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Multifocal motor neuropathy

MedGen UID:
581615
Concept ID:
C0393847
Disease or Syndrome
Synonyms: MMN; MMN - Motor neuropathy with multiple conduction block; MMNCB; Motor neuropathy with multiple conduction block; multifocal motor neuropathy; Multifocal motor neuropathy with conduction block; multifocal motor neuropathy with conduction block
SNOMED CT: Multifocal motor neuropathy (230591002); MMN - Motor neuropathy with multiple conduction block (230591002); Motor neuropathy with multiple conduction block (230591002)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0018979
Orphanet: ORPHA641

Definition

Multifocal motor neuropathy (MMN) is a rare acquired immune-mediatedneuropathy characterized clinically by a purely motor deficit with conduction block and asymmetric multifocal weakness, fasciculations, and cramping. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultifocal motor neuropathy

Professional guidelines

PubMed

Tavee J, Brannagan TH 3rd, Lenihan MW, Muppidi S, Kellermeyer L, D Donofrio P; AANEM
Muscle Nerve 2023 Oct;68(4):356-374. Epub 2023 Jul 11 doi: 10.1002/mus.27922. PMID: 37432872
Callaghan BC, Price RS, Chen KS, Feldman EL
JAMA Neurol 2015 Dec;72(12):1510-8. doi: 10.1001/jamaneurol.2015.2347. PMID: 26437251Free PMC Article
Nobile-Orazio E
J Neurol 2005 Apr;252(4):385-95. doi: 10.1007/s00415-005-0805-0. PMID: 15834625

Recent clinical studies

Etiology

Tavee J, Brannagan TH 3rd, Lenihan MW, Muppidi S, Kellermeyer L, D Donofrio P; AANEM
Muscle Nerve 2023 Oct;68(4):356-374. Epub 2023 Jul 11 doi: 10.1002/mus.27922. PMID: 37432872
Keddie S, Eftimov F, van den Berg LH, Brassington R, de Haan RJ, van Schaik IN
Cochrane Database Syst Rev 2022 Jan 11;1(1):CD004429. doi: 10.1002/14651858.CD004429.pub3. PMID: 35015296Free PMC Article
Delmont E, Azulay JP, Giorgi R, Attarian S, Verschueren A, Uzenot D, Pouget J
Neurology 2006 Aug 22;67(4):592-6. doi: 10.1212/01.wnl.0000234063.51897.20. PMID: 16924010
Van Doorn PA, Garssen MP
Curr Opin Neurol 2002 Oct;15(5):623-31. doi: 10.1097/00019052-200210000-00014. PMID: 12352007
Hughes RA
Baillieres Clin Neurol 1994 Apr;3(1):45-72. PMID: 7921591

Diagnosis

Naum R, Gwathmey KG
Handb Clin Neurol 2023;195:587-608. doi: 10.1016/B978-0-323-98818-6.00004-2. PMID: 37562888
Garg N, Park SB, Vucic S, Yiannikas C, Spies J, Howells J, Huynh W, Matamala JM, Krishnan AV, Pollard JD, Cornblath DR, Reilly MM, Kiernan MC
J Neurol Neurosurg Psychiatry 2017 Jun;88(6):474-483. Epub 2016 Dec 21 doi: 10.1136/jnnp-2016-313526. PMID: 28003344Free PMC Article
Callaghan BC, Price RS, Chen KS, Feldman EL
JAMA Neurol 2015 Dec;72(12):1510-8. doi: 10.1001/jamaneurol.2015.2347. PMID: 26437251Free PMC Article
Whitesell J
Semin Neurol 2010 Sep;30(4):356-64. Epub 2010 Oct 12 doi: 10.1055/s-0030-1267279. PMID: 20941668
Wijesekera LC, Leigh PN
Orphanet J Rare Dis 2009 Feb 3;4:3. doi: 10.1186/1750-1172-4-3. PMID: 19192301Free PMC Article

Therapy

Tavee J, Brannagan TH 3rd, Lenihan MW, Muppidi S, Kellermeyer L, D Donofrio P; AANEM
Muscle Nerve 2023 Oct;68(4):356-374. Epub 2023 Jul 11 doi: 10.1002/mus.27922. PMID: 37432872
Briani C, Visentin A
Neurotherapeutics 2022 Apr;19(3):874-884. Epub 2022 Mar 28 doi: 10.1007/s13311-022-01222-x. PMID: 35349079Free PMC Article
Keddie S, Eftimov F, van den Berg LH, Brassington R, de Haan RJ, van Schaik IN
Cochrane Database Syst Rev 2022 Jan 11;1(1):CD004429. doi: 10.1002/14651858.CD004429.pub3. PMID: 35015296Free PMC Article
Callaghan BC, Price RS, Chen KS, Feldman EL
JAMA Neurol 2015 Dec;72(12):1510-8. doi: 10.1001/jamaneurol.2015.2347. PMID: 26437251Free PMC Article
Lünemann JD, Nimmerjahn F, Dalakas MC
Nat Rev Neurol 2015 Feb;11(2):80-9. Epub 2015 Jan 6 doi: 10.1038/nrneurol.2014.253. PMID: 25561275

Prognosis

Gwathmey KG, Smith AG
Neurol Clin 2020 Aug;38(3):711-735. Epub 2020 Jun 11 doi: 10.1016/j.ncl.2020.03.008. PMID: 32703478
Guimarães-Costa R, Bombelli F, Léger JM
Presse Med 2013 Jun;42(6 Pt 2):e217-24. Epub 2013 Apr 25 doi: 10.1016/j.lpm.2013.01.057. PMID: 23623583
Whitesell J
Semin Neurol 2010 Sep;30(4):356-64. Epub 2010 Oct 12 doi: 10.1055/s-0030-1267279. PMID: 20941668
Wijesekera LC, Leigh PN
Orphanet J Rare Dis 2009 Feb 3;4:3. doi: 10.1186/1750-1172-4-3. PMID: 19192301Free PMC Article
Van Doorn PA, Garssen MP
Curr Opin Neurol 2002 Oct;15(5):623-31. doi: 10.1097/00019052-200210000-00014. PMID: 12352007

Clinical prediction guides

Herraets I, van Rosmalen M, Bos J, van Eijk R, Cats E, Jongbloed B, Vlam L, Piepers S, van Asseldonk JT, Goedee HS, van den Berg L, van der Pol WL
Neurology 2020 Oct 6;95(14):e1979-e1987. Epub 2020 Jul 30 doi: 10.1212/WNL.0000000000010538. PMID: 32732293
Garg N, Park SB, Howells J, Vucic S, Yiannikas C, Mathey EK, Nguyen T, Noto Y, Barnett MH, Krishnan AV, Spies J, Bostock H, Pollard JD, Kiernan MC
Eur J Neurol 2019 Aug;26(8):1121-1129. Epub 2019 Apr 26 doi: 10.1111/ene.13953. PMID: 30882969
Berger M, Allen JA
Muscle Nerve 2015 Mar;51(3):315-26. Epub 2015 Jan 29 doi: 10.1002/mus.24526. PMID: 25418426Free PMC Article
Dalakas MC
J Peripher Nerv Syst 2012 May;17 Suppl 2:34-9. doi: 10.1111/j.1529-8027.2012.00393.x. PMID: 22548621
Cats EA, Jacobs BC, Yuki N, Tio-Gillen AP, Piepers S, Franssen H, van Asseldonk JT, van den Berg LH, van der Pol WL
Neurology 2010 Nov 30;75(22):1961-7. Epub 2010 Oct 20 doi: 10.1212/WNL.0b013e3181ff94c2. PMID: 20962291

Recent systematic reviews

Keddie S, Eftimov F, van den Berg LH, Brassington R, de Haan RJ, van Schaik IN
Cochrane Database Syst Rev 2022 Jan 11;1(1):CD004429. doi: 10.1002/14651858.CD004429.pub3. PMID: 35015296Free PMC Article
Lunn MP, Nobile-Orazio E
Cochrane Database Syst Rev 2016 Oct 4;10(10):CD002827. doi: 10.1002/14651858.CD002827.pub4. PMID: 27701752Free PMC Article
Umapathi T, Hughes RA, Nobile-Orazio E, Léger JM
Cochrane Database Syst Rev 2015 Mar 4;2015(3):CD003217. doi: 10.1002/14651858.CD003217.pub5. PMID: 25739040Free PMC Article
Umapathi T, Hughes RA, Nobile-Orazio E, Léger JM
Cochrane Database Syst Rev 2012 Apr 18;(4):CD003217. doi: 10.1002/14651858.CD003217.pub4. PMID: 22513910
Fergusson D, Hutton B, Sharma M, Tinmouth A, Wilson K, Cameron DW, Hebert PC
Transfusion 2005 Oct;45(10):1640-57. doi: 10.1111/j.1537-2995.2005.00581.x. PMID: 16181216

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