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Systemic lupus erythematosus encephalitis

MedGen UID:
581707
•Concept ID:
C0393968
•
Disease or Syndrome
Synonyms: Cerebral lupus; Cerebral systemic lupus erythematosus; Lupus encephalopathy
SNOMED CT: Systemic lupus erythematosus encephalitis (95644001); Lupus encephalopathy (95644001); Cerebral lupus (95644001); Cerebral systemic lupus erythematosus (95644001)

Professional guidelines

PubMed

The diagnosis and treatment of catatonia.
Rogers JP, Zandi MS, David AS
Clin Med (Lond) 2023 May;23(3):242-245. doi: 10.7861/clinmed.2023-0113. PMID: 37236789Free PMC Article

Recent clinical studies

Etiology

Central Nervous System Systemic Lupus Erythematosus: Pathophysiologic, Clinical, and Imaging Features.
Ota Y, Srinivasan A, Capizzano AA, Bapuraj JR, Kim J, Kurokawa R, Baba A, Moritani T
Radiographics 2022 Jan-Feb;42(1):212-232. doi: 10.1148/rg.210045. PMID: 34990324
Management of inflammatory neurologic and psychiatric manifestations of systemic lupus erythematosus: A systematic review.
Papachristos DA, Oon S, Hanly JG, Nikpour M
Semin Arthritis Rheum 2021 Feb;51(1):49-71. Epub 2020 Dec 17 doi: 10.1016/j.semarthrit.2020.12.004. PMID: 33360230
The association between systemic autoimmune disorders and epilepsy and its clinical implications.
Steriade C, Titulaer MJ, Vezzani A, Sander JW, Thijs RD
Brain 2021 Mar 3;144(2):372-390. doi: 10.1093/brain/awaa362. PMID: 33221878
Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines.
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500
EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs.
Bertsias GK, Ioannidis JP, Aringer M, Bollen E, Bombardieri S, Bruce IN, Cervera R, Dalakas M, Doria A, Hanly JG, Huizinga TW, Isenberg D, Kallenberg C, Piette JC, Schneider M, Scolding N, Smolen J, Stara A, Tassiulas I, Tektonidou M, Tincani A, van Buchem MA, van Vollenhoven R, Ward M, Gordon C, Boumpas DT
Ann Rheum Dis 2010 Dec;69(12):2074-82. Epub 2010 Aug 19 doi: 10.1136/ard.2010.130476. PMID: 20724309

Diagnosis

Neuropsychiatric involvement in systemic lupus erythematosus: A review.
Carrión-Barberà I, Salman-Monte TC, Vílchez-Oya F, Monfort J
Autoimmun Rev 2021 Apr;20(4):102780. Epub 2021 Feb 18 doi: 10.1016/j.autrev.2021.102780. PMID: 33609799
Update οn the diagnosis and management of systemic lupus erythematosus.
Fanouriakis A, Tziolos N, Bertsias G, Boumpas DT
Ann Rheum Dis 2021 Jan;80(1):14-25. Epub 2020 Oct 13 doi: 10.1136/annrheumdis-2020-218272. PMID: 33051219
Lupus Vasculitis.
Calle-Botero E, Abril A
Curr Rheumatol Rep 2020 Aug 26;22(10):71. doi: 10.1007/s11926-020-00937-0. PMID: 32845454
Neuropsychiatric lupus: new mechanistic insights and future treatment directions.
Schwartz N, Stock AD, Putterman C
Nat Rev Rheumatol 2019 Mar;15(3):137-152. doi: 10.1038/s41584-018-0156-8. PMID: 30659245Free PMC Article
Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines.
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500

Therapy

Neuropsychiatric Systemic Lupus Erythematosus: Molecules Involved in Its Imunopathogenesis, Clinical Features, and Treatment.
Justiz-Vaillant AA, Gopaul D, Soodeen S, Arozarena-Fundora R, Barbosa OA, Unakal C, Thompson R, Pandit B, Umakanthan S, Akpaka PE
Molecules 2024 Feb 6;29(4) doi: 10.3390/molecules29040747. PMID: 38398500Free PMC Article
The diagnosis and treatment of catatonia.
Rogers JP, Zandi MS, David AS
Clin Med (Lond) 2023 May;23(3):242-245. doi: 10.7861/clinmed.2023-0113. PMID: 37236789Free PMC Article
Catatonia in systemic lupus erythematosus: case based review.
Sundaram TG, Muhammed H, Gupta L, Lawrence A, Misra R, Aggarwal A
Rheumatol Int 2022 Aug;42(8):1461-1476. Epub 2021 Sep 27 doi: 10.1007/s00296-021-05006-y. PMID: 34580753
Management of inflammatory neurologic and psychiatric manifestations of systemic lupus erythematosus: A systematic review.
Papachristos DA, Oon S, Hanly JG, Nikpour M
Semin Arthritis Rheum 2021 Feb;51(1):49-71. Epub 2020 Dec 17 doi: 10.1016/j.semarthrit.2020.12.004. PMID: 33360230
Update οn the diagnosis and management of systemic lupus erythematosus.
Fanouriakis A, Tziolos N, Bertsias G, Boumpas DT
Ann Rheum Dis 2021 Jan;80(1):14-25. Epub 2020 Oct 13 doi: 10.1136/annrheumdis-2020-218272. PMID: 33051219

Prognosis

Microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus.
Nikolopoulos D, Manolakou T, Polissidis A, Filia A, Bertsias G, Koutmani Y, Boumpas DT
Ann Rheum Dis 2023 May;82(5):646-657. Epub 2023 Mar 10 doi: 10.1136/ard-2022-223506. PMID: 36898766Free PMC Article
Update οn the diagnosis and management of systemic lupus erythematosus.
Fanouriakis A, Tziolos N, Bertsias G, Boumpas DT
Ann Rheum Dis 2021 Jan;80(1):14-25. Epub 2020 Oct 13 doi: 10.1136/annrheumdis-2020-218272. PMID: 33051219
Advances in the diagnosis, pathogenesis and treatment of neuropsychiatric systemic lupus erythematosus.
Moore E, Huang MW, Putterman C
Curr Opin Rheumatol 2020 Mar;32(2):152-158. doi: 10.1097/BOR.0000000000000682. PMID: 31895125Free PMC Article
Neuropsychiatric lupus: new mechanistic insights and future treatment directions.
Schwartz N, Stock AD, Putterman C
Nat Rev Rheumatol 2019 Mar;15(3):137-152. doi: 10.1038/s41584-018-0156-8. PMID: 30659245Free PMC Article
Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines.
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500

Clinical prediction guides

The diagnosis and treatment of catatonia.
Rogers JP, Zandi MS, David AS
Clin Med (Lond) 2023 May;23(3):242-245. doi: 10.7861/clinmed.2023-0113. PMID: 37236789Free PMC Article
Microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus.
Nikolopoulos D, Manolakou T, Polissidis A, Filia A, Bertsias G, Koutmani Y, Boumpas DT
Ann Rheum Dis 2023 May;82(5):646-657. Epub 2023 Mar 10 doi: 10.1136/ard-2022-223506. PMID: 36898766Free PMC Article
Management of inflammatory neurologic and psychiatric manifestations of systemic lupus erythematosus: A systematic review.
Papachristos DA, Oon S, Hanly JG, Nikpour M
Semin Arthritis Rheum 2021 Feb;51(1):49-71. Epub 2020 Dec 17 doi: 10.1016/j.semarthrit.2020.12.004. PMID: 33360230
Advances in the diagnosis, pathogenesis and treatment of neuropsychiatric systemic lupus erythematosus.
Moore E, Huang MW, Putterman C
Curr Opin Rheumatol 2020 Mar;32(2):152-158. doi: 10.1097/BOR.0000000000000682. PMID: 31895125Free PMC Article
Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines.
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500

Recent systematic reviews

Neuropsychiatric lupus in late- and early-onset systemic lupus erythematosus patients: a systematic review and meta-analysis.
Pamuk ON, Raza AA, Hasni S
Rheumatology (Oxford) 2024 Jan 4;63(1):8-15. doi: 10.1093/rheumatology/kead297. PMID: 37341643Free PMC Article
Suicidal behavior in patients with systematic lupus erythematosus: Systematic literature review and genetic linkage disequilibrium analysis.
Parperis K, Kyriakou A, Voskarides K, Chatzittofis A
Semin Arthritis Rheum 2022 Jun;54:151997. Epub 2022 Mar 19 doi: 10.1016/j.semarthrit.2022.151997. PMID: 35344734
Management of inflammatory neurologic and psychiatric manifestations of systemic lupus erythematosus: A systematic review.
Papachristos DA, Oon S, Hanly JG, Nikpour M
Semin Arthritis Rheum 2021 Feb;51(1):49-71. Epub 2020 Dec 17 doi: 10.1016/j.semarthrit.2020.12.004. PMID: 33360230
Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines.
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500
Neuro-ophthalmologic manifestations of systemic lupus erythematosus: a systematic review.
Man BL, Mok CC, Fu YP
Int J Rheum Dis 2014 Jun;17(5):494-501. Epub 2014 Mar 28 doi: 10.1111/1756-185X.12337. PMID: 24673755

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