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Hungry bone syndrome

MedGen UID:
575151
•Concept ID:
C0342635
•
Disease or Syndrome
Synonym: Hungry bones syndrome
SNOMED CT: Hungry bone syndrome (237883001); Hungry bones syndrome (237883001)

Professional guidelines

PubMed

Characteristics, management and outcomes of primary hyperparathyroidism from 2009 to 2021: a single centre report from South Africa.
Govind K, Paruk IM, Motala AA
BMC Endocr Disord 2024 Apr 25;24(1):53. doi: 10.1186/s12902-024-01583-8. PMID: 38664758Free PMC Article
Parathyroidectomy in the Management of Secondary Hyperparathyroidism.
Lau WL, Obi Y, Kalantar-Zadeh K
Clin J Am Soc Nephrol 2018 Jun 7;13(6):952-961. Epub 2018 Mar 9 doi: 10.2215/CJN.10390917. PMID: 29523679Free PMC Article
Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature.
Witteveen JE, van Thiel S, Romijn JA, Hamdy NA
Eur J Endocrinol 2013 Mar;168(3):R45-53. Epub 2013 Feb 20 doi: 10.1530/EJE-12-0528. PMID: 23152439

Recent clinical studies

Etiology

Predictive Risk Score for Postparathyroidectomy Hungry Bone Syndrome in Patients With Secondary Hyperparathyroidism.
Amjad W, Ginzberg SP, Passman JE, Heintz J, Kelz RR, Wachtel H
J Clin Endocrinol Metab 2024 Feb 20;109(3):603-610. doi: 10.1210/clinem/dgad636. PMID: 37897423
Hungry bone syndrome after parathyroid surgery.
Tai YL, Shen HY, Nai WH, Fu JF, Wang IK, Huang CC, Weng CH, Lee CC, Huang WH, Yang HY, Hsu CW, Yen TH
Hemodial Int 2023 Apr;27(2):134-145. Epub 2023 Jan 31 doi: 10.1111/hdi.13067. PMID: 36719854
Parathyroidectomy in the Management of Secondary Hyperparathyroidism.
Lau WL, Obi Y, Kalantar-Zadeh K
Clin J Am Soc Nephrol 2018 Jun 7;13(6):952-961. Epub 2018 Mar 9 doi: 10.2215/CJN.10390917. PMID: 29523679Free PMC Article
Hungry bone syndrome.
Jain N, Reilly RF
Curr Opin Nephrol Hypertens 2017 Jul;26(4):250-255. doi: 10.1097/MNH.0000000000000327. PMID: 28375869
Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature.
Witteveen JE, van Thiel S, Romijn JA, Hamdy NA
Eur J Endocrinol 2013 Mar;168(3):R45-53. Epub 2013 Feb 20 doi: 10.1530/EJE-12-0528. PMID: 23152439

Diagnosis

Bilateral giant parathyroid adenoma and hungry bone syndrome: a case report.
Martínez-Loya C, Granados-Gutiérrez DE, Torrens-Chacón A, Rodríguez-Luna DA, Frayre-García ZE, Villegas-Vázquez L, Enríquez-Sánchez LB
J Med Case Rep 2023 Sep 1;17(1):373. doi: 10.1186/s13256-023-04102-w. PMID: 37653552Free PMC Article
Hungry bone syndrome after parathyroid surgery.
Tai YL, Shen HY, Nai WH, Fu JF, Wang IK, Huang CC, Weng CH, Lee CC, Huang WH, Yang HY, Hsu CW, Yen TH
Hemodial Int 2023 Apr;27(2):134-145. Epub 2023 Jan 31 doi: 10.1111/hdi.13067. PMID: 36719854
Intensive calcium monitoring improves outcomes on hungry bone syndrome in hyperparathyroidism.
Ferreira JL, de Brito Marques F, Freire L, Soares V, Guerreiro L, Silva S, Guedes C
Endocr Regul 2021 Jan 29;55(1):30-41. doi: 10.2478/enr-2021-0005. PMID: 33600669
Bone metabolism markers and hungry bone syndrome after parathyroidectomy in dialysis patients with secondary hyperparathyroidism.
Ge Y, Yang G, Wang N, Zha X, Yu X, Mao H, Sun B, Zeng M, Zhang B, Xing C
Int Urol Nephrol 2019 Aug;51(8):1443-1449. Epub 2019 Jul 1 doi: 10.1007/s11255-019-02217-y. PMID: 31264087
Hungry bone syndrome.
Jain N, Reilly RF
Curr Opin Nephrol Hypertens 2017 Jul;26(4):250-255. doi: 10.1097/MNH.0000000000000327. PMID: 28375869

Therapy

Predictive Risk Score for Postparathyroidectomy Hungry Bone Syndrome in Patients With Secondary Hyperparathyroidism.
Amjad W, Ginzberg SP, Passman JE, Heintz J, Kelz RR, Wachtel H
J Clin Endocrinol Metab 2024 Feb 20;109(3):603-610. doi: 10.1210/clinem/dgad636. PMID: 37897423
Hungry bone syndrome after parathyroid surgery.
Tai YL, Shen HY, Nai WH, Fu JF, Wang IK, Huang CC, Weng CH, Lee CC, Huang WH, Yang HY, Hsu CW, Yen TH
Hemodial Int 2023 Apr;27(2):134-145. Epub 2023 Jan 31 doi: 10.1111/hdi.13067. PMID: 36719854
Parathyroidectomy in the Management of Secondary Hyperparathyroidism.
Lau WL, Obi Y, Kalantar-Zadeh K
Clin J Am Soc Nephrol 2018 Jun 7;13(6):952-961. Epub 2018 Mar 9 doi: 10.2215/CJN.10390917. PMID: 29523679Free PMC Article
Hungry bone syndrome.
Jain N, Reilly RF
Curr Opin Nephrol Hypertens 2017 Jul;26(4):250-255. doi: 10.1097/MNH.0000000000000327. PMID: 28375869
Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature.
Witteveen JE, van Thiel S, Romijn JA, Hamdy NA
Eur J Endocrinol 2013 Mar;168(3):R45-53. Epub 2013 Feb 20 doi: 10.1530/EJE-12-0528. PMID: 23152439

Prognosis

Predictive Risk Score for Postparathyroidectomy Hungry Bone Syndrome in Patients With Secondary Hyperparathyroidism.
Amjad W, Ginzberg SP, Passman JE, Heintz J, Kelz RR, Wachtel H
J Clin Endocrinol Metab 2024 Feb 20;109(3):603-610. doi: 10.1210/clinem/dgad636. PMID: 37897423
Dynamic nomogram for predicting hungry bone syndrome before parathyroidectomy.
Cao R, Jiang H, Liang G, Zhang W
Endocrine 2024 Jan;83(1):196-204. Epub 2023 Aug 28 doi: 10.1007/s12020-023-03493-6. PMID: 37640988
Hungry bone syndrome after parathyroid surgery.
Tai YL, Shen HY, Nai WH, Fu JF, Wang IK, Huang CC, Weng CH, Lee CC, Huang WH, Yang HY, Hsu CW, Yen TH
Hemodial Int 2023 Apr;27(2):134-145. Epub 2023 Jan 31 doi: 10.1111/hdi.13067. PMID: 36719854
Osteocalcin is an Independent Predictor for Hungry Bone Syndrome After Parathyroidectomy.
Ko WC, Liu CL, Lee JJ, Liu TP, Wu CJ, Cheng SP
World J Surg 2020 Mar;44(3):795-802. doi: 10.1007/s00268-019-05251-0. PMID: 31659413
Bone metabolism markers and hungry bone syndrome after parathyroidectomy in dialysis patients with secondary hyperparathyroidism.
Ge Y, Yang G, Wang N, Zha X, Yu X, Mao H, Sun B, Zeng M, Zhang B, Xing C
Int Urol Nephrol 2019 Aug;51(8):1443-1449. Epub 2019 Jul 1 doi: 10.1007/s11255-019-02217-y. PMID: 31264087

Clinical prediction guides

Predictive Risk Score for Postparathyroidectomy Hungry Bone Syndrome in Patients With Secondary Hyperparathyroidism.
Amjad W, Ginzberg SP, Passman JE, Heintz J, Kelz RR, Wachtel H
J Clin Endocrinol Metab 2024 Feb 20;109(3):603-610. doi: 10.1210/clinem/dgad636. PMID: 37897423
Dynamic nomogram for predicting hungry bone syndrome before parathyroidectomy.
Cao R, Jiang H, Liang G, Zhang W
Endocrine 2024 Jan;83(1):196-204. Epub 2023 Aug 28 doi: 10.1007/s12020-023-03493-6. PMID: 37640988
Hungry bone syndrome after parathyroid surgery.
Tai YL, Shen HY, Nai WH, Fu JF, Wang IK, Huang CC, Weng CH, Lee CC, Huang WH, Yang HY, Hsu CW, Yen TH
Hemodial Int 2023 Apr;27(2):134-145. Epub 2023 Jan 31 doi: 10.1111/hdi.13067. PMID: 36719854
Osteocalcin is an Independent Predictor for Hungry Bone Syndrome After Parathyroidectomy.
Ko WC, Liu CL, Lee JJ, Liu TP, Wu CJ, Cheng SP
World J Surg 2020 Mar;44(3):795-802. doi: 10.1007/s00268-019-05251-0. PMID: 31659413
Parathyroidectomy in the Management of Secondary Hyperparathyroidism.
Lau WL, Obi Y, Kalantar-Zadeh K
Clin J Am Soc Nephrol 2018 Jun 7;13(6):952-961. Epub 2018 Mar 9 doi: 10.2215/CJN.10390917. PMID: 29523679Free PMC Article

Recent systematic reviews

Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature.
Witteveen JE, van Thiel S, Romijn JA, Hamdy NA
Eur J Endocrinol 2013 Mar;168(3):R45-53. Epub 2013 Feb 20 doi: 10.1530/EJE-12-0528. PMID: 23152439

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