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Syringocystadenoma papilliferum

MedGen UID:
98362
Concept ID:
C0406803
Neoplastic Process
Synonyms: Papillary Syringocystadenoma; Papillary Syringocystadenomas; Papilliferum, Syringocystadenoma; Syringocystadenoma Papilliferum; Syringocystadenoma Papilliferums; Syringocystadenoma, Papillary
SNOMED CT: Papillary syringadenoma (8934006); Papillary syringocystadenoma (8934006); Syringocystadenoma papilliferum (8934006); Nevus syringocystadenomatosus papilliferus (239121009); Syringocystadenoma papilliferum (239121009)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0019392
Orphanet: ORPHA840

Definition

A rare non-malignant adnexal neoplasm that originates from the apocrine or eccrine sweat glands and is characterized histologically by cystic, papillary, and ductal invaginations into the dermis lined by double-layered outer cuboidal and luminal high columnar epithelium and connected to the epidermis. Dilated capillaries and a dense infiltrate of plasma cells are characteristic. Clinically, lesions are asymptomatic with a heterogeneous, non-distinctive appearance ranging from skin-colored to pink papules or plaques, occurring most commonly in the head and neck area. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSyringocystadenoma papilliferum
Follow this link to review classifications for Syringocystadenoma papilliferum in Orphanet.

Professional guidelines

Recent clinical studies

Etiology

Ye Q, Wu Q, Jia M, Li FZ, Fang S
Dermatology 2023;239(1):140-147. Epub 2022 Sep 9 doi: 10.1159/000526143. PMID: 36088908
Aggarwal D, Chatterjee D, Keshavamurthy V, Chhikara K, Saikia UN, Radotra BD, De D, Singh MP
Indian J Dermatol Venereol Leprol 2023 Jan-Mar;89(2):266-273. doi: 10.25259/IJDVL_845_20. PMID: 34623039
Das A, Mohanty S, Gharami RC, Chowdhury SN, Kumar P, Das NK, Bandyopadhyay D
Clin Exp Dermatol 2021 Dec;46(8):1452-1461. Epub 2021 Jul 6 doi: 10.1111/ced.14753. PMID: 34022084
Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179
Muñoz-Pérez MA, García-Hernandez MJ, Ríos JJ, Camacho F
J Eur Acad Dermatol Venereol 2002 Jul;16(4):319-24. doi: 10.1046/j.1468-3083.2002.00543.x. PMID: 12224685

Diagnosis

Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Tseng MC, Amin B, Barmettler A
Orbit 2018 Jun;37(3):171-174. Epub 2017 Oct 20 doi: 10.1080/01676830.2017.1383477. PMID: 29053036
Mundi JP, Rose AE, Boyd KP, Patel RR, Lipkin G
Dermatol Online J 2013 Dec 16;19(12):20722. PMID: 24365013
Ferringer T
Cutis 2011 Dec;88(6):268, 273-4. PMID: 22372162
Barbarino S, McCormick SA, Lauer SA, Milman T
Ophthalmic Plast Reconstr Surg 2009 May-Jun;25(3):185-8. doi: 10.1097/IOP.0b013e3181a39512. PMID: 19454927

Therapy

Pang S, Cevik J, Sreedharan S, Wilks DJ
Ann Plast Surg 2024 Jun 1;92(6):711-719. Epub 2024 May 9 doi: 10.1097/SAP.0000000000003879. PMID: 38725109
Alegría-Landa V, Jo-Velasco M, Santonja C, Eraña I, Vergara-Sanchez A, Kutzner H, Requena L
J Cutan Pathol 2020 Jan;47(1):12-16. Epub 2019 Sep 4 doi: 10.1111/cup.13572. PMID: 31449665
Cassarino DS, Su A, Robbins BA, Altree-Tacha D, Ra S
J Cutan Pathol 2017 Jun;44(6):544-547. Epub 2017 Apr 20 doi: 10.1111/cup.12939. PMID: 28343365
Watanabe Y, Shido K, Niihori T, Niizuma H, Katata Y, Iizuka C, Oba D, Moriya K, Saito-Nanjo Y, Onuma M, Rikiishi T, Sasahara Y, Watanabe M, Aiba S, Saito R, Sonoda Y, Tominaga T, Aoki Y, Kure S
Am J Med Genet A 2016 Jan;170A(1):189-94. Epub 2015 Sep 11 doi: 10.1002/ajmg.a.37376. PMID: 26360803

Prognosis

Zwierz A, Masna K, Burduk P
J Int Adv Otol 2022 Nov;18(6):544-547. doi: 10.5152/iao.2022.21594. PMID: 36349679Free PMC Article
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Satter E, Grady D, Schlocker CT
Dermatol Online J 2014 Apr 16;20(4):22335. PMID: 24746298
Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179
Muñoz-Pérez MA, García-Hernandez MJ, Ríos JJ, Camacho F
J Eur Acad Dermatol Venereol 2002 Jul;16(4):319-24. doi: 10.1046/j.1468-3083.2002.00543.x. PMID: 12224685

Clinical prediction guides

Omer M, Na S, Joshipura D, Robinson-Bostom L
R I Med J (2013) 2024 Jul 1;107(7):14-16. PMID: 38917308
Zwierz A, Masna K, Burduk P
J Int Adv Otol 2022 Nov;18(6):544-547. doi: 10.5152/iao.2022.21594. PMID: 36349679Free PMC Article
Rammeh-Rommani S, Fezaa B, Chelbi E, Kammoun MR, Ben Jilani SB, Zermani R
Pathologica 2006 Jun;98(3):178-80. PMID: 17036946
Yamamoto O, Doi Y, Hamada T, Hisaoka M, Sasaguri Y
Br J Dermatol 2002 Nov;147(5):936-45. doi: 10.1046/j.1365-2133.2002.05027.x. PMID: 12410704
Umbert P, Winkelmann RK
J Cutan Pathol 1976;3(2):75-87. doi: 10.1111/j.1600-0560.1976.tb00850.x. PMID: 993400

Recent systematic reviews

Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691
Pang S, Cevik J, Sreedharan S, Wilks DJ
Ann Plast Surg 2024 Jun 1;92(6):711-719. Epub 2024 May 9 doi: 10.1097/SAP.0000000000003879. PMID: 38725109

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