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Vaginal Intraepithelial Neoplasia

MedGen UID:
87546
Concept ID:
C0346208
Neoplastic Process
Synonyms: Intraepithelial Neoplasia of the Vagina; Intraepithelial Neoplasia of Vagina; Intraepithelial Neoplasm of the Vagina; Intraepithelial Neoplasm of Vagina; Intraepithelial Tumor of the Vagina; Intraepithelial Tumor of Vagina; Vaginal intraepithelial neoplasia; Vaginal Intraepithelial Neoplasm; Vaginal Intraepithelial Tumor; Vaginal SIL; Vaginal Squamous Intraepithelial Lesion; VAIN - Vaginal intraepithelial neoplasia
SNOMED CT: Vaginal intraepithelial neoplasia (254894004); VAIN - Vaginal intraepithelial neoplasia (254894004)

Definition

A superficial neoplastic process involving exclusively the vaginal squamous epithelium without extension to underlying tissue. It is classified as low- or high-grade intraepithelial neoplasia. [from NCI]

Professional guidelines

PubMed

Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Rountis A, Pergialiotis V, Tsetsa P, Rodolakis A, Haidopoulos D
Int J Clin Pract 2020 Nov;74(11):e13598. Epub 2020 Aug 4 doi: 10.1111/ijcp.13598. PMID: 32602195
Gurumurthy M, Cruickshank ME
J Low Genit Tract Dis 2012 Jul;16(3):306-12. doi: 10.1097/LGT.0b013e31823da7fb. PMID: 22460272

Recent clinical studies

Etiology

Inayama Y, Takamatsu S, Hamanishi J, Mizuno K, Horinouchi N, Yamanoi K, Taki M, Murakami R, Yamaguchi K, Kosaka K, Efthimiou O, Kawakami K, Furukawa TA, Mandai M
Obstet Gynecol 2023 Aug 1;142(2):307-318. Epub 2023 Jul 5 doi: 10.1097/AOG.0000000000005256. PMID: 37411024
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Rountis A, Pergialiotis V, Tsetsa P, Rodolakis A, Haidopoulos D
Int J Clin Pract 2020 Nov;74(11):e13598. Epub 2020 Aug 4 doi: 10.1111/ijcp.13598. PMID: 32602195
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Gurumurthy M, Cruickshank ME
J Low Genit Tract Dis 2012 Jul;16(3):306-12. doi: 10.1097/LGT.0b013e31823da7fb. PMID: 22460272

Diagnosis

Dong H, Li H, Wang L, Yuan Y, Zhang D, Zhou L, Wang T, Yang C
Eur J Obstet Gynecol Reprod Biol 2023 Aug;287:232-236. Epub 2023 Jun 22 doi: 10.1016/j.ejogrb.2023.06.020. PMID: 37392699
Boonlikit S
Curr Probl Cancer 2022 Apr;46(2):100792. Epub 2021 Sep 20 doi: 10.1016/j.currproblcancer.2021.100792. PMID: 34579973
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Frega A, Sopracordevole F, Assorgi C, Lombardi D, DE Sanctis V, Catalano A, Matteucci E, Milazzo GN, Ricciardi E, Moscarini M
Anticancer Res 2013 Jan;33(1):29-38. PMID: 23267125
Audet-Lapointe P, Body G, Vauclair R, Drouin P, Ayoub J
Gynecol Oncol 1990 Feb;36(2):232-9. doi: 10.1016/0090-8258(90)90180-s. PMID: 2404839

Therapy

Inayama Y, Takamatsu S, Hamanishi J, Mizuno K, Horinouchi N, Yamanoi K, Taki M, Murakami R, Yamaguchi K, Kosaka K, Efthimiou O, Kawakami K, Furukawa TA, Mandai M
Obstet Gynecol 2023 Aug 1;142(2):307-318. Epub 2023 Jul 5 doi: 10.1097/AOG.0000000000005256. PMID: 37411024
Freitas G, Costa A
Eur J Obstet Gynecol Reprod Biol 2023 May;284:175-179. Epub 2023 Mar 20 doi: 10.1016/j.ejogrb.2023.03.014. PMID: 37004357
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Rountis A, Pergialiotis V, Tsetsa P, Rodolakis A, Haidopoulos D
Int J Clin Pract 2020 Nov;74(11):e13598. Epub 2020 Aug 4 doi: 10.1111/ijcp.13598. PMID: 32602195
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907

Prognosis

Borella F, Gallio N, Mangherini L, Cassoni P, Bertero L, Benedetto C, Preti M
J Med Virol 2023 Nov;95(11):e29238. doi: 10.1002/jmv.29238. PMID: 38009696
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Gurumurthy M, Cruickshank ME
J Low Genit Tract Dis 2012 Jul;16(3):306-12. doi: 10.1097/LGT.0b013e31823da7fb. PMID: 22460272
Jobson VW, Campion MJ
Obstet Gynecol Clin North Am 1991 Sep;18(3):511-24. PMID: 1659681
Audet-Lapointe P, Body G, Vauclair R, Drouin P, Ayoub J
Gynecol Oncol 1990 Feb;36(2):232-9. doi: 10.1016/0090-8258(90)90180-s. PMID: 2404839

Clinical prediction guides

Borella F, Gallio N, Mangherini L, Cassoni P, Bertero L, Benedetto C, Preti M
J Med Virol 2023 Nov;95(11):e29238. doi: 10.1002/jmv.29238. PMID: 38009696
Freitas G, Costa A
Eur J Obstet Gynecol Reprod Biol 2023 May;284:175-179. Epub 2023 Mar 20 doi: 10.1016/j.ejogrb.2023.03.014. PMID: 37004357
Boonlikit S
Curr Probl Cancer 2022 Apr;46(2):100792. Epub 2021 Sep 20 doi: 10.1016/j.currproblcancer.2021.100792. PMID: 34579973
Bradbury M, Xercavins N, García-Jiménez Á, Pérez-Benavente A, Franco-Camps S, Cabrera S, Sánchez-Iglesias JL, De La Torre J, Díaz-Feijoo B, Gil-Moreno A, Centeno-Mediavilla C
J Low Genit Tract Dis 2019 Jan;23(1):7-12. doi: 10.1097/LGT.0000000000000431. PMID: 30161052
Zolciak-Siwinska A, Gruszczynska E, Jonska-Gmyrek J, Kulik A, Michalski W
Eur J Obstet Gynecol Reprod Biol 2015 Nov;194:73-7. Epub 2015 Aug 22 doi: 10.1016/j.ejogrb.2015.08.018. PMID: 26334358

Recent systematic reviews

Inayama Y, Takamatsu S, Hamanishi J, Mizuno K, Horinouchi N, Yamanoi K, Taki M, Murakami R, Yamaguchi K, Kosaka K, Efthimiou O, Kawakami K, Furukawa TA, Mandai M
Obstet Gynecol 2023 Aug 1;142(2):307-318. Epub 2023 Jul 5 doi: 10.1097/AOG.0000000000005256. PMID: 37411024
Inayama Y, Yamanishi Y, Nakatani E, Aratake J, Sasagasako N, Yamada K, Gou R, Kawamura A, Yamanishi M, Kosaka K
Gynecol Oncol 2021 Jan;160(1):140-147. Epub 2020 Oct 1 doi: 10.1016/j.ygyno.2020.09.031. PMID: 33010966
Bertoli HK, Rasmussen CL, Sand FL, Albieri V, Norrild B, Verdoodt F, Kjaer SK
Int J Cancer 2019 Jul 1;145(1):78-86. Epub 2019 Jan 11 doi: 10.1002/ijc.32078. PMID: 30561092
Tranoulis A, Laios A, Mitsopoulos V, Lutchman-Singh K, Thomakos N
Eur J Obstet Gynecol Reprod Biol 2017 Nov;218:129-136. Epub 2017 Sep 27 doi: 10.1016/j.ejogrb.2017.09.020. PMID: 28985547
Smith JS, Backes DM, Hoots BE, Kurman RJ, Pimenta JM
Obstet Gynecol 2009 Apr;113(4):917-924. doi: 10.1097/AOG.0b013e31819bd6e0. PMID: 19305339

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