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Developmental delay

MedGen UID:
98410
•Concept ID:
C0424605
•
Mental or Behavioral Dysfunction
Synonyms: Delayed development; Developmental delays
SNOMED CT: Developmental delay (248290002)

Definition

Failure to meet, or late achievement of developmental milestones. [from NCI]

Professional guidelines

PubMed

Clinical Practice Guideline: Tympanostomy Tubes in Children (Update).
Rosenfeld RM, Tunkel DE, Schwartz SR, Anne S, Bishop CE, Chelius DC, Hackell J, Hunter LL, Keppel KL, Kim AH, Kim TW, Levine JM, Maksimoski MT, Moore DJ, Preciado DA, Raol NP, Vaughan WK, Walker EA, Monjur TM
Otolaryngol Head Neck Surg 2022 Feb;166(1_suppl):S1-S55. doi: 10.1177/01945998211065662. PMID: 35138954
Craniosynostosis - Recognition, clinical characteristics, and treatment.
Kajdic N, Spazzapan P, Velnar T
Bosn J Basic Med Sci 2018 May 20;18(2):110-116. doi: 10.17305/bjbms.2017.2083. PMID: 28623672Free PMC Article
Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies.
Miller DT, Adam MP, Aradhya S, Biesecker LG, Brothman AR, Carter NP, Church DM, Crolla JA, Eichler EE, Epstein CJ, Faucett WA, Feuk L, Friedman JM, Hamosh A, Jackson L, Kaminsky EB, Kok K, Krantz ID, Kuhn RM, Lee C, Ostell JM, Rosenberg C, Scherer SW, Spinner NB, Stavropoulos DJ, Tepperberg JH, Thorland EC, Vermeesch JR, Waggoner DJ, Watson MS, Martin CL, Ledbetter DH
Am J Hum Genet 2010 May 14;86(5):749-64. doi: 10.1016/j.ajhg.2010.04.006. PMID: 20466091Free PMC Article

Recent clinical studies

Etiology

Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 Years.
Takahashi I, Obara T, Ishikuro M, Murakami K, Ueno F, Noda A, Onuma T, Shinoda G, Nishimura T, Tsuchiya KJ, Kuriyama S
JAMA Pediatr 2023 Oct 1;177(10):1039-1046. doi: 10.1001/jamapediatrics.2023.3057. PMID: 37603356Free PMC Article
The Beneficial Effects of Massage on Motor Development and Sensory Processing in Young Children with Developmental Delay: A Randomized Control Trial Study.
Lu WP, Tsai WH, Lin LY, Hong RB, Hwang YS
Dev Neurorehabil 2019 Oct;22(7):487-495. Epub 2018 Oct 30 doi: 10.1080/17518423.2018.1537317. PMID: 30376388
Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis.
Veroniki AA, Rios P, Cogo E, Straus SE, Finkelstein Y, Kealey R, Reynen E, Soobiah C, Thavorn K, Hutton B, Hemmelgarn BR, Yazdi F, D'Souza J, MacDonald H, Tricco AC
BMJ Open 2017 Jul 20;7(7):e017248. doi: 10.1136/bmjopen-2017-017248. PMID: 28729328Free PMC Article
Developmental Delay: When and How to Screen.
Vitrikas K, Savard D, Bucaj M
Am Fam Physician 2017 Jul 1;96(1):36-43. PMID: 28671370
Plagiocephaly and Developmental Delay: A Systematic Review.
Martiniuk AL, Vujovich-Dunn C, Park M, Yu W, Lucas BR
J Dev Behav Pediatr 2017 Jan;38(1):67-78. doi: 10.1097/DBP.0000000000000376. PMID: 28009719

Diagnosis

Deciphering Intellectual Disability.
Gupta N
Indian J Pediatr 2023 Feb;90(2):160-167. Epub 2022 Nov 28 doi: 10.1007/s12098-022-04345-3. PMID: 36441387
Developmental delay: identification and management at primary care level.
Choo YY, Agarwal P, How CH, Yeleswarapu SP
Singapore Med J 2019 Mar;60(3):119-123. doi: 10.11622/smedj.2019025. PMID: 30997518Free PMC Article
The Beneficial Effects of Massage on Motor Development and Sensory Processing in Young Children with Developmental Delay: A Randomized Control Trial Study.
Lu WP, Tsai WH, Lin LY, Hong RB, Hwang YS
Dev Neurorehabil 2019 Oct;22(7):487-495. Epub 2018 Oct 30 doi: 10.1080/17518423.2018.1537317. PMID: 30376388
A clinical approach to developmental delay and intellectual disability.
Vasudevan P, Suri M
Clin Med (Lond) 2017 Dec;17(6):558-561. doi: 10.7861/clinmedicine.17-6-558. PMID: 29196358Free PMC Article
A copy number variation morbidity map of developmental delay.
Cooper GM, Coe BP, Girirajan S, Rosenfeld JA, Vu TH, Baker C, Williams C, Stalker H, Hamid R, Hannig V, Abdel-Hamid H, Bader P, McCracken E, Niyazov D, Leppig K, Thiese H, Hummel M, Alexander N, Gorski J, Kussmann J, Shashi V, Johnson K, Rehder C, Ballif BC, Shaffer LG, Eichler EE
Nat Genet 2011 Aug 14;43(9):838-46. doi: 10.1038/ng.909. PMID: 21841781Free PMC Article

Therapy

Spoken language outcomes in limited language preschoolers with autism and global developmental delay: RCT of early intervention approaches.
Kasari C, Shire S, Shih W, Landa R, Levato L, Smith T
Autism Res 2023 Jun;16(6):1236-1246. Epub 2023 Apr 18 doi: 10.1002/aur.2932. PMID: 37070270Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
McGoldrick E, Stewart F, Parker R, Dalziel SR
Cochrane Database Syst Rev 2020 Dec 25;12(12):CD004454. doi: 10.1002/14651858.CD004454.pub4. PMID: 33368142Free PMC Article
Marijuana: the effects on pregnancy, the fetus, and the newborn.
Martin GI
J Perinatol 2020 Oct;40(10):1470-1476. Epub 2020 Jun 7 doi: 10.1038/s41372-020-0708-z. PMID: 32507859
Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis.
Veroniki AA, Rios P, Cogo E, Straus SE, Finkelstein Y, Kealey R, Reynen E, Soobiah C, Thavorn K, Hutton B, Hemmelgarn BR, Yazdi F, D'Souza J, MacDonald H, Tricco AC
BMJ Open 2017 Jul 20;7(7):e017248. doi: 10.1136/bmjopen-2017-017248. PMID: 28729328Free PMC Article
Interventions to improve gross motor performance in children with neurodevelopmental disorders: a meta-analysis.
Lucas BR, Elliott EJ, Coggan S, Pinto RZ, Jirikowic T, McCoy SW, Latimer J
BMC Pediatr 2016 Nov 29;16(1):193. doi: 10.1186/s12887-016-0731-6. PMID: 27899082Free PMC Article

Prognosis

High-Risk Infant Follow-Up After NICU Discharge: Current Care Models and Future Considerations.
Litt JS, Campbell DE
Clin Perinatol 2023 Mar;50(1):225-238. doi: 10.1016/j.clp.2022.11.004. PMID: 36868707
How to use the Bayley Scales of Infant and Toddler Development.
Del Rosario C, Slevin M, Molloy EJ, Quigley J, Nixon E
Arch Dis Child Educ Pract Ed 2021 Apr;106(2):108-112. Epub 2020 Aug 28 doi: 10.1136/archdischild-2020-319063. PMID: 32859738
Infantile Exotropia and Developmental Delay.
Lueder GT, Galli M
J Pediatr Ophthalmol Strabismus 2018 Jul 1;55(4):225-228. Epub 2018 May 1 doi: 10.3928/01913913-20180213-05. PMID: 29709041
Validation of the modified checklist for Autism in toddlers, revised with follow-up (M-CHAT-R/F).
Robins DL, Casagrande K, Barton M, Chen CM, Dumont-Mathieu T, Fein D
Pediatrics 2014 Jan;133(1):37-45. Epub 2013 Dec 23 doi: 10.1542/peds.2013-1813. PMID: 24366990Free PMC Article
Screening for developmental delay.
Mackrides PS, Ryherd SJ
Am Fam Physician 2011 Sep 1;84(5):544-9. PMID: 21888305

Clinical prediction guides

Clinical and genetic characterization of CACNA1A-related disease.
Lipman AR, Fan X, Shen Y, Chung WK
Clin Genet 2022 Oct;102(4):288-295. Epub 2022 Jun 26 doi: 10.1111/cge.14180. PMID: 35722745Free PMC Article
How to use the Bayley Scales of Infant and Toddler Development.
Del Rosario C, Slevin M, Molloy EJ, Quigley J, Nixon E
Arch Dis Child Educ Pract Ed 2021 Apr;106(2):108-112. Epub 2020 Aug 28 doi: 10.1136/archdischild-2020-319063. PMID: 32859738
The mutational and phenotypic spectrum of TUBA1A-associated tubulinopathy.
Hebebrand M, Hüffmeier U, Trollmann R, Hehr U, Uebe S, Ekici AB, Kraus C, Krumbiegel M, Reis A, Thiel CT, Popp B
Orphanet J Rare Dis 2019 Feb 11;14(1):38. doi: 10.1186/s13023-019-1020-x. PMID: 30744660Free PMC Article
The Beneficial Effects of Massage on Motor Development and Sensory Processing in Young Children with Developmental Delay: A Randomized Control Trial Study.
Lu WP, Tsai WH, Lin LY, Hong RB, Hwang YS
Dev Neurorehabil 2019 Oct;22(7):487-495. Epub 2018 Oct 30 doi: 10.1080/17518423.2018.1537317. PMID: 30376388
Newborn screening for Krabbe disease in New York State: the first eight years' experience.
Orsini JJ, Kay DM, Saavedra-Matiz CA, Wenger DA, Duffner PK, Erbe RW, Biski C, Martin M, Krein LM, Nichols M, Kurtzberg J, Escolar ML, Adams DJ, Arnold GL, Iglesias A, Galvin-Parton P, Kronn DF, Kwon JM, Levy PA, Pellegrino JE, Shur N, Wasserstein MP, Caggana M; New York State Krabbe Disease Consortium
Genet Med 2016 Mar;18(3):239-48. Epub 2016 Jan 21 doi: 10.1038/gim.2015.211. PMID: 26795590

Recent systematic reviews

Calcium channelopathies and intellectual disability: a systematic review.
Kessi M, Chen B, Peng J, Yan F, Yang L, Yin F
Orphanet J Rare Dis 2021 May 13;16(1):219. doi: 10.1186/s13023-021-01850-0. PMID: 33985586Free PMC Article
Congenital myasthenic syndromes.
Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article
Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis.
Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, Overweg J, Sauma L, Specchio LM, Tennison M, Cardoso TMO, Shinnar S, Schmidt D, Geleijns K, Braun KPJ
Lancet Neurol 2017 Jul;16(7):523-531. Epub 2017 May 5 doi: 10.1016/S1474-4422(17)30114-X. PMID: 28483337
Interventions to improve gross motor performance in children with neurodevelopmental disorders: a meta-analysis.
Lucas BR, Elliott EJ, Coggan S, Pinto RZ, Jirikowic T, McCoy SW, Latimer J
BMC Pediatr 2016 Nov 29;16(1):193. doi: 10.1186/s12887-016-0731-6. PMID: 27899082Free PMC Article
Comprehensive evaluation of the child with intellectual disability or global developmental delays.
Moeschler JB, Shevell M; Committee on Genetics
Pediatrics 2014 Sep;134(3):e903-18. doi: 10.1542/peds.2014-1839. PMID: 25157020Free PMC Article

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