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Endemic Burkitt Lymphoma

MedGen UID:
87474
•Concept ID:
C0343640
•
Neoplastic Process
Synonyms: African Lymphoma; Lymphoma, African
SNOMED CT: Endemic Burkitt's lymphoma (419770008); Endemic Burkitt lymphoma (419770008); African Burkitt lymphoma (240531002); African Burkitt's lymphoma (240531002)

Definition

A clinical variant of Burkitt lymphoma that occurs in equatorial Africa. The Epstein-Barr virus has been detected in all patients. It is the most common malignancy of childhood in this area. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndemic Burkitt Lymphoma

Professional guidelines

PubMed

Burkitt lymphoma: The effect of age, sex and delay to diagnosis on treatment completion and outcome of treatment in 934 Patients in Cameroon.
Hesseling PB, Afungchwi GM, Njodzeka BW, Wharin P, Kouya FN, Kruger M
PLoS One 2024;19(3):e0299777. Epub 2024 Mar 11 doi: 10.1371/journal.pone.0299777. PMID: 38466670Free PMC Article
The use of anthracyclines in the treatment of endemic Burkitt lymphoma.
Molyneux E, Schwalbe E, Chagaluka G, Banda K, Israels T, Depani S, Mittermayer-Vassallo K, Windebank K, Mvula J, Njiram'madzi J, O'Brien S, Carey P, Bailey S
Br J Haematol 2017 Jun;177(6):984-990. Epub 2016 Nov 28 doi: 10.1111/bjh.14440. PMID: 27891583
Intussusception as a presenting feature of Burkitt lymphoma: implications for management and outcome.
England RJ, Pillay K, Davidson A, Numanoglu A, Millar AJ
Pediatr Surg Int 2012 Mar;28(3):267-70. Epub 2011 Oct 4 doi: 10.1007/s00383-011-2982-5. PMID: 21969235

Recent clinical studies

Etiology

Childhood cancer: Estimating regional and global incidence.
Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E
Cancer Epidemiol 2021 Apr;71(Pt B):101662. Epub 2020 Jan 8 doi: 10.1016/j.canep.2019.101662. PMID: 31924557
HIV-associated Burkitt lymphoma.
Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838
Kaposi Sarcoma-Associated Herpesvirus Infection and Endemic Burkitt Lymphoma.
Oluoch PO, Oduor CI, Forconi CS, Ong'echa JM, Münz C, Dittmer DP, Bailey JA, Moormann AM
J Infect Dis 2020 Jun 16;222(1):111-120. doi: 10.1093/infdis/jiaa060. PMID: 32072172Free PMC Article
An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma.
Murray PG, Young LS
Blood 2019 Aug 15;134(7):591-596. Epub 2019 Jun 11 doi: 10.1182/blood.2019000568. PMID: 31186275
Does EBV alter the pathogenesis of malaria?
Matar CG, Jacobs NT, Speck SH, Lamb TJ, Moormann AM
Parasite Immunol 2015 Sep;37(9):433-45. doi: 10.1111/pim.12212. PMID: 26121587Free PMC Article

Diagnosis

Simplified detection of Epstein-Barr virus for diagnosis of endemic Burkitt lymphoma.
Gardner A, Alvarez J, Genovese C, Snodgrass R, Kopparthy V, Erickson D, Cesarman E
Blood Adv 2022 Jun 28;6(12):3650-3654. doi: 10.1182/bloodadvances.2022007297. PMID: 35240680Free PMC Article
Malaria Infection and Risk for Endemic Burkitt Lymphoma: A Systematic Review and Meta-Analysis.
Kotepui KU, Kotepui M
Int J Environ Res Public Health 2021 May 30;18(11) doi: 10.3390/ijerph18115886. PMID: 34070881Free PMC Article
Epstein-Barr virus microRNAs in the pathogenesis of human cancers.
Caetano BFR, Jorge BAS, Müller-Coan BG, Elgui de Oliveira D
Cancer Lett 2021 Feb 28;499:14-23. Epub 2020 Nov 25 doi: 10.1016/j.canlet.2020.11.019. PMID: 33248209
Childhood cancer: Estimating regional and global incidence.
Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E
Cancer Epidemiol 2021 Apr;71(Pt B):101662. Epub 2020 Jan 8 doi: 10.1016/j.canep.2019.101662. PMID: 31924557
Parasite Infection, Carcinogenesis and Human Malignancy.
van Tong H, Brindley PJ, Meyer CG, Velavan TP
EBioMedicine 2017 Feb;15:12-23. Epub 2016 Dec 2 doi: 10.1016/j.ebiom.2016.11.034. PMID: 27956028Free PMC Article

Therapy

Malaria Infection and Risk for Endemic Burkitt Lymphoma: A Systematic Review and Meta-Analysis.
Kotepui KU, Kotepui M
Int J Environ Res Public Health 2021 May 30;18(11) doi: 10.3390/ijerph18115886. PMID: 34070881Free PMC Article
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
Survival of children with endemic Burkitt lymphoma in a prospective clinical care project in Uganda.
McGoldrick SM, Mutyaba I, Adams SV, Larsen A, Krantz EM, Namirembe C, Mooka P, Nabakooza S, Ndagire M, Mubiru K, Nabwana M, Nankinga R, Gerdts S, Gordon-Maclean C, Geriga F, Omoding A, Sessle E, Kambugu J, Uldrick TS, Orem J, Casper C
Pediatr Blood Cancer 2019 Sep;66(9):e27813. Epub 2019 Jun 3 doi: 10.1002/pbc.27813. PMID: 31157502
Therapeutic Strategies against Epstein-Barr Virus-Associated Cancers Using Proteasome Inhibitors.
Hui KF, Tam KP, Chiang AKS
Viruses 2017 Nov 21;9(11) doi: 10.3390/v9110352. PMID: 29160853Free PMC Article
The use of anthracyclines in the treatment of endemic Burkitt lymphoma.
Molyneux E, Schwalbe E, Chagaluka G, Banda K, Israels T, Depani S, Mittermayer-Vassallo K, Windebank K, Mvula J, Njiram'madzi J, O'Brien S, Carey P, Bailey S
Br J Haematol 2017 Jun;177(6):984-990. Epub 2016 Nov 28 doi: 10.1111/bjh.14440. PMID: 27891583

Prognosis

Childhood cancer: Estimating regional and global incidence.
Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E
Cancer Epidemiol 2021 Apr;71(Pt B):101662. Epub 2020 Jan 8 doi: 10.1016/j.canep.2019.101662. PMID: 31924557
HIV-associated Burkitt lymphoma.
Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838
Survival of children with endemic Burkitt lymphoma in a prospective clinical care project in Uganda.
McGoldrick SM, Mutyaba I, Adams SV, Larsen A, Krantz EM, Namirembe C, Mooka P, Nabakooza S, Ndagire M, Mubiru K, Nabwana M, Nankinga R, Gerdts S, Gordon-Maclean C, Geriga F, Omoding A, Sessle E, Kambugu J, Uldrick TS, Orem J, Casper C
Pediatr Blood Cancer 2019 Sep;66(9):e27813. Epub 2019 Jun 3 doi: 10.1002/pbc.27813. PMID: 31157502
Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences.
Kaymaz Y, Oduor CI, Yu H, Otieno JA, Ong'echa JM, Moormann AM, Bailey JA
Mol Cancer Res 2017 May;15(5):563-576. doi: 10.1158/1541-7786.MCR-16-0305. PMID: 28465297Free PMC Article
Incidence of Endemic Burkitt Lymphoma in Three Regions of Mozambique.
O'Callaghan-Gordo C, Casabonne D, Carrilho C, Ferro J, Lorenzoni C, Zaqueu C, Nhabomba A, Aguilar R, Bassat Q, de Sanjosé S, Dobaño C, Kogevinas M
Am J Trop Med Hyg 2016 Dec 7;95(6):1459-1462. Epub 2016 Oct 31 doi: 10.4269/ajtmh.16-0424. PMID: 27799648Free PMC Article

Clinical prediction guides

Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma.
Muriuki BM, Forconi CS, Kirwa EK, Maina TK, Ariera BO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM
PLoS One 2023;18(8):e0275046. Epub 2023 Aug 30 doi: 10.1371/journal.pone.0275046. PMID: 37647275Free PMC Article
Epidemiology of adult and pediatric Burkitt lymphoma in Canada: sequelae of the HIV epidemic.
Roy SF, Ghazawi FM, Le M, Lagacé F, Roy CF, Rahme E, Savin E, Zubarev A, Sasseville D, Popradi G, Litvinov IV
Curr Oncol 2020 Apr;27(2):83-89. Epub 2020 May 1 doi: 10.3747/co.27.5775. PMID: 32489250Free PMC Article
Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences.
Kaymaz Y, Oduor CI, Yu H, Otieno JA, Ong'echa JM, Moormann AM, Bailey JA
Mol Cancer Res 2017 May;15(5):563-576. doi: 10.1158/1541-7786.MCR-16-0305. PMID: 28465297Free PMC Article
Parasite Infection, Carcinogenesis and Human Malignancy.
van Tong H, Brindley PJ, Meyer CG, Velavan TP
EBioMedicine 2017 Feb;15:12-23. Epub 2016 Dec 2 doi: 10.1016/j.ebiom.2016.11.034. PMID: 27956028Free PMC Article
Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma.
Abate F, Ambrosio MR, Mundo L, Laginestra MA, Fuligni F, Rossi M, Zairis S, Gazaneo S, De Falco G, Lazzi S, Bellan C, Rocca BJ, Amato T, Marasco E, Etebari M, Ogwang M, Calbi V, Ndede I, Patel K, Chumba D, Piccaluga PP, Pileri S, Leoncini L, Rabadan R
PLoS Pathog 2015 Oct;11(10):e1005158. Epub 2015 Oct 15 doi: 10.1371/journal.ppat.1005158. PMID: 26468873Free PMC Article

Recent systematic reviews

Malaria Infection and Risk for Endemic Burkitt Lymphoma: A Systematic Review and Meta-Analysis.
Kotepui KU, Kotepui M
Int J Environ Res Public Health 2021 May 30;18(11) doi: 10.3390/ijerph18115886. PMID: 34070881Free PMC Article
Reproductive organ involvement in non-Hodgkin lymphoma during pregnancy: a systematic review.
Horowitz NA, Benyamini N, Wohlfart K, Brenner B, Avivi I
Lancet Oncol 2013 Jun;14(7):e275-82. doi: 10.1016/S1470-2045(12)70589-2. PMID: 23725710

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