Benign idiopathic neonatal seizures

MedGen UID:: 140738
•Concept ID:: C0393693
•: Disease or Syndrome

Synonyms:	Benign Neonatal Epilepsy, Nonfamilial; Benign Neonatal Non Familial Convulsions; Benign Neonatal Non-Familial Convulsions; Benign Neonatal Nonfamilial Epilepsy; Benign Non Familial Neonatal Convulsions; Benign Non-Familial Neonatal Convulsions; Convulsions, Benign Neonatal, Non-Familial; Epilepsy, Benign Neonatal, Non-Familial; Epilepsy, Benign Neonatal, Nonfamilial; Non Familial Benign Neonatal Convulsions; Non Familial Benign Neonatal Epilepsy; Non-Familial Benign Neonatal Convulsions; Non-Familial Benign Neonatal Epilepsy
SNOMED CT:	Benign non-familial neonatal convulsions (230411000)

Monarch Initiative:	MONDO:0018981

Definition

A rare neonatal epilepsy syndrome characterized by seizures without specific underlying etiology, occurring during the first days of life in infants with an otherwise normal neurological state and no family history of neonatal convulsions. The most commonly partial and clonic seizures usually last for one to three minutes. Repeated seizures may lead to status epilepticus lasting up to 20 hours. Overall, remission rates are high and neurological outcome is favorable. [from MONDO]

Professional guidelines

PubMed

ACR Appropriateness Criteria® Seizures-Child.

Expert Panel on Pediatric Imaging, Trofimova A, Milla SS, Ryan ME, Pruthi S, Blount JP, Desai NK, Glenn OA, Islam MP, Kadom N, Mirsky DM, Myseros JS, Partap S, Radhakrishnan R, Rose E, Soares BP, Trout AT, Udayasankar UK, Whitehead MT, Karmazyn B
J Am Coll Radiol 2021 May;18(5S):S199-S211. doi: 10.1016/j.jacr.2021.02.020. PMID: 33958113

HCN and KV7 (M-) channels as targets for epilepsy treatment.

Shah MM, Huang Z, Martinello K
Neuropharmacology 2013 Jun;69:75-81. Epub 2012 Mar 15 doi: 10.1016/j.neuropharm.2012.03.005. PMID: 22446478 Free PMC Article

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