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Anal melanoma

MedGen UID:
91151
•Concept ID:
C0349538
•
Neoplastic Process
Synonyms: Anal Malignant Melanoma; anal malignant melanoma; Anal Melanoma; anal melanoma; anus melanoma; anus melanoma (disease); Cancer anal melanoma; malignant anus melanoma; Malignant melanoma of anus; Malignant Melanoma of Anus; malignant melanoma of anus; Malignant Melanoma of the Anus; malignant melanoma of the anus; melanoma (disease) of anus; Melanoma of Anus; melanoma of anus; Melanoma of the Anus; melanoma of the anus
SNOMED CT: Cancer anal melanoma (276821000); Malignant melanoma of anus (276821000)
 
Monarch Initiative: MONDO:0006081

Definition

A melanoma arising from the anus. Clinical presentation includes rectal bleeding, tenesmus, pain, and change in bowel habit. The prognosis is usually poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal melanoma

Professional guidelines

PubMed

Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
A case series of anal melanoma including the results of treatment with imatinib in selected patients.
Knowles J, Lynch AC, Warrier SK, Henderson M, Heriot AG
Colorectal Dis 2016 Sep;18(9):877-82. doi: 10.1111/codi.13209. PMID: 26546509
Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment.
Longo WE, Vernava AM 3rd, Wade TP, Coplin MA, Virgo KS, Johnson FE
Am Surg 1995 Jun;61(6):495-500. PMID: 7762897

Recent clinical studies

Etiology

Impact of adjuvant therapies following surgery for anal melanoma.
Wong DL, Glazer ES, Tsao M, Deneve JL, Fleming MD, Shibata D
Am J Surg 2022 Jun;223(6):1132-1143. Epub 2021 Nov 11 doi: 10.1016/j.amjsurg.2021.10.041. PMID: 34801225
Epidemiology and survival outcomes of primary gastrointestinal melanoma: a SEER-based population study.
Zheng Y, Cong C, Su C, Sun Y, Xing L
Int J Clin Oncol 2020 Nov;25(11):1951-1959. Epub 2020 Aug 1 doi: 10.1007/s10147-020-01759-x. PMID: 32740718
Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967

Diagnosis

Resectable Anal Melanoma Detected by Rectal Retroflexion.
Pagani W, Sheikh U, Skef W
Clin Gastroenterol Hepatol 2021 May;19(5):A25. Epub 2020 Apr 6 doi: 10.1016/j.cgh.2020.03.061. PMID: 32272246
Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967
Uncommon Anal Neoplasms.
Roy AC, Wattchow D, Astill D, Singh S, Pendlebury S, Gormly K, Segelov E
Surg Oncol Clin N Am 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009. PMID: 27889033
Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005

Therapy

Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005
Anorectal malignant melanoma: curative abdominoperineal resection: patient selection with 18F-FDG-PET/CT.
Falch C, Mueller S, Kirschniak A, Braun M, Koenigsrainer A, Klumpp B
World J Surg Oncol 2016 Jul 15;14(1):185. doi: 10.1186/s12957-016-0938-x. PMID: 27422527Free PMC Article
A case series of anal melanoma including the results of treatment with imatinib in selected patients.
Knowles J, Lynch AC, Warrier SK, Henderson M, Heriot AG
Colorectal Dis 2016 Sep;18(9):877-82. doi: 10.1111/codi.13209. PMID: 26546509
Pregnancy and maternal outcomes in women with prior or current gastrointestinal malignancies.
Al-Ibrahim A, Parrish J, Dunn E, Swallow C, Maxwell C
J Obstet Gynaecol Can 2014 Jan;36(1):34-41. doi: 10.1016/S1701-2163(15)30681-2. PMID: 24444285
Melanoma of the anal canal: a case series.
Homsi J, Garrett C
Dis Colon Rectum 2007 Jul;50(7):1004-10. doi: 10.1007/s10350-007-0242-5. PMID: 17468984

Prognosis

Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma.
Paolino G, Podo Brunetti A, De Rosa C, Cantisani C, Rongioletti F, Carugno A, Zerbinati N, Valenti M, Mascagni D, Tosti G, Mercuri SR, Pampena R
Melanoma Res 2024 Dec 1;34(6):487-496. Epub 2024 Oct 4 doi: 10.1097/CMR.0000000000001003. PMID: 39361336Free PMC Article
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967
Uncommon Anal Neoplasms.
Roy AC, Wattchow D, Astill D, Singh S, Pendlebury S, Gormly K, Segelov E
Surg Oncol Clin N Am 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009. PMID: 27889033
Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005

Clinical prediction guides

Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma.
Paolino G, Podo Brunetti A, De Rosa C, Cantisani C, Rongioletti F, Carugno A, Zerbinati N, Valenti M, Mascagni D, Tosti G, Mercuri SR, Pampena R
Melanoma Res 2024 Dec 1;34(6):487-496. Epub 2024 Oct 4 doi: 10.1097/CMR.0000000000001003. PMID: 39361336Free PMC Article
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Anorectal malignant melanoma: curative abdominoperineal resection: patient selection with 18F-FDG-PET/CT.
Falch C, Mueller S, Kirschniak A, Braun M, Koenigsrainer A, Klumpp B
World J Surg Oncol 2016 Jul 15;14(1):185. doi: 10.1186/s12957-016-0938-x. PMID: 27422527Free PMC Article
Malignant melanoma of anorectal region: a clinicopathologic study of 61 cases.
Tariq MU, Ud Din N, Ud Din NF, Fatima S, Ahmad Z
Ann Diagn Pathol 2014 Oct;18(5):275-81. Epub 2014 Aug 8 doi: 10.1016/j.anndiagpath.2014.08.002. PMID: 25163722
Anal versus rectal melanoma: does site of origin predict outcome?
Bello DM, Smyth E, Perez D, Khan S, Temple LK, Ariyan CE, Weiser MR, Carvajal RD
Dis Colon Rectum 2013 Feb;56(2):150-7. doi: 10.1097/DCR.0b013e31827901dd. PMID: 23303142Free PMC Article

Recent systematic reviews

Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma.
Paolino G, Podo Brunetti A, De Rosa C, Cantisani C, Rongioletti F, Carugno A, Zerbinati N, Valenti M, Mascagni D, Tosti G, Mercuri SR, Pampena R
Melanoma Res 2024 Dec 1;34(6):487-496. Epub 2024 Oct 4 doi: 10.1097/CMR.0000000000001003. PMID: 39361336Free PMC Article

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