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Diffuse Malignant Mesothelioma

MedGen UID:
97895
•Concept ID:
C0392400
•
Neoplastic Process
Synonym: Malignant Diffuse Mesothelioma

Definition

A diffuse malignant neoplasm that arises from mesothelial cells, usually in the pleura or peritoneum. Histologic variants include biphasic, epithelioid, sarcomatoid, and desmoplastic mesothelioma. [from NCI]

Professional guidelines

PubMed

Sepsis in the Postpneumonectomy Space: Pathogenesis, Recognition, and Management.
Shamji FM
Thorac Surg Clin 2021 Nov;31(4):407-416. doi: 10.1016/j.thorsurg.2021.08.001. PMID: 34696853
Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies.
Cagle PT, Churg A
Arch Pathol Lab Med 2005 Nov;129(11):1421-7. doi: 10.5858/2005-129-1421-DDOBAM. PMID: 16253023
Diagnosis and treatment of pleural mesothelioma.
Rusch VW
Semin Surg Oncol 1990;6(5):279-85. doi: 10.1002/ssu.2980060510. PMID: 2237087

Recent clinical studies

Etiology

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Sepsis in the Postpneumonectomy Space: Pathogenesis, Recognition, and Management.
Shamji FM
Thorac Surg Clin 2021 Nov;31(4):407-416. doi: 10.1016/j.thorsurg.2021.08.001. PMID: 34696853
The Diagnosis of Pleural Tumors Other Than Mesothelioma.
Attanoos RL, Pugh MR
Arch Pathol Lab Med 2018 Aug;142(8):902-913. doi: 10.5858/arpa.2017-0537-RA. PMID: 30040453
Pulmonary sarcomatous tumors.
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765
Diffuse malignant mesothelioma: a review.
Rom WN, Lockey JE
West J Med 1982 Dec;137(6):548-54. PMID: 6761970Free PMC Article

Diagnosis

Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations.
Carbone M, Pass HI, Ak G, Alexander HR Jr, Baas P, Baumann F, Blakely AM, Bueno R, Bzura A, Cardillo G, Churpek JE, Dianzani I, De Rienzo A, Emi M, Emri S, Felley-Bosco E, Fennell DA, Flores RM, Grosso F, Hayward NK, Hesdorffer M, Hoang CD, Johansson PA, Kindler HL, Kittaneh M, Krausz T, Mansfield A, Metintas M, Minaai M, Mutti L, Nielsen M, O'Byrne K, Opitz I, Pastorino S, Pentimalli F, de Perrot M, Pritchard A, Ripley RT, Robinson B, Rusch V, Taioli E, Takinishi Y, Tanji M, Tsao AS, Tuncer AM, Walpole S, Wolf A, Yang H, Yoshikawa Y, Zolondick A, Schrump DS, Hassan R
J Thorac Oncol 2022 Jul;17(7):873-889. Epub 2022 Apr 21 doi: 10.1016/j.jtho.2022.03.014. PMID: 35462085Free PMC Article
Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
The Diagnosis of Pleural Tumors Other Than Mesothelioma.
Attanoos RL, Pugh MR
Arch Pathol Lab Med 2018 Aug;142(8):902-913. doi: 10.5858/arpa.2017-0537-RA. PMID: 30040453
Diffuse malignant mesothelioma.
Oviedo SP, Cagle PT
Arch Pathol Lab Med 2012 Aug;136(8):882-8. doi: 10.5858/arpa.2012-0142-CR. PMID: 22849735
Pulmonary sarcomatous tumors.
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765

Therapy

Sepsis in the Postpneumonectomy Space: Pathogenesis, Recognition, and Management.
Shamji FM
Thorac Surg Clin 2021 Nov;31(4):407-416. doi: 10.1016/j.thorsurg.2021.08.001. PMID: 34696853
Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases.
Butnor KJ, Brownlee NA, Mahar A, Pavlisko EN, Sporn TA, Roggli VL
Lung Cancer 2016 May;95:1-7. Epub 2016 Feb 18 doi: 10.1016/j.lungcan.2016.02.007. PMID: 27040844
Mechanisms of pleurodesis.
Rodriguez-Panadero F, Montes-Worboys A
Respiration 2012;83(2):91-8. Epub 2012 Jan 20 doi: 10.1159/000335419. PMID: 22286268
Mechanisms of asbestos-induced carcinogenesis.
Toyokuni S
Nagoya J Med Sci 2009 Feb;71(1-2):1-10. PMID: 19358470Free PMC Article
Pathology of malignant mesothelioma.
Attanoos RL, Gibbs AR
Histopathology 1997 May;30(5):403-18. doi: 10.1046/j.1365-2559.1997.5460776.x. PMID: 9181361

Prognosis

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
The Diagnosis of Pleural Tumors Other Than Mesothelioma.
Attanoos RL, Pugh MR
Arch Pathol Lab Med 2018 Aug;142(8):902-913. doi: 10.5858/arpa.2017-0537-RA. PMID: 30040453
Pathology of the pleura: what the pulmonologists need to know.
Cagle PT, Allen TC
Respirology 2011 Apr;16(3):430-8. doi: 10.1111/j.1440-1843.2011.01957.x. PMID: 21362105
Pulmonary sarcomatous tumors.
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765
Localized malignant mesothelioma.
Allen TC, Cagle PT, Churg AM, Colby TV, Gibbs AR, Hammar SP, Corson JM, Grimes MM, Ordonez NG, Roggli V, Travis WD, Wick MR
Am J Surg Pathol 2005 Jul;29(7):866-73. doi: 10.1097/01.pas.0000165529.78945.dc. PMID: 15958850

Clinical prediction guides

Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations.
Carbone M, Pass HI, Ak G, Alexander HR Jr, Baas P, Baumann F, Blakely AM, Bueno R, Bzura A, Cardillo G, Churpek JE, Dianzani I, De Rienzo A, Emi M, Emri S, Felley-Bosco E, Fennell DA, Flores RM, Grosso F, Hayward NK, Hesdorffer M, Hoang CD, Johansson PA, Kindler HL, Kittaneh M, Krausz T, Mansfield A, Metintas M, Minaai M, Mutti L, Nielsen M, O'Byrne K, Opitz I, Pastorino S, Pentimalli F, de Perrot M, Pritchard A, Ripley RT, Robinson B, Rusch V, Taioli E, Takinishi Y, Tanji M, Tsao AS, Tuncer AM, Walpole S, Wolf A, Yang H, Yoshikawa Y, Zolondick A, Schrump DS, Hassan R
J Thorac Oncol 2022 Jul;17(7):873-889. Epub 2022 Apr 21 doi: 10.1016/j.jtho.2022.03.014. PMID: 35462085Free PMC Article
Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel.
Marchevsky AM, Khoor A, Walts AE, Nicholson AG, Zhang YZ, Roggli V, Carney J, Roden AC, Tazelaar HD, Larsen BT, LeStang N, Chirieac LR, Klebe S, Tsao MS, De Perrot M, Pierre A, Hwang DM, Hung YP, Mino-Kenudson M, Travis W, Sauter J, Beasley MB, Galateau-Sallé F
Mod Pathol 2020 Feb;33(2):281-296. Epub 2019 Sep 4 doi: 10.1038/s41379-019-0352-3. PMID: 31485011Free PMC Article
Malignant peritoneal mesothelioma and Crohn disease.
Butnor KJ, Pavlisko EN, Sporn TA, Roggli VL
J Clin Pathol 2017 Mar;70(3):228-232. Epub 2016 Aug 2 doi: 10.1136/jclinpath-2016-203945. PMID: 27484913
Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases.
Butnor KJ, Brownlee NA, Mahar A, Pavlisko EN, Sporn TA, Roggli VL
Lung Cancer 2016 May;95:1-7. Epub 2016 Feb 18 doi: 10.1016/j.lungcan.2016.02.007. PMID: 27040844
Animal models of malignant mesothelioma.
Kane AB
Inhal Toxicol 2006 Nov;18(12):1001-4. doi: 10.1080/08958370600835393. PMID: 16920675

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