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Fibrofolliculoma

MedGen UID:
138032
Concept ID:
C0346011
Neoplastic Process
Synonym: Fibrofolliculomas
SNOMED CT: Fibrofolliculoma (128683008); Follicular fibroma (128683008); Fibrofolliculoma (254699007)
 
HPO: HP:0030436

Definition

Fibrofolliculoma is a clinically asymptomatic, 2-4 mm, skin-colored, dome-shaped smooth papule. It usually arises in the form of multiple lesions in adults in different areas such as the scalp, forehead, face, and neck. According to histology, the lesion is a fibrotic hamartoma characterized by infundibular epithelial proliferation and perifollicular fibrous proliferation. [from HPO]

Term Hierarchy

Conditions with this feature

Birt-Hogg-Dube syndrome 2
MedGen UID:
1841312
Concept ID:
C5830676
Disease or Syndrome
Birt-Hogg-Dube syndrome-2 (BHD2) is characterized by lipomatosis and fibrofolliculomas as well as renal cell carcinoma and other cancers (van de Beek et al., 2023). For a general phenotypic description and a discussion of genetic heterogeneity of BHD, see BHD1 (135150).
Birt-Hogg-Dube syndrome 1
MedGen UID:
1051978
Concept ID:
CN375946
Disease or Syndrome
Any Birt-Hogg-Dube (BHD) syndrome in which the cause of the disease is a variation in the FLCN gene.

Professional guidelines

PubMed

Vincent A, Farley M, Chan E, James WD
J Am Acad Dermatol 2003 Oct;49(4):698-705. doi: 10.1067/s0190-9622(03)01582-2. PMID: 14512919

Recent clinical studies

Etiology

Haneke E, Happle R
J Cutan Pathol 2024 Feb;51(2):170-175. Epub 2023 Aug 30 doi: 10.1111/cup.14522. PMID: 37649357
Díez-Montero C, Alonso MD, Marquez PIG, Schellini SA, Galindo-Ferreiro A
Arq Bras Oftalmol 2020 Nov-Dec;83(6):485-489. doi: 10.5935/0004-2749.20200092. PMID: 33470275
Tellechea O, Cardoso JC, Reis JP, Ramos L, Gameiro AR, Coutinho I, Baptista AP
An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8. doi: 10.1590/abd1806-4841.20154114. PMID: 26734858Free PMC Article
Vernooij M, Claessens T, Luijten M, van Steensel MA, Coull BJ
Fam Cancer 2013 Sep;12(3):381-5. doi: 10.1007/s10689-013-9600-8. PMID: 23307118
Palmirotta R, Savonarola A, Ludovici G, Donati P, Cavaliere F, DE Marchis ML, Ferroni P, Guadagni F
Anticancer Res 2010 Mar;30(3):751-7. PMID: 20392993

Diagnosis

Díez-Montero C, Alonso MD, Marquez PIG, Schellini SA, Galindo-Ferreiro A
Arq Bras Oftalmol 2020 Nov-Dec;83(6):485-489. doi: 10.5935/0004-2749.20200092. PMID: 33470275
Tellechea O, Cardoso JC, Reis JP, Ramos L, Gameiro AR, Coutinho I, Baptista AP
An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8. doi: 10.1590/abd1806-4841.20154114. PMID: 26734858Free PMC Article
Vernooij M, Claessens T, Luijten M, van Steensel MA, Coull BJ
Fam Cancer 2013 Sep;12(3):381-5. doi: 10.1007/s10689-013-9600-8. PMID: 23307118
Chang JK, Lee DC, Chang MH
Korean J Ophthalmol 2007 Sep;21(3):169-71. doi: 10.3341/kjo.2007.21.3.169. PMID: 17804924Free PMC Article
Welsch MJ, Krunic A, Medenica MM
Int J Dermatol 2005 Aug;44(8):668-73. doi: 10.1111/j.1365-4632.2004.02095.x. PMID: 16101870

Therapy

Hasumi H, Baba M, Hasumi Y, Furuya M, Yao M
Int J Urol 2016 Mar;23(3):204-10. Epub 2015 Nov 25 doi: 10.1111/iju.13015. PMID: 26608100
Gijezen LM, Vernooij M, Martens H, Oduber CE, Henquet CJ, Starink TM, Prins MH, Menko FH, Nelemans PJ, van Steensel MA
PLoS One 2014;9(6):e99071. Epub 2014 Jun 9 doi: 10.1371/journal.pone.0099071. PMID: 24910976Free PMC Article

Prognosis

Park HJ, Kim YJ, Kim MJ, Kim HC
PLoS One 2022;17(6):e0269358. Epub 2022 Jun 6 doi: 10.1371/journal.pone.0269358. PMID: 35666727Free PMC Article
Sattler EC, Syunyaeva Z, Reithmair M, Dempke W, Steinlein OK
Eur J Cancer 2021 Jul;151:168-174. Epub 2021 May 14 doi: 10.1016/j.ejca.2021.04.013. PMID: 34000505
Díez-Montero C, Alonso MD, Marquez PIG, Schellini SA, Galindo-Ferreiro A
Arq Bras Oftalmol 2020 Nov-Dec;83(6):485-489. doi: 10.5935/0004-2749.20200092. PMID: 33470275
Hasumi H, Baba M, Hasumi Y, Furuya M, Yao M
Int J Urol 2016 Mar;23(3):204-10. Epub 2015 Nov 25 doi: 10.1111/iju.13015. PMID: 26608100
Kuroda N, Tanaka A, Ohe C, Mikami S, Nagashima Y, Sasaki T, Inoue K, Hes O, Michal M, Brunelli M, Martignoni G
Histol Histopathol 2012 Nov;27(11):1407-12. doi: 10.14670/HH-27.1407. PMID: 23018240

Clinical prediction guides

Omorodion I, Lee J, Gru AA, Zlotoff BJ
Dermatol Online J 2021 Oct 15;27(10) doi: 10.5070/D3271055628. PMID: 35130389
Sattler EC, Syunyaeva Z, Reithmair M, Dempke W, Steinlein OK
Eur J Cancer 2021 Jul;151:168-174. Epub 2021 May 14 doi: 10.1016/j.ejca.2021.04.013. PMID: 34000505
Treichel AM, Pithadia DJ, Lee CR, Oyerinde O, Moss J, Darling TN
Histopathology 2021 Oct;79(4):619-628. Epub 2021 Jul 21 doi: 10.1111/his.14392. PMID: 33882161Free PMC Article
Díez-Montero C, Alonso MD, Marquez PIG, Schellini SA, Galindo-Ferreiro A
Arq Bras Oftalmol 2020 Nov-Dec;83(6):485-489. doi: 10.5935/0004-2749.20200092. PMID: 33470275
Misago N, Narisawa Y
Clin Exp Dermatol 2009 Dec;34(8):892-4. Epub 2009 Jan 15 doi: 10.1111/j.1365-2230.2008.03065.x. PMID: 19196303

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