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Benign Liver Neoplasm

MedGen UID:
635614
•Concept ID:
C0496870
•
Neoplastic Process
Synonyms: Benign Liver and Intrahepatic Bile Duct Neoplasm; Benign neoplasm of liver; Benign tumor of liver
SNOMED CT: Benign neoplasm of liver (92186001); Benign tumor of liver (92186001)

Definition

A neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Viral hepatitis in haemophilia: historical perspective and current management.
Isfordink CJ, van Erpecum KJ, van der Valk M, Mauser-Bunschoten EP, Makris M
Br J Haematol 2021 Oct;195(2):174-185. Epub 2021 May 6 doi: 10.1111/bjh.17438. PMID: 33955555
Focal Nodular Hyperplasia and Hepatic Adenoma: Evaluation and Management.
Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174

Recent clinical studies

Etiology

Regression of multiple hepatocellular adenomas after cessation of oral contraceptive pills: a case report and review of the current literature.
Moors G, Poels H, Vandecaveye V, Roskams T, Verslype C
Acta Gastroenterol Belg 2021 Jul-Sep;84(3):505-508. doi: 10.51821/84.3.017. PMID: 34599577
Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Laparoscopic hepatectomy is superior to open procedures for hepatic hemangioma.
Yan C, Li BH, Sun XT, Yu DC
Hepatobiliary Pancreat Dis Int 2021 Apr;20(2):142-146. Epub 2020 Sep 13 doi: 10.1016/j.hbpd.2020.09.001. PMID: 32980268
PET-avid hepatocellular adenomas: incidental findings associated with HNF1-α mutated lesions.
Lee SY, Kingham TP, LaGratta MD, Jessurun J, Cherqui D, Jarnagin WR, Kluger MD
HPB (Oxford) 2016 Jan;18(1):41-8. Epub 2015 Dec 11 doi: 10.1016/j.hpb.2015.07.001. PMID: 26776850Free PMC Article
Systematic review of hepatocellular adenoma in China and other regions.
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

Diagnosis

Regression of multiple hepatocellular adenomas after cessation of oral contraceptive pills: a case report and review of the current literature.
Moors G, Poels H, Vandecaveye V, Roskams T, Verslype C
Acta Gastroenterol Belg 2021 Jul-Sep;84(3):505-508. doi: 10.51821/84.3.017. PMID: 34599577
Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Hepatocellular adenoma showing high uptake of (18)F-fluorodeoxyglucose (FDG) via an increased expression of glucose transporter 2 (GLUT-2).
Nakashima T, Takayama Y, Nishie A, Asayama Y, Baba S, Yamashita Y, Shirabe K, Kubo Y, Hida T, Honda H
Clin Imaging 2014 Nov-Dec;38(6):888-91. Epub 2014 Jun 12 doi: 10.1016/j.clinimag.2014.06.005. PMID: 25034402
Ruptured cystic mesenchymal hamartoma: an unusual cause of neonatal ascites.
George JC, Cohen MD, Tarver RD, Rosales RN
Pediatr Radiol 1994;24(4):304-5. doi: 10.1007/BF02015467. PMID: 7800461
Benign liver tumors.
Ros PR, Li KC
Curr Probl Diagn Radiol 1989 May-Jun;18(3):125-55. doi: 10.1016/0363-0188(89)90027-3. PMID: 2544347

Therapy

Regression of multiple hepatocellular adenomas after cessation of oral contraceptive pills: a case report and review of the current literature.
Moors G, Poels H, Vandecaveye V, Roskams T, Verslype C
Acta Gastroenterol Belg 2021 Jul-Sep;84(3):505-508. doi: 10.51821/84.3.017. PMID: 34599577
Laparoscopic hepatectomy is superior to open procedures for hepatic hemangioma.
Yan C, Li BH, Sun XT, Yu DC
Hepatobiliary Pancreat Dis Int 2021 Apr;20(2):142-146. Epub 2020 Sep 13 doi: 10.1016/j.hbpd.2020.09.001. PMID: 32980268
Systematic review of hepatocellular adenoma in China and other regions.
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

Prognosis

Laparoscopic hepatectomy is superior to open procedures for hepatic hemangioma.
Yan C, Li BH, Sun XT, Yu DC
Hepatobiliary Pancreat Dis Int 2021 Apr;20(2):142-146. Epub 2020 Sep 13 doi: 10.1016/j.hbpd.2020.09.001. PMID: 32980268
PET-avid hepatocellular adenomas: incidental findings associated with HNF1-α mutated lesions.
Lee SY, Kingham TP, LaGratta MD, Jessurun J, Cherqui D, Jarnagin WR, Kluger MD
HPB (Oxford) 2016 Jan;18(1):41-8. Epub 2015 Dec 11 doi: 10.1016/j.hpb.2015.07.001. PMID: 26776850Free PMC Article
Systematic review of hepatocellular adenoma in China and other regions.
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

Clinical prediction guides

Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Laparoscopic hepatectomy is superior to open procedures for hepatic hemangioma.
Yan C, Li BH, Sun XT, Yu DC
Hepatobiliary Pancreat Dis Int 2021 Apr;20(2):142-146. Epub 2020 Sep 13 doi: 10.1016/j.hbpd.2020.09.001. PMID: 32980268
PET-avid hepatocellular adenomas: incidental findings associated with HNF1-α mutated lesions.
Lee SY, Kingham TP, LaGratta MD, Jessurun J, Cherqui D, Jarnagin WR, Kluger MD
HPB (Oxford) 2016 Jan;18(1):41-8. Epub 2015 Dec 11 doi: 10.1016/j.hpb.2015.07.001. PMID: 26776850Free PMC Article
Systematic review of hepatocellular adenoma in China and other regions.
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790
Laparoscopic enucleation of liver tumors. Corkscrew technique revisited.
Makdissi FF, Surjan RC, Machado MA
J Surg Oncol 2009 Mar 1;99(3):166-8. doi: 10.1002/jso.21206. PMID: 19065641

Recent systematic reviews

Systematic review of hepatocellular adenoma in China and other regions.
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

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