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Idiopathic central precocious puberty

MedGen UID:
575094
•Concept ID:
C0342544
•
Disease or Syndrome
Synonyms: Idiopathic Central Precocious Puberty; idiopathic central precocious puberty
SNOMED CT: Idiopathic central precocious puberty (237817008)
 
Monarch Initiative: MONDO:0015713
Orphanet: ORPHA169615

Definition

Central precocious puberty for which no underlying cause can be identified. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic central precocious puberty
Follow this link to review classifications for Idiopathic central precocious puberty in Orphanet.

Professional guidelines

PubMed

Gonadotropin-releasing hormone analogue and recombinant human growth hormone treatment for idiopathic central precocious puberty in girls.
Shi Y, Ma Z, Yang X, Ying Y, Luo X, Hou L
Front Endocrinol (Lausanne) 2022;13:1085385. Epub 2022 Dec 14 doi: 10.3389/fendo.2022.1085385. PMID: 36589818Free PMC Article
Benefits from the first year of GnRHa therapy in boys with idiopathic central precocious puberty when initiating treatment after age 9 years: findings from a real-world retrospective study.
Ni MM, Yang ST, Wu WW, Wang SS, Li M, Liu QQ, Ji X
BMC Endocr Disord 2022 Dec 2;22(1):299. doi: 10.1186/s12902-022-01207-z. PMID: 36456936Free PMC Article
Treatment with Depot Leuprolide Acetate in Girls with Idiopathic Precocious Puberty: What Parameter should be Used in Deciding on the Initial Dose?
Vurallı D, Alikaşifoğlu A, İyigün İ, Canoruç D, Ozon A, Gönç N, Kandemir N
J Clin Res Pediatr Endocrinol 2020 Mar 19;12(1):37-44. Epub 2019 Jul 26 doi: 10.4274/jcrpe.galenos.2019.2019.0060. PMID: 31347350Free PMC Article

Recent clinical studies

Etiology

Differentiation of Idiopathic Central Precocious Puberty From Premature Thelarche Using Principal Component Analysis.
Cleemann Wang A, Hagen CP, Johannsen TH, Madsen AG, Cleemann LH, Christiansen P, Main KM, Juul A, Jensen RB
J Clin Endocrinol Metab 2024 Jan 18;109(2):370-379. doi: 10.1210/clinem/dgad535. PMID: 37698163
An updated meta-analysis of the relationship between vitamin D levels and precocious puberty.
Cheng H, Chen D, Gao H
Front Endocrinol (Lausanne) 2023;14:1298374. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1298374. PMID: 38116317Free PMC Article
Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study.
Canton APM, Tinano FR, Guasti L, Montenegro LR, Ryan F, Shears D, de Melo ME, Gomes LG, Piana MP, Brauner R, Espino-Aguilar R, Escribano-Muñoz A, Paganoni A, Read JE, Korbonits M, Seraphim CE, Costa SS, Krepischi AC, Jorge AAL, David A, Kaisinger LR, Ong KK, Perry JRB, Abreu AP, Kaiser UB, Argente J, Mendonca BB, Brito VN, Howard SR, Latronico AC
Lancet Diabetes Endocrinol 2023 Aug;11(8):545-554. Epub 2023 Jun 26 doi: 10.1016/S2213-8587(23)00131-6. PMID: 37385287Free PMC Article
Arterial Spin Labeling and Central Precocious Puberty.
Denis J, Dangouloff-Ros V, Pinto G, Flechtner I, Piketty M, Samara D, Levy R, Grévent D, Millischer AE, Brunelle F, Prevot V, Polak M, Boddaert N
Clin Neuroradiol 2020 Mar;30(1):137-144. Epub 2018 Nov 5 doi: 10.1007/s00062-018-0738-5. PMID: 30397727
McCune-Albright syndrome.
Dumitrescu CE, Collins MT
Orphanet J Rare Dis 2008 May 19;3:12. doi: 10.1186/1750-1172-3-12. PMID: 18489744Free PMC Article

Diagnosis

Differentiation of Idiopathic Central Precocious Puberty From Premature Thelarche Using Principal Component Analysis.
Cleemann Wang A, Hagen CP, Johannsen TH, Madsen AG, Cleemann LH, Christiansen P, Main KM, Juul A, Jensen RB
J Clin Endocrinol Metab 2024 Jan 18;109(2):370-379. doi: 10.1210/clinem/dgad535. PMID: 37698163
An updated meta-analysis of the relationship between vitamin D levels and precocious puberty.
Cheng H, Chen D, Gao H
Front Endocrinol (Lausanne) 2023;14:1298374. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1298374. PMID: 38116317Free PMC Article
Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study.
Canton APM, Tinano FR, Guasti L, Montenegro LR, Ryan F, Shears D, de Melo ME, Gomes LG, Piana MP, Brauner R, Espino-Aguilar R, Escribano-Muñoz A, Paganoni A, Read JE, Korbonits M, Seraphim CE, Costa SS, Krepischi AC, Jorge AAL, David A, Kaisinger LR, Ong KK, Perry JRB, Abreu AP, Kaiser UB, Argente J, Mendonca BB, Brito VN, Howard SR, Latronico AC
Lancet Diabetes Endocrinol 2023 Aug;11(8):545-554. Epub 2023 Jun 26 doi: 10.1016/S2213-8587(23)00131-6. PMID: 37385287Free PMC Article
Endocrine-disrupting chemicals and their effects on puberty.
Lopez-Rodriguez D, Franssen D, Heger S, Parent AS
Best Pract Res Clin Endocrinol Metab 2021 Sep;35(5):101579. Epub 2021 Sep 17 doi: 10.1016/j.beem.2021.101579. PMID: 34563408
McCune-Albright syndrome.
Dumitrescu CE, Collins MT
Orphanet J Rare Dis 2008 May 19;3:12. doi: 10.1186/1750-1172-3-12. PMID: 18489744Free PMC Article

Therapy

An updated meta-analysis of the relationship between vitamin D levels and precocious puberty.
Cheng H, Chen D, Gao H
Front Endocrinol (Lausanne) 2023;14:1298374. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1298374. PMID: 38116317Free PMC Article
Basal gonadotropin levels combine with pelvic ultrasound and pituitary volume: a machine learning diagnostic model of idiopathic central precocious puberty.
Chen T, Zhang D
BMC Pediatr 2023 Nov 29;23(1):603. doi: 10.1186/s12887-023-04432-0. PMID: 38017451Free PMC Article
Gonadotropin-releasing hormone analogue and recombinant human growth hormone treatment for idiopathic central precocious puberty in girls.
Shi Y, Ma Z, Yang X, Ying Y, Luo X, Hou L
Front Endocrinol (Lausanne) 2022;13:1085385. Epub 2022 Dec 14 doi: 10.3389/fendo.2022.1085385. PMID: 36589818Free PMC Article
Herbal Medicine for Idiopathic Central Precocious Puberty: A Systematic Review and Meta-Analysis.
Lee YB, Lee JA, Lee HL
J Altern Complement Med 2020 Nov;26(11):976-999. Epub 2020 Jul 10 doi: 10.1089/acm.2019.0312. PMID: 32654496
Histrelin for central precocious puberty-a single surgeon experience.
Rosati S, Maarouf R, Brown K, Poppe M, Parrish D, Haynes J, Lanning D
J Surg Res 2015 Oct;198(2):355-9. Epub 2015 Mar 30 doi: 10.1016/j.jss.2015.03.071. PMID: 25899147

Prognosis

Differentiation of Idiopathic Central Precocious Puberty From Premature Thelarche Using Principal Component Analysis.
Cleemann Wang A, Hagen CP, Johannsen TH, Madsen AG, Cleemann LH, Christiansen P, Main KM, Juul A, Jensen RB
J Clin Endocrinol Metab 2024 Jan 18;109(2):370-379. doi: 10.1210/clinem/dgad535. PMID: 37698163
Basal gonadotropin levels combine with pelvic ultrasound and pituitary volume: a machine learning diagnostic model of idiopathic central precocious puberty.
Chen T, Zhang D
BMC Pediatr 2023 Nov 29;23(1):603. doi: 10.1186/s12887-023-04432-0. PMID: 38017451Free PMC Article
Molecular analysis of MKRN3 gene in Turkish girls with sporadic and familial idiopathic central precocious puberty.
Kırkgöz T, Kaygusuz SB, Alavanda C, Helvacıoğlu D, Abalı ZY, Tosun BG, Eltan M, Menevşe TS, Guran T, Arman A, Turan S, Bereket A
J Pediatr Endocrinol Metab 2023 Apr 25;36(4):401-408. Epub 2023 Mar 9 doi: 10.1515/jpem-2022-0645. PMID: 36883204
Gonadotropin-releasing hormone analogue and recombinant human growth hormone treatment for idiopathic central precocious puberty in girls.
Shi Y, Ma Z, Yang X, Ying Y, Luo X, Hou L
Front Endocrinol (Lausanne) 2022;13:1085385. Epub 2022 Dec 14 doi: 10.3389/fendo.2022.1085385. PMID: 36589818Free PMC Article
Noninvasive radiomics-based method for evaluating idiopathic central precocious puberty in girls.
Jiang H, Shu Z, Luo X, Wu M, Wang M, Feng Q, Chen J, Lin C, Ding Z
J Int Med Res 2021 Feb;49(2):300060521991023. doi: 10.1177/0300060521991023. PMID: 33596690Free PMC Article

Clinical prediction guides

Differentiation of Idiopathic Central Precocious Puberty From Premature Thelarche Using Principal Component Analysis.
Cleemann Wang A, Hagen CP, Johannsen TH, Madsen AG, Cleemann LH, Christiansen P, Main KM, Juul A, Jensen RB
J Clin Endocrinol Metab 2024 Jan 18;109(2):370-379. doi: 10.1210/clinem/dgad535. PMID: 37698163
Basal gonadotropin levels combine with pelvic ultrasound and pituitary volume: a machine learning diagnostic model of idiopathic central precocious puberty.
Chen T, Zhang D
BMC Pediatr 2023 Nov 29;23(1):603. doi: 10.1186/s12887-023-04432-0. PMID: 38017451Free PMC Article
A Clinical Study of Girls With Idiopathic Central Precocious Puberty and Psychological Behavior Problems.
Xie LL, Yang Y, Xiong XY, Yang L, Wu X, Zhang DG
Clin Pediatr (Phila) 2023 Sep;62(8):914-918. Epub 2023 Jan 20 doi: 10.1177/00099228221149551. PMID: 36661073
Genetic factors of idiopathic central precocious puberty and their polygenic risk in early puberty.
Lin WD, Cheng CF, Wang CH, Liang WM, Chen CH, Hsieh AR, Chiu ML, Lin TH, Liao CC, Huang SM, Tsai CH, Chang CY, Lin YJ, Tsai FJ
Eur J Endocrinol 2021 Aug 27;185(4):441-451. doi: 10.1530/EJE-21-0424. PMID: 34288885
Arterial Spin Labeling and Central Precocious Puberty.
Denis J, Dangouloff-Ros V, Pinto G, Flechtner I, Piketty M, Samara D, Levy R, Grévent D, Millischer AE, Brunelle F, Prevot V, Polak M, Boddaert N
Clin Neuroradiol 2020 Mar;30(1):137-144. Epub 2018 Nov 5 doi: 10.1007/s00062-018-0738-5. PMID: 30397727

Recent systematic reviews

An updated meta-analysis of the relationship between vitamin D levels and precocious puberty.
Cheng H, Chen D, Gao H
Front Endocrinol (Lausanne) 2023;14:1298374. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1298374. PMID: 38116317Free PMC Article
Long-term efficacy and safety of gonadotropin-releasing hormone analog treatment in children with idiopathic central precocious puberty: A systematic review and meta-analysis.
Luo X, Liang Y, Hou L, Wu W, Ying Y, Ye F
Clin Endocrinol (Oxf) 2021 May;94(5):786-796. Epub 2021 Jan 26 doi: 10.1111/cen.14410. PMID: 33387371Free PMC Article
Herbal Medicine for Idiopathic Central Precocious Puberty: A Systematic Review and Meta-Analysis.
Lee YB, Lee JA, Lee HL
J Altern Complement Med 2020 Nov;26(11):976-999. Epub 2020 Jul 10 doi: 10.1089/acm.2019.0312. PMID: 32654496

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