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Grade 2 Vaginal Intraepithelial Neoplasia

MedGen UID:
83887
Concept ID:
C0349555
Neoplastic Process
Synonyms: Grade II Vaginal Intraepithelial Neoplasia; Intraepithelial Neoplasia of the Vagina Grade 2; Intraepithelial Neoplasia of Vagina Grade 2; Moderate vaginal dysplasia; Vaginal intraepithelial neoplasia grade 2; Vaginal Intraepithelial Neoplasia Grade 2; VAIN - Vaginal intraepithelial neoplasia 2
SNOMED CT: Vaginal intraepithelial neoplasia grade 2 (276872009); VAIN - Vaginal intraepithelial neoplasia 2 (276872009); Moderate vaginal dysplasia (276872009)

Definition

Vaginal intraepithelial neoplasia characterized by the presence of nuclear intraepithelial neoplastic changes in the lower two-thirds of the epithelium and parakeratosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Vaginal Intraepithelial Neoplasia

Professional guidelines

PubMed

Rhodes HE, Chenevert L, Munsell M
J Low Genit Tract Dis 2014 Apr;18(2):115-21. doi: 10.1097/LGT.0b013e31829f52f4. PMID: 24189311

Recent clinical studies

Etiology

Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Arbyn M, Smith SB, Temin S, Sultana F, Castle P; Collaboration on Self-Sampling and HPV Testing
BMJ 2018 Dec 5;363:k4823. doi: 10.1136/bmj.k4823. PMID: 30518635Free PMC Article
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article

Diagnosis

Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Arbyn M, Smith SB, Temin S, Sultana F, Castle P; Collaboration on Self-Sampling and HPV Testing
BMJ 2018 Dec 5;363:k4823. doi: 10.1136/bmj.k4823. PMID: 30518635Free PMC Article
Vieira-Baptista P, Marchitelli C, Haefner HK, Donders G, Pérez-López F
Int Urogynecol J 2017 May;28(5):675-679. Epub 2017 Mar 14 doi: 10.1007/s00192-017-3295-6. PMID: 28293790
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article
Audet-Lapointe P, Body G, Vauclair R, Drouin P, Ayoub J
Gynecol Oncol 1990 Feb;36(2):232-9. doi: 10.1016/0090-8258(90)90180-s. PMID: 2404839

Therapy

Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Joura EA, Giuliano AR, Iversen OE, Bouchard C, Mao C, Mehlsen J, Moreira ED Jr, Ngan Y, Petersen LK, Lazcano-Ponce E, Pitisuttithum P, Restrepo JA, Stuart G, Woelber L, Yang YC, Cuzick J, Garland SM, Huh W, Kjaer SK, Bautista OM, Chan IS, Chen J, Gesser R, Moeller E, Ritter M, Vuocolo S, Luxembourg A; Broad Spectrum HPV Vaccine Study
N Engl J Med 2015 Feb 19;372(8):711-23. doi: 10.1056/NEJMoa1405044. PMID: 25693011

Prognosis

Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Joura EA, Giuliano AR, Iversen OE, Bouchard C, Mao C, Mehlsen J, Moreira ED Jr, Ngan Y, Petersen LK, Lazcano-Ponce E, Pitisuttithum P, Restrepo JA, Stuart G, Woelber L, Yang YC, Cuzick J, Garland SM, Huh W, Kjaer SK, Bautista OM, Chan IS, Chen J, Gesser R, Moeller E, Ritter M, Vuocolo S, Luxembourg A; Broad Spectrum HPV Vaccine Study
N Engl J Med 2015 Feb 19;372(8):711-23. doi: 10.1056/NEJMoa1405044. PMID: 25693011
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955

Clinical prediction guides

Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Stuebs FA, Mergel F, Koch MC, Dietl AK, Schulmeyer CE, Adler W, Geppert C, Hartman A, Knöll A, Beckmann MW, Gass P, Mehlhorn G
Arch Gynecol Obstet 2023 May;307(5):1567-1572. Epub 2022 Oct 22 doi: 10.1007/s00404-022-06815-7. PMID: 36271921Free PMC Article
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Boonlikit S
Curr Probl Cancer 2022 Apr;46(2):100792. Epub 2021 Sep 20 doi: 10.1016/j.currproblcancer.2021.100792. PMID: 34579973
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article

Recent systematic reviews

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Arbyn M, Simon M, de Sanjosé S, Clarke MA, Poljak M, Rezhake R, Berkhof J, Nyaga V, Gultekin M, Canfell K, Wentzensen N
Lancet Oncol 2022 Jul;23(7):950-960. Epub 2022 Jun 13 doi: 10.1016/S1470-2045(22)00294-7. PMID: 35709810
Bergman H, Buckley BS, Villanueva G, Petkovic J, Garritty C, Lutje V, Riveros-Balta AX, Low N, Henschke N
Cochrane Database Syst Rev 2019 Nov 22;2019(11) doi: 10.1002/14651858.CD013479. PMID: 31755549Free PMC Article
Bertoli HK, Rasmussen CL, Sand FL, Albieri V, Norrild B, Verdoodt F, Kjaer SK
Int J Cancer 2019 Jul 1;145(1):78-86. Epub 2019 Jan 11 doi: 10.1002/ijc.32078. PMID: 30561092
Mustafa RA, Santesso N, Khatib R, Mustafa AA, Wiercioch W, Kehar R, Gandhi S, Chen Y, Cheung A, Hopkins J, Ma B, Lloyd N, Wu D, Broutet N, Schünemann HJ
Int J Gynaecol Obstet 2016 Mar;132(3):259-65. Epub 2015 Nov 12 doi: 10.1016/j.ijgo.2015.07.024. PMID: 26851054

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