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Necrobiosis lipoidica diabeticorum

MedGen UID:
98226
•Concept ID:
C0392445
•
Disease or Syndrome
Synonyms: Diabeticorum, Necrobiosis Lipoidica; Necrobiosis Lipoidica Diabeticorum
SNOMED CT: Necrobiosis diabeticorum (56391002); Diabetic necrobiosis lipoidica (56391002); NLD - Necrobiosis lipoidica diabeticorum (56391002); Necrobiosis lipoidica diabeticorum (56391002); Oppenheim-Urbach disease (56391002)

Professional guidelines

PubMed

Treatment options for necrobiosis lipoidica: a systematic review.
Nihal A, Caplan AS, Rosenbach M, Damsky W, Mangold AR, Shields BE
Int J Dermatol 2023 Dec;62(12):1529-1537. Epub 2023 Sep 29 doi: 10.1111/ijd.16856. PMID: 37772666
Laser and light therapies for the treatment of necrobiosis lipoidica.
Rajabi-Estarabadi A, Aickara DJ, Hirsch M, Williams NM, Maranda EL, Van Badiavas E
Lasers Med Sci 2021 Apr;36(3):497-506. Epub 2020 Sep 24 doi: 10.1007/s10103-020-03147-3. PMID: 32970197
Update: Treatment of necrobiosis lipoidica.
Peckruhn M, Tittelbach J, Elsner P
J Dtsch Dermatol Ges 2017 Feb;15(2):151-157. doi: 10.1111/ddg.13186. PMID: 28214312

Recent clinical studies

Etiology

Necrobiosis lipoidica in a Nigerian woman - Report of a case.
Yahya H
Niger J Clin Pract 2019 Nov;22(11):1626-1628. doi: 10.4103/njcp.njcp_40_19. PMID: 31719288
Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises.
Weghuber D, Barrientos-Pérez M, Kovarenko M
Ann Nutr Metab 2019;74(4):339-347. Epub 2019 May 16 doi: 10.1159/000500234. PMID: 31096219
Dermatological and musculoskeletal assessment of diabetic foot: A narrative review.
Arsanjani Shirazi A, Nasiri M, Yazdanpanah L
Diabetes Metab Syndr 2016 Apr-Jun;10(2 Suppl 1):S158-64. Epub 2016 Mar 12 doi: 10.1016/j.dsx.2016.03.004. PMID: 27016885
Perforating necrobiosis lipoidica in a girl with type 1 diabetes mellitus: a new case reported.
Hammami H, Youssef S, Jaber K, Dhaoui MR, Doss N
Dermatol Online J 2008 Jul 15;14(7):11. PMID: 18718195
Necrobiosis lipoidica diabeticorum in children and adolescents: a clue for underlying renal and retinal disease.
Verrotti A, Chiarelli F, Amerio P, Morgese G
Pediatr Dermatol 1995 Sep;12(3):220-3. doi: 10.1111/j.1525-1470.1995.tb00162.x. PMID: 7501550

Diagnosis

Atypical Ulcerative Necrobiosis Lipoidica Diabeticorum: A Case Study.
Blevins M
Int J Low Extrem Wounds 2023 Mar;22(1):185-189. Epub 2021 Mar 20 doi: 10.1177/1534734621999269. PMID: 33745343
Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises.
Weghuber D, Barrientos-Pérez M, Kovarenko M
Ann Nutr Metab 2019;74(4):339-347. Epub 2019 May 16 doi: 10.1159/000500234. PMID: 31096219
Necrobiosis lipoidica diabeticorum.
Richardson AS, Hossler EW
Cutis 2015 May;95(5):252, 265-6. PMID: 26057508
Palmar erythema.
Serrao R, Zirwas M, English JC
Am J Clin Dermatol 2007;8(6):347-56. doi: 10.2165/00128071-200708060-00004. PMID: 18039017
NECROBIOSIS LIPOIDICA?DIABETICORUM.
NARVA WM, RINGROSE EJ, CUTLER RE
Arch Dermatol 1964 Apr;89:625-7. PMID: 14107651

Therapy

Necrobiosis lipoidica in a Nigerian woman - Report of a case.
Yahya H
Niger J Clin Pract 2019 Nov;22(11):1626-1628. doi: 10.4103/njcp.njcp_40_19. PMID: 31719288
Dermatologic manifestations of diabetes mellitus: a review.
Murphy-Chutorian B, Han G, Cohen SR
Endocrinol Metab Clin North Am 2013 Dec;42(4):869-98. doi: 10.1016/j.ecl.2013.07.004. PMID: 24286954
Necrobiosis lipoidica diabeticorum.
Körber A, Dissemond J
CMAJ 2007 Dec 4;177(12):1498. doi: 10.1503/cmaj.070024. PMID: 18056597Free PMC Article
Necrobiosis lipoidica diabeticorum treated with chloroquine.
Nguyen K, Washenik K, Shupack J
J Am Acad Dermatol 2002 Feb;46(2 Suppl Case Reports):S34-6. doi: 10.1067/mjd.2002.104969. PMID: 11807467
Cutaneous signs of diabetes mellitus.
Stawiski MA, Voorhees JJ
Cutis 1976 Sep;18(3):415-21. PMID: 797552

Prognosis

A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus.
Mistry BD, Alavi A, Ali S, Mistry N
Int J Dermatol 2017 Dec;56(12):1319-1327. Epub 2017 Jun 26 doi: 10.1111/ijd.13610. PMID: 28650076
Dermatologic manifestations of diabetes mellitus: a review.
Murphy-Chutorian B, Han G, Cohen SR
Endocrinol Metab Clin North Am 2013 Dec;42(4):869-98. doi: 10.1016/j.ecl.2013.07.004. PMID: 24286954
Non-ulcerative skin pathologies of the diabetic foot.
Bristow I
Diabetes Metab Res Rev 2008 May-Jun;24 Suppl 1:S84-9. doi: 10.1002/dmrr.818. PMID: 18357585
Palmar erythema.
Serrao R, Zirwas M, English JC
Am J Clin Dermatol 2007;8(6):347-56. doi: 10.2165/00128071-200708060-00004. PMID: 18039017
Necrobiosis lipoidica and diabetic control revisited.
Cohen O, Yaniv R, Karasik A, Trau H
Med Hypotheses 1996 Apr;46(4):348-50. doi: 10.1016/s0306-9877(96)90184-x. PMID: 8733162

Clinical prediction guides

The 2017 Banting Memorial Lecture The diabetic lower limb - a forty year journey: from clinical observation to clinical science.
Boulton AJM
Diabet Med 2019 Dec;36(12):1539-1549. Epub 2019 Feb 14 doi: 10.1111/dme.13901. PMID: 30659650
Prevalence of cutaneous manifestations of diabetes mellitus.
Ahmed K, Muhammad Z, Qayum I
J Ayub Med Coll Abbottabad 2009 Apr-Jun;21(2):76-9. PMID: 20524475
Non-ulcerative skin pathologies of the diabetic foot.
Bristow I
Diabetes Metab Res Rev 2008 May-Jun;24 Suppl 1:S84-9. doi: 10.1002/dmrr.818. PMID: 18357585
gli-1 Oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum.
Macaron NC, Cohen C, Chen SC, Arbiser JL
Arch Dermatol 2005 Feb;141(2):259-62. doi: 10.1001/archderm.141.2.259. PMID: 15724024
Necrobiosis lipoidica. An immunofluorescence study.
Ullman S, Dahl MV
Arch Dermatol 1977 Dec;113(12):1671-3. PMID: 596895

Recent systematic reviews

A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus.
Mistry BD, Alavi A, Ali S, Mistry N
Int J Dermatol 2017 Dec;56(12):1319-1327. Epub 2017 Jun 26 doi: 10.1111/ijd.13610. PMID: 28650076

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