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Leprosy reversal reaction

MedGen UID:
575606
•Concept ID:
C0343461
•
Disease or Syndrome
Synonyms: RR - Leprosy reversal reaction; Type RR leprosy
SNOMED CT: RR - Leprosy reversal reaction (240405001); Type RR leprosy (240405001); Leprosy reversal reaction (240405001)

Professional guidelines

PubMed

Leprosy: diagnosis and management in a developed setting.
Turner D, McGuinness SL, Leder K
Intern Med J 2015 Jan;45(1):109-12. doi: 10.1111/imj.12638. PMID: 25582940
Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions.
Legendre DP, Muzny CA, Swiatlo E
Pharmacotherapy 2012 Jan;32(1):27-37. doi: 10.1002/PHAR.1009. PMID: 22392826
Reversal reactions in leprosy and their management.
Rose P, Waters MF
Lepr Rev 1991 Jun;62(2):113-21. doi: 10.5935/0305-7518.19910013. PMID: 1870373

Recent clinical studies

Etiology

Evaluation of cellular phenotypes implicated in immunopathogenesis and monitoring immune reconstitution inflammatory syndrome in HIV/leprosy cases.
Giacoia-Gripp CB, Sales AM, Nery JA, Santos-Oliveira JR, de Oliveira AL, Sarno EN, Morgado MG
PLoS One 2011;6(12):e28735. Epub 2011 Dec 21 doi: 10.1371/journal.pone.0028735. PMID: 22205964Free PMC Article
Granulomatous reactivation during the course of a leprosy infection: reaction or relapse.
Trindade MA, Benard G, Ura S, Ghidella CC, Avelleira JC, Vianna FR, Marques AB, Naafs B, Fleury RN
PLoS Negl Trop Dis 2010 Dec 21;4(12):e921. doi: 10.1371/journal.pntd.0000921. PMID: 21200422Free PMC Article
Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.
Misch EA, Macdonald M, Ranjit C, Sapkota BR, Wells RD, Siddiqui MR, Kaplan G, Hawn TR
PLoS Negl Trop Dis 2008 May 7;2(5):e231. doi: 10.1371/journal.pntd.0000231. PMID: 18461142Free PMC Article
Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.
Bochud PY, Hawn TR, Siddiqui MR, Saunderson P, Britton S, Abraham I, Argaw AT, Janer M, Zhao LP, Kaplan G, Aderem A
J Infect Dis 2008 Jan 15;197(2):253-61. doi: 10.1086/524688. PMID: 18177245Free PMC Article

Diagnosis

Successful plasma exchange in type 1 leprosy reversal reaction.
Lucht F, Rifle G, Portier H, Chalopin JM, Bonhomme J
Br Med J (Clin Res Ed) 1984 Dec 15;289(6459):1647-8. doi: 10.1136/bmj.289.6459.1647. PMID: 6439359Free PMC Article

Therapy

Evaluation of cellular phenotypes implicated in immunopathogenesis and monitoring immune reconstitution inflammatory syndrome in HIV/leprosy cases.
Giacoia-Gripp CB, Sales AM, Nery JA, Santos-Oliveira JR, de Oliveira AL, Sarno EN, Morgado MG
PLoS One 2011;6(12):e28735. Epub 2011 Dec 21 doi: 10.1371/journal.pone.0028735. PMID: 22205964Free PMC Article
Type 1 leprosy reversal reaction treated with topical tacrolimus along with systemic corticosteroids.
Safa G, Darrieux L, Coic A, Tisseau L
Indian J Med Sci 2009 Aug;63(8):359-62. PMID: 19770527
Lepromatous leprosy reversal reaction.
Chirch LM, Jimenez VE
Lancet Infect Dis 2005 Jan;5(1):64. doi: 10.1016/S1473-3099(04)01256-3. PMID: 15620563
Leprosy reversal reaction in HIV-positive patients.
Blum L, Flageul B, Sow S, Launois P, Vignon-Pennamen MD, Coll A, Millan J
Int J Lepr Other Mycobact Dis 1993 Jun;61(2):214-7. PMID: 8371030
Successful plasma exchange in type 1 leprosy reversal reaction.
Lucht F, Rifle G, Portier H, Chalopin JM, Bonhomme J
Br Med J (Clin Res Ed) 1984 Dec 15;289(6459):1647-8. doi: 10.1136/bmj.289.6459.1647. PMID: 6439359Free PMC Article

Prognosis

Granulomatous reactivation during the course of a leprosy infection: reaction or relapse.
Trindade MA, Benard G, Ura S, Ghidella CC, Avelleira JC, Vianna FR, Marques AB, Naafs B, Fleury RN
PLoS Negl Trop Dis 2010 Dec 21;4(12):e921. doi: 10.1371/journal.pntd.0000921. PMID: 21200422Free PMC Article

Clinical prediction guides

Evaluation of cellular phenotypes implicated in immunopathogenesis and monitoring immune reconstitution inflammatory syndrome in HIV/leprosy cases.
Giacoia-Gripp CB, Sales AM, Nery JA, Santos-Oliveira JR, de Oliveira AL, Sarno EN, Morgado MG
PLoS One 2011;6(12):e28735. Epub 2011 Dec 21 doi: 10.1371/journal.pone.0028735. PMID: 22205964Free PMC Article
Comparison of S-100 and OKT6 antisera in human skin.
Modlin RL, Rowden G, Taylor CR, Rea TH
J Invest Dermatol 1984 Sep;83(3):206-9. doi: 10.1111/1523-1747.ep12263574. PMID: 6381607

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