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Flu-Like Symptoms

MedGen UID:
140262
•Concept ID:
C0392171
•
Sign or Symptom
Synonyms: ILI; Influenza-Like Illness

Definition

Complaints describing a pattern similar to influenza, which may include one or more of the following symptoms: fever, chills, muscle or body aches, cough, sore throat, rhinitis, or fatigue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFlu-Like Symptoms

Professional guidelines

PubMed

Listeriosis in pregnancy: An umbrella review of maternal exposure, treatment and neonatal complications.
Khsim IEF, Mohanaraj-Anton A, Horte IB, Lamont RF, Khan KS, Jørgensen JS, Amezcua-Prieto C
BJOG 2022 Aug;129(9):1427-1433. Epub 2022 Jan 17 doi: 10.1111/1471-0528.17073. PMID: 34954888
Brucella - Virulence Factors, Pathogenesis and Treatment.
Głowacka P, Żakowska D, Naylor K, Niemcewicz M, Bielawska-Drózd A
Pol J Microbiol 2018 Jun 30;67(2):151-161. doi: 10.21307/pjm-2018-029. PMID: 30015453Free PMC Article
EUROPAEM EMF Guideline 2016 for the prevention, diagnosis and treatment of EMF-related health problems and illnesses.
Belyaev I, Dean A, Eger H, Hubmann G, Jandrisovits R, Kern M, Kundi M, Moshammer H, Lercher P, Müller K, Oberfeld G, Ohnsorge P, Pelzmann P, Scheingraber C, Thill R
Rev Environ Health 2016 Sep 1;31(3):363-97. doi: 10.1515/reveh-2016-0011. PMID: 27454111

Recent clinical studies

Etiology

Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial.
Yang H, Shi W, Fan J, Wang X, Song Y, Lian Y, Shan W, Wang Q
Neurotherapeutics 2023 Apr;20(3):870-880. Epub 2023 Mar 30 doi: 10.1007/s13311-023-01353-9. PMID: 36995682Free PMC Article
COVID-19 and the antiphospholipid syndrome.
Serrano M, Espinosa G, Serrano A, Cervera R
Autoimmun Rev 2022 Dec;21(12):103206. Epub 2022 Oct 3 doi: 10.1016/j.autrev.2022.103206. PMID: 36195247Free PMC Article
Listeriosis in pregnancy: An umbrella review of maternal exposure, treatment and neonatal complications.
Khsim IEF, Mohanaraj-Anton A, Horte IB, Lamont RF, Khan KS, Jørgensen JS, Amezcua-Prieto C
BJOG 2022 Aug;129(9):1427-1433. Epub 2022 Jan 17 doi: 10.1111/1471-0528.17073. PMID: 34954888
Rocky Mountain Spotted Fever.
Phillips J
Workplace Health Saf 2017 Jan;65(1):48. doi: 10.1177/2165079916683711. PMID: 28055518
Hantavirus.
Hawes S, Seabolt JP
Clin Lab Sci 2003 Winter;16(1):39-42. PMID: 12587657

Diagnosis

Cutaneous Coccidiomycosis.
Brown M, Zhou AE, Jaffe DF, Pfau RG
Am J Dermatopathol 2024 Feb 1;46(2):111-113. Epub 2023 Dec 6 doi: 10.1097/DAD.0000000000002601. PMID: 38055960
Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review.
Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, Mohammadi P, Nomovi M, Mowla A
J Neurol Sci 2021 Sep 15;428:117607. Epub 2021 Aug 3 doi: 10.1016/j.jns.2021.117607. PMID: 34365148Free PMC Article
Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians.
Batah SS, Fabro AT
Respir Med 2021 Jan;176:106239. Epub 2020 Nov 19 doi: 10.1016/j.rmed.2020.106239. PMID: 33246294Free PMC Article
New onset refractory status epilepticus (NORSE).
Sculier C, Gaspard N
Seizure 2019 May;68:72-78. Epub 2018 Sep 29 doi: 10.1016/j.seizure.2018.09.018. PMID: 30482654
Chikungunya virus infection: an overview.
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Therapy

Feasibility and impact of ketogenic dietary interventions in polycystic kidney disease: KETO-ADPKD-a randomized controlled trial.
Cukoski S, Lindemann CH, Arjune S, Todorova P, Brecht T, Kühn A, Oehm S, Strubl S, Becker I, Kämmerer U, Torres JA, Meyer F, Schömig T, Hokamp NG, Siedek F, Gottschalk I, Benzing T, Schmidt J, Antczak P, Weimbs T, Grundmann F, Müller RU
Cell Rep Med 2023 Nov 21;4(11):101283. Epub 2023 Nov 7 doi: 10.1016/j.xcrm.2023.101283. PMID: 37935200Free PMC Article
Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial.
Yang H, Shi W, Fan J, Wang X, Song Y, Lian Y, Shan W, Wang Q
Neurotherapeutics 2023 Apr;20(3):870-880. Epub 2023 Mar 30 doi: 10.1007/s13311-023-01353-9. PMID: 36995682Free PMC Article
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial.
Wrangle JM, Velcheti V, Patel MR, Garrett-Mayer E, Hill EG, Ravenel JG, Miller JS, Farhad M, Anderton K, Lindsey K, Taffaro-Neskey M, Sherman C, Suriano S, Swiderska-Syn M, Sion A, Harris J, Edwards AR, Rytlewski JA, Sanders CM, Yusko EC, Robinson MD, Krieg C, Redmond WL, Egan JO, Rhode PR, Jeng EK, Rock AD, Wong HC, Rubinstein MP
Lancet Oncol 2018 May;19(5):694-704. Epub 2018 Apr 5 doi: 10.1016/S1470-2045(18)30148-7. PMID: 29628312Free PMC Article
Fluoropolymer-associated illness.
Hays HL, Spiller H
Clin Toxicol (Phila) 2014 Sep-Oct;52(8):848-55. doi: 10.3109/15563650.2014.946610. PMID: 25200453
Cocaine-levamisole thrombotic vasculopathy.
Dy IA, Wiernik PH
Semin Thromb Hemost 2012 Nov;38(8):780-2. Epub 2012 Oct 6 doi: 10.1055/s-0032-1328889. PMID: 23041983

Prognosis

COVID-19 and cardiovascular manifestations.
Parvu S, Müller K, Dahdal D, Cosmin I, Christodorescu R, Duda-Seiman D, Man D, Sharma A, Dragoi R, Baneu P, Dragan S
Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4509-4519. doi: 10.26355/eurrev_202206_29090. PMID: 35776052
Cardiovascular Manifestations of COVID-19.
Nandy S, Wan SH, Brenes-Salazar J
Curr Cardiol Rev 2021;17(4):e230421187503. doi: 10.2174/1573403X16999201102213827. PMID: 33143614Free PMC Article
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article
New onset refractory status epilepticus (NORSE).
Sculier C, Gaspard N
Seizure 2019 May;68:72-78. Epub 2018 Sep 29 doi: 10.1016/j.seizure.2018.09.018. PMID: 30482654
Lyme borreliosis.
Holt DA, Pattani NJ, Sinnott JT 4th, Bradley E
Infect Control Hosp Epidemiol 1991 Aug;12(8):493-6. doi: 10.1086/646394. PMID: 1918895

Clinical prediction guides

Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial.
Yang H, Shi W, Fan J, Wang X, Song Y, Lian Y, Shan W, Wang Q
Neurotherapeutics 2023 Apr;20(3):870-880. Epub 2023 Mar 30 doi: 10.1007/s13311-023-01353-9. PMID: 36995682Free PMC Article
COVID-19 and cardiovascular manifestations.
Parvu S, Müller K, Dahdal D, Cosmin I, Christodorescu R, Duda-Seiman D, Man D, Sharma A, Dragoi R, Baneu P, Dragan S
Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4509-4519. doi: 10.26355/eurrev_202206_29090. PMID: 35776052
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article
Human babesiosis in Alsace.
Paleau A, Candolfi E, Souply L, De Briel D, Delarbre JM, Lipsker D, Jouglin M, Malandrin L, Hansmann Y, Martinot M
Med Mal Infect 2020 Sep;50(6):486-491. Epub 2019 Sep 20 doi: 10.1016/j.medmal.2019.08.007. PMID: 31548143
Chikungunya virus infection: an overview.
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Recent systematic reviews

COVID-19 and the Immune Response: A Multi-Phasic Approach to the Treatment of COVID-19.
Sapir T, Averch Z, Lerman B, Bodzin A, Fishman Y, Maitra R
Int J Mol Sci 2022 Aug 3;23(15) doi: 10.3390/ijms23158606. PMID: 35955740Free PMC Article
COVID-19 and cardiovascular manifestations.
Parvu S, Müller K, Dahdal D, Cosmin I, Christodorescu R, Duda-Seiman D, Man D, Sharma A, Dragoi R, Baneu P, Dragan S
Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4509-4519. doi: 10.26355/eurrev_202206_29090. PMID: 35776052
Propionyl-L-carnitine for intermittent claudication.
Kamoen V, Vander Stichele R, Campens L, De Bacquer D, Van Bortel L, de Backer TL
Cochrane Database Syst Rev 2021 Dec 26;12(12):CD010117. doi: 10.1002/14651858.CD010117.pub2. PMID: 34954832Free PMC Article
Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review.
Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, Mohammadi P, Nomovi M, Mowla A
J Neurol Sci 2021 Sep 15;428:117607. Epub 2021 Aug 3 doi: 10.1016/j.jns.2021.117607. PMID: 34365148Free PMC Article
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article

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