Vulval intraepithelial neoplasia grade 3

MedGen UID:: 578818
•Concept ID:: C0349560
•: Neoplastic Process

Synonyms:

Severe dysplasia of vulva; VIN (vulval intraepithelial neoplasia) grade 3; VIN III; VIN III - vulval intraepithelial neoplasia grade III; Vulval high grade squamous intraepithelial lesion; Vulval HSIL (high grade squamous intraepithelial lesion); Vulval intraepithelial neoplasia grade III; Vulvar intraepithelial neoplasia, grade III

SNOMED CT:

Vulvar intraepithelial neoplasia, grade III (20365006); VIN III (20365006); Vulval high grade squamous intraepithelial lesion (276875006); Vulval HSIL (high grade squamous intraepithelial lesion) (276875006); Vulval intraepithelial neoplasia grade III (276875006); Vulval intraepithelial neoplasia grade 3 (276875006); Severe dysplasia of vulva (276875006); VIN III - vulval intraepithelial neoplasia grade III (276875006); VIN (vulval intraepithelial neoplasia) grade 3 (276875006)

Professional guidelines

PubMed

Safety and efficacy of topical artesunate for the treatment of vulvar intraepithelial neoplasia 2/3.

Michener CM, Ricci S, AlHilli M, Beffa L, Debernardo R, Waggoner SE, Brainard J, Plesa M, Belinson JL, Trimble CL
Gynecol Oncol 2023 Nov;178:102-109. Epub 2023 Oct 14 doi: 10.1016/j.ygyno.2023.10.003. PMID: 37839312

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.

Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755 Free PMC Article

Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia.

Lawrie TA, Nordin A, Chakrabarti M, Bryant A, Kaushik S, Pepas L
Cochrane Database Syst Rev 2016 Jan 5;2016(1):CD011837. doi: 10.1002/14651858.CD011837.pub2. PMID: 26728940 Free PMC Article

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Recent clinical studies

Etiology

Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT³VIN): a multicentre, open-label, randomised, phase 2 trial.

Tristram A, Hurt CN, Madden T, Powell N, Man S, Hibbitts S, Dutton P, Jones S, Nordin AJ, Naik R, Fiander A, Griffiths G
Lancet Oncol 2014 Nov;15(12):1361-8. Epub 2014 Oct 7 doi: 10.1016/S1470-2045(14)70456-5. PMID: 25304851

Smoking and multicentric vulval intraepithelial neoplasia.

Khan AM, Freeman-Wang T, Pisal N, Singer A
J Obstet Gynaecol 2009 Feb;29(2):123-5. doi: 10.1080/01443610802668938. PMID: 19274545

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