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Follicular neoplasm

MedGen UID:
634233
•Concept ID:
C0474808
•
Neoplastic Process
Synonym: Follicular tumor
SNOMED CT: Follicular tumor (363640004); Follicular neoplasm (363640004)

Professional guidelines

PubMed

Follicular Neoplasm of Thyroid Revisited: Current Differential Diagnosis and the Impact of Molecular Testing.
Ohori NP, Nishino M
Adv Anat Pathol 2023 Jan 1;30(1):11-23. Epub 2022 Sep 14 doi: 10.1097/PAP.0000000000000368. PMID: 36102526
Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors.
Jung CK, Kim Y, Jeon S, Jo K, Lee S, Bae JS
Hum Pathol 2018 Nov;81:9-17. Epub 2018 May 1 doi: 10.1016/j.humpath.2018.04.018. PMID: 29723601
The 2017 Bethesda System for Reporting Thyroid Cytopathology.
Cibas ES, Ali SZ
Thyroid 2017 Nov;27(11):1341-1346. doi: 10.1089/thy.2017.0500. PMID: 29091573

Recent clinical studies

Etiology

Development and validation of a predictive model for assessing the risk of follicular carcinoma in thyroid nodules identified as suspicious by intraoperative frozen section.
Li C, Luo Y, Gan Y, Jiang Y, Li Q, Huang J
Front Endocrinol (Lausanne) 2024;15:1431247. Epub 2024 Sep 26 doi: 10.3389/fendo.2024.1431247. PMID: 39391875Free PMC Article

Diagnosis

Development and validation of a predictive model for assessing the risk of follicular carcinoma in thyroid nodules identified as suspicious by intraoperative frozen section.
Li C, Luo Y, Gan Y, Jiang Y, Li Q, Huang J
Front Endocrinol (Lausanne) 2024;15:1431247. Epub 2024 Sep 26 doi: 10.3389/fendo.2024.1431247. PMID: 39391875Free PMC Article

Therapy

Efficacy and safety of ultrasound-guided microwave ablation versus surgical resection for Bethesda category IV thyroid nodules: A retrospective comparative study.
Yang J, Zhang Y, Li X, Zhao Y, Han X, Chen G, Chu X, Li R, Wang J, Huang F, Liu C, Xu S
Front Endocrinol (Lausanne) 2022;13:924993. Epub 2022 Sep 23 doi: 10.3389/fendo.2022.924993. PMID: 36213294Free PMC Article
Clinicoradiological Characteristics in the Differential Diagnosis of Follicular-Patterned Lesions of the Thyroid: A Multicenter Cohort Study.
Lee JH, Ha EJ, Lee DH, Han M, Park JH, Kim JH
Korean J Radiol 2022 Jul;23(7):763-772. Epub 2022 May 31 doi: 10.3348/kjr.2022.0079. PMID: 35695317Free PMC Article
Clinicopathological features of in situ follicular neoplasm and relations with follicular lymphoma in Japan.
Ogata S, Miyoshi H, Arakawa F, Shimono J, Yamada K, Yanagida E, Nambu M, Iwashita A, Haraoka S, Ohshima K
Ann Hematol 2020 Feb;99(2):241-253. Epub 2020 Jan 2 doi: 10.1007/s00277-019-03841-5. PMID: 31897674
Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA): From A to Z.
Dionigi G, Lavazza M, Bacuzzi A, Inversini D, Pappalardo V, Tufano RP, Kim HY, Anuwong A
Surg Technol Int 2017 Feb 7;30:103-112. PMID: 28182829
Controversies in the surgical management of thyroid follicular neoplasms. Retrospective analysis of 721 patients.
Conzo G, Calò PG, Gambardella C, Tartaglia E, Mauriello C, Della Pietra C, Medas F, Santa Cruz R, Podda F, Santini L, Troncone G
Int J Surg 2014;12 Suppl 1:S29-34. Epub 2014 May 22 doi: 10.1016/j.ijsu.2014.05.013. PMID: 24859409

Prognosis

US Risk Stratification System for Follicular Thyroid Neoplasms.
Li J, Li C, Zhou X, Huang J, Yang P, Cang Y, Zhai H, Huang R, Mu Y, Gou X, Zhang Y, Yu J, Liang P
Radiology 2023 Nov;309(2):e230949. doi: 10.1148/radiol.230949. PMID: 37987664
Thyroid paraganglioma: A diagnostic pitfall in thyroid FNA.
Satturwar SP, Rossi ED, Maleki Z, Cantley RL, Faquin WC, Pantanowitz L
Cancer Cytopathol 2021 Jun;129(6):439-449. Epub 2020 Nov 24 doi: 10.1002/cncy.22390. PMID: 33232572
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
Short Review: Genomic Alterations in Hürthle Cell Carcinoma.
Ganly I, McFadden DG
Thyroid 2019 Apr;29(4):471-479. doi: 10.1089/thy.2019.0088. PMID: 30848171
The 2017 Bethesda System for Reporting Thyroid Cytopathology.
Cibas ES, Ali SZ
Thyroid 2017 Nov;27(11):1341-1346. doi: 10.1089/thy.2017.0500. PMID: 29091573

Clinical prediction guides

US Risk Stratification System for Follicular Thyroid Neoplasms.
Li J, Li C, Zhou X, Huang J, Yang P, Cang Y, Zhai H, Huang R, Mu Y, Gou X, Zhang Y, Yu J, Liang P
Radiology 2023 Nov;309(2):e230949. doi: 10.1148/radiol.230949. PMID: 37987664
Current controversies in the management of patients with indeterminate thyroid nodules.
Alqahtani SM
Saudi Med J 2023 Jul;44(7):633-639. doi: 10.15537/smj.2023.44.7.2023-0049. PMID: 37463711Free PMC Article
Diagnostic significance of CyclinD1 and D2-40 expression for follicular neoplasm of the thyroid.
Liu J, Tao LL, Yu GY, Chen G, Wang Z, Mei KY, Xu XL, Shi XX, Li TL, Yin WH
Pathol Res Pract 2022 Jan;229:153739. Epub 2021 Dec 11 doi: 10.1016/j.prp.2021.153739. PMID: 34920294
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
The 2017 Bethesda System for Reporting Thyroid Cytopathology.
Cibas ES, Ali SZ
Thyroid 2017 Nov;27(11):1341-1346. doi: 10.1089/thy.2017.0500. PMID: 29091573

Recent systematic reviews

Differentiated high grade thyroid carcinomas: Diagnostic consideration and clinical features.
Tondi Resta I, Gubbiotti MA, Montone KT, Livolsi VA, Baloch ZW
Hum Pathol 2024 Feb;144:53-60. Epub 2024 Jan 19 doi: 10.1016/j.humpath.2024.01.002. PMID: 38244615
Malignancy Risk of Follicular Neoplasm (Bethesda IV) With Variable Cutoffs of Tumor Size: A Systemic Review and Meta-Analysis.
Cho YY, Ahn SH, Lee EK, Park YJ, Choi D, Kim BY, Jung CH, Mok JO, Kim CH, Kim SW
J Clin Endocrinol Metab 2024 Apr 19;109(5):1383-1392. doi: 10.1210/clinem/dgad684. PMID: 38113188
Detailed fine needle aspiration cytopathology findings of noninvasive follicular thyroid neoplasm with papillary-like nuclear features with nuclear grading correlated to that of biopsy and Bethesda category and systematic review.
Kaçar Özkara S, Turan G
Diagn Cytopathol 2023 Dec;51(12):758-771. Epub 2023 Sep 8 doi: 10.1002/dc.25219. PMID: 37688282
Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Is Not a Cytological Diagnosis, but It Influences Cytological Diagnosis Outcomes: A Systematic Review and Meta-Analysis.
Haaga E, Kalfert D, Ludvíková M, Kholová I
Acta Cytol 2022;66(2):85-105. Epub 2021 Nov 15 doi: 10.1159/000519757. PMID: 34781293Free PMC Article
Is galectin-3 a good method for the detection of malignancy in patients with thyroid nodules and a cytologic diagnosis of "follicular neoplasm"? A critical appraisal of the evidence.
Sanabria A, Carvalho AL, Piana de Andrade V, Pablo Rodrigo J, Vartanian JG, Rinaldo A, Ikeda MK, Devaney KO, Magrin J, Augusto Soares F, Ferlito A, Kowalski LP
Head Neck 2007 Nov;29(11):1046-54. doi: 10.1002/hed.20642. PMID: 17525969

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