U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Halo nevus

MedGen UID:
141636
•Concept ID:
C0474824
•
Neoplastic Process
Synonyms: Halo nevi; Leukoderma acquisitum centrifugum of Sutton
SNOMED CT: Halo nevus (78325005); Halo nevus (398028009); Sutton's nevus (398028009)
 
Monarch Initiative: MONDO:0006778
OMIM®: 234300

Definition

A melanocytic nevus characterized by circumferential depigmentation. It is usually associated with a brisk lymphocytic infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHalo nevus

Professional guidelines

PubMed

The role of reflectance confocal microscopy in the diagnosis and management of pigmentary disorders: A review.
Farabi B, Khan S, Jamgochian M, Atak MF, Jain M, Rao BK
J Cosmet Dermatol 2023 Dec;22(12):3213-3222. Epub 2023 Sep 27 doi: 10.1111/jocd.15827. PMID: 37759421
Management of resistant halo nevi.
Awad SS, Abdel Aziz RT, Mohammed SS
J Cosmet Laser Ther 2019;21(2):118-121. Epub 2018 May 9 doi: 10.1080/14764172.2018.1469772. PMID: 29741410
Risk factors and treatment responses in patients with vitiligo in Japan--A retrospective large-scale study.
Ohguchi R, Kato H, Furuhashi T, Nakamura M, Nishida E, Watanabe S, Shintani Y, Morita A
Kaohsiung J Med Sci 2015 May;31(5):260-4. Epub 2015 Mar 12 doi: 10.1016/j.kjms.2015.02.003. PMID: 25910561

Recent clinical studies

Etiology

Prognostic factors in childhood vitiligo.
Villegas-Calzada MF, Acatitla-Acevedo GA, Anda-Ortiz N, Morales-Sánchez MA
Bol Med Hosp Infant Mex 2024;81(2):73-78. doi: 10.24875/BMHIM.23000083. PMID: 38768496
Aberrant expression of HMB45 and negative PRAME expression in halo nevi.
Ruby KN, Li Z, Yan S
J Cutan Pathol 2021 Apr;48(4):519-525. Epub 2020 Nov 25 doi: 10.1111/cup.13916. PMID: 33184871
Autoimmune diseases in Turner syndrome: an overview.
De Sanctis V, Khater D
Acta Biomed 2019 Sep 6;90(3):341-344. doi: 10.23750/abm.v90i3.8737. PMID: 31580326Free PMC Article
Association of halo nevus/i and vitiligo in childhood: a retrospective observational study.
Patrizi A, Bentivogli M, Raone B, Dondi A, Tabanelli M, Neri I
J Eur Acad Dermatol Venereol 2013 Feb;27(2):e148-52. Epub 2012 Mar 15 doi: 10.1111/j.1468-3083.2012.04504.x. PMID: 22416855
Inverse halo nevus.
Gupta S, Gupta S, Mahendra A, Gupta S
Dermatol Surg 2006 Jun;32(6):871-2. doi: 10.1111/j.1524-4725.2006.32180.x. PMID: 16792661

Diagnosis

The role of reflectance confocal microscopy in the diagnosis and management of pigmentary disorders: A review.
Farabi B, Khan S, Jamgochian M, Atak MF, Jain M, Rao BK
J Cosmet Dermatol 2023 Dec;22(12):3213-3222. Epub 2023 Sep 27 doi: 10.1111/jocd.15827. PMID: 37759421
Agminated Halo Nevus: A Novel Presentation.
Hassab-El-Naby HMM, Rageh MA
Am J Dermatopathol 2023 Jun 1;45(6):388-390. Epub 2023 Mar 20 doi: 10.1097/DAD.0000000000002417. PMID: 36939134
An approach to hypopigmentation.
Hill JP, Batchelor JM
BMJ 2017 Jan 12;356:i6534. doi: 10.1136/bmj.i6534. PMID: 28082370
Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.
Wick MR, Santa Cruz DJ, Gru AA
Semin Diagn Pathol 2017 Jan;34(1):99-107. Epub 2016 Nov 29 doi: 10.1053/j.semdp.2016.11.008. PMID: 27979335
Unilateral Poliosis of Eyelashes.
Vainstein G, Nemet AY
Ophthalmic Plast Reconstr Surg 2016 May-Jun;32(3):e73-4. doi: 10.1097/IOP.0000000000000250. PMID: 25105522

Therapy

Prognostic factors in childhood vitiligo.
Villegas-Calzada MF, Acatitla-Acevedo GA, Anda-Ortiz N, Morales-Sánchez MA
Bol Med Hosp Infant Mex 2024;81(2):73-78. doi: 10.24875/BMHIM.23000083. PMID: 38768496
Multiple Halo Nevi Induced by Intense Sun Exposure.
Loesch AJ, Kleinerman R, Lau G
J Drugs Dermatol 2023 Dec 1;22(12):e31-e32. doi: 10.36849/JDD.6792. PMID: 38051850
Multiple halo naevi associated with tocilizumab.
Kuet K, Goodfield M
Clin Exp Dermatol 2014 Aug;39(6):717-9. Epub 2014 Jul 1 doi: 10.1111/ced.12385. PMID: 24986573
"Halo nevi" and UV radiation.
Pustisek N, Sikanić-Dugić N, Hirsl-Hećej V, Domljan ML
Coll Antropol 2010 Apr;34 Suppl 2:295-7. PMID: 21305746
Inverse halo nevus.
Gupta S, Gupta S, Mahendra A, Gupta S
Dermatol Surg 2006 Jun;32(6):871-2. doi: 10.1111/j.1524-4725.2006.32180.x. PMID: 16792661

Prognosis

Prognostic factors in childhood vitiligo.
Villegas-Calzada MF, Acatitla-Acevedo GA, Anda-Ortiz N, Morales-Sánchez MA
Bol Med Hosp Infant Mex 2024;81(2):73-78. doi: 10.24875/BMHIM.23000083. PMID: 38768496
Differences in the immune microenvironment between improved and non-improved cases of vitiligo after halo nevus excision.
Kano S, Nakamura M, Nojiri Y, Magara T, Yoshimitsu M, Kato H, Morita A
J Dermatol Sci 2023 Mar;109(3):136-142. Epub 2023 Mar 21 doi: 10.1016/j.jdermsci.2023.03.004. PMID: 36966028
The natural history of halo nevi: a retrospective case series.
Aouthmany M, Weinstein M, Zirwas MJ, Brodell RT
J Am Acad Dermatol 2012 Oct;67(4):582-6. Epub 2012 Mar 2 doi: 10.1016/j.jaad.2011.11.937. PMID: 22387032
Vitiligo: a review of the published work.
Yaghoobi R, Omidian M, Bagherani N
J Dermatol 2011 May;38(5):419-31. doi: 10.1111/j.1346-8138.2010.01139.x. PMID: 21667529
Inverse halo nevus.
Gupta S, Gupta S, Mahendra A, Gupta S
Dermatol Surg 2006 Jun;32(6):871-2. doi: 10.1111/j.1524-4725.2006.32180.x. PMID: 16792661

Clinical prediction guides

Analysis of granulysin expression in vitiligo and halo-nevus.
Hlača N, Vičić M, Kaštelan M, Dekanić A, Prpić-Massari L
Sci Rep 2024 Jul 17;14(1):16580. doi: 10.1038/s41598-024-67494-9. PMID: 39020008Free PMC Article
Differences in the immune microenvironment between improved and non-improved cases of vitiligo after halo nevus excision.
Kano S, Nakamura M, Nojiri Y, Magara T, Yoshimitsu M, Kato H, Morita A
J Dermatol Sci 2023 Mar;109(3):136-142. Epub 2023 Mar 21 doi: 10.1016/j.jdermsci.2023.03.004. PMID: 36966028
Aberrant expression of HMB45 and negative PRAME expression in halo nevi.
Ruby KN, Li Z, Yan S
J Cutan Pathol 2021 Apr;48(4):519-525. Epub 2020 Nov 25 doi: 10.1111/cup.13916. PMID: 33184871
Prognostic value and clinical significance of halo naevi regarding vitiligo.
van Geel N, Vandenhaute S, Speeckaert R, Brochez L, Mollet I, De Cooman L, Lambert J
Br J Dermatol 2011 Apr;164(4):743-9. Epub 2011 Mar 16 doi: 10.1111/j.1365-2133.2010.10154.x. PMID: 21114480
The immune response in halo nevi.
Zeff RA, Freitag A, Grin CM, Grant-Kels JM
J Am Acad Dermatol 1997 Oct;37(4):620-4. doi: 10.1016/s0190-9622(97)70181-6. PMID: 9344203

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...