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Microalbuminuric diabetic nephropathy

MedGen UID:
588452
•Concept ID:
C0403518
•
Disease or Syndrome
Synonyms: Incipient diabetic nephropathy; Microalbuminuric nephropathy due to diabetes mellitus
SNOMED CT: Microalbuminuric diabetic nephropathy (236499007); Incipient diabetic nephropathy (236499007); Microalbuminuric nephropathy due to diabetes mellitus (236499007)

Professional guidelines

PubMed

Management of the diabetic patient with advanced chronic kidney disease.
Alicic RZ, Tuttle KR
Semin Dial 2010 Mar-Apr;23(2):140-7. Epub 2010 Mar 30 doi: 10.1111/j.1525-139X.2010.00700.x. PMID: 20374553
Albuminuria: a target for treatment of type 2 diabetic nephropathy.
de Zeeuw D
Semin Nephrol 2007 Mar;27(2):172-81. doi: 10.1016/j.semnephrol.2007.01.002. PMID: 17418686
Treatment of diabetic nephropathy in its early stages.
Deferrari G, Ravera M, Berruti V
Diabetes Metab Res Rev 2003 Mar-Apr;19(2):101-14. doi: 10.1002/dmrr.363. PMID: 12673778

Recent clinical studies

Etiology

Potential Role of N-Cadherin in Diagnosis and Prognosis of Diabetic Nephropathy.
Ali H, Abu-Farha M, Hammad MM, Devarajan S, Bahbahani Y, Al-Khairi I, Cherian P, Alsairafi Z, Vijayan V, Al-Mulla F, Attar AA, Abubaker J
Front Endocrinol (Lausanne) 2022;13:882700. Epub 2022 May 31 doi: 10.3389/fendo.2022.882700. PMID: 35712247Free PMC Article
Retinal Microcirculation Alterations in Microalbuminuric Diabetic Patients With and Without Retinopathy.
Ucgul Atilgan C, Atilgan KG, Kosekahya P, Goker YS, Karatepe MS, Caglayan M, Citirik M
Semin Ophthalmol 2021 Aug 18;36(5-6):406-412. Epub 2021 Mar 10 doi: 10.1080/08820538.2021.1896745. PMID: 33689564
Nonproteinuric progressive diabetic kidney disease.
Zoccali C, Mallamaci F
Curr Opin Nephrol Hypertens 2019 May;28(3):227-232. doi: 10.1097/MNH.0000000000000489. PMID: 30672815
Lipoprotein abnormalities in diabetic nephropathy.
Hirano T
Kidney Int Suppl 1999 Jul;71:S22-4. doi: 10.1046/j.1523-1755.1999.07106.x. PMID: 10412730
Renal protection and angiotensin converting enzyme inhibition in microalbuminuric type I and type II diabetic patients.
Cooper ME
J Hypertens Suppl 1996 Dec;14(6):S11-4. PMID: 9023709

Diagnosis

Potential Role of N-Cadherin in Diagnosis and Prognosis of Diabetic Nephropathy.
Ali H, Abu-Farha M, Hammad MM, Devarajan S, Bahbahani Y, Al-Khairi I, Cherian P, Alsairafi Z, Vijayan V, Al-Mulla F, Attar AA, Abubaker J
Front Endocrinol (Lausanne) 2022;13:882700. Epub 2022 May 31 doi: 10.3389/fendo.2022.882700. PMID: 35712247Free PMC Article
Retinal Microcirculation Alterations in Microalbuminuric Diabetic Patients With and Without Retinopathy.
Ucgul Atilgan C, Atilgan KG, Kosekahya P, Goker YS, Karatepe MS, Caglayan M, Citirik M
Semin Ophthalmol 2021 Aug 18;36(5-6):406-412. Epub 2021 Mar 10 doi: 10.1080/08820538.2021.1896745. PMID: 33689564
Retinal Microcirculation in Predicting Diabetic Nephropathy in Type 2 Diabetic Patients without Retinopathy.
Cankurtaran V, Inanc M, Tekin K, Turgut F
Ophthalmologica 2020;243(4):271-279. Epub 2019 Nov 26 doi: 10.1159/000504943. PMID: 31775153
'Progressive diabetic nephropathy. How useful is microalbuminuria?: contra'.
MacIsaac RJ, Ekinci EI, Jerums G
Kidney Int 2014 Jul;86(1):50-7. Epub 2014 Apr 9 doi: 10.1038/ki.2014.98. PMID: 24717301
Albumin-like material in urine.
Comper WD, Osicka TM
Kidney Int Suppl 2004 Nov;(92):S65-6. doi: 10.1111/j.1523-1755.2004.09217.x. PMID: 15485422

Therapy

Glucose control, diabetic retinopathy, and hemodialysis induction in subjects with normo-microalbuminuric type 2 diabetic patients with normal renal function followed for 15 years.
Moriya T, Hayashi A, Matsubara M, Suzuki A, Ouchi M
J Diabetes Complications 2022 Jan;36(1):108080. Epub 2021 Oct 29 doi: 10.1016/j.jdiacomp.2021.108080. PMID: 34740544
Nonproteinuric progressive diabetic kidney disease.
Zoccali C, Mallamaci F
Curr Opin Nephrol Hypertens 2019 May;28(3):227-232. doi: 10.1097/MNH.0000000000000489. PMID: 30672815
Losartan in diabetic nephropathy.
Perico N, Ruggenenti P, Remuzzi G
Expert Rev Cardiovasc Ther 2004 Jul;2(4):473-83. doi: 10.1586/14779072.2.4.473. PMID: 15225108
Diabetic nephropathy. Its relationship to hypertension and means of pharmacological intervention.
Baba T, Neugebauer S, Watanabe T
Drugs 1997 Aug;54(2):197-234. doi: 10.2165/00003495-199754020-00002. PMID: 9257079
Renal protection and angiotensin converting enzyme inhibition in microalbuminuric type I and type II diabetic patients.
Cooper ME
J Hypertens Suppl 1996 Dec;14(6):S11-4. PMID: 9023709

Prognosis

Potential Role of N-Cadherin in Diagnosis and Prognosis of Diabetic Nephropathy.
Ali H, Abu-Farha M, Hammad MM, Devarajan S, Bahbahani Y, Al-Khairi I, Cherian P, Alsairafi Z, Vijayan V, Al-Mulla F, Attar AA, Abubaker J
Front Endocrinol (Lausanne) 2022;13:882700. Epub 2022 May 31 doi: 10.3389/fendo.2022.882700. PMID: 35712247Free PMC Article
Glucose control, diabetic retinopathy, and hemodialysis induction in subjects with normo-microalbuminuric type 2 diabetic patients with normal renal function followed for 15 years.
Moriya T, Hayashi A, Matsubara M, Suzuki A, Ouchi M
J Diabetes Complications 2022 Jan;36(1):108080. Epub 2021 Oct 29 doi: 10.1016/j.jdiacomp.2021.108080. PMID: 34740544
Retinal Microcirculation in Predicting Diabetic Nephropathy in Type 2 Diabetic Patients without Retinopathy.
Cankurtaran V, Inanc M, Tekin K, Turgut F
Ophthalmologica 2020;243(4):271-279. Epub 2019 Nov 26 doi: 10.1159/000504943. PMID: 31775153
Nonproteinuric progressive diabetic kidney disease.
Zoccali C, Mallamaci F
Curr Opin Nephrol Hypertens 2019 May;28(3):227-232. doi: 10.1097/MNH.0000000000000489. PMID: 30672815
Losartan in diabetic nephropathy.
Perico N, Ruggenenti P, Remuzzi G
Expert Rev Cardiovasc Ther 2004 Jul;2(4):473-83. doi: 10.1586/14779072.2.4.473. PMID: 15225108

Clinical prediction guides

Glucose control, diabetic retinopathy, and hemodialysis induction in subjects with normo-microalbuminuric type 2 diabetic patients with normal renal function followed for 15 years.
Moriya T, Hayashi A, Matsubara M, Suzuki A, Ouchi M
J Diabetes Complications 2022 Jan;36(1):108080. Epub 2021 Oct 29 doi: 10.1016/j.jdiacomp.2021.108080. PMID: 34740544
Nonproteinuric progressive diabetic kidney disease.
Zoccali C, Mallamaci F
Curr Opin Nephrol Hypertens 2019 May;28(3):227-232. doi: 10.1097/MNH.0000000000000489. PMID: 30672815
'Progressive diabetic nephropathy. How useful is microalbuminuria?: contra'.
MacIsaac RJ, Ekinci EI, Jerums G
Kidney Int 2014 Jul;86(1):50-7. Epub 2014 Apr 9 doi: 10.1038/ki.2014.98. PMID: 24717301
Losartan in diabetic nephropathy.
Perico N, Ruggenenti P, Remuzzi G
Expert Rev Cardiovasc Ther 2004 Jul;2(4):473-83. doi: 10.1586/14779072.2.4.473. PMID: 15225108
Renal protection and angiotensin converting enzyme inhibition in microalbuminuric type I and type II diabetic patients.
Cooper ME
J Hypertens Suppl 1996 Dec;14(6):S11-4. PMID: 9023709

Recent systematic reviews

WITHDRAWN: Angiotensin converting enzyme inhibitors in normotensive diabetic patients with microalbuminuria.
Lovell HG
Cochrane Database Syst Rev 2007 Jul 18;(1):CD002183. doi: 10.1002/14651858.CD002183.pub2. PMID: 17636698
Angiotensin converting enzyme inhibitors in normotensive diabetic patients with microalbuminuria.
Lovell HG
Cochrane Database Syst Rev 2001;(1):CD002183. doi: 10.1002/14651858.CD002183. PMID: 11279757
Angiotensin converting enzyme inhibitors in normotensive diabetic patients with microalbuminuria.
Lovell HG
Cochrane Database Syst Rev 2000;(2):CD002183. doi: 10.1002/14651858.CD002183. PMID: 10796871

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