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Hepatitis C, Chronic

MedGen UID:
105623
Concept ID:
C0524910
Disease or Syndrome
Synonym: Chronic Hepatitis C
SNOMED CT: Chronic type C viral hepatitis (128302006); Chronic hepatitis C (128302006)

Definition

Persistent and long-standing hepatitis C infection. Presenting signs and symptoms may be mild but severe findings likely indicate progression to advanced disease including cirrhosis and liver cancer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis C, Chronic

Professional guidelines

PubMed

Abu-Freha N, Mathew Jacob B, Elhoashla A, Afawi Z, Abu-Hammad T, Elsana F, Paz S, Etzion O
Eur J Gen Pract 2022 Dec;28(1):102-108. doi: 10.1080/13814788.2022.2056161. PMID: 35579223Free PMC Article
Lanini S, Ustianowski A, Pisapia R, Zumla A, Ippolito G
Infect Dis Clin North Am 2019 Dec;33(4):1045-1062. doi: 10.1016/j.idc.2019.08.004. PMID: 31668190
Zeuzem S
Dtsch Arztebl Int 2017 Jan 9;114(1-02):11-21. doi: 10.3238/arztebl.2017.0011. PMID: 28143635Free PMC Article

Recent clinical studies

Etiology

Te H, Doucette K
Clin Transplant 2019 Sep;33(9):e13514. Epub 2019 Apr 14 doi: 10.1111/ctr.13514. PMID: 30817047
Mysore KR, Leung DH
Clin Liver Dis 2018 Nov;22(4):703-722. Epub 2018 Aug 22 doi: 10.1016/j.cld.2018.06.002. PMID: 30266158
Ahmad J
BMJ 2017 Jul 6;358:j2861. doi: 10.1136/bmj.j2861. PMID: 28684552
Conde I, Vinaixa C, Berenguer M
Med Clin (Barc) 2017 Jan 20;148(2):78-85. Epub 2016 Nov 14 doi: 10.1016/j.medcli.2016.09.019. PMID: 27855947
Macías J, Vispo E, Pineda JA, Soriano V
Curr Opin HIV AIDS 2011 Nov;6(6):491-500. doi: 10.1097/COH.0b013e32834bca2d. PMID: 21918436

Diagnosis

Manns MP, Maasoumy B
Nat Rev Gastroenterol Hepatol 2022 Aug;19(8):533-550. Epub 2022 May 20 doi: 10.1038/s41575-022-00608-8. PMID: 35595834Free PMC Article
Mysore KR, Leung DH
Clin Liver Dis 2018 Nov;22(4):703-722. Epub 2018 Aug 22 doi: 10.1016/j.cld.2018.06.002. PMID: 30266158
Kusari A, Ahluwalia J
N Engl J Med 2018 Aug 9;379(6):567. doi: 10.1056/NEJMicm1802078. PMID: 30089065
Ahmad J
BMJ 2017 Jul 6;358:j2861. doi: 10.1136/bmj.j2861. PMID: 28684552
Macías J, Vispo E, Pineda JA, Soriano V
Curr Opin HIV AIDS 2011 Nov;6(6):491-500. doi: 10.1097/COH.0b013e32834bca2d. PMID: 21918436

Therapy

Jakobsen JC, Nielsen EE, Feinberg J, Katakam KK, Fobian K, Hauser G, Poropat G, Djurisic S, Weiss KH, Bjelakovic M, Bjelakovic G, Klingenberg SL, Liu JP, Nikolova D, Koretz RL, Gluud C
Cochrane Database Syst Rev 2017 Sep 18;9(9):CD012143. doi: 10.1002/14651858.CD012143.pub3. PMID: 28922704Free PMC Article
Jakobsen JC, Nielsen EE, Feinberg J, Katakam KK, Fobian K, Hauser G, Poropat G, Djurisic S, Weiss KH, Bjelakovic M, Bjelakovic G, Klingenberg SL, Liu JP, Nikolova D, Koretz RL, Gluud C
Cochrane Database Syst Rev 2017 Jun 6;6(6):CD012143. doi: 10.1002/14651858.CD012143.pub2. PMID: 28585310Free PMC Article
Menon RM, Polepally AR, Khatri A, Awni WM, Dutta S
Clin Pharmacokinet 2017 Oct;56(10):1125-1137. doi: 10.1007/s40262-017-0520-x. PMID: 28236252
Nikolova K, Gluud C, Grevstad B, Jakobsen JC
Cochrane Database Syst Rev 2014 Apr 6;2014(4):CD009182. doi: 10.1002/14651858.CD009182.pub2. PMID: 24706397Free PMC Article
Med Lett Drugs Ther 2014 Jan 20;56(1434):5-6. PMID: 24457562

Prognosis

Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM
Hepatology 2020 Nov;72(5):1605-1616. Epub 2020 Oct 27 doi: 10.1002/hep.31173. PMID: 32043613
Williams R
Hepatol Int 2019 Jul;13(4):403-406. Epub 2019 Jul 4 doi: 10.1007/s12072-019-09959-y. PMID: 31273617Free PMC Article
Simoncini GM, Koren DE
J Am Board Fam Med 2019 May-Jun;32(3):428-430. doi: 10.3122/jabfm.2019.03.180286. PMID: 31068409
Wu T, Konyn PG, Cattaneo AW, Saab S
Dig Dis Sci 2019 Jul;64(7):1782-1788. Epub 2019 Feb 13 doi: 10.1007/s10620-019-05511-y. PMID: 30756208
Falade-Nwulia O, Sulkowski MS, Merkow A, Latkin C, Mehta SH
J Viral Hepat 2018 Mar;25(3):220-227. doi: 10.1111/jvh.12859. PMID: 29316030Free PMC Article

Clinical prediction guides

Valva P, Ríos DA, De Matteo E, Preciado MV
World J Gastroenterol 2016 Jan 28;22(4):1367-81. doi: 10.3748/wjg.v22.i4.1367. PMID: 26819506Free PMC Article
Dhingra S, Ward SC, Thung SN
World J Gastroenterol 2016 Jan 28;22(4):1357-66. doi: 10.3748/wjg.v22.i4.1357. PMID: 26819505Free PMC Article
Guido M, Mangia A, Faa G; Gruppo Italiano Patologi Apparato Digerente (GIPAD); Società Italiana di Anatomia Patologica e Citopatologia Diagnostica/International Academy of Pathology, Italian division (SIAPEC/IAP)
Dig Liver Dis 2011 Mar;43 Suppl 4:S331-43. doi: 10.1016/S1590-8658(11)60589-6. PMID: 21459339
Sterling RK, Lissen E, Clumeck N, Sola R, Correa MC, Montaner J, S Sulkowski M, Torriani FJ, Dieterich DT, Thomas DL, Messinger D, Nelson M; APRICOT Clinical Investigators
Hepatology 2006 Jun;43(6):1317-25. doi: 10.1002/hep.21178. PMID: 16729309
Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS, Lok AS
Hepatology 2003 Aug;38(2):518-26. doi: 10.1053/jhep.2003.50346. PMID: 12883497

Recent systematic reviews

Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM
Hepatology 2020 Nov;72(5):1605-1616. Epub 2020 Oct 27 doi: 10.1002/hep.31173. PMID: 32043613
Jakobsen JC, Nielsen EE, Feinberg J, Katakam KK, Fobian K, Hauser G, Poropat G, Djurisic S, Weiss KH, Bjelakovic M, Bjelakovic G, Klingenberg SL, Liu JP, Nikolova D, Koretz RL, Gluud C
Cochrane Database Syst Rev 2017 Sep 18;9(9):CD012143. doi: 10.1002/14651858.CD012143.pub3. PMID: 28922704Free PMC Article
Jakobsen JC, Nielsen EE, Feinberg J, Katakam KK, Fobian K, Hauser G, Poropat G, Djurisic S, Weiss KH, Bjelakovic M, Bjelakovic G, Klingenberg SL, Liu JP, Nikolova D, Koretz RL, Gluud C
Cochrane Database Syst Rev 2017 Jun 6;6(6):CD012143. doi: 10.1002/14651858.CD012143.pub2. PMID: 28585310Free PMC Article
Polaris Observatory HCV Collaborators
Lancet Gastroenterol Hepatol 2017 Mar;2(3):161-176. Epub 2016 Dec 16 doi: 10.1016/S2468-1253(16)30181-9. PMID: 28404132
Mohsen A, Norris S
BMJ Clin Evid 2010 Feb 3;2010 PMID: 21718581Free PMC Article

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