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Acquired cutis laxa

MedGen UID:: 590500
•Concept ID:: C0406549
•: Disease or Syndrome

Synonyms:	acquired cutis laxa; Cutis laxa acquisita; cutis laxa acquisita; Cutis laxa, acquired type
SNOMED CT:	Acquired cutis laxa (19726003); Cutis laxa, acquired type (19726003)
Modes of inheritance:	Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Not genetically inherited (Orphanet)

Monarch Initiative:	MONDO:0016446
Orphanet:	ORPHA228285

Definition

An instance of cutis laxa that is acquired during the lifetime of the individual. [from MONDO]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAcquired cutis laxa

Acquired dermis elastic tissue disorder with decreased elastic tissue
- Acquired cutis laxa

Follow this link to review classifications for Acquired cutis laxa in Orphanet.

Recent clinical studies

Etiology

Clinical features in adults with acquired cutis laxa: a retrospective review.

O'Connell KA, Schaefer M, Atzmony L, Vleugels RA, Choate K, LaChance AH, Min MS
Br J Dermatol 2023 May 24;188(6):800-816. doi: 10.1093/bjd/ljad043. PMID: 36849736 Free PMC Article

A Clinical Classification Scheme for Tracheobronchomegaly (Mounier-Kuhn Syndrome).

Payandeh J, McGillivray B, McCauley G, Wilcox P, Swiston JR, Lehman A
Lung 2015 Oct;193(5):815-22. Epub 2015 Jul 19 doi: 10.1007/s00408-015-9757-z. PMID: 26189148

Generalized cutis laxa associated with heavy chain deposition disease.

Tan S, Pon K, Bargman J, Ghazarian D
J Cutan Med Surg 2003 Sep-Oct;7(5):390-4. Epub 2003 Sep 24 doi: 10.1007/s10227-002-0128-z. PMID: 14973644

Acquired cutis laxa associated with multiple myeloma.

Gupta A, Helm TN
Cutis 2002 Feb;69(2):114-8. PMID: 11868975

See all (4)

Diagnosis

Acquired cutis laxa: a clinical review.

Khodeir J, Ohanian P, Feghali J
Int J Dermatol 2024 Oct;63(10):1334-1356. Epub 2024 Jun 25 doi: 10.1111/ijd.17338. PMID: 38924070

Type I acquired cutis laxa: Report of a unique progressive case and short review.

Peralta-Amaro AL, Quintal-Ramírez MJ, Esteban-Prado A, Chávez-Sánchez IN, Vera-Lastra OL, López-Velasco A, Acosta-Jiménez E, Cano-Viveros MI
Am J Med Sci 2024 Apr;367(4):268-273. Epub 2024 Jan 24 doi: 10.1016/j.amjms.2024.01.015. PMID: 38278360

Clinical features in adults with acquired cutis laxa: a retrospective review.

O'Connell KA, Schaefer M, Atzmony L, Vleugels RA, Choate K, LaChance AH, Min MS
Br J Dermatol 2023 May 24;188(6):800-816. doi: 10.1093/bjd/ljad043. PMID: 36849736 Free PMC Article

Acquired cutis laxa from heavy chain deposition disease.

Gillion V, Vekemans MC, Rinsant A, Aydin S, Colmant C, Bridoux F, Goffin E
Kidney Int 2022 Dec;102(6):1432-1433. doi: 10.1016/j.kint.2022.08.035. PMID: 36411025

Acquired Cutis Laxa.

Jain A
Turk J Haematol 2020 Aug 28;37(3):212-213. Epub 2020 Apr 24 doi: 10.4274/tjh.galenos.2020.2020.0121. PMID: 32329984 Free PMC Article

See all (25)

Therapy

Type I acquired cutis laxa: Report of a unique progressive case and short review.

Successful treatment of acquired cutis laxa with urticarial eruption by diphenyl sulfone.

Zheng BQ, Yan YL, Ou M, Wang XH
Clin Exp Dermatol 2021 Apr;46(3):599-603. Epub 2020 Oct 15 doi: 10.1111/ced.14451. PMID: 33058256

Fractional Carbon Dioxide Laser Treatment for Textural Improvement and Symptomatic Relief of Acquired Cutis Laxa of the Neck.

Nathan NR, O'Connor DM, Lee JJ, Cornejo KM, Tan JK, Tsao SS, Manstein D
Lasers Surg Med 2021 Apr;53(4):427-428. Epub 2020 Aug 8 doi: 10.1002/lsm.23308. PMID: 32770692

A Clinical Classification Scheme for Tracheobronchomegaly (Mounier-Kuhn Syndrome).

Payandeh J, McGillivray B, McCauley G, Wilcox P, Swiston JR, Lehman A
Lung 2015 Oct;193(5):815-22. Epub 2015 Jul 19 doi: 10.1007/s00408-015-9757-z. PMID: 26189148

Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature.

McCarty MJ, Davidson JM, Cardone JS, Anderson LL
Cutis 1996 Apr;57(4):267-70. PMID: 8727781

See all (13)

Prognosis

Acquired cutis laxa associated with cutaneous mastocytosis.

Hoang MV, Dang PV, Bui DV, Mejbel H, Mani DT, Smoller BR, Phung TL
Dermatol Online J 2015 Jul 15;21(7) PMID: 26436968

Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy.

Silveira L, Torres I, Salvino MA, Follador I, Bittencourt AL
Am J Dermatopathol 2013 Jun;35(4):e67-71. doi: 10.1097/DAD.0b013e31827bceaf. PMID: 23694828

Acquired cutis laxa associated with multiple myeloma.

Gupta A, Helm TN
Cutis 2002 Feb;69(2):114-8. PMID: 11868975

Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature.

McCarty MJ, Davidson JM, Cardone JS, Anderson LL
Cutis 1996 Apr;57(4):267-70. PMID: 8727781

Postinflammatory elastolysis and cutis laxa. A case report.

Lewis PG, Hood AF, Barnett NK, Holbrook KA
J Am Acad Dermatol 1990 Jan;22(1):40-8. doi: 10.1016/0190-9622(90)70005-3. PMID: 2298964

See all (5)

Clinical prediction guides

Acquired cutis laxa: a clinical review.

Khodeir J, Ohanian P, Feghali J
Int J Dermatol 2024 Oct;63(10):1334-1356. Epub 2024 Jun 25 doi: 10.1111/ijd.17338. PMID: 38924070

A rare case of secondary cutaneous lymphoplasmacytic lymphoma clinically presenting as acquired cutis laxa.

Lim DJ, Yang HJ, Lee MY, Lee WJ, Won CH, Chang SE, Lee MW
J Cutan Pathol 2024 Feb;51(2):135-139. Epub 2023 Oct 25 doi: 10.1111/cup.14551. PMID: 37877413

A Clinical Classification Scheme for Tracheobronchomegaly (Mounier-Kuhn Syndrome).

Payandeh J, McGillivray B, McCauley G, Wilcox P, Swiston JR, Lehman A
Lung 2015 Oct;193(5):815-22. Epub 2015 Jul 19 doi: 10.1007/s00408-015-9757-z. PMID: 26189148

Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers.

O'Malley JT, D'Agati VD, Sherman WH, Grossman ME
JAMA Dermatol 2014 Nov;150(11):1192-6. doi: 10.1001/jamadermatol.2014.725. PMID: 25133950

Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-λ and IgA-κ gammopathy following treatment of a nodal plasmacytoma.

New HD, Callen JP
Arch Dermatol 2011 Mar;147(3):323-8. doi: 10.1001/archdermatol.2011.26. PMID: 21422340

See all (10)