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Onchodermatitis

MedGen UID:: 576009
•Concept ID:: C0344020
•: Disease or Syndrome

Synonym:	Cutaneous onchocerciasis
SNOMED CT:	Cutaneous onchocerciasis (240836004); Onchodermatitis (240836004)

Professional guidelines

PubMed

Field-Based Evidence of Single and Few Doses of Annual Ivermectin Treatment Efficacy in Eliminating Skin Microfilaria Load after a Decade of Intervention.

Osue HO
Ethiop J Health Sci 2017 Mar;27(2):129-138. doi: 10.4314/ejhs.v27i2.5. PMID: 28579708 Free PMC Article

Immune responses directed against microfilariae correlate with severity of clinical onchodermatitis and treatment history.

Ali MM, Baraka OZ, AbdelRahman SI, Sulaiman SM, Williams JF, Homeida MM, Mackenzie CD
J Infect Dis 2003 Feb 15;187(4):714-7. Epub 2003 Jan 29 doi: 10.1086/367709. PMID: 12599094

Ivermectin treatment in severe asymmetric reactive onchodermatitis (sowda) in Sudan.

Baraka OZ, Mahmoud BM, Ali MM, Ali MH, el Sheikh EA, Homeida MM, Mackenzie CD, Williams JF
Trans R Soc Trop Med Hyg 1995 May-Jun;89(3):312-5. doi: 10.1016/0035-9203(95)90559-6. PMID: 7660447

See all (8)

Recent clinical studies

Etiology

Persistence of onchocerciasis and associated dermatologic and ophthalmic pathologies after 27 years of ivermectin mass drug administration in the middle belt of Ghana.

Otabil KB, Basáñez MG, Ankrah B, Opoku SA, Kyei DO, Hagan R, Ababio R, Bart-Plange EJ, Babae TN, Kudzordzi PC, Darko VA, Bamfo JG, Ameyaw J, Raji AS, Hadermann A, Schallig HDFH, Colebunders R
Trop Med Int Health 2023 Nov;28(11):844-854. Epub 2023 Oct 17 doi: 10.1111/tmi.13937. PMID: 37846505

Late-onset onchocercal skin disease among Ethiopian immigrants.

Baum S, Greenberger S, Pavlotsky F, Solomon M, Enk CD, Schwartz E, Barzilai A
Br J Dermatol 2014 Nov;171(5):1078-83. Epub 2014 Oct 28 doi: 10.1111/bjd.13005. PMID: 24673403

Onchocerciasis in Anambra State, Southeast Nigeria: endemicity and clinical manifestations.

Mbanefo EC, Eneanya CI, Nwaorgu OC, Otiji MO, Oguoma VM, Ogolo BA
Postgrad Med J 2010 Oct;86(1020):578-83. Epub 2010 Aug 10 doi: 10.1136/pgmj.2009.094946. PMID: 20702432

Effects of Ivermectin with and without doxycycline on clinical symptoms of onchocerciasis.

Masud H, Qureshi TQ, Dukley M
J Coll Physicians Surg Pak 2009 Jan;19(1):34-8. PMID: 19149978

Onchodermatitis--correlation between skin disease and parasitic load in an endemic focus in Ecuador.

Hay RJ, Mackenzie CD, Guderian R, Noble WC, Proano JR, Williams JF
Br J Dermatol 1989 Aug;121(2):187-98. doi: 10.1111/j.1365-2133.1989.tb01798.x. PMID: 2775644

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Diagnosis

Persistence of onchocerciasis and associated dermatologic and ophthalmic pathologies after 27 years of ivermectin mass drug administration in the middle belt of Ghana.

Late-onset onchocercal skin disease among Ethiopian immigrants.

Baum S, Greenberger S, Pavlotsky F, Solomon M, Enk CD, Schwartz E, Barzilai A
Br J Dermatol 2014 Nov;171(5):1078-83. Epub 2014 Oct 28 doi: 10.1111/bjd.13005. PMID: 24673403

Onchodermatitis.

Murdoch ME
Curr Opin Infect Dis 2010 Apr;23(2):124-31. doi: 10.1097/QCO.0b013e328336a256. PMID: 20071985

Immune responses directed against microfilariae correlate with severity of clinical onchodermatitis and treatment history.

Ali MM, Baraka OZ, AbdelRahman SI, Sulaiman SM, Williams JF, Homeida MM, Mackenzie CD
J Infect Dis 2003 Feb 15;187(4):714-7. Epub 2003 Jan 29 doi: 10.1086/367709. PMID: 12599094

Ivermectin treatment of hyperreactive onchodermatitis (sowda) in Liberia.

Darge K, Büttner DW
Trop Med Parasitol 1995 Dec;46(4):206-12. PMID: 8826099

See all (14)

Therapy

Persistence of onchocerciasis and associated dermatologic and ophthalmic pathologies after 27 years of ivermectin mass drug administration in the middle belt of Ghana.

Onchocerciasis in Yemen: moving forward towards an elimination program.

Al-Kubati AS, Mackenzie CD, Boakye D, Al-Qubati Y, Al-Samie AR, Awad IE, Thylefors B, Hopkins A
Int Health 2018 Mar 1;10(suppl_1):i89-i96. doi: 10.1093/inthealth/ihx055. PMID: 29471343

Onchodermatitis.

Murdoch ME
Curr Opin Infect Dis 2010 Apr;23(2):124-31. doi: 10.1097/QCO.0b013e328336a256. PMID: 20071985

Pachydermatous eosinophilic dermatitis.

Jacyk WK, Simson IW, Slater DN, Leiferman KM
Br J Dermatol 1996 Mar;134(3):469-74. PMID: 8731671

Ivermectin treatment in severe asymmetric reactive onchodermatitis (sowda) in Sudan.

Baraka OZ, Mahmoud BM, Ali MM, Ali MH, el Sheikh EA, Homeida MM, Mackenzie CD, Williams JF
Trans R Soc Trop Med Hyg 1995 May-Jun;89(3):312-5. doi: 10.1016/0035-9203(95)90559-6. PMID: 7660447

See all (21)

Prognosis

Effects of Ivermectin with and without doxycycline on clinical symptoms of onchocerciasis.

Masud H, Qureshi TQ, Dukley M
J Coll Physicians Surg Pak 2009 Jan;19(1):34-8. PMID: 19149978

Ivermectin treatment of hyperreactive onchodermatitis (sowda) in Liberia.

Darge K, Büttner DW
Trop Med Parasitol 1995 Dec;46(4):206-12. PMID: 8826099

Improvement in severe onchocercal skin disease after a single dose of ivermectin.

Pacqué M, Elmets C, Dukuly ZD, Muñoz B, White AT, Taylor HR, Greene BM
Am J Med 1991 May;90(5):590-4. PMID: 2029016

See all (3)

Clinical prediction guides

Onchocerciasis: the clinical and epidemiological burden of skin disease in Africa.

Murdoch ME, Asuzu MC, Hagan M, Makunde WH, Ngoumou P, Ogbuagu KF, Okello D, Ozoh G, Remme J
Ann Trop Med Parasitol 2002 Apr;96(3):283-96. doi: 10.1179/000349802125000826. PMID: 12061975

Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariae and schistosomes.

Tischendorf FW, Brattig NW, Büttner DW, Pieper A, Lintzel M
Acta Trop 1996 Dec 16;62(3):171-82. doi: 10.1016/s0001-706x(96)00038-1. PMID: 9025985

Identification of Onchocerca volvulus collagen as an antigen mainly recognized by antibodies in chronic hyper-reactive onchodermatitis (sowda).

Garate T, Conraths FJ, Harnett W, Buttner DW, Parkhouse RM
Am J Trop Med Hyg 1996 May;54(5):490-7. doi: 10.4269/ajtmh.1996.54.490. PMID: 8644904

Ivermectin treatment of hyperreactive onchodermatitis (sowda) in Liberia.

Darge K, Büttner DW
Trop Med Parasitol 1995 Dec;46(4):206-12. PMID: 8826099

Improvement in severe onchocercal skin disease after a single dose of ivermectin.

Pacqué M, Elmets C, Dukuly ZD, Muñoz B, White AT, Taylor HR, Greene BM
Am J Med 1991 May;90(5):590-4. PMID: 2029016

See all (15)