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Osteomalacia in adults

MedGen UID:
141658
•Concept ID:
C0477680
•
Disease or Syndrome

Professional guidelines

PubMed

New developments in our understanding of vitamin metabolism, action and treatment.
Christakos S, Li S, De La Cruz J, Bikle DD
Metabolism 2019 Sep;98:112-120. Epub 2019 Jun 19 doi: 10.1016/j.metabol.2019.06.010. PMID: 31226354Free PMC Article

Recent clinical studies

Etiology

Calcifediol (25OH Vitamin D(3)) Deficiency: A Risk Factor from Early to Old Age.
Bouillon R, Antonio L, Olarte OR
Nutrients 2022 Mar 10;14(6) doi: 10.3390/nu14061168. PMID: 35334824Free PMC Article
Endocrinology of bone mineralization: An update.
Jannin A, Kerlan V, Desailloud R
Ann Endocrinol (Paris) 2022 Feb;83(1):46-53. Epub 2021 Dec 16 doi: 10.1016/j.ando.2021.12.001. PMID: 34921812
Consensus Recommendations for the Diagnosis and Management of X-Linked Hypophosphatemia in Belgium.
Laurent MR, De Schepper J, Trouet D, Godefroid N, Boros E, Heinrichs C, Bravenboer B, Velkeniers B, Lammens J, Harvengt P, Cavalier E, Kaux JF, Lombet J, De Waele K, Verroken C, van Hoeck K, Mortier GR, Levtchenko E, Vande Walle J
Front Endocrinol (Lausanne) 2021;12:641543. Epub 2021 Mar 19 doi: 10.3389/fendo.2021.641543. PMID: 33815294Free PMC Article
Nutritional rickets & osteomalacia: A practical approach to management.
Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone 2019 Apr;121:149-162. Epub 2018 Dec 18 doi: 10.1016/j.bone.2018.12.011. PMID: 30576866

Diagnosis

Diagnosis and management of tumor-induced osteomalacia: a single center experience.
Hacisahinogullari H, Tekin S, Tanrikulu S, Saribeyliler G, Yalin GY, Bilgic B, Isik EG, Salduz A, Tuncer S, Gul N, Uzum AK, Aral F, Tanakol R, Selcukbiricik OS
Endocrine 2023 Nov;82(2):427-434. Epub 2023 Jul 22 doi: 10.1007/s12020-023-03450-3. PMID: 37480497
Burosumab for the Treatment of Tumor-Induced Osteomalacia.
Jan de Beur SM, Miller PD, Weber TJ, Peacock M, Insogna K, Kumar R, Rauch F, Luca D, Cimms T, Roberts MS, San Martin J, Carpenter TO
J Bone Miner Res 2021 Apr;36(4):627-635. Epub 2021 Jan 12 doi: 10.1002/jbmr.4233. PMID: 33338281Free PMC Article
Nutritional rickets & osteomalacia: A practical approach to management.
Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Phosphate wasting disorders in adults.
Marcucci G, Masi L, Ferrarì S, Haffner D, Javaid MK, Kamenický P, Reginster JY, Rizzoli R, Brandi ML
Osteoporos Int 2018 Nov;29(11):2369-2387. Epub 2018 Jul 16 doi: 10.1007/s00198-018-4618-2. PMID: 30014155
Antacid-induced osteomalacia.
Boutsen Y, Devogelaer JP, Malghem J, Noel H, Nagant de Deuxchaisnes C
Clin Rheumatol 1996 Jan;15(1):75-80. doi: 10.1007/BF02231691. PMID: 8929782

Therapy

Burosumab: Current status and future prospects.
Goyal A, Tandon N
Best Pract Res Clin Endocrinol Metab 2024 Mar;38(2):101826. Epub 2023 Sep 30 doi: 10.1016/j.beem.2023.101826. PMID: 37858479
Burosumab Improves Patient-Reported Outcomes in Adults With Tumor-Induced Osteomalacia: Mixed-Methods Analysis.
Jan de Beur SM, Cimms T, Nixon A, Theodore-Oklota C, Luca D, Roberts MS, Egan S, Graham CA, Hribal E, Evans CJ, Wood S, Williams A
J Bone Miner Res 2023 Nov;38(11):1654-1664. Epub 2023 Sep 4 doi: 10.1002/jbmr.4900. PMID: 37578099
Burosumab for the Treatment of Tumor-Induced Osteomalacia.
Jan de Beur SM, Miller PD, Weber TJ, Peacock M, Insogna K, Kumar R, Rauch F, Luca D, Cimms T, Roberts MS, San Martin J, Carpenter TO
J Bone Miner Res 2021 Apr;36(4):627-635. Epub 2021 Jan 12 doi: 10.1002/jbmr.4233. PMID: 33338281Free PMC Article
Antacid-induced osteomalacia.
Boutsen Y, Devogelaer JP, Malghem J, Noel H, Nagant de Deuxchaisnes C
Clin Rheumatol 1996 Jan;15(1):75-80. doi: 10.1007/BF02231691. PMID: 8929782
Hypophosphataemic osteomalacia in adults.
Lancet 1971 Jun 26;1(7713):1343. PMID: 4103760

Prognosis

Approach to Hypophosphatemic Rickets.
Ackah SA, Imel EA
J Clin Endocrinol Metab 2022 Dec 17;108(1):209-220. doi: 10.1210/clinem/dgac488. PMID: 35981346Free PMC Article
Kienböck's disease in 2021.
Camus EJ, Van Overstraeten L
Orthop Traumatol Surg Res 2022 Feb;108(1S):103161. Epub 2021 Nov 30 doi: 10.1016/j.otsr.2021.103161. PMID: 34861414
Fibrogenesis Imperfecta Ossium.
Bhadada SK, Dhaliwal R, Dhiman V, Rao SD
Calcif Tissue Int 2019 May;104(5):561-569. Epub 2019 May 8 doi: 10.1007/s00223-019-00547-8. PMID: 31069441
Hypophosphatasia: An overview For 2017.
Whyte MP
Bone 2017 Sep;102:15-25. Epub 2017 Feb 24 doi: 10.1016/j.bone.2017.02.011. PMID: 28238808
Hypophosphatasia: validation and expansion of the clinical nosology for children from 25 years experience with 173 pediatric patients.
Whyte MP, Zhang F, Wenkert D, McAlister WH, Mack KE, Benigno MC, Coburn SP, Wagy S, Griffin DM, Ericson KL, Mumm S
Bone 2015 Jun;75:229-39. Epub 2015 Feb 27 doi: 10.1016/j.bone.2015.02.022. PMID: 25731960

Clinical prediction guides

Calcifediol (25OH Vitamin D(3)) Deficiency: A Risk Factor from Early to Old Age.
Bouillon R, Antonio L, Olarte OR
Nutrients 2022 Mar 10;14(6) doi: 10.3390/nu14061168. PMID: 35334824Free PMC Article
Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia.
Linglart A, Imel EA, Whyte MP, Portale AA, Högler W, Boot AM, Padidela R, Van't Hoff W, Gottesman GS, Chen A, Skrinar A, Scott Roberts M, Carpenter TO
J Clin Endocrinol Metab 2022 Feb 17;107(3):813-824. doi: 10.1210/clinem/dgab729. PMID: 34636899Free PMC Article
Fibrogenesis Imperfecta Ossium.
Bhadada SK, Dhaliwal R, Dhiman V, Rao SD
Calcif Tissue Int 2019 May;104(5):561-569. Epub 2019 May 8 doi: 10.1007/s00223-019-00547-8. PMID: 31069441
Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone 2019 Apr;121:149-162. Epub 2018 Dec 18 doi: 10.1016/j.bone.2018.12.011. PMID: 30576866
Calcium and Bone Metabolism Indices.
Song L
Adv Clin Chem 2017;82:1-46. Epub 2017 Aug 7 doi: 10.1016/bs.acc.2017.06.005. PMID: 28939209

Recent systematic reviews

Intracranial Phosphaturic Mesenchymal Tumors: A Systematic Literature Review of a Rare Entity.
Sánchez Muñoz R, Sanmillan JL, Vidal Sarró N, Martín Quintero G, Martí Duce D, Gabarrós Canals A
World Neurosurg 2024 Jul;187:70-81. Epub 2024 Mar 30 doi: 10.1016/j.wneu.2024.03.138. PMID: 38561034
Hereditary Hypophosphatemic Rickets with Hypercalciuria Presenting with Enthesopathy, Renal Cysts, and High Serum c-Terminal FGF23: Single-Center Experience and Systematic Review.
Dodamani MH, Memon SS, Karlekar M, Lila AR, Khan M, Sarathi V, Arya S, Jamale T, Thakare S, Patil VA, Shah NS, Bergwitz C, Bandgar TR
Calcif Tissue Int 2024 Feb;114(2):137-146. Epub 2023 Nov 19 doi: 10.1007/s00223-023-01156-2. PMID: 37981601
Tumor-induced Osteomalacia: A Systematic Review and Individual Patient's Data Analysis.
Rendina D, Abate V, Cacace G, D'Elia L, De Filippo G, Del Vecchio S, Galletti F, Cuocolo A, Strazzullo P
J Clin Endocrinol Metab 2022 Jul 14;107(8):e3428-e3436. doi: 10.1210/clinem/dgac253. PMID: 35468192
Vitamin D supplementation for bone health in adults with epilepsy: A systematic review.
Fernandez H, Mohammed HT, Patel T
Epilepsia 2018 Apr;59(4):885-896. Epub 2018 Feb 4 doi: 10.1111/epi.14015. PMID: 29399794
En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review.
Meng T, Zhou W, Li B, Yin H, Li Z, Zhou L, Kong J, Yan W, Yang X, Liu T, Song D, Xiao J
World J Surg Oncol 2015 May 8;13:176. doi: 10.1186/s12957-015-0589-3. PMID: 25951872Free PMC Article

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