2015:763093. Epub 2015 Sep 16 doi: 10.1155/2015/763093. PMID: 26451377Free PMC Article

Recent clinical studies

Etiology

Iridocorneal Endothelial Syndrome: Case Report of Essential Progressive Iris Atrophy.
Beganovic AP, Vodencarevic AN, Halilbasic M, Medjedovic A
Med Arch 2022 Jun;76(3):224-228. doi: 10.5455/medarh.2022.76.224-228. PMID: 36200117Free PMC Article
Atypical Case of Bilateral Chandler Syndrome With Recurrent Band Keratopathy.
Agarwal M, Dhiman R, Subramanian K
Cornea 2021 Oct 1;40(10):1353-1356. doi: 10.1097/ICO.0000000000002610. PMID: 33264150
The iridocorneal endothelial syndrome.
Silva L, Najafi A, Suwan Y, Teekhasaenee C, Ritch R
Surv Ophthalmol 2018 Sep-Oct;63(5):665-676. Epub 2018 Jan 11 doi: 10.1016/j.survophthal.2018.01.001. PMID: 29331589
Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects.
Chandran P, Rao HL, Mandal AK, Choudhari NS, Garudadri CS, Senthil S
PLoS One 2017;12(3):e0171884. Epub 2017 Mar 10 doi: 10.1371/journal.pone.0171884. PMID: 28282413Free PMC Article
Diagnosis and Management of Iridocorneal Endothelial Syndrome.
Sacchetti M, Mantelli F, Marenco M, Macchi I, Ambrosio O, Rama P
Biomed Res Int 2015;2015:763093. Epub 2015 Sep 16 doi: 10.1155/2015/763093. PMID: 26451377Free PMC Article

Diagnosis

Iridocorneal Endothelial Syndrome: Case Report of Essential Progressive Iris Atrophy.
Beganovic AP, Vodencarevic AN, Halilbasic M, Medjedovic A
Med Arch 2022 Jun;76(3):224-228. doi: 10.5455/medarh.2022.76.224-228. PMID: 36200117Free PMC Article
Atypical Case of Bilateral Chandler Syndrome With Recurrent Band Keratopathy.
Agarwal M, Dhiman R, Subramanian K
Cornea 2021 Oct 1;40(10):1353-1356. doi: 10.1097/ICO.0000000000002610. PMID: 33264150
The iridocorneal endothelial syndrome.
Silva L, Najafi A, Suwan Y, Teekhasaenee C, Ritch R
Surv Ophthalmol 2018 Sep-Oct;63(5):665-676. Epub 2018 Jan 11 doi: 10.1016/j.survophthal.2018.01.001. PMID: 29331589
Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects.
Chandran P, Rao HL, Mandal AK, Choudhari NS, Garudadri CS, Senthil S
PLoS One 2017;12(3):e0171884. Epub 2017 Mar 10 doi: 10.1371/journal.pone.0171884. PMID: 28282413Free PMC Article
Diagnosis and Management of Iridocorneal Endothelial Syndrome.
Sacchetti M, Mantelli F, Marenco M, Macchi I, Ambrosio O, Rama P
Biomed Res Int 2015;2015:763093. Epub 2015 Sep 16 doi: 10.1155/2015/763093. PMID: 26451377Free PMC Article

Therapy

Atypical Case of Bilateral Chandler Syndrome With Recurrent Band Keratopathy.
Agarwal M, Dhiman R, Subramanian K
Cornea 2021 Oct 1;40(10):1353-1356. doi: 10.1097/ICO.0000000000002610. PMID: 33264150

Prognosis

Cornea thinning in two cases of ICE syndrome.
Harvey MM, Schmitz JW
BMJ Case Rep 2020 Sep 28;13(9) doi: 10.1136/bcr-2020-236354. PMID: 32988977Free PMC Article
Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects.
Chandran P, Rao HL, Mandal AK, Choudhari NS, Garudadri CS, Senthil S
PLoS One 2017;12(3):e0171884. Epub 2017 Mar 10 doi: 10.1371/journal.pone.0171884. PMID: 28282413Free PMC Article
Boston Type 1 Keratoprosthesis for Iridocorneal Endothelial Syndromes.
Phillips DL, Goins KM, Greiner MA, Alward WL, Kwon YH, Wagoner MD
Cornea 2015 Nov;34(11):1383-6. doi: 10.1097/ICO.0000000000000616. PMID: 26398156

Clinical prediction guides

Iridocorneal Endothelial Syndrome: Case Report of Essential Progressive Iris Atrophy.
Beganovic AP, Vodencarevic AN, Halilbasic M, Medjedovic A
Med Arch 2022 Jun;76(3):224-228. doi: 10.5455/medarh.2022.76.224-228. PMID: 36200117Free PMC Article
Atypical Case of Bilateral Chandler Syndrome With Recurrent Band Keratopathy.
Agarwal M, Dhiman R, Subramanian K
Cornea 2021 Oct 1;40(10):1353-1356. doi: 10.1097/ICO.0000000000002610. PMID: 33264150

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