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Caffeine withdrawal

MedGen UID:
636735
•Concept ID:
C0521652
•
Mental or Behavioral Dysfunction
Synonym: Caffeine withdrawal syndrome
SNOMED CT: Caffeine withdrawal (95635002); Caffeine withdrawal syndrome (95635002)

Professional guidelines

PubMed

The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment.
Nowaczewska M, Wiciński M, Kaźmierczak W
Nutrients 2020 Jul 28;12(8) doi: 10.3390/nu12082259. PMID: 32731623Free PMC Article
Challenges in Treatment of Inappropriate Sinus Tachycardia.
Ruzieh M, Moustafa A, Sabbagh E, Karim MM, Karim S
Curr Cardiol Rev 2018 Mar 14;14(1):42-44. doi: 10.2174/1573403X13666171129183826. PMID: 29189171Free PMC Article
DSM-5 criteria for substance use disorders: recommendations and rationale.
Hasin DS, O'Brien CP, Auriacombe M, Borges G, Bucholz K, Budney A, Compton WM, Crowley T, Ling W, Petry NM, Schuckit M, Grant BF
Am J Psychiatry 2013 Aug;170(8):834-51. doi: 10.1176/appi.ajp.2013.12060782. PMID: 23903334Free PMC Article

Recent clinical studies

Etiology

Caffeine consumption and withdrawal among patients in the intensive care unit.
Edwards F, Bright M, Dux C, Coyer F, Laupland KB
Aust Crit Care 2024 May;37(3):436-440. Epub 2023 Apr 27 doi: 10.1016/j.aucc.2023.03.004. PMID: 37120336
Reduction in caffeine withdrawal after open-label decaffeinated coffee.
Mills L, Lee JC, Boakes R, Colagiuri B
J Psychopharmacol 2023 Feb;37(2):181-191. Epub 2023 Jan 11 doi: 10.1177/02698811221147152. PMID: 36628993
Caffeine supplementation in the hospital: Potential role for the treatment of caffeine withdrawal.
Agritelley MS, Goldberger JJ
Food Chem Toxicol 2021 Jul;153:112228. Epub 2021 Apr 28 doi: 10.1016/j.fct.2021.112228. PMID: 33932520
DSM-5 criteria for substance use disorders: recommendations and rationale.
Hasin DS, O'Brien CP, Auriacombe M, Borges G, Bucholz K, Budney A, Compton WM, Crowley T, Ling W, Petry NM, Schuckit M, Grant BF
Am J Psychiatry 2013 Aug;170(8):834-51. doi: 10.1176/appi.ajp.2013.12060782. PMID: 23903334Free PMC Article
Fasting headache.
Torelli P, Manzoni GC
Curr Pain Headache Rep 2010 Aug;14(4):284-91. doi: 10.1007/s11916-010-0119-5. PMID: 20490742

Diagnosis

Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan.
Magdy R, El Desouky ED, Hammad EM, Salem MR, Mahfouz NA, Fathy W, Al-Azayem SA, Naguib EM, Hussein M
Headache 2023 Mar;63(3):360-367. doi: 10.1111/head.14483. PMID: 36942412
Craving espresso: the dialetics in classifying caffeine as an abuse drug.
Dos Santos MKF, Gavioli EC, Rosa LS, de Paula Soares-Rachetti V, Lobão-Soares B
Naunyn Schmiedebergs Arch Pharmacol 2018 Dec;391(12):1301-1318. Epub 2018 Oct 18 doi: 10.1007/s00210-018-1570-9. PMID: 30338342
DSM-5 criteria for substance use disorders: recommendations and rationale.
Hasin DS, O'Brien CP, Auriacombe M, Borges G, Bucholz K, Budney A, Compton WM, Crowley T, Ling W, Petry NM, Schuckit M, Grant BF
Am J Psychiatry 2013 Aug;170(8):834-51. doi: 10.1176/appi.ajp.2013.12060782. PMID: 23903334Free PMC Article
Should caffeine abuse, dependence, or withdrawal be added to DSM-IV and ICD-10?
Hughes JR, Oliveto AH, Helzer JE, Higgins ST, Bickel WK
Am J Psychiatry 1992 Jan;149(1):33-40. doi: 10.1176/ajp.149.1.33. PMID: 1728182
Psychotropic effects of caffeine.
Clementz GL, Dailey JW
Am Fam Physician 1988 May;37(5):167-72. PMID: 3284301

Therapy

Caffeine for Headaches: Helpful or Harmful? A Brief Review of the Literature.
Zduńska A, Cegielska J, Zduński S, Domitrz I
Nutrients 2023 Jul 17;15(14) doi: 10.3390/nu15143170. PMID: 37513588Free PMC Article
The impact of daily caffeine intake on nighttime sleep in young adult men.
Weibel J, Lin YS, Landolt HP, Kistler J, Rehm S, Rentsch KM, Slawik H, Borgwardt S, Cajochen C, Reichert CF
Sci Rep 2021 Feb 25;11(1):4668. doi: 10.1038/s41598-021-84088-x. PMID: 33633278Free PMC Article
The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment.
Nowaczewska M, Wiciński M, Kaźmierczak W
Nutrients 2020 Jul 28;12(8) doi: 10.3390/nu12082259. PMID: 32731623Free PMC Article
Diet and Headache: Part 1.
Martin VT, Vij B
Headache 2016 Oct;56(9):1543-1552. doi: 10.1111/head.12953. PMID: 27699780
Fasting headache.
Torelli P, Manzoni GC
Curr Pain Headache Rep 2010 Aug;14(4):284-91. doi: 10.1007/s11916-010-0119-5. PMID: 20490742

Prognosis

Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake.
Weibel J, Lin YS, Landolt HP, Garbazza C, Kolodyazhniy V, Kistler J, Rehm S, Rentsch K, Borgwardt S, Cajochen C, Reichert CF
Prog Neuropsychopharmacol Biol Psychiatry 2020 Apr 20;99:109851. Epub 2019 Dec 19 doi: 10.1016/j.pnpbp.2019.109851. PMID: 31866308
Caffeine use disorder: An item-response theory analysis of proposed DSM-5 criteria.
Ágoston C, Urbán R, Richman MJ, Demetrovics Z
Addict Behav 2018 Jun;81:109-116. Epub 2018 Feb 9 doi: 10.1016/j.addbeh.2018.02.012. PMID: 29454178
Migraine exacerbation during Ramadan fasting.
Abu-Salameh I, Plakht Y, Ifergane G
J Headache Pain 2010 Dec;11(6):513-7. Epub 2010 Jul 22 doi: 10.1007/s10194-010-0242-z. PMID: 20652352Free PMC Article
A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features.
Juliano LM, Griffiths RR
Psychopharmacology (Berl) 2004 Oct;176(1):1-29. Epub 2004 Sep 21 doi: 10.1007/s00213-004-2000-x. PMID: 15448977
The first-of-Ramadan headache.
Awada A, al Jumah M
Headache 1999 Jul-Aug;39(7):490-3. doi: 10.1046/j.1526-4610.1999.3907490.x. PMID: 11279933

Clinical prediction guides

The caffeine dilemma: unraveling the intricate relationship between caffeine use disorder, caffeine withdrawal symptoms and mental well-being in adults.
Bodur M, Kaya S, Ilhan-Esgin M, Çakiroğlu FP, Özçelik AÖ
Public Health Nutr 2024 Feb 2;27(1):e57. doi: 10.1017/S1368980024000399. PMID: 38305102Free PMC Article
Reduction in caffeine withdrawal after open-label decaffeinated coffee.
Mills L, Lee JC, Boakes R, Colagiuri B
J Psychopharmacol 2023 Feb;37(2):181-191. Epub 2023 Jan 11 doi: 10.1177/02698811221147152. PMID: 36628993
Diet and Headache: Part 1.
Martin VT, Vij B
Headache 2016 Oct;56(9):1543-1552. doi: 10.1111/head.12953. PMID: 27699780
Caffeine withdrawal and high-intensity endurance cycling performance.
Irwin C, Desbrow B, Ellis A, O'Keeffe B, Grant G, Leveritt M
J Sports Sci 2011 Mar;29(5):509-15. doi: 10.1080/02640414.2010.541480. PMID: 21279864
Caffeine and its effects on pregnancy and the neonate.
McKim EM
J Nurse Midwifery 1991 Jul-Aug;36(4):226-31. doi: 10.1016/0091-2182(91)90083-2. PMID: 1895171

Recent systematic reviews

Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine.
Carvalho A, Marticorena FM, Grecco BH, Barreto G, Saunders B
Sports Med 2022 Sep;52(9):2209-2220. Epub 2022 May 10 doi: 10.1007/s40279-022-01685-0. PMID: 35536449
Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review.
Bright M, Raman V, Laupland KB
BMC Anesthesiol 2021 Mar 31;21(1):100. doi: 10.1186/s12871-021-01320-x. PMID: 33789583Free PMC Article

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