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Maculopapular drug eruption

MedGen UID:
590491
•Concept ID:
C0406537
•
Disease or Syndrome
Synonyms: Drug Eruption, Maculopapular; Drug Eruptions, Maculopapular; Drug Reaction, Morbilliform; Drug Reactions, Morbilliform; Eruption, Maculopapular Drug; Eruptions, Maculopapular Drug; Exanthem, Maculopapular; Exanthem, Morbilliform; Exanthems, Maculopapular; Exanthems, Morbilliform; Maculopapular Drug Eruption; Maculopapular Drug Eruptions; Maculopapular Exanthem; Maculopapular Exanthems; Morbilliform Drug Reaction; Morbilliform Drug Reactions; Morbilliform Exanthem; Morbilliform Exanthems; Reaction, Morbilliform Drug; Reactions, Morbilliform Drug
SNOMED CT: Maculopapular drug eruption (238814003)

Definition

Dermatoid drug eruption characterized by widespread erythematous macules and papules often associated with a mild fever and itch. [from MeSH]

Professional guidelines

PubMed

Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity.
Musette P, Brandi ML, Cacoub P, Kaufman JM, Rizzoli R, Reginster JY
Osteoporos Int 2010 May;21(5):723-32. Epub 2009 Nov 17 doi: 10.1007/s00198-009-1097-5. PMID: 19921087

Recent clinical studies

Etiology

Langerhans' cell distribution in drug eruption.
Dascalu DI, Kletter Y, Baratz M, Brenner S
Acta Derm Venereol 1992;72(3):175-7. PMID: 1357851

Diagnosis

Tuberculosis treatment-related lichenoid drug eruptions.
Katran ZY, Bulut I, Babalık A
Int J Mycobacteriol 2022 Oct-Dec;11(4):469-471. doi: 10.4103/ijmy.ijmy_151_22. PMID: 36510939
Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graft-versus-host disease.
Wegner J, Weidenthaler-Barth B, Engelbert J, Knothe M, Braun C, Helbig D, Sacher C, Kreft A, Wagner EM, Ziemer M, Meyer RG, von Stebut E
Exp Dermatol 2021 Dec;30(12):1814-1819. Epub 2021 Jul 5 doi: 10.1111/exd.14416. PMID: 34223669
Delayed hypersensitivity reaction resulting in maculopapular-type eruption due to entecavir in the treatment of chronic hepatitis B.
Kim JT, Jeong HW, Choi KH, Yoon TY, Sung N, Choi YK, Kim EH, Chae HB
World J Gastroenterol 2014 Nov 14;20(42):15931-6. doi: 10.3748/wjg.v20.i42.15931. PMID: 25400481Free PMC Article
Histopathologic features of exanthematous drug eruptions of the macular and papular type.
Naim M, Weyers W, Metze D
Am J Dermatopathol 2011 Oct;33(7):695-704. doi: 10.1097/DAD.0b013e31820a285d. PMID: 21785331

Therapy

Pregabalin-induced delayed cutaneous hypersensitivity reaction occurring after 40 days of use: a case report.
Zhang M, Du K, Lu Y, Wu W, Yan H, Jiang Q, Liu L, Feng X
J Int Med Res 2024 Apr;52(4):3000605241245004. doi: 10.1177/03000605241245004. PMID: 38635889Free PMC Article
In vitro detection of suspected drug in maculopapular drug reaction to antibiotics using secreted cytokines from drug-specific activated T cells.
Dharanisankar S, Chandrashekar L, Selvarajan S, Rajappa M, Ramassamy S
Clin Exp Dermatol 2023 Jun 5;48(6):636-641. doi: 10.1093/ced/llad053. PMID: 36755422
Tuberculosis treatment-related lichenoid drug eruptions.
Katran ZY, Bulut I, Babalık A
Int J Mycobacteriol 2022 Oct-Dec;11(4):469-471. doi: 10.4103/ijmy.ijmy_151_22. PMID: 36510939
Maculopapular Drug Eruption Caused by Apalutamide: Case Report and Review of the Literature.
Katayama H, Saeki H, Osada SI
J Nippon Med Sch 2022 Nov 9;89(5):550-554. Epub 2021 Sep 14 doi: 10.1272/jnms.JNMS.2022_89-503. PMID: 34526471
Delayed hypersensitivity reaction resulting in maculopapular-type eruption due to entecavir in the treatment of chronic hepatitis B.
Kim JT, Jeong HW, Choi KH, Yoon TY, Sung N, Choi YK, Kim EH, Chae HB
World J Gastroenterol 2014 Nov 14;20(42):15931-6. doi: 10.3748/wjg.v20.i42.15931. PMID: 25400481Free PMC Article

Prognosis

Pregabalin-induced delayed cutaneous hypersensitivity reaction occurring after 40 days of use: a case report.
Zhang M, Du K, Lu Y, Wu W, Yan H, Jiang Q, Liu L, Feng X
J Int Med Res 2024 Apr;52(4):3000605241245004. doi: 10.1177/03000605241245004. PMID: 38635889Free PMC Article
In vitro detection of suspected drug in maculopapular drug reaction to antibiotics using secreted cytokines from drug-specific activated T cells.
Dharanisankar S, Chandrashekar L, Selvarajan S, Rajappa M, Ramassamy S
Clin Exp Dermatol 2023 Jun 5;48(6):636-641. doi: 10.1093/ced/llad053. PMID: 36755422

Clinical prediction guides

In vitro detection of suspected drug in maculopapular drug reaction to antibiotics using secreted cytokines from drug-specific activated T cells.
Dharanisankar S, Chandrashekar L, Selvarajan S, Rajappa M, Ramassamy S
Clin Exp Dermatol 2023 Jun 5;48(6):636-641. doi: 10.1093/ced/llad053. PMID: 36755422
Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graft-versus-host disease.
Wegner J, Weidenthaler-Barth B, Engelbert J, Knothe M, Braun C, Helbig D, Sacher C, Kreft A, Wagner EM, Ziemer M, Meyer RG, von Stebut E
Exp Dermatol 2021 Dec;30(12):1814-1819. Epub 2021 Jul 5 doi: 10.1111/exd.14416. PMID: 34223669

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