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Idiopathic trigeminal neuralgia

MedGen UID:
97963
•Concept ID:
C0393786
•
Disease or Syndrome
Synonyms: Idiopathic Trigeminal Neuralgia; Idiopathic Trigeminal Neuralgias; Neuralgia, Idiopathic Trigeminal; Trigeminal Neuralgia, Idiopathic
SNOMED CT: Idiopathic trigeminal neuralgia (230537000)

Professional guidelines

PubMed

Medication Management of Neuropathic Pain Disorders.
Fisher R, Clarkson E
Dent Clin North Am 2024 Jan;68(1):121-131. Epub 2023 Aug 30 doi: 10.1016/j.cden.2023.07.010. PMID: 37951629
Acupuncture treatment on idiopathic trigeminal neuralgia: A systematic review protocol.
Liu H, Li XW, Du J
Medicine (Baltimore) 2019 Jan;98(4):e14239. doi: 10.1097/MD.0000000000014239. PMID: 30681609Free PMC Article
Pulsed radiofrequency treatment for idiopathic trigeminal neuralgia: a retrospective analysis of the causes for ineffective pain relief.
Luo F, Meng L, Wang T, Yu X, Shen Y, Ji N
Eur J Pain 2013 Sep;17(8):1189-92. Epub 2013 Jan 16 doi: 10.1002/j.1532-2149.2012.00278.x. PMID: 23322665

Recent clinical studies

Etiology

Comparison of Effectiveness and Safety between Intraoperative 3D-CT-Guided and C-Arm-Guided Percutaneous Balloon Compression for Idiopathic Trigeminal Neuralgia:  A  Multi-Center Retrospective Study.
Xiao X, Wei Z, Ren H, Sun H, Luo F
Pain Res Manag 2021;2021:9306532. Epub 2021 Jun 7 doi: 10.1155/2021/9306532. PMID: 34194588Free PMC Article
Novel fluoroscopic landmark to significantly facilitate the visualization of foramen ovale in treating idiopathic trigeminal neuralgia.
He L, Zhao W, Su PP, Guo G, Yue J, Ni J, Yang L, Guan Z
Reg Anesth Pain Med 2021 Apr;46(4):350-353. Epub 2020 Dec 16 doi: 10.1136/rapm-2020-102081. PMID: 33328267
Effect of Acupuncture on Cognitive Function and Quality of Life in Patients With Idiopathic Trigeminal Neuralgia.
Gao J, Zhao C, Jiang W, Zheng B, He Y
J Nerv Ment Dis 2019 Mar;207(3):171-174. doi: 10.1097/NMD.0000000000000937. PMID: 30720599
The efficacy and safety of combined pulsed and conventional radiofrequency treatment of refractory cases of idiopathic trigeminal neuralgia: a retrospective study.
Ali Eissa AA, Reyad RM, Saleh EG, El-Saman A
J Anesth 2015 Oct;29(5):728-33. Epub 2015 May 19 doi: 10.1007/s00540-015-2029-5. PMID: 25987324
Functional and sensory evaluation of patients with idiopathic trigeminal neuralgia: comparison with controls.
Ichida MC, Alvarenga da Silva L, Teixeira MJ, de Siqueira JT, de Siqueira SR
Clin Neurol Neurosurg 2015 Mar;130:114-21. Epub 2015 Jan 6 doi: 10.1016/j.clineuro.2014.12.024. PMID: 25603125

Diagnosis

Craniofacial neuralgias.
Katta-Charles SD
NeuroRehabilitation 2020;47(3):299-314. doi: 10.3233/NRE-208004. PMID: 32986621
Peripheral Nerve Stimulation for Refractory Trigeminal Pain: Recent Single-Institution Case Series With Long-Term Follow-Up and Review of the Literature.
Bina RW, Palsma RS, Weinand ME, Kasoff WS
Neuromodulation 2020 Aug;23(6):796-804. Epub 2020 Mar 5 doi: 10.1111/ner.13132. PMID: 32141164
Trigeminal Neuralgia.
Cruccu G
Continuum (Minneap Minn) 2017 Apr;23(2, Selected Topics in Outpatient Neurology):396-420. doi: 10.1212/CON.0000000000000451. PMID: 28375911
Sensory abnormalities and masticatory function after microvascular decompression or balloon compression for trigeminal neuralgia compared with carbamazepine and healthy controls.
Ichida MC, de Almeida AN, da Nobrega JC, Teixeira MJ, de Siqueira JT, de Siqueira SR
J Neurosurg 2015 Jun;122(6):1315-23. Epub 2015 Apr 3 doi: 10.3171/2014.9.JNS14346. PMID: 25839918
Functional and sensory evaluation of patients with idiopathic trigeminal neuralgia: comparison with controls.
Ichida MC, Alvarenga da Silva L, Teixeira MJ, de Siqueira JT, de Siqueira SR
Clin Neurol Neurosurg 2015 Mar;130:114-21. Epub 2015 Jan 6 doi: 10.1016/j.clineuro.2014.12.024. PMID: 25603125

Therapy

Botulinum toxin A and neuropathic pain: An update.
Spagna A, Attal N
Toxicon 2023 Aug 15;232:107208. Epub 2023 Jun 27 doi: 10.1016/j.toxicon.2023.107208. PMID: 37385479
Craniofacial neuralgias.
Katta-Charles SD
NeuroRehabilitation 2020;47(3):299-314. doi: 10.3233/NRE-208004. PMID: 32986621
Effect of Acupuncture on Cognitive Function and Quality of Life in Patients With Idiopathic Trigeminal Neuralgia.
Gao J, Zhao C, Jiang W, Zheng B, He Y
J Nerv Ment Dis 2019 Mar;207(3):171-174. doi: 10.1097/NMD.0000000000000937. PMID: 30720599
Botulinum toxin in trigeminal neuralgia.
Castillo-Álvarez F, Hernando de la Bárcena I, Marzo-Sola ME
Med Clin (Barc) 2017 Jan 6;148(1):28-32. Epub 2016 Oct 12 doi: 10.1016/j.medcli.2016.07.032. PMID: 27743594
Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia in rats and idiopathic trigeminal neuralgia in patients.
Gu N, Niu JY, Liu WT, Sun YY, Liu S, Lv Y, Dong HL, Song XJ, Xiong LZ
Eur J Pain 2012 Sep;16(8):1094-105. doi: 10.1002/j.1532-2149.2012.00113.x. PMID: 22354664

Prognosis

Botulinum toxin A and neuropathic pain: An update.
Spagna A, Attal N
Toxicon 2023 Aug 15;232:107208. Epub 2023 Jun 27 doi: 10.1016/j.toxicon.2023.107208. PMID: 37385479
Peripheral Nerve Stimulation for Refractory Trigeminal Pain: Recent Single-Institution Case Series With Long-Term Follow-Up and Review of the Literature.
Bina RW, Palsma RS, Weinand ME, Kasoff WS
Neuromodulation 2020 Aug;23(6):796-804. Epub 2020 Mar 5 doi: 10.1111/ner.13132. PMID: 32141164
Effect of Acupuncture on Cognitive Function and Quality of Life in Patients With Idiopathic Trigeminal Neuralgia.
Gao J, Zhao C, Jiang W, Zheng B, He Y
J Nerv Ment Dis 2019 Mar;207(3):171-174. doi: 10.1097/NMD.0000000000000937. PMID: 30720599
Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia in rats and idiopathic trigeminal neuralgia in patients.
Gu N, Niu JY, Liu WT, Sun YY, Liu S, Lv Y, Dong HL, Song XJ, Xiong LZ
Eur J Pain 2012 Sep;16(8):1094-105. doi: 10.1002/j.1532-2149.2012.00113.x. PMID: 22354664
Operative findings and outcomes of microvascular decompression for trigeminal neuralgia in 35 patients affected by multiple sclerosis.
Broggi G, Ferroli P, Franzini A, Nazzi V, Farina L, La Mantia L, Milanese C
Neurosurgery 2004 Oct;55(4):830-8; discussion 838-9. PMID: 15458591

Clinical prediction guides

Botulinum toxin A and neuropathic pain: An update.
Spagna A, Attal N
Toxicon 2023 Aug 15;232:107208. Epub 2023 Jun 27 doi: 10.1016/j.toxicon.2023.107208. PMID: 37385479
Effect of Acupuncture on Cognitive Function and Quality of Life in Patients With Idiopathic Trigeminal Neuralgia.
Gao J, Zhao C, Jiang W, Zheng B, He Y
J Nerv Ment Dis 2019 Mar;207(3):171-174. doi: 10.1097/NMD.0000000000000937. PMID: 30720599
The Effectiveness and Safety of Thermocoagulation Radiofrequency Treatment of the Ophthalmic Division (V1) and/or Maxillary (V2) and Mandibular (V3) Division in Idiopathic Trigeminal Neuralgia: An Observational Study.
Huang Q, Liu X, Chen J, Bao C, Liu D, Fang Z, Liang X, Lu Z, Wan L
Pain Physician 2016 Sep-Oct;19(7):E1041-7. PMID: 27676675
Radiofrequency thermocoagulation for V2/V3 idiopathic trigeminal neuralgia: effect of treatment temperatures on long-term clinical outcomes: A Cohort Study.
Yao P, Deng YY, Hong T, Wang ZB, Ma JM, Zhu YQ, Li HX, Ding YY, Pan SN
Medicine (Baltimore) 2016 Jun;95(26):e4019. doi: 10.1097/MD.0000000000004019. PMID: 27368021Free PMC Article
The efficacy and safety of combined pulsed and conventional radiofrequency treatment of refractory cases of idiopathic trigeminal neuralgia: a retrospective study.
Ali Eissa AA, Reyad RM, Saleh EG, El-Saman A
J Anesth 2015 Oct;29(5):728-33. Epub 2015 May 19 doi: 10.1007/s00540-015-2029-5. PMID: 25987324

Recent systematic reviews

Radiofrequency thermoablation of the peripheral branches of trigeminal nerve versus the Gasserian ganglion for treating idiopathic trigeminal neuralgia: A systematic review and meta-analysis.
Abduhamid AS, Alomari MS, Ghaddaf AA, Mullah AN, Alsharif A, Alqrni AM, Haider M
J Clin Neurosci 2022 Oct;104:42-47. Epub 2022 Aug 11 doi: 10.1016/j.jocn.2022.08.005. PMID: 35963063
Herbal medicine for the management of idiopathic trigeminal neuralgia: A protocol for a systematic review of controlled trials.
Hwang JH, Ku J
Medicine (Baltimore) 2020 Jun 19;99(25):e20779. doi: 10.1097/MD.0000000000020779. PMID: 32569221Free PMC Article
Efficacy of gabapentin in the treatment of trigeminal neuralgia: A systematic review of randomized controlled trials.
Ta PCP, Dinh HQ, Nguyen K, Lin S, Ong YL, Ariyawardana A
J Investig Clin Dent 2019 Nov;10(4):e12448. Epub 2019 Aug 11 doi: 10.1111/jicd.12448. PMID: 31402607

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