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Lichen planus pigmentosus

MedGen UID:
590349
Concept ID:
C0406366
Disease or Syndrome
Synonyms: Lichen planus pigmentosa; lichen planus pigmentosa; lichen planus pigmentosus; Lichen planus pigmentosus inversus; lichen planus pigmentosus inversus; LP pigmentosa; LP pigmentosus; Post-inflammatory hyperpigmentation in lichen planus
SNOMED CT: Lichen planus pigmentosus (717061002); Lichen planus pigmentosa (717061002); Lichen planus pigmentosus inversus (717061002); Post-inflammatory hyperpigmentation in lichen planus (238649008)
 
Monarch Initiative: MONDO:0016774
Orphanet: ORPHA254463

Definition

A rare variant of cutaneous lichen planus with the presence of hyperpigmented lichenoid lesions in sun-exposed or flexural areas of the body. A rare disease in Europe but it is common in Indian populations and in the Middle East. The overall prevalence is unknown. There is no difference in distribution between males and females. The disease usually appears in the third and fourth decade of life. The lesions are asymptomatic or mildly pruritic. Skin changes are dark brown or slate gray macules or papules with, in most cases, a diffuse pigmentation pattern. They most commonly affect the face, neck and upper limbs. Cause is unknown but various factors (e.g. viral infections and certain topical agents including mustard oil and henna hair dyes) can trigger the disease. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLichen planus pigmentosus
Follow this link to review classifications for Lichen planus pigmentosus in Orphanet.

Professional guidelines

PubMed

Kumarasinghe SPW, Pandya A, Chandran V, Rodrigues M, Dlova NC, Kang HY, Ramam M, Dayrit JF, Goh BK, Parsad D
Int J Dermatol 2019 Mar;58(3):263-272. Epub 2018 Sep 3 doi: 10.1111/ijd.14189. PMID: 30176055
Wu A, Vaidya S
J Cutan Med Surg 2018 Nov/Dec;22(6):643-645. doi: 10.1177/1203475418782132. PMID: 30322299
Puza C, Cardones AR
G Ital Dermatol Venereol 2017 Dec;152(6):607-614. Epub 2017 Sep 12 doi: 10.23736/S0392-0488.17.05778-9. PMID: 28895668

Recent clinical studies

Etiology

Sarkar R, Vinay K, Bishnoi A, Poojary S, Gupta M, Kumaran MS, Jain A, Gurumurthy C, Arora P, Kandhari R, Rathi S, Zawar V, Gupta V, Ravivarma VN, Rodrigues M, Parsad D
Indian J Dermatol Venereol Leprol 2023 Jan-Frebuary;89(1):41-46. doi: 10.25259/IJDVL_804_2021. PMID: 35593293
Rutnin S, Udompanich S, Pratumchart N, Harnchoowong S, Vachiramon V
Biomed Res Int 2019;2019:5829185. Epub 2019 Oct 28 doi: 10.1155/2019/5829185. PMID: 31781623Free PMC Article
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159
Puza C, Cardones AR
G Ital Dermatol Venereol 2017 Dec;152(6):607-614. Epub 2017 Sep 12 doi: 10.23736/S0392-0488.17.05778-9. PMID: 28895668
Patel AB, Kubba R, Kubba A
Indian J Dermatol Venereol Leprol 2013 May-Jun;79(3):367-75. doi: 10.4103/0378-6323.110798. PMID: 23619441

Diagnosis

Wang RF, Ko D, Friedman BJ, Lim HW, Mohammad TF
J Am Acad Dermatol 2023 Feb;88(2):271-288. Epub 2022 Feb 11 doi: 10.1016/j.jaad.2022.01.051. PMID: 35151757
Syder N, Sicco K, Gutierrez D
J Drugs Dermatol 2022 Mar 1;21(3):324-330. doi: 10.36849/JDD.6454. PMID: 35254753
Aurangabadkar SJ
Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):10-17. doi: 10.4103/ijdvl.IJDVL_1086_16. PMID: 30027914
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159
Khanna N, Rasool S
Indian J Dermatol Venereol Leprol 2011 Sep-Oct;77(5):552-63; quiz 564. doi: 10.4103/0378-6323.84046. PMID: 21860153

Therapy

Shah S, Baskaran N, Vinay K, Bishnoi A, Parsad D, Kumaran MS
Int J Dermatol 2023 Dec;62(12):1447-1457. Epub 2023 Sep 28 doi: 10.1111/ijd.16859. PMID: 37767951
Aurangabadkar SJ
Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):10-17. doi: 10.4103/ijdvl.IJDVL_1086_16. PMID: 30027914
Vashi N, Newlove T, Chu J, Patel R, Stein J
Dermatol Online J 2011 Oct 15;17(10):30. PMID: 22031656
Khanna N, Rasool S
Indian J Dermatol Venereol Leprol 2011 Sep-Oct;77(5):552-63; quiz 564. doi: 10.4103/0378-6323.84046. PMID: 21860153
Bhutani LK, Bedi TR, Pandhi RK, Nayak NC
Dermatologica 1974;149(1):43-50. doi: 10.1159/000251470. PMID: 4154221

Prognosis

Shah S, Baskaran N, Vinay K, Bishnoi A, Parsad D, Kumaran MS
Int J Dermatol 2023 Dec;62(12):1447-1457. Epub 2023 Sep 28 doi: 10.1111/ijd.16859. PMID: 37767951
Dabas G, Vinay K, Parsad D, Chatterjee D, Kumaran MS
Clin Exp Dermatol 2019 Mar;44(2):190-193. Epub 2018 Jun 26 doi: 10.1111/ced.13696. PMID: 29947025
Cheng HM, Chuah SY, Gan EY, Jhingan A, Thng STG
Australas J Dermatol 2018 Nov;59(4):322-327. Epub 2018 Apr 10 doi: 10.1111/ajd.12813. PMID: 29635779
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159
Pock L, Jelínková L, Drlík L, Abrhámová S, Vojtechovská S, Sezemská D, Borodácová I, Hercogová J
J Eur Acad Dermatol Venereol 2001 Sep;15(5):452-4. doi: 10.1046/j.1468-3083.2001.00347.x. PMID: 11763389

Clinical prediction guides

Shah S, Baskaran N, Vinay K, Bishnoi A, Parsad D, Kumaran MS
Int J Dermatol 2023 Dec;62(12):1447-1457. Epub 2023 Sep 28 doi: 10.1111/ijd.16859. PMID: 37767951
Krueger L, Saizan A, Stein JA, Elbuluk N
Int J Dermatol 2022 Jan;61(1):7-19. Epub 2021 Jul 7 doi: 10.1111/ijd.15741. PMID: 34235719
Gupta V, Yadav D, Satapathy S, Upadhyay A, Mahajan S, Ramam M, Sharma VK
Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):341-347. doi: 10.25259/IJDVL_877_19. PMID: 33943064
Yadav A, Garg T, Mandal AK, Chander R
J Cosmet Dermatol 2018 Dec;17(6):1293-1294. Epub 2018 Jul 11 doi: 10.1111/jocd.12686. PMID: 29998547
Sassolas B, Zagnoli A, Leroy JP, Guillet G
Clin Exp Dermatol 1994 Jan;19(1):70-3. doi: 10.1111/j.1365-2230.1994.tb01122.x. PMID: 8313644

Recent systematic reviews

Mitchell K, Silverberg N
J Drugs Dermatol 2022 Aug 1;21(8):850-853. doi: 10.36849/JDD.6760. PMID: 35946962

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