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Follicle stimulating hormone deficiency

MedGen UID:
574994
•Concept ID:
C0342386
•
Disease or Syndrome
Synonyms: Follicle-stimulating hormone deficiency; FSH deficiency
SNOMED CT: Follicle stimulating hormone deficiency (190480009)

Definition

Subnormal concentration of follicle stimulating hormone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFollicle stimulating hormone deficiency

Professional guidelines

PubMed

Clomiphene in treatment of male infertility due to isolated follicle-stimulating-hormone deficiency.
McConnon J, Killinger D, Gracey W, Ghany F
Lancet 1979 Sep 8;2(8141):525-6. doi: 10.1016/s0140-6736(79)91577-0. PMID: 90239

Recent clinical studies

Etiology

Hypothalamic-Pituitary Dysfunctions Other Than Growth Hormone Deficiency in Cancer Survivors.
van Iersel L, Chemaitilly W
Front Horm Res 2021;54:36-46. Epub 2021 Feb 8 doi: 10.1159/000513806. PMID: 33556939
Gender Differences in the Relationship between Sex Hormone Deficiency and Soft Drusen.
Kwon HJ, Lee SM, Pak KY, Park SW, Lee JE, Byon IS
Curr Eye Res 2017 Nov;42(11):1527-1536. Epub 2017 Sep 14 doi: 10.1080/02713683.2017.1337155. PMID: 28910205
Central precocious puberty following the diagnosis and treatment of paediatric cancer and central nervous system tumours: presentation and long-term outcomes.
Chemaitilly W, Merchant TE, Li Z, Barnes N, Armstrong GT, Ness KK, Pui CH, Kun LE, Robison LL, Hudson MM, Sklar CA, Gajjar A
Clin Endocrinol (Oxf) 2016 Mar;84(3):361-71. Epub 2015 Nov 16 doi: 10.1111/cen.12964. PMID: 26464129Free PMC Article
Chronic neuroendocrinological sequelae of radiation therapy.
Sklar CA, Constine LS
Int J Radiat Oncol Biol Phys 1995 Mar 30;31(5):1113-21. doi: 10.1016/0360-3016(94)00427-M. PMID: 7713777
Diagnosis and treatment of children with growth hormone deficiency.
Preece MA
Clin Endocrinol Metab 1982 Mar;11(1):1-24. doi: 10.1016/s0300-595x(82)80035-2. PMID: 6807584

Diagnosis

Hypothalamic-Pituitary Dysfunctions Other Than Growth Hormone Deficiency in Cancer Survivors.
van Iersel L, Chemaitilly W
Front Horm Res 2021;54:36-46. Epub 2021 Feb 8 doi: 10.1159/000513806. PMID: 33556939
Gender Differences in the Relationship between Sex Hormone Deficiency and Soft Drusen.
Kwon HJ, Lee SM, Pak KY, Park SW, Lee JE, Byon IS
Curr Eye Res 2017 Nov;42(11):1527-1536. Epub 2017 Sep 14 doi: 10.1080/02713683.2017.1337155. PMID: 28910205
Genetics of human hypogonadotropic hypogonadism.
Layman LC
Am J Med Genet 1999 Dec 29;89(4):240-8. doi: 10.1002/(sici)1096-8628(19991229)89:4<240::aid-ajmg8>3.0.co;2-7. PMID: 10727999
Polycystic ovaries--disorder or sign?
Lancet 1990 Nov 3;336(8723):1099-100. PMID: 1977983
Diagnosis and treatment of children with growth hormone deficiency.
Preece MA
Clin Endocrinol Metab 1982 Mar;11(1):1-24. doi: 10.1016/s0300-595x(82)80035-2. PMID: 6807584

Therapy

Male reproductive endocrinology: when to replace gonadotropins.
Trussell JC
Semin Reprod Med 2013 Jul;31(4):237-44. Epub 2013 Jun 17 doi: 10.1055/s-0033-1345270. PMID: 23775378
Follicular development and oocyte maturation in hypogonadotrophic women employing recombinant follicle-stimulating hormone: the role of oestradiol.
Fauser BC
Hum Reprod Update 1997 Mar-Apr;3(2):101-8. doi: 10.1093/humupd/3.2.101. PMID: 9286734
Polycystic ovaries--disorder or sign?
Lancet 1990 Nov 3;336(8723):1099-100. PMID: 1977983
Isolated follicle-stimulating hormone deficiency in men: successful long-term gonadotropin therapy.
Al-Ansari AA, Khalil TH, Kelani Y, Mortimer CH
Fertil Steril 1984 Oct;42(4):618-26. doi: 10.1016/s0015-0282(16)48148-3. PMID: 6436064
Diagnosis and treatment of children with growth hormone deficiency.
Preece MA
Clin Endocrinol Metab 1982 Mar;11(1):1-24. doi: 10.1016/s0300-595x(82)80035-2. PMID: 6807584

Prognosis

Central precocious puberty following the diagnosis and treatment of paediatric cancer and central nervous system tumours: presentation and long-term outcomes.
Chemaitilly W, Merchant TE, Li Z, Barnes N, Armstrong GT, Ness KK, Pui CH, Kun LE, Robison LL, Hudson MM, Sklar CA, Gajjar A
Clin Endocrinol (Oxf) 2016 Mar;84(3):361-71. Epub 2015 Nov 16 doi: 10.1111/cen.12964. PMID: 26464129Free PMC Article
Mutations along the pituitary-gonadal axis affecting sexual maturation: novel information from transgenic and knockout mice.
Huhtaniemi I
Mol Cell Endocrinol 2006 Jul 25;254-255:84-90. Epub 2006 May 30 doi: 10.1016/j.mce.2006.04.015. PMID: 16730882
Endocrine manifestations of craniopharyngioma.
Halac I, Zimmerman D
Childs Nerv Syst 2005 Aug;21(8-9):640-8. Epub 2005 Jul 27 doi: 10.1007/s00381-005-1246-x. PMID: 16047216
Usefulness of sequential urinary follicle-stimulating hormone and luteinizing hormone measurements in the diagnosis of adolescent hypogonadotropism in males.
Kulin H, Demers L, Chinchilli V, Martel J, Stevens L
J Clin Endocrinol Metab 1994 May;78(5):1208-11. doi: 10.1210/jcem.78.5.8175980. PMID: 8175980
Diagnosis and treatment of children with growth hormone deficiency.
Preece MA
Clin Endocrinol Metab 1982 Mar;11(1):1-24. doi: 10.1016/s0300-595x(82)80035-2. PMID: 6807584

Clinical prediction guides

Central precocious puberty following the diagnosis and treatment of paediatric cancer and central nervous system tumours: presentation and long-term outcomes.
Chemaitilly W, Merchant TE, Li Z, Barnes N, Armstrong GT, Ness KK, Pui CH, Kun LE, Robison LL, Hudson MM, Sklar CA, Gajjar A
Clin Endocrinol (Oxf) 2016 Mar;84(3):361-71. Epub 2015 Nov 16 doi: 10.1111/cen.12964. PMID: 26464129Free PMC Article
Mutations along the pituitary-gonadal axis affecting sexual maturation: novel information from transgenic and knockout mice.
Huhtaniemi I
Mol Cell Endocrinol 2006 Jul 25;254-255:84-90. Epub 2006 May 30 doi: 10.1016/j.mce.2006.04.015. PMID: 16730882
The role of follicle-stimulating hormone in spermatogenesis: lessons from knockout animal models.
Sairam MR, Krishnamurthy H
Arch Med Res 2001 Nov-Dec;32(6):601-8. doi: 10.1016/s0188-4409(01)00328-9. PMID: 11750736
Follicular development and oocyte maturation in hypogonadotrophic women employing recombinant follicle-stimulating hormone: the role of oestradiol.
Fauser BC
Hum Reprod Update 1997 Mar-Apr;3(2):101-8. doi: 10.1093/humupd/3.2.101. PMID: 9286734
Chronic neuroendocrinological sequelae of radiation therapy.
Sklar CA, Constine LS
Int J Radiat Oncol Biol Phys 1995 Mar 30;31(5):1113-21. doi: 10.1016/0360-3016(94)00427-M. PMID: 7713777

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