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atopy

MedGen UID:
98234
•Concept ID:
C0392707
•
Pathologic Function
Synonym: Atopy
SNOMED CT: Atopic state (115665000); Atopic diathesis (115665000); Atopy (115665000); Atopic reaction (55985003)

Definition

A genetic predisposition to form IgE antibodies in response to exposure to allergens and therefore, for the development of immediate (type I) hypersensitivity and atopic conditions, such as allergic rhinitis; bronchial asthma, atopic dermatitis, and food allergy. Mutations of specific alleles on the long arm of chromosome 5 have been associated with higher levels of IL-4 and IgE and are known as IL-4 promoter polymorphisms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVatopy

Professional guidelines

PubMed

Chromosome 22q11.2 Deletion (DiGeorge Syndrome): Immunologic Features, Diagnosis, and Management.
Biggs SE, Gilchrist B, May KR
Curr Allergy Asthma Rep 2023 Apr;23(4):213-222. Epub 2023 Mar 10 doi: 10.1007/s11882-023-01071-4. PMID: 36897497Free PMC Article
Clinical practice guidelines for the diagnosis and management of atopic dermatitis.
Kulthanan K, Tuchinda P, Nitiyarom R, Chunharas A, Chantaphakul H, Aunhachoke K, Chularojanamontri L, Rajatanavin N, Jirapongsananuruk O, Vichyanond P, Chatchatee P, Sangsupawanich P, Wananukul S, Singalavanija S, Trakanwittayarak S, Rerkpattanapipat T, Thongngarm T, Wisuthsarewong W, Limpongsanurak W, Kamchaisatian W, Noppakun N
Asian Pac J Allergy Immunol 2021 Sep;39(3):145-155. doi: 10.12932/AP-010221-1050. PMID: 34246205
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.
Sicherer SH, Sampson HA
J Allergy Clin Immunol 2014 Feb;133(2):291-307; quiz 308. Epub 2013 Dec 31 doi: 10.1016/j.jaci.2013.11.020. PMID: 24388012

Recent clinical studies

Etiology

Independent and interactive effects of eye rubbing and atopy on keratoconus.
Yang K, Li D, Xu L, Pang C, Zhao D, Ren S
Front Immunol 2022;13:999435. Epub 2022 Sep 29 doi: 10.3389/fimmu.2022.999435. PMID: 36248837Free PMC Article
Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children.
Kim H, Sitarik AR, Woodcroft K, Johnson CC, Zoratti E
Curr Allergy Asthma Rep 2019 Mar 11;19(4):22. doi: 10.1007/s11882-019-0851-9. PMID: 30859338Free PMC Article
Contact dermatitis in atopic individuals.
Spiewak R
Curr Opin Allergy Clin Immunol 2012 Oct;12(5):491-7. doi: 10.1097/ACI.0b013e328357b05a. PMID: 22885887
Genetics of asthma.
Blumenthal JB, Blumenthal MN
Med Clin North Am 2002 Sep;86(5):937-50. doi: 10.1016/s0025-7125(02)00028-7. PMID: 12428539
Atopy and work.
Nordman H
Scand J Work Environ Health 1984 Dec;10(6 Spec No):481-5. doi: 10.5271/sjweh.2312. PMID: 6398914

Diagnosis

Human toxocariasis and atopy.
Magnaval JF, Fillaux J, Cassaing S, Valentin A, Iriart X, Berry A
Parasite 2020;27:32. Epub 2020 May 13 doi: 10.1051/parasite/2020029. PMID: 32400389Free PMC Article
Fungi and Atopy.
Barnes C
Clin Rev Allergy Immunol 2019 Dec;57(3):439-448. doi: 10.1007/s12016-019-08750-z. PMID: 31321665
The overlap between allergy and immunodeficiency.
Sokol K, Milner JD
Curr Opin Pediatr 2018 Dec;30(6):848-854. doi: 10.1097/MOP.0000000000000697. PMID: 30407976
Genetics of asthma.
Blumenthal JB, Blumenthal MN
Med Clin North Am 2002 Sep;86(5):937-50. doi: 10.1016/s0025-7125(02)00028-7. PMID: 12428539
Atopy and work.
Nordman H
Scand J Work Environ Health 1984 Dec;10(6 Spec No):481-5. doi: 10.5271/sjweh.2312. PMID: 6398914

Therapy

Treatment Effect of Omalizumab on Severe Pediatric Atopic Dermatitis: The ADAPT Randomized Clinical Trial.
Chan S, Cornelius V, Cro S, Harper JI, Lack G
JAMA Pediatr 2020 Jan 1;174(1):29-37. doi: 10.1001/jamapediatrics.2019.4476. PMID: 31764962Free PMC Article
Primary Prevention of Cow's Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow's Milk Formula at Birth: A Randomized Clinical Trial.
Urashima M, Mezawa H, Okuyama M, Urashima T, Hirano D, Gocho N, Tachimoto H
JAMA Pediatr 2019 Dec 1;173(12):1137-1145. doi: 10.1001/jamapediatrics.2019.3544. PMID: 31633778Free PMC Article
Fungi and Atopy.
Barnes C
Clin Rev Allergy Immunol 2019 Dec;57(3):439-448. doi: 10.1007/s12016-019-08750-z. PMID: 31321665
Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children.
Kim H, Sitarik AR, Woodcroft K, Johnson CC, Zoratti E
Curr Allergy Asthma Rep 2019 Mar 11;19(4):22. doi: 10.1007/s11882-019-0851-9. PMID: 30859338Free PMC Article
Probiotics for treating eczema.
Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, Murrell DF, Tang ML, Roberts A, Boyle RJ
Cochrane Database Syst Rev 2018 Nov 21;11(11):CD006135. doi: 10.1002/14651858.CD006135.pub3. PMID: 30480774Free PMC Article

Prognosis

Why do some Children Get Sick with Recurrent Respiratory Infections?
Cardinale F, La Torre F, Tricarico LG, Verriello G, Mastrorilli C
Curr Pediatr Rev 2024;20(3):203-215. doi: 10.2174/1573396320666230912103056. PMID: 37702165
Career Advice for Young Allergy Patients.
Radon K, Nowak D, Vogelberg C, Ruëff F
Dtsch Arztebl Int 2016 Aug 8;113(31-32):519-24. doi: 10.3238/arztebl.2016.0519. PMID: 27581504Free PMC Article
Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management.
Rampton D, Folkersen J, Fishbane S, Hedenus M, Howaldt S, Locatelli F, Patni S, Szebeni J, Weiss G
Haematologica 2014 Nov;99(11):1671-6. doi: 10.3324/haematol.2014.111492. PMID: 25420283Free PMC Article
Chemical atopy.
Puangpet P, Lai-Cheong J, McFadden JP
Contact Dermatitis 2013 Apr;68(4):208-13. doi: 10.1111/cod.12029. PMID: 23510341
Occupational dermatoses.
Beltrani VS
Curr Opin Allergy Clin Immunol 2003 Apr;3(2):115-23. doi: 10.1097/00130832-200304000-00005. PMID: 12750608

Clinical prediction guides

Plasma protein signatures of adult asthma.
Smilnak GJ, Lee Y, Chattopadhyay A, Wyss AB, White JD, Sikdar S, Jin J, Grant AJ, Motsinger-Reif AA, Li JL, Lee M, Yu B, London SJ
Allergy 2024 Mar;79(3):643-655. Epub 2024 Jan 23 doi: 10.1111/all.16000. PMID: 38263798Free PMC Article
Atopy and Specific Cancer Sites: a Review of Epidemiological Studies.
Cui Y, Hill AW
Clin Rev Allergy Immunol 2016 Dec;51(3):338-352. doi: 10.1007/s12016-016-8559-2. PMID: 27277132
Obesity and atopy.
Boulet LP
Clin Exp Allergy 2015 Jan;45(1):75-86. doi: 10.1111/cea.12435. PMID: 25323112
The allergic asthma phenotype.
Schatz M, Rosenwasser L
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):645-8; quiz 649. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.004. PMID: 25439351
Pulmonary aspergillosis: a clinical review.
Kousha M, Tadi R, Soubani AO
Eur Respir Rev 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011. PMID: 21881144Free PMC Article

Recent systematic reviews

Antibiotic exposure and adverse long-term health outcomes in children: A systematic review and meta-analysis.
Duong QA, Pittet LF, Curtis N, Zimmermann P
J Infect 2022 Sep;85(3):213-300. Epub 2022 Jan 10 doi: 10.1016/j.jinf.2022.01.005. PMID: 35021114
The Prevalence and Risk Factors for Keratoconus: A Systematic Review and Meta-Analysis.
Hashemi H, Heydarian S, Hooshmand E, Saatchi M, Yekta A, Aghamirsalim M, Valadkhan M, Mortazavi M, Hashemi A, Khabazkhoob M
Cornea 2020 Feb;39(2):263-270. doi: 10.1097/ICO.0000000000002150. PMID: 31498247
The Impact of Mediterranean Dietary Patterns During Pregnancy on Maternal and Offspring Health.
Amati F, Hassounah S, Swaka A
Nutrients 2019 May 17;11(5) doi: 10.3390/nu11051098. PMID: 31108910Free PMC Article
Probiotics for treating eczema.
Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, Murrell DF, Tang ML, Roberts A, Boyle RJ
Cochrane Database Syst Rev 2018 Nov 21;11(11):CD006135. doi: 10.1002/14651858.CD006135.pub3. PMID: 30480774Free PMC Article
Vitamin D supplementation in pregnancy: a systematic review.
Harvey NC, Holroyd C, Ntani G, Javaid K, Cooper P, Moon R, Cole Z, Tinati T, Godfrey K, Dennison E, Bishop NJ, Baird J, Cooper C
Health Technol Assess 2014 Jul;18(45):1-190. doi: 10.3310/hta18450. PMID: 25025896Free PMC Article

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