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Neutropenic colitis

MedGen UID:
586418
•Concept ID:
C0400823
•
Disease or Syndrome
SNOMED CT: Neutropenic colitis (235755005)

Professional guidelines

PubMed

Approach to the patient with infectious colitis: clinical features, work-up and treatment.
Iqbal T, DuPont HL
Curr Opin Gastroenterol 2021 Jan;37(1):66-75. doi: 10.1097/MOG.0000000000000693. PMID: 33105253
Colon perforation in multiple myeloma patients - A complication of high-dose steroid treatment.
Vaxman I, Al Saleh AS, Kumar S, Nitin M, Dispenzieri A, Buadi F, Dingli D, Lacy M, Muchtar E, Hobbs M, Fonder A, Hwa L, Visram A, Kapoor P, Siddiqui M, Lust J, Kyle R, Rajkumar V, Hayman S, Leung N, Gonsalves W, Kourelis T, Warsame R, Gertz MA
Cancer Med 2020 Dec;9(23):8895-8901. Epub 2020 Oct 6 doi: 10.1002/cam4.3507. PMID: 33022868Free PMC Article
Neutropenic colitis after treatment of acute myelogenous leukemia with idarubicin and cytosine arabinoside.
Hogan WJ, Letendre L, Litzow MR, Tefferi A, Hoagland HC, Pruthi RK, Kaufmann SH
Mayo Clin Proc 2002 Aug;77(8):760-2. doi: 10.4065/77.8.760. PMID: 12173711

Recent clinical studies

Etiology

Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): an interim analysis of the multicentre, double-blind, randomised phase 3 study.
Shitara K, Rha SY, Wyrwicz LS, Oshima T, Karaseva N, Osipov M, Yasui H, Yabusaki H, Afanasyev S, Park YK, Al-Batran SE, Yoshikawa T, Yanez P, Dib Bartolomeo M, Lonardi S, Tabernero J, Van Cutsem E, Janjigian YY, Oh DY, Xu J, Fang X, Shih CS, Bhagia P, Bang YJ; KEYNOTE-585 investigators
Lancet Oncol 2024 Feb;25(2):212-224. Epub 2023 Dec 19 doi: 10.1016/S1470-2045(23)00541-7. PMID: 38134948
Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (TROPiCS-02): a randomised, open-label, multicentre, phase 3 trial.
Rugo HS, Bardia A, Marmé F, Cortés J, Schmid P, Loirat D, Trédan O, Ciruelos E, Dalenc F, Gómez Pardo P, Jhaveri KL, Delaney R, Valdez T, Wang H, Motwani M, Yoon OK, Verret W, Tolaney SM
Lancet 2023 Oct 21;402(10411):1423-1433. Epub 2023 Aug 23 doi: 10.1016/S0140-6736(23)01245-X. PMID: 37633306
Pediatric oncologic emergencies: Clinical and imaging review for pediatricians.
Handa A, Nozaki T, Makidono A, Okabe T, Morita Y, Fujita K, Matsusako M, Kono T, Kurihara Y, Hasegawa D, Kumamoto T, Ogawa C, Yuza Y, Manabe A
Pediatr Int 2019 Feb;61(2):122-139. Epub 2019 Feb 7 doi: 10.1111/ped.13755. PMID: 30565795
Colonic toxicity of administered drugs and chemicals.
Cappell MS
Am J Gastroenterol 2004 Jun;99(6):1175-90. doi: 10.1111/j.1572-0241.2004.30192.x. PMID: 15180742
Host factors predisposing to anaerobic infections.
Finegold SM
FEMS Immunol Med Microbiol 1993 Mar;6(2-3):159-63. doi: 10.1111/j.1574-695X.1993.tb00319.x. PMID: 8518753

Diagnosis

Approach to the patient with infectious colitis: clinical features, work-up and treatment.
Iqbal T, DuPont HL
Curr Opin Gastroenterol 2021 Jan;37(1):66-75. doi: 10.1097/MOG.0000000000000693. PMID: 33105253
Pediatric oncologic emergencies: Clinical and imaging review for pediatricians.
Handa A, Nozaki T, Makidono A, Okabe T, Morita Y, Fujita K, Matsusako M, Kono T, Kurihara Y, Hasegawa D, Kumamoto T, Ogawa C, Yuza Y, Manabe A
Pediatr Int 2019 Feb;61(2):122-139. Epub 2019 Feb 7 doi: 10.1111/ped.13755. PMID: 30565795
Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Neutropenic enterocolitis.
Rodrigues FG, Dasilva G, Wexner SD
World J Gastroenterol 2017 Jan 7;23(1):42-47. doi: 10.3748/wjg.v23.i1.42. PMID: 28104979Free PMC Article
CT imaging of colitis.
Thoeni RF, Cello JP
Radiology 2006 Sep;240(3):623-38. doi: 10.1148/radiol.2403050818. PMID: 16926320

Therapy

Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): an interim analysis of the multicentre, double-blind, randomised phase 3 study.
Shitara K, Rha SY, Wyrwicz LS, Oshima T, Karaseva N, Osipov M, Yasui H, Yabusaki H, Afanasyev S, Park YK, Al-Batran SE, Yoshikawa T, Yanez P, Dib Bartolomeo M, Lonardi S, Tabernero J, Van Cutsem E, Janjigian YY, Oh DY, Xu J, Fang X, Shih CS, Bhagia P, Bang YJ; KEYNOTE-585 investigators
Lancet Oncol 2024 Feb;25(2):212-224. Epub 2023 Dec 19 doi: 10.1016/S1470-2045(23)00541-7. PMID: 38134948
Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (TROPiCS-02): a randomised, open-label, multicentre, phase 3 trial.
Rugo HS, Bardia A, Marmé F, Cortés J, Schmid P, Loirat D, Trédan O, Ciruelos E, Dalenc F, Gómez Pardo P, Jhaveri KL, Delaney R, Valdez T, Wang H, Motwani M, Yoon OK, Verret W, Tolaney SM
Lancet 2023 Oct 21;402(10411):1423-1433. Epub 2023 Aug 23 doi: 10.1016/S0140-6736(23)01245-X. PMID: 37633306
Approach to the patient with infectious colitis: clinical features, work-up and treatment.
Iqbal T, DuPont HL
Curr Opin Gastroenterol 2021 Jan;37(1):66-75. doi: 10.1097/MOG.0000000000000693. PMID: 33105253
Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Neutropenic enterocolitis.
Rodrigues FG, Dasilva G, Wexner SD
World J Gastroenterol 2017 Jan 7;23(1):42-47. doi: 10.3748/wjg.v23.i1.42. PMID: 28104979Free PMC Article

Prognosis

Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Significance of abdominal ultrasound in inflammatory bowel disease.
Dietrich CF
Dig Dis 2009;27(4):482-93. Epub 2009 Nov 4 doi: 10.1159/000233287. PMID: 19897964
Colonic toxicity of administered drugs and chemicals.
Cappell MS
Am J Gastroenterol 2004 Jun;99(6):1175-90. doi: 10.1111/j.1572-0241.2004.30192.x. PMID: 15180742
Host factors predisposing to anaerobic infections.
Finegold SM
FEMS Immunol Med Microbiol 1993 Mar;6(2-3):159-63. doi: 10.1111/j.1574-695X.1993.tb00319.x. PMID: 8518753
Collagenous colitis, eosinophilic colitis, and neutropenic colitis.
Ettinghausen SE
Surg Clin North Am 1993 Oct;73(5):993-1016. doi: 10.1016/s0039-6109(16)46137-2. PMID: 8378836

Clinical prediction guides

Emerging Toxicities of Antibody-Drug Conjugates for Breast Cancer: Clinical Prioritization of Adverse Events from the FDA Adverse Event Reporting System.
Cecco S, Puligheddu S, Fusaroli M, Gerratana L, Yan M, Zamagni C, De Ponti F, Raschi E
Target Oncol 2024 May;19(3):435-445. Epub 2024 May 2 doi: 10.1007/s11523-024-01058-9. PMID: 38696126Free PMC Article
A multicentre dose-escalating study of cabazitaxel (XRP6258) in combination with capecitabine in patients with metastatic breast cancer progressing after anthracycline and taxane treatment: a phase I/II study.
Villanueva C, Awada A, Campone M, Machiels JP, Besse T, Magherini E, Dubin F, Semiond D, Pivot X
Eur J Cancer 2011 May;47(7):1037-45. Epub 2011 Feb 19 doi: 10.1016/j.ejca.2011.01.001. PMID: 21339064
Triapine and cytarabine is an active combination in patients with acute leukemia or myelodysplastic syndrome.
Yee KW, Cortes J, Ferrajoli A, Garcia-Manero G, Verstovsek S, Wierda W, Thomas D, Faderl S, King I, O'brien SM, Jeha S, Andreeff M, Cahill A, Sznol M, Giles FJ
Leuk Res 2006 Jul;30(7):813-22. Epub 2006 Feb 14 doi: 10.1016/j.leukres.2005.12.013. PMID: 16478631
Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer.
Chau I, Brown G, Cunningham D, Tait D, Wotherspoon A, Norman AR, Tebbutt N, Hill M, Ross PJ, Massey A, Oates J
J Clin Oncol 2006 Feb 1;24(4):668-74. doi: 10.1200/JCO.2005.04.4875. PMID: 16446339
Neutropenic colitis after treatment of acute myelogenous leukemia with idarubicin and cytosine arabinoside.
Hogan WJ, Letendre L, Litzow MR, Tefferi A, Hoagland HC, Pruthi RK, Kaufmann SH
Mayo Clin Proc 2002 Aug;77(8):760-2. doi: 10.4065/77.8.760. PMID: 12173711

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