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Miller Fisher syndrome

MedGen UID:
95994
Concept ID:
C0393799
Disease or Syndrome
Synonyms: Fisher Syndrome; Guillain Barre Syndrome, Miller Fisher Variant; Guillain-Barre Syndrome, Miller Fisher Variant; Miller Fisher Syndrome; Miller Fisher Variant of Guillain Barre Syndrome; Miller-Fisher Syndrome; Ophthalmoplegia, Ataxia and Areflexia Syndrome; Syndrome, Fisher; Syndrome, Miller Fisher; Syndrome, Miller-Fisher
SNOMED CT: Fisher syndrome (1767005); Fisher's syndrome (1767005); Ophthalmoplegia, ataxia, areflexia syndrome (1767005); Miller-Fisher variant of Guillain-Barre syndrome (1767005); Miller-Fisher syndrome (1767005)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005851
Orphanet: ORPHA98919

Definition

Miller-Fisher syndrome (MFS) is a rare cranial nerve variant of Guillain-Barré syndrome (GBS; see this term). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiller Fisher syndrome
Follow this link to review classifications for Miller Fisher syndrome in Orphanet.

Professional guidelines

PubMed

van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
J Peripher Nerv Syst 2023 Dec;28(4):535-563. Epub 2023 Oct 10 doi: 10.1111/jns.12594. PMID: 37814551
Lonati D, Schicchi A, Crevani M, Buscaglia E, Scaravaggi G, Maida F, Cirronis M, Petrolini VM, Locatelli CA
Toxins (Basel) 2020 Aug 7;12(8) doi: 10.3390/toxins12080509. PMID: 32784744Free PMC Article

Recent clinical studies

Etiology

van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
J Peripher Nerv Syst 2023 Dec;28(4):535-563. Epub 2023 Oct 10 doi: 10.1111/jns.12594. PMID: 37814551
Tavee J, Brannagan TH 3rd, Lenihan MW, Muppidi S, Kellermeyer L, D Donofrio P; AANEM
Muscle Nerve 2023 Oct;68(4):356-374. Epub 2023 Jul 11 doi: 10.1002/mus.27922. PMID: 37432872
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
Wakerley BR, Uncini A, Yuki N; GBS Classification Group; GBS Classification Group
Nat Rev Neurol 2014 Sep;10(9):537-44. Epub 2014 Jul 29 doi: 10.1038/nrneurol.2014.138. PMID: 25072194

Diagnosis

van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
Al Othman B, Raabe J, Kini A, Lee AG
Curr Opin Ophthalmol 2019 Nov;30(6):462-466. doi: 10.1097/ICU.0000000000000611. PMID: 31567467
Horton E, Krishnamoorthy S, Reynolds L
BMJ Case Rep 2014 Jul 30;2014 doi: 10.1136/bcr-2014-205336. PMID: 25080547Free PMC Article
Wakerley BR, Uncini A, Yuki N; GBS Classification Group; GBS Classification Group
Nat Rev Neurol 2014 Sep;10(9):537-44. Epub 2014 Jul 29 doi: 10.1038/nrneurol.2014.138. PMID: 25072194
Teener JW
Semin Neurol 2012 Nov;32(5):512-6. Epub 2013 May 15 doi: 10.1055/s-0033-1334470. PMID: 23677659

Therapy

van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
J Peripher Nerv Syst 2023 Dec;28(4):535-563. Epub 2023 Oct 10 doi: 10.1111/jns.12594. PMID: 37814551
Tavee J, Brannagan TH 3rd, Lenihan MW, Muppidi S, Kellermeyer L, D Donofrio P; AANEM
Muscle Nerve 2023 Oct;68(4):356-374. Epub 2023 Jul 11 doi: 10.1002/mus.27922. PMID: 37432872
Al Othman B, Raabe J, Kini A, Lee AG
Curr Opin Ophthalmol 2019 Nov;30(6):462-466. doi: 10.1097/ICU.0000000000000611. PMID: 31567467
Wijdicks EF, Klein CJ
Mayo Clin Proc 2017 Mar;92(3):467-479. doi: 10.1016/j.mayocp.2016.12.002. PMID: 28259232

Prognosis

van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
J Peripher Nerv Syst 2023 Dec;28(4):535-563. Epub 2023 Oct 10 doi: 10.1111/jns.12594. PMID: 37814551
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
van Doorn PA
Presse Med 2013 Jun;42(6 Pt 2):e193-201. Epub 2013 Apr 28 doi: 10.1016/j.lpm.2013.02.328. PMID: 23628447
Teener JW
Semin Neurol 2012 Nov;32(5):512-6. Epub 2013 May 15 doi: 10.1055/s-0033-1334470. PMID: 23677659

Clinical prediction guides

Lee SU, Kim HJ, Choi JY, Choi KD, Kim JS
JAMA Neurol 2024 Jul 1;81(7):762-770. doi: 10.1001/jamaneurol.2024.1123. PMID: 38739407
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
J Peripher Nerv Syst 2023 Dec;28(4):535-563. Epub 2023 Oct 10 doi: 10.1111/jns.12594. PMID: 37814551
Doets AY, Verboon C, van den Berg B, Harbo T, Cornblath DR, Willison HJ, Islam Z, Attarian S, Barroso FA, Bateman K, Benedetti L, van den Bergh P, Casasnovas C, Cavaletti G, Chavada G, Claeys KG, Dardiotis E, Davidson A, van Doorn PA, Feasby TE, Galassi G, Gorson KC, Hartung HP, Hsieh ST, Hughes RAC, Illa I, Islam B, Kusunoki S, Kuwabara S, Lehmann HC, Miller JAL, Mohammad QD, Monges S, Nobile Orazio E, Pardo J, Pereon Y, Rinaldi S, Querol L, Reddel SW, Reisin RC, Shahrizaila N, Sindrup SH, Waqar W, Jacobs BC; IGOS Consortium
Brain 2018 Oct 1;141(10):2866-2877. doi: 10.1093/brain/awy232. PMID: 30247567
van Doorn PA
Presse Med 2013 Jun;42(6 Pt 2):e193-201. Epub 2013 Apr 28 doi: 10.1016/j.lpm.2013.02.328. PMID: 23628447

Recent systematic reviews

Alijanzadeh D, Soltani A, Afra F, Salmanpour F, Loghman AH, Samieefar N, Rezaei N
BMC Neurol 2023 Sep 21;23(1):332. doi: 10.1186/s12883-023-03375-4. PMID: 37735648Free PMC Article
Neophytou P, Artemiadis A, Hadjigeorgiou GM, Zis P
Acta Neurol Belg 2023 Oct;123(5):1693-1701. Epub 2023 Jul 19 doi: 10.1007/s13760-023-02336-5. PMID: 37468803Free PMC Article
Li Z, Li X, Shen J, Chan MTV, Wu WKK
Environ Sci Pollut Res Int 2021 May;28(17):20939-20944. Epub 2021 Mar 6 doi: 10.1007/s11356-021-13233-w. PMID: 33677662Free PMC Article
Keithlin J, Sargeant J, Thomas MK, Fazil A
BMC Public Health 2014 Nov 22;14:1203. doi: 10.1186/1471-2458-14-1203. PMID: 25416162Free PMC Article
Overell JR, Hsieh ST, Odaka M, Yuki N, Willison HJ
Cochrane Database Syst Rev 2007 Jan 24;2007(1):CD004761. doi: 10.1002/14651858.CD004761.pub2. PMID: 17253522Free PMC Article

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