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Iatrogenic or traumatic pituitary deficiency

MedGen UID:
575005
•Concept ID:
C0342400
•
Disease or Syndrome
Synonyms: Hypopituitarism secondary to head trauma; iatrogenic or traumatic pituitary deficiency; Post-traumatic hypopituitarism; Post-traumatic pituitary deficiency
SNOMED CT: Hypopituitarism secondary to head trauma (237699005); Post-traumatic hypopituitarism (237699005)
 
Monarch Initiative: MONDO:0019845
Orphanet: ORPHA95619

Definition

A rare, acquired, endocrine disorder characterized by deficiency of one or more of the pituitary hormones resulting as a consequence of traumatic or medically-induced injury of the pituitary gland. Clinical presentation is variable depending on the nature and acuity of the injury and the resulting order and amount of hormone deficiency. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIatrogenic or traumatic pituitary deficiency

Professional guidelines

PubMed

2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility.
Smith HAB, Besunder JB, Betters KA, Johnson PN, Srinivasan V, Stormorken A, Farrington E, Golianu B, Godshall AJ, Acinelli L, Almgren C, Bailey CH, Boyd JM, Cisco MJ, Damian M, deAlmeida ML, Fehr J, Fenton KE, Gilliland F, Grant MJC, Howell J, Ruggles CA, Simone S, Su F, Sullivan JE, Tegtmeyer K, Traube C, Williams S, Berkenbosch JW
Pediatr Crit Care Med 2022 Feb 1;23(2):e74-e110. doi: 10.1097/PCC.0000000000002873. PMID: 35119438
Unexplained Lymphadenopathy: Evaluation and Differential Diagnosis.
Gaddey HL, Riegel AM
Am Fam Physician 2016 Dec 1;94(11):896-903. PMID: 27929264
Hepatic abscess: Diagnosis and management.
Lardière-Deguelte S, Ragot E, Amroun K, Piardi T, Dokmak S, Bruno O, Appere F, Sibert A, Hoeffel C, Sommacale D, Kianmanesh R
J Visc Surg 2015 Sep;152(4):231-43. Epub 2015 Mar 12 doi: 10.1016/j.jviscsurg.2015.01.013. PMID: 25770745

Recent clinical studies

Etiology

Pediatric Moderate and Severe Traumatic Brain Injury: A Systematic Review of Clinical Practice Guideline Recommendations.
Ben Abdeljelil A, Freire GC, Yanchar N, Turgeon AF, Beno S, Bérubé M, Stang A, Stelfox T, Zemek R, Beaulieu E, Gagnon IJ, Gabbe B, Lauzier F, Labrosse M, Tardif PA, Deshommes T, Gnanvi J, Moore L
J Neurotrauma 2023 Nov;40(21-22):2270-2281. Epub 2023 Aug 16 doi: 10.1089/neu.2023.0149. PMID: 37341019
Iatrogenic Atrioventricular Block.
Cheung CC, Mori S, Gerstenfeld EP
Card Electrophysiol Clin 2021 Dec;13(4):711-720. Epub 2021 Sep 25 doi: 10.1016/j.ccep.2021.06.010. PMID: 34689898
Central diabetes insipidus in children: Diagnosis and management.
Patti G, Ibba A, Morana G, Napoli F, Fava D, di Iorgi N, Maghnie M
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101440. Epub 2020 Jun 29 doi: 10.1016/j.beem.2020.101440. PMID: 32646670
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793

Diagnosis

Hypopituitarism.
Fleseriu M, Christ-Crain M, Langlois F, Gadelha M, Melmed S
Lancet 2024 Jun 15;403(10444):2632-2648. Epub 2024 May 9 doi: 10.1016/S0140-6736(24)00342-8. PMID: 38735295
Pediatric Moderate and Severe Traumatic Brain Injury: A Systematic Review of Clinical Practice Guideline Recommendations.
Ben Abdeljelil A, Freire GC, Yanchar N, Turgeon AF, Beno S, Bérubé M, Stang A, Stelfox T, Zemek R, Beaulieu E, Gagnon IJ, Gabbe B, Lauzier F, Labrosse M, Tardif PA, Deshommes T, Gnanvi J, Moore L
J Neurotrauma 2023 Nov;40(21-22):2270-2281. Epub 2023 Aug 16 doi: 10.1089/neu.2023.0149. PMID: 37341019
Diagnosis and Management of Central Diabetes Insipidus in Adults.
Tomkins M, Lawless S, Martin-Grace J, Sherlock M, Thompson CJ
J Clin Endocrinol Metab 2022 Sep 28;107(10):2701-2715. doi: 10.1210/clinem/dgac381. PMID: 35771962Free PMC Article
Central diabetes insipidus in children: Diagnosis and management.
Patti G, Ibba A, Morana G, Napoli F, Fava D, di Iorgi N, Maghnie M
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101440. Epub 2020 Jun 29 doi: 10.1016/j.beem.2020.101440. PMID: 32646670
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793

Therapy

Safety of systemic hormone replacement therapy in breast cancer survivors: a systematic review and meta-analysis.
Poggio F, Del Mastro L, Bruzzone M, Ceppi M, Razeti MG, Fregatti P, Ruelle T, Pronzato P, Massarotti C, Franzoi MA, Lambertini M, Tagliamento M
Breast Cancer Res Treat 2022 Jan;191(2):269-275. Epub 2021 Nov 3 doi: 10.1007/s10549-021-06436-9. PMID: 34731351
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793
Interventions to prevent hypothermia at birth in preterm and/or low birth weight infants.
McCall EM, Alderdice F, Halliday HL, Vohra S, Johnston L
Cochrane Database Syst Rev 2018 Feb 12;2(2):CD004210. doi: 10.1002/14651858.CD004210.pub5. PMID: 29431872Free PMC Article
The management of menopause in women with a history of endometriosis: a systematic review.
Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM
Hum Reprod Update 2017 Jul 1;23(4):481-500. doi: 10.1093/humupd/dmx011. PMID: 28498913Free PMC Article
Rehabilitation following carpal tunnel release.
Peters S, Page MJ, Coppieters MW, Ross M, Johnston V
Cochrane Database Syst Rev 2016 Feb 17;2(2):CD004158. doi: 10.1002/14651858.CD004158.pub3. PMID: 26884379Free PMC Article

Prognosis

Iatrogenic Decompensated Heart Failure.
Tran P, Banerjee P
Curr Heart Fail Rep 2020 Apr;17(2):21-27. doi: 10.1007/s11897-020-00452-4. PMID: 32086714Free PMC Article
Efficacy of a bundle approach in preventing the incidence of ventilator associated pneumonia (VAP).
Burja S, Belec T, Bizjak N, Mori J, Markota A, Sinkovič A
Bosn J Basic Med Sci 2018 Feb 20;18(1):105-109. doi: 10.17305/bjbms.2017.2278. PMID: 28976870Free PMC Article
Endocrinology Update: Hypopituitarism.
Heidelbaugh JJ
FP Essent 2016 Dec;451:25-30. PMID: 27936532
Esophageal perforation.
Nirula R
Surg Clin North Am 2014 Feb;94(1):35-41. Epub 2013 Nov 5 doi: 10.1016/j.suc.2013.10.003. PMID: 24267495
Medically indicated--iatrogenic prematurity.
Wong AE, Grobman WA
Clin Perinatol 2011 Sep;38(3):423-39. Epub 2011 Jul 23 doi: 10.1016/j.clp.2011.06.002. PMID: 21890017

Clinical prediction guides

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae.
Pavlovic D, Pekic S, Stojanovic M, Popovic V
Pituitary 2019 Jun;22(3):270-282. doi: 10.1007/s11102-019-00957-9. PMID: 30929221
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article
EEG in Creutzfeldt-Jakob disease.
Wieser HG, Schindler K, Zumsteg D
Clin Neurophysiol 2006 May;117(5):935-51. Epub 2006 Jan 25 doi: 10.1016/j.clinph.2005.12.007. PMID: 16442343

Recent systematic reviews

Pediatric Moderate and Severe Traumatic Brain Injury: A Systematic Review of Clinical Practice Guideline Recommendations.
Ben Abdeljelil A, Freire GC, Yanchar N, Turgeon AF, Beno S, Bérubé M, Stang A, Stelfox T, Zemek R, Beaulieu E, Gagnon IJ, Gabbe B, Lauzier F, Labrosse M, Tardif PA, Deshommes T, Gnanvi J, Moore L
J Neurotrauma 2023 Nov;40(21-22):2270-2281. Epub 2023 Aug 16 doi: 10.1089/neu.2023.0149. PMID: 37341019
Safety of systemic hormone replacement therapy in breast cancer survivors: a systematic review and meta-analysis.
Poggio F, Del Mastro L, Bruzzone M, Ceppi M, Razeti MG, Fregatti P, Ruelle T, Pronzato P, Massarotti C, Franzoi MA, Lambertini M, Tagliamento M
Breast Cancer Res Treat 2022 Jan;191(2):269-275. Epub 2021 Nov 3 doi: 10.1007/s10549-021-06436-9. PMID: 34731351
Creutzfeldt-Jakob disease: a systematic review of global incidence, prevalence, infectivity, and incubation.
Uttley L, Carroll C, Wong R, Hilton DA, Stevenson M
Lancet Infect Dis 2020 Jan;20(1):e2-e10. doi: 10.1016/S1473-3099(19)30615-2. PMID: 31876504
Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis.
Chu DK, Kim LH, Young PJ, Zamiri N, Almenawer SA, Jaeschke R, Szczeklik W, Schünemann HJ, Neary JD, Alhazzani W
Lancet 2018 Apr 28;391(10131):1693-1705. Epub 2018 Apr 26 doi: 10.1016/S0140-6736(18)30479-3. PMID: 29726345
Estimating per-act HIV transmission risk: a systematic review.
Patel P, Borkowf CB, Brooks JT, Lasry A, Lansky A, Mermin J
AIDS 2014 Jun 19;28(10):1509-19. doi: 10.1097/QAD.0000000000000298. PMID: 24809629Free PMC Article

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