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Anaplastic ganglioglioma

MedGen UID:
140906
Concept ID:
C0431112
Neoplastic Process
Synonyms: AGNG; Anaplastic Ganglioglioma; anaplastic ganglioglioma; Ganglioglioma, anaplastic
SNOMED CT: Ganglioglioma, anaplastic (128912009); Anaplastic ganglioglioma (1157071000)
 
Monarch Initiative: MONDO:0016734
Orphanet: ORPHA251957

Definition

A rare mixed neuronal-glial tumor characterized by a mostly supratentorial space-occupying lesion often involving the temporal lobe, although it may occur anywhere in the central nervous system. The tumor shows anaplastic features in its glial component and is considered WHO grade III, which may, albeit inconsistently, indicate more aggressive behavior and less favorable prognosis. Clinical symptoms vary according to the location, the most common manifestation being seizures. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic ganglioglioma
Follow this link to review classifications for Anaplastic ganglioglioma in Orphanet.

Professional guidelines

PubMed

Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Mallick S, Benson R, Melgandi W, Giridhar P, Rath GK
Childs Nerv Syst 2018 Jun;34(6):1207-1213. Epub 2018 Mar 29 doi: 10.1007/s00381-018-3780-3. PMID: 29594461

Recent clinical studies

Etiology

Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A
Neuropathol Appl Neurobiol 2022 Dec;48(7):e12847. Epub 2022 Sep 16 doi: 10.1111/nan.12847. PMID: 35977725
Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Abdel Razek AAK, Elsebaie NA, Zamora C, Castillo M
J Comput Assist Tomogr 2020 May/Jun;44(3):356-369. doi: 10.1097/RCT.0000000000001010. PMID: 32217897
Avinash KS, Thakar S, Aryan S, Ghosal N, Hegde AS
Neurol India 2019 Jul-Aug;67(4):1100-1106. doi: 10.4103/0028-3886.266259. PMID: 31512645
Zanello M, Pagès M, Roux A, Peeters S, Dezamis E, Puget S, Devaux B, Sainte-Rose C, Zerah M, Louvel G, Dumont SN, Meder JF, Grill J, Huberfeld G, Chrétien F, Parraga E, Sauvageon X, Varlet P, Pallud J
Br J Neurosurg 2017 Apr;31(2):227-233. Epub 2016 Aug 23 doi: 10.1080/02688697.2016.1220506. PMID: 27550627

Diagnosis

Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A
Neuropathol Appl Neurobiol 2022 Dec;48(7):e12847. Epub 2022 Sep 16 doi: 10.1111/nan.12847. PMID: 35977725
Chen PA, Chen YC, Wei KC, Chen KT
World Neurosurg 2020 Feb;134:629-634.e1. Epub 2019 Nov 29 doi: 10.1016/j.wneu.2019.11.129. PMID: 31790835
Kaymak-Cihan M, Erdiş E, Bozkurt S, Ünver-Korğalı E
Turk J Pediatr 2018;60(1):102-106. doi: 10.24953/turkjped.2018.01.017. PMID: 30102489
Sinning M, Letelier R, Rosas C, Fuenzalida M, Lemus D
Biol Res 2012;45(2):135-8. doi: 10.4067/S0716-97602012000200005. PMID: 23096357
Chou S, Varikatt W, Dexter M, Ng T
J Clin Neurosci 2010 Jul;17(7):920-2. doi: 10.1016/j.jocn.2009.10.022. PMID: 20399667

Therapy

Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Marks AM, Bindra RS, DiLuna ML, Huttner A, Jairam V, Kahle KT, Kieran MW
Pediatr Blood Cancer 2018 May;65(5):e26969. Epub 2018 Jan 30 doi: 10.1002/pbc.26969. PMID: 29380516
Lüdemann W, Banan R, Hartmann C, Bertalanffy H, Di Rocco C
Childs Nerv Syst 2017 Feb;33(2):227-231. Epub 2016 Dec 5 doi: 10.1007/s00381-016-3302-0. PMID: 27921213
Zanello M, Pagès M, Roux A, Peeters S, Dezamis E, Puget S, Devaux B, Sainte-Rose C, Zerah M, Louvel G, Dumont SN, Meder JF, Grill J, Huberfeld G, Chrétien F, Parraga E, Sauvageon X, Varlet P, Pallud J
Br J Neurosurg 2017 Apr;31(2):227-233. Epub 2016 Aug 23 doi: 10.1080/02688697.2016.1220506. PMID: 27550627
Bautista F, Paci A, Minard-Colin V, Dufour C, Grill J, Lacroix L, Varlet P, Valteau-Couanet D, Geoerger B
Pediatr Blood Cancer 2014 Jun;61(6):1101-3. Epub 2013 Dec 3 doi: 10.1002/pbc.24891. PMID: 24375920

Prognosis

Vlachos N, Lampros MG, Zigouris A, Voulgaris S, Alexiou GA
Neurosurg Rev 2022 Feb;45(1):295-304. Epub 2021 Jul 27 doi: 10.1007/s10143-021-01612-3. PMID: 34312775
Marks AM, Bindra RS, DiLuna ML, Huttner A, Jairam V, Kahle KT, Kieran MW
Pediatr Blood Cancer 2018 May;65(5):e26969. Epub 2018 Jan 30 doi: 10.1002/pbc.26969. PMID: 29380516
Rusiecki D, Lach B, Manoranjan B, Fleming A, Ajani O, Singh SK
Hum Pathol 2017 Jan;59:125-130. Epub 2016 Sep 3 doi: 10.1016/j.humpath.2016.08.007. PMID: 27597523
Bautista F, Paci A, Minard-Colin V, Dufour C, Grill J, Lacroix L, Varlet P, Valteau-Couanet D, Geoerger B
Pediatr Blood Cancer 2014 Jun;61(6):1101-3. Epub 2013 Dec 3 doi: 10.1002/pbc.24891. PMID: 24375920
Sinning M, Letelier R, Rosas C, Fuenzalida M, Lemus D
Biol Res 2012;45(2):135-8. doi: 10.4067/S0716-97602012000200005. PMID: 23096357

Clinical prediction guides

Lisievici AC, Pasov D, Georgescu TA, Lisievici MG, Sajin M
J Med Life 2021 Mar-Apr;14(2):170-175. doi: 10.25122/jml-2021-0054. PMID: 34104239Free PMC Article
Murakami C, Yamazaki T, Shintoku R, Aihara M, Yoshimoto Y, Matsumura N, Nobusawa S, Ikota H, Hirato J, Yokoo H
Neuropathology 2018 Oct;38(5):498-502. Epub 2018 Jun 4 doi: 10.1111/neup.12479. PMID: 29869356
Zanello M, Pagès M, Roux A, Peeters S, Dezamis E, Puget S, Devaux B, Sainte-Rose C, Zerah M, Louvel G, Dumont SN, Meder JF, Grill J, Huberfeld G, Chrétien F, Parraga E, Sauvageon X, Varlet P, Pallud J
Br J Neurosurg 2017 Apr;31(2):227-233. Epub 2016 Aug 23 doi: 10.1080/02688697.2016.1220506. PMID: 27550627
Sinning M, Letelier R, Rosas C, Fuenzalida M, Lemus D
Biol Res 2012;45(2):135-8. doi: 10.4067/S0716-97602012000200005. PMID: 23096357
Selvanathan SK, Hammouche S, Salminen HJ, Jenkinson MD
J Neurooncol 2011 Dec;105(3):539-45. Epub 2011 May 29 doi: 10.1007/s11060-011-0615-4. PMID: 21626070

Recent systematic reviews

Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Bouali S, Ben Said I, Zehani A, Drissi C, Bouhoula A, Kallel J, Jemel H
World Neurosurg 2018 Nov;119:220-231. Epub 2018 Aug 8 doi: 10.1016/j.wneu.2018.07.278. PMID: 30098436

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