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Meconium stained amniotic fluid

MedGen UID:
604683
Concept ID:
C0426209
Finding
Synonyms: Amniotic fluid -meconium stain; Meconium in Amniotic Fluid; Meconium Stained Amniotic Fluid; Meconium stained liquor; Meconium staining of amniotic fluid; Meconium-stained amniotic fluid
SNOMED CT: Amniotic fluid -meconium stain (168092006); Meconium stained liquor (168092006); Meconium stained amniotic fluid (168092006)
 
HPO: HP:0012420

Definition

Amniotic fluid containing the earliest stools of a mammalian infant. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeconium stained amniotic fluid

Conditions with this feature

Hyperekplexia 3
MedGen UID:
766202
Concept ID:
C3553288
Disease or Syndrome
The signs and symptoms of hereditary hyperekplexia typically fade by age 1. However, older individuals with hereditary hyperekplexia may still startle easily and have periods of rigidity, which can cause them to fall down. They may also continue to have hypnagogic myoclonus or movements during sleep. As they get older, individuals with this condition may have a low tolerance for crowded places and loud noises. People with hereditary hyperekplexia who have epilepsy have the seizure disorder throughout their lives.\n\nHereditary hyperekplexia may explain some cases of sudden infant death syndrome (SIDS), which is a major cause of unexplained death in babies younger than 1 year.\n\nOther signs and symptoms of hereditary hyperekplexia can include muscle twitches when falling asleep (hypnagogic myoclonus) and movements of the arms or legs while asleep. Some infants, when tapped on the nose, extend their head forward and have spasms of the limb and neck muscles. Rarely, infants with hereditary hyperekplexia experience recurrent seizures (epilepsy).\n\nHereditary hyperekplexia is a condition in which affected infants have increased muscle tone (hypertonia) and an exaggerated startle reaction to unexpected stimuli, especially loud noises. Following the startle reaction, infants experience a brief period in which they are very rigid and unable to move. During these rigid periods, some infants stop breathing, which, if prolonged, can be fatal. Infants with hereditary hyperekplexia have hypertonia at all times, except when they are sleeping.
ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder
MedGen UID:
862975
Concept ID:
C4014538
Disease or Syndrome
ADNP-related disorder is characterized by hypotonia, severe speech and motor delay, mild-to-severe intellectual disability, and characteristic facial features (prominent forehead, high anterior hairline, wide and depressed nasal bridge, and short nose with full, upturned nasal tip) based on a cohort of 78 individuals. Features of autism spectrum disorder are common (stereotypic behavior, impaired social interaction). Other common findings include additional behavioral problems, sleep disturbance, brain abnormalities, seizures, feeding issues, gastrointestinal problems, visual dysfunction (hypermetropia, strabismus, cortical visual impairment), musculoskeletal anomalies, endocrine issues including short stature and hormonal deficiencies, cardiac and urinary tract anomalies, and hearing loss.
PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome
MedGen UID:
1641154
Concept ID:
C4693860
Disease or Syndrome
Chung-Jansen syndrome (CHUJANS) is characterized by global developmental delay apparent from infancy, impaired intellectual development or learning difficulties, behavioral abnormalities, dysmorphic features, and obesity. The severity of the phenotype and additional features are variable (summary by Jansen et al., 2018).

Professional guidelines

PubMed

Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Lee RH, Mara Greenberg, Metz TD, Pettker CM
Am J Obstet Gynecol 2021 Feb;224(2):B2-B9. Epub 2020 Nov 13 doi: 10.1016/j.ajog.2020.11.002. PMID: 33197417
Wood AM, Livingston EG, Hughes BL, Kuller JA
Obstet Gynecol Surv 2018 Feb;73(2):103-109. doi: 10.1097/OGX.0000000000000524. PMID: 29480924
Sentilhes L, Vayssière C, Beucher G, Deneux-Tharaux C, Deruelle P, Diemunsch P, Gallot D, Haumonté JB, Heimann S, Kayem G, Lopez E, Parant O, Schmitz T, Sellier Y, Rozenberg P, d'Ercole C
Eur J Obstet Gynecol Reprod Biol 2013 Sep;170(1):25-32. Epub 2013 Jun 28 doi: 10.1016/j.ejogrb.2013.05.015. PMID: 23810846

Recent clinical studies

Etiology

Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Xiao J, Li Z, Song Y, Sun Y, Shi H, Chen D, Zhang Y
Can J Gastroenterol Hepatol 2021;2021:6679322. Epub 2021 May 30 doi: 10.1155/2021/6679322. PMID: 34195157Free PMC Article
Hensel KL, Buchanan S, Brown SK, Rodriguez M, Cruser dA
Am J Obstet Gynecol 2015 Jan;212(1):108.e1-9. Epub 2014 Jul 25 doi: 10.1016/j.ajog.2014.07.043. PMID: 25068560Free PMC Article
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962
Wood CL
J Nurse Midwifery 1994 Mar-Apr;39(2 Suppl):106S-109S. doi: 10.1016/0091-2182(94)90068-x. PMID: 8035240

Diagnosis

Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Lee RH, Mara Greenberg, Metz TD, Pettker CM
Am J Obstet Gynecol 2021 Feb;224(2):B2-B9. Epub 2020 Nov 13 doi: 10.1016/j.ajog.2020.11.002. PMID: 33197417
Kelly LE, Shivananda S, Murthy P, Srinivasjois R, Shah PS
Cochrane Database Syst Rev 2017 Jun 28;6(6):CD006183. doi: 10.1002/14651858.CD006183.pub2. PMID: 28658507Free PMC Article
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962
Wood CL
J Nurse Midwifery 1994 Mar-Apr;39(2 Suppl):106S-109S. doi: 10.1016/0091-2182(94)90068-x. PMID: 8035240

Therapy

Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Lee RH, Mara Greenberg, Metz TD, Pettker CM
Am J Obstet Gynecol 2021 Feb;224(2):B2-B9. Epub 2020 Nov 13 doi: 10.1016/j.ajog.2020.11.002. PMID: 33197417
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Hensel KL, Buchanan S, Brown SK, Rodriguez M, Cruser dA
Am J Obstet Gynecol 2015 Jan;212(1):108.e1-9. Epub 2014 Jul 25 doi: 10.1016/j.ajog.2014.07.043. PMID: 25068560Free PMC Article

Prognosis

McKenna KA, Leaman L
Am Fam Physician 2024 Jun;109(6):525-532. PMID: 38905550
Li YT, Li CX, Huang CJ, Wen QY, Deng SM, Zhu LP, Liu ZF, Chen ZG
J Trop Pediatr 2022 Aug 4;68(5) doi: 10.1093/tropej/fmac064. PMID: 35962981
Kelly LE, Shivananda S, Murthy P, Srinivasjois R, Shah PS
Cochrane Database Syst Rev 2017 Jun 28;6(6):CD006183. doi: 10.1002/14651858.CD006183.pub2. PMID: 28658507Free PMC Article
Vain NE, Batton DG
Semin Fetal Neonatal Med 2017 Aug;22(4):214-219. Epub 2017 Apr 11 doi: 10.1016/j.siny.2017.04.002. PMID: 28411000
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962

Clinical prediction guides

Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Li YT, Li CX, Huang CJ, Wen QY, Deng SM, Zhu LP, Liu ZF, Chen ZG
J Trop Pediatr 2022 Aug 4;68(5) doi: 10.1093/tropej/fmac064. PMID: 35962981
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Sentilhes L, Vayssière C, Beucher G, Deneux-Tharaux C, Deruelle P, Diemunsch P, Gallot D, Haumonté JB, Heimann S, Kayem G, Lopez E, Parant O, Schmitz T, Sellier Y, Rozenberg P, d'Ercole C
Eur J Obstet Gynecol Reprod Biol 2013 Sep;170(1):25-32. Epub 2013 Jun 28 doi: 10.1016/j.ejogrb.2013.05.015. PMID: 23810846

Recent systematic reviews

Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Kelly LE, Shivananda S, Murthy P, Srinivasjois R, Shah PS
Cochrane Database Syst Rev 2017 Jun 28;6(6):CD006183. doi: 10.1002/14651858.CD006183.pub2. PMID: 28658507Free PMC Article
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Siriwachirachai T, Sangkomkamhang US, Lumbiganon P, Laopaiboon M
Cochrane Database Syst Rev 2014 Nov 6;2014(11):CD007772. doi: 10.1002/14651858.CD007772.pub3. PMID: 25374369Free PMC Article

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