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Congestive Ophthalmopathy

MedGen UID:
91222
•Concept ID:
C0376323
•
Disease or Syndrome
Synonyms: Congestive Ophthalmopathies; Edematous Ophthalmopathies; Edematous Ophthalmopathy; Infiltrative Ophthalmopathies; Infiltrative Ophthalmopathy; Ophthalmopathy, Congestive; Ophthalmopathy, Edematous; Ophthalmopathy, Infiltrative

Professional guidelines

PubMed

Thyroid-associated ophthalmopathy: clinical features, pathogenesis, and management.
Yamada M, Li AW, Wall JR
Crit Rev Clin Lab Sci 2000 Dec;37(6):523-49. doi: 10.1080/10408360091174303. PMID: 11192331

Recent clinical studies

Etiology

Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves' disease with and without ophthalmopathy: correlation with clinical features.
Gopinath B, Musselman R, Adams CL, Tani J, Beard N, Wall JR
Thyroid 2006 Oct;16(10):967-74. doi: 10.1089/thy.2006.16.967. PMID: 17042681
Antibodies targeting the calcium binding skeletal muscle protein calsequestrin are specific markers of ophthalmopathy and sensitive indicators of ocular myopathy in patients with Graves' disease.
Gopinath B, Musselman R, Beard N, El-Kaissi S, Tani J, Adams CL, Wall JR
Clin Exp Immunol 2006 Jul;145(1):56-62. doi: 10.1111/j.1365-2249.2006.03110.x. PMID: 16792674Free PMC Article
Eye muscle antibodies and subtype of thyroid-associated ophthalmopathy.
Kaspar M, Archibald C, De BA, Li AW, Yamada M, Chang CH, Kahaly G, Wall JR
Thyroid 2002 Mar;12(3):187-91. doi: 10.1089/105072502753600115. PMID: 11952037
Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' hyperthyroidism.
Gunji K, De Bellis A, Li AW, Yamada M, Kubota S, Ackrell B, Wengrowicz S, Bellastella A, Bizzarro A, Sinisi A, Wall JR
J Clin Endocrinol Metab 2000 Apr;85(4):1641-7. doi: 10.1210/jcem.85.4.6553. PMID: 10770210
Thyroid-associated ophthalmopathy in black South African patients with Graves' disease: relationship to antiflavoprotein antibodies.
Joffe B, Gunji K, Panz V, Zouvanis M, Swanson J, Ackrell BA, Wall JR
Thyroid 1998 Nov;8(11):1023-7. doi: 10.1089/thy.1998.8.1023. PMID: 9848717

Diagnosis

Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves' disease with and without ophthalmopathy: correlation with clinical features.
Gopinath B, Musselman R, Adams CL, Tani J, Beard N, Wall JR
Thyroid 2006 Oct;16(10):967-74. doi: 10.1089/thy.2006.16.967. PMID: 17042681
Antibodies targeting the calcium binding skeletal muscle protein calsequestrin are specific markers of ophthalmopathy and sensitive indicators of ocular myopathy in patients with Graves' disease.
Gopinath B, Musselman R, Beard N, El-Kaissi S, Tani J, Adams CL, Wall JR
Clin Exp Immunol 2006 Jul;145(1):56-62. doi: 10.1111/j.1365-2249.2006.03110.x. PMID: 16792674Free PMC Article
Eye muscle antibodies in Graves' ophthalmopathy: pathogenic or secondary epiphenomenon?
Mizokami T, Salvi M, Wall JR
J Endocrinol Invest 2004 Mar;27(3):221-9. doi: 10.1007/BF03345270. PMID: 15164997
Thyroid-associated ophthalmopathy: clinical features, pathogenesis, and management.
Yamada M, Li AW, Wall JR
Crit Rev Clin Lab Sci 2000 Dec;37(6):523-49. doi: 10.1080/10408360091174303. PMID: 11192331
Serum antibodies against the flavoprotein subunit of succinate dehydrogenase are sensitive markers of eye muscle autoimmunity in patients with Graves' hyperthyroidism.
Gunji K, De Bellis A, Kubota S, Swanson J, Wengrowicz S, Cochran B, Ackrell BA, Salvi M, Bellastella A, Bizzarro A, Sinisi AA, Wall JR
J Clin Endocrinol Metab 1999 Apr;84(4):1255-62. doi: 10.1210/jcem.84.4.5640. PMID: 10199764

Therapy

Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves' disease with and without ophthalmopathy: correlation with clinical features.
Gopinath B, Musselman R, Adams CL, Tani J, Beard N, Wall JR
Thyroid 2006 Oct;16(10):967-74. doi: 10.1089/thy.2006.16.967. PMID: 17042681
Thyroid-associated ophthalmopathy in black South African patients with Graves' disease: relationship to antiflavoprotein antibodies.
Joffe B, Gunji K, Panz V, Zouvanis M, Swanson J, Ackrell BA, Wall JR
Thyroid 1998 Nov;8(11):1023-7. doi: 10.1089/thy.1998.8.1023. PMID: 9848717
Cyclosporin improves Graves' ophthalmopathy.
Weetman AP, McGregor AM, Ludgate M, Beck L, Mills PV, Lazarus JH, Hall R
Lancet 1983 Aug 27;2(8348):486-9. doi: 10.1016/s0140-6736(83)90514-7. PMID: 6136647
Plasma exchange in conjunction with immunosuppressive drug therapy in the treatment of endocrine exophthalmos.
Sawers JS, Irvine WJ, Toft AD, Urbaniak SJ, Donaldson AA
J Clin Lab Immunol 1981 Nov;6(3):245-50. PMID: 6896074
Dysthyroid optic neuropathy. Clinical profile and rationale for management.
Trobe JD, Glaser JS, Laflamme P
Arch Ophthalmol 1978 Jul;96(7):1199-1209. doi: 10.1001/archopht.1978.03910060033007. PMID: 666628

Prognosis

Thyroid-associated ophthalmopathy: clinical features, pathogenesis, and management.
Yamada M, Li AW, Wall JR
Crit Rev Clin Lab Sci 2000 Dec;37(6):523-49. doi: 10.1080/10408360091174303. PMID: 11192331
Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' hyperthyroidism.
Gunji K, De Bellis A, Li AW, Yamada M, Kubota S, Ackrell B, Wengrowicz S, Bellastella A, Bizzarro A, Sinisi A, Wall JR
J Clin Endocrinol Metab 2000 Apr;85(4):1641-7. doi: 10.1210/jcem.85.4.6553. PMID: 10770210
Serum antibodies against the flavoprotein subunit of succinate dehydrogenase are sensitive markers of eye muscle autoimmunity in patients with Graves' hyperthyroidism.
Gunji K, De Bellis A, Kubota S, Swanson J, Wengrowicz S, Cochran B, Ackrell BA, Salvi M, Bellastella A, Bizzarro A, Sinisi AA, Wall JR
J Clin Endocrinol Metab 1999 Apr;84(4):1255-62. doi: 10.1210/jcem.84.4.5640. PMID: 10199764
Thyroid-associated ophthalmopathy in black South African patients with Graves' disease: relationship to antiflavoprotein antibodies.
Joffe B, Gunji K, Panz V, Zouvanis M, Swanson J, Ackrell BA, Wall JR
Thyroid 1998 Nov;8(11):1023-7. doi: 10.1089/thy.1998.8.1023. PMID: 9848717

Clinical prediction guides

Thyroid-associated ophthalmopathy: clinical features, pathogenesis, and management.
Yamada M, Li AW, Wall JR
Crit Rev Clin Lab Sci 2000 Dec;37(6):523-49. doi: 10.1080/10408360091174303. PMID: 11192331
Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' hyperthyroidism.
Gunji K, De Bellis A, Li AW, Yamada M, Kubota S, Ackrell B, Wengrowicz S, Bellastella A, Bizzarro A, Sinisi A, Wall JR
J Clin Endocrinol Metab 2000 Apr;85(4):1641-7. doi: 10.1210/jcem.85.4.6553. PMID: 10770210
Serum antibodies against the flavoprotein subunit of succinate dehydrogenase are sensitive markers of eye muscle autoimmunity in patients with Graves' hyperthyroidism.
Gunji K, De Bellis A, Kubota S, Swanson J, Wengrowicz S, Cochran B, Ackrell BA, Salvi M, Bellastella A, Bizzarro A, Sinisi AA, Wall JR
J Clin Endocrinol Metab 1999 Apr;84(4):1255-62. doi: 10.1210/jcem.84.4.5640. PMID: 10199764
Thyroid-associated ophthalmopathy in black South African patients with Graves' disease: relationship to antiflavoprotein antibodies.
Joffe B, Gunji K, Panz V, Zouvanis M, Swanson J, Ackrell BA, Wall JR
Thyroid 1998 Nov;8(11):1023-7. doi: 10.1089/thy.1998.8.1023. PMID: 9848717
Painful oculomotor nerve palsy due to dural-cavernous sinus shunt.
Hawke SH, Mullie MA, Hoyt WF, Hallinan JM, Halmagyi GM
Arch Neurol 1989 Nov;46(11):1252-5. doi: 10.1001/archneur.1989.00520470126040. PMID: 2818263

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