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Nodulocystic acne

MedGen UID:
590449
•Concept ID:
C0406482
•
Disease or Syndrome
SNOMED CT: Nodulocystic acne (238745007)

Professional guidelines

PubMed

A review of isotretinoin in the treatment of frontal fibrosing alopecia.
Shahpar A, Nezhad NZ, Sahaf AS, Ahramiyanpour N
J Cosmet Dermatol 2024 Jun;23(6):1956-1963. Epub 2024 Mar 3 doi: 10.1111/jocd.16245. PMID: 38433314
Current Issues in the Treatment of Acne Vulgaris.
Habeshian KA, Cohen BA
Pediatrics 2020 May;145(Suppl 2):S225-S230. doi: 10.1542/peds.2019-2056L. PMID: 32358215
Acne: systemic treatment.
Katsambas A, Papakonstantinou A
Clin Dermatol 2004 Sep-Oct;22(5):412-8. doi: 10.1016/j.clindermatol.2004.03.014. PMID: 15556728

Recent clinical studies

Etiology

Choroidal vascular changes in acne patients under isotretinoin treatment.
Sekeryapan Gediz B, Corak Eroglu F, Aydogan M, Aydugan MT, Kilinc Hekimsoy H
Cutan Ocul Toxicol 2021 Jun;40(2):125-129. Epub 2021 Apr 19 doi: 10.1080/15569527.2021.1914075. PMID: 33866916
Isotretinoin treatment in nodulocystic acne with and without polycystic ovary syndrome: efficacy and determinants of relapse.
Cakir GA, Erdogan FG, Gurler A
Int J Dermatol 2013 Mar;52(3):371-6. Epub 2012 Sep 24 doi: 10.1111/j.1365-4632.2012.05691.x. PMID: 22998438
Adverse effects of retinoids.
David M, Hodak E, Lowe NJ
Med Toxicol Adverse Drug Exp 1988 Jul-Aug;3(4):273-88. doi: 10.1007/BF03259940. PMID: 3054426
Isotretinoin revisited.
Shalita AR, Armstrong RB, Leyden JJ, Pochi PE, Strauss JS
Cutis 1988 Dec 29;42(6A):1-19. PMID: 2974796
Isotretinoin and tetracycline in the management of severe nodulocystic acne.
Lester RS, Schachter GD, Light MJ
Int J Dermatol 1985 May;24(4):252-7. doi: 10.1111/j.1365-4362.1985.tb05775.x. PMID: 3159698

Diagnosis

A Unified Concept of Acne in the PAPA Spectrum Disorders.
Maitrepierre F, Marzano AV, Lipsker D
Dermatology 2021;237(5):827-834. Epub 2020 Sep 16 doi: 10.1159/000509874. PMID: 32937626
Does exposure to isotretinoin increase the risk for the development of inflammatory bowel disease? A meta-analysis.
Lee SY, Jamal MM, Nguyen ET, Bechtold ML, Nguyen DL
Eur J Gastroenterol Hepatol 2016 Feb;28(2):210-6. doi: 10.1097/MEG.0000000000000496. PMID: 26545085
Isotretinoin-associated Sweet's syndrome: a case report.
Moghimi J, Pahlevan D, Azizzadeh M, Hamidi H, Pourazizi M
Daru 2014 Oct 17;22(1):69. doi: 10.1186/s40199-014-0069-2. PMID: 25324016Free PMC Article
Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne.
Dhir R, Gehi NP, Agarwal R, More YE
Indian J Dermatol Venereol Leprol 2008 Mar-Apr;74(2):187. doi: 10.4103/0378-6323.39727. PMID: 18401903
Nodulocystic acne as a phenotypic feature of the XYY genotype.
Voorhees JJ, Wilkins JW Jr, Hayes E, Harrell ER
Arch Dermatol 1972 Jun;105(6):913-9. PMID: 4260543

Therapy

A Unified Concept of Acne in the PAPA Spectrum Disorders.
Maitrepierre F, Marzano AV, Lipsker D
Dermatology 2021;237(5):827-834. Epub 2020 Sep 16 doi: 10.1159/000509874. PMID: 32937626
Current Issues in the Treatment of Acne Vulgaris.
Habeshian KA, Cohen BA
Pediatrics 2020 May;145(Suppl 2):S225-S230. doi: 10.1542/peds.2019-2056L. PMID: 32358215
Acne: systemic treatment.
Katsambas A, Papakonstantinou A
Clin Dermatol 2004 Sep-Oct;22(5):412-8. doi: 10.1016/j.clindermatol.2004.03.014. PMID: 15556728
Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders.
Fitton A, Goa KL
Drugs 1991 May;41(5):780-98. doi: 10.2165/00003495-199141050-00007. PMID: 1712709
Isotretinoin revisited.
Shalita AR, Armstrong RB, Leyden JJ, Pochi PE, Strauss JS
Cutis 1988 Dec 29;42(6A):1-19. PMID: 2974796

Prognosis

Choroidal vascular changes in acne patients under isotretinoin treatment.
Sekeryapan Gediz B, Corak Eroglu F, Aydogan M, Aydugan MT, Kilinc Hekimsoy H
Cutan Ocul Toxicol 2021 Jun;40(2):125-129. Epub 2021 Apr 19 doi: 10.1080/15569527.2021.1914075. PMID: 33866916
Pyoderma gangrenosum following isotretinoin therapy for acne nodulocystic.
Tinoco MP, Tamler C, Maciel G, Soares D, Avelleira JC, Azulay D
Int J Dermatol 2008 Sep;47(9):953-6. doi: 10.1111/j.1365-4632.2008.03662.x. PMID: 18937662
Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne.
Dhir R, Gehi NP, Agarwal R, More YE
Indian J Dermatol Venereol Leprol 2008 Mar-Apr;74(2):187. doi: 10.4103/0378-6323.39727. PMID: 18401903
Acne in infancy and acne genetics.
Herane MI, Ando I
Dermatology 2003;206(1):24-8. doi: 10.1159/000067819. PMID: 12566802
Isotretinoin and tetracycline in the management of severe nodulocystic acne.
Lester RS, Schachter GD, Light MJ
Int J Dermatol 1985 May;24(4):252-7. doi: 10.1111/j.1365-4362.1985.tb05775.x. PMID: 3159698

Clinical prediction guides

Cold anesthesia for pain reduction during intralesional steroid injection for nodulocystic acne.
Park SJ, Shin SH, Koh YG, Kim GH, Rho NK, Park KY
J Cosmet Dermatol 2023 Dec;22(12):3375-3378. Epub 2023 May 23 doi: 10.1111/jocd.15829. PMID: 37218601
Evaluation of the gastrointestinal findings of nodulocystic acnepatients during systemic isotretinoin therapy.
Tabanlioğlu Onan D, Hazar Tantoğlu B, Alli N, Özkan S, Samsar U, Köseoğlu HT, Artüz RF
Turk J Med Sci 2016 Apr 19;46(3):820-4. doi: 10.3906/sag-1412-142. PMID: 27513262
Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne.
Dhir R, Gehi NP, Agarwal R, More YE
Indian J Dermatol Venereol Leprol 2008 Mar-Apr;74(2):187. doi: 10.4103/0378-6323.39727. PMID: 18401903
Acne in infancy and acne genetics.
Herane MI, Ando I
Dermatology 2003;206(1):24-8. doi: 10.1159/000067819. PMID: 12566802
Isotretinoin revisited.
Shalita AR, Armstrong RB, Leyden JJ, Pochi PE, Strauss JS
Cutis 1988 Dec 29;42(6A):1-19. PMID: 2974796

Recent systematic reviews

Low dose of isotretinoin: A comprehensive review.
Abdelmaksoud A, Lotti T, Anadolu R, Goldust M, Ayhan E, Dave DD, Vestita M, Ebik B, Gupta M
Dermatol Ther 2020 Mar;33(2):e13251. Epub 2020 Feb 20 doi: 10.1111/dth.13251. PMID: 32022958
Acne: comparing hormonal approaches to antibiotics and isotretinoin.
Larsen TH, Jemec GB
Expert Opin Pharmacother 2003 Jul;4(7):1097-103. doi: 10.1517/14656566.4.7.1097. PMID: 12831336

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