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Detrusor sphincter dyssynergia

MedGen UID:
574618
•Concept ID:
C0341747
•
Disease or Syndrome
Synonyms: Detrusor and sphincter dyssynergia; detrusor sphincter dyssynergia; detrusor sphincter dyssynergia (disease); DSD - Detrusor and sphincter dyssynergia
SNOMED CT: Detrusor and sphincter dyssynergia (236655005); DSD - Detrusor and sphincter dyssynergia (236655005)
 
HPO: HP:0025488
Monarch Initiative: MONDO:0001447

Definition

A urodynamic anomaly characterized by bladder outlet obstruction from detrusor muscle contraction with concomitant involuntary urethral sphincter activation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDetrusor sphincter dyssynergia

Professional guidelines

PubMed

A Review of Botulinum Toxin A for the Treatment of Neurogenic Bladder.
Cooley LF, Kielb S
PM R 2019 Feb;11(2):192-200. Epub 2019 Feb 13 doi: 10.1016/j.pmrj.2018.07.016. PMID: 30138720
Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy.
Ogawa T, Sakakibara R, Kuno S, Ishizuka O, Kitta T, Yoshimura N
Nat Rev Urol 2017 Feb;14(2):79-89. Epub 2016 Dec 13 doi: 10.1038/nrurol.2016.254. PMID: 27958390
Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects.
Reynard JM, Vass J, Sullivan ME, Mamas M
Spinal Cord 2003 Jan;41(1):1-11. doi: 10.1038/sj.sc.3101378. PMID: 12494314

Recent clinical studies

Etiology

Detrusor sphincter dyssynergia: can a more specific definition distinguish between patients with and without an underlying neurological disorder?
Gross O, Leitner L, Rasenack M, Schubert M, Kessler TM
Spinal Cord 2021 Sep;59(9):1026-1033. Epub 2021 May 7 doi: 10.1038/s41393-021-00635-3. PMID: 33963273Free PMC Article
Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury.
Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M, Del Popolo G
World J Urol 2018 Oct;36(10):1517-1527. Epub 2018 May 11 doi: 10.1007/s00345-018-2301-z. PMID: 29752515
Diagnosis and clinical evaluation of neurogenic bladder.
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
OnabotulinumtoxinA and multiple sclerosis.
Schurch B, Carda S
Ann Phys Rehabil Med 2014 Jul;57(5):302-314. Epub 2014 Jun 5 doi: 10.1016/j.rehab.2014.05.004. PMID: 24953702
Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects.
Reynard JM, Vass J, Sullivan ME, Mamas M
Spinal Cord 2003 Jan;41(1):1-11. doi: 10.1038/sj.sc.3101378. PMID: 12494314

Diagnosis

Diagnosis and clinical evaluation of neurogenic bladder.
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
OnabotulinumtoxinA and multiple sclerosis.
Schurch B, Carda S
Ann Phys Rehabil Med 2014 Jul;57(5):302-314. Epub 2014 Jun 5 doi: 10.1016/j.rehab.2014.05.004. PMID: 24953702
Urodynamics: with a focus on appropriate indications.
Lenherr SM, Clemens JQ
Urol Clin North Am 2013 Nov;40(4):545-57. Epub 2013 Aug 8 doi: 10.1016/j.ucl.2013.07.001. PMID: 24182974
Diagnosing detrusor sphincter dyssynergia in the neurological patient.
Bacsu CD, Chan L, Tse V
BJU Int 2012 Apr;109 Suppl 3:31-4. doi: 10.1111/j.1464-410X.2012.11042.x. PMID: 22458490
Detrusor-sphincter dyssynergia.
Castro-Diaz D, Taracena Lafuente JM
Int J Clin Pract Suppl 2006 Dec;(151):17-21. doi: 10.1111/j.1742-1241.2006.01183.x. PMID: 17169006

Therapy

A Review of Botulinum Toxin A for the Treatment of Neurogenic Bladder.
Cooley LF, Kielb S
PM R 2019 Feb;11(2):192-200. Epub 2019 Feb 13 doi: 10.1016/j.pmrj.2018.07.016. PMID: 30138720
OnabotulinumtoxinA and multiple sclerosis.
Schurch B, Carda S
Ann Phys Rehabil Med 2014 Jul;57(5):302-314. Epub 2014 Jun 5 doi: 10.1016/j.rehab.2014.05.004. PMID: 24953702
Urethral stents for detrusor sphincter dyssynergia.
Nambirajan T, Woolsey S, Mahendra V, Stone AR, Walsh IK
BJU Int 2005 Feb;95(3):350-3. doi: 10.1111/j.1464-410X.2005.05298.x. PMID: 15679792
Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects.
Reynard JM, Vass J, Sullivan ME, Mamas M
Spinal Cord 2003 Jan;41(1):1-11. doi: 10.1038/sj.sc.3101378. PMID: 12494314
Detrusor-sphincter dyssynergia.
McGuire EJ, Brady S
J Urol 1979 Jun;121(6):774-7. doi: 10.1016/s0022-5347(17)56987-6. PMID: 458950

Prognosis

Upper urinary tract function of patients with multiple sclerosis.
Piquet V, Turmel N, Chesnel C, Haddad R, Lebreton F, Amarenco G, Hentzen C
Neurourol Urodyn 2022 Jan;41(1):498-505. Epub 2021 Dec 21 doi: 10.1002/nau.24860. PMID: 34931344
Pharmacotherapeutic management of lower urinary tract symptoms in Multiple Sclerosis patients.
Zanghì A, Cimino S, Urzì D, Privitera S, Zagari F, Lanza G, Patti F, D'Amico E
Expert Opin Pharmacother 2020 Aug;21(12):1449-1454. Epub 2020 May 26 doi: 10.1080/14656566.2020.1767068. PMID: 32452702
The management of paediatric neurogenic bladder: an approach in a resource-poor setting.
Maison POM, Lazarus J
Paediatr Int Child Health 2017 Nov;37(4):280-285. Epub 2017 Jul 17 doi: 10.1080/20469047.2017.1351745. PMID: 28714784
Lower urinary tract dysfunction in patients with multiple sclerosis.
Panicker JN, Fowler CJ
Handb Clin Neurol 2015;130:371-81. doi: 10.1016/B978-0-444-63247-0.00021-3. PMID: 26003255
Role of permanent stents.
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859

Clinical prediction guides

Determination of tibial somatosensory evoked potentials predicts detrusor sphincter dyssynergia in children with neurogenic bladder dysfunction.
Erdogan ET, Ozel K, Matur Z, Alizada O, Canaz H, Alatas I
Neurourol Urodyn 2023 Jun;42(5):1132-1139. Epub 2023 Apr 26 doi: 10.1002/nau.25185. PMID: 37185999
Consistency of uroflowmetry analysis in children among observers.
Sekerci CA, Tanidir Y, Tarcan T, Yucel S
Neurourol Urodyn 2023 Mar;42(3):662-668. Epub 2023 Feb 7 doi: 10.1002/nau.25141. PMID: 36749112
Association of bladder trabeculation and neurogenic bladder with spinal cord injury.
Won YH, Kim DS, Kim GW, Park SH, Ko MH, Seo JH
J Int Med Res 2022 Jun;50(6):3000605221104768. doi: 10.1177/03000605221104768. PMID: 35689375Free PMC Article
The Relationship Between Urinary Symptom Severity And Functional Status İn Patients With Stroke.
Özcan F, Özişler Z
Scott Med J 2022 May;67(2):64-70. Epub 2022 Jan 5 doi: 10.1177/00369330211072247. PMID: 34985348
Detrusor sphincter dyssynergia: can a more specific definition distinguish between patients with and without an underlying neurological disorder?
Gross O, Leitner L, Rasenack M, Schubert M, Kessler TM
Spinal Cord 2021 Sep;59(9):1026-1033. Epub 2021 May 7 doi: 10.1038/s41393-021-00635-3. PMID: 33963273Free PMC Article

Recent systematic reviews

Chronic Urinary Retention in Multiple Sclerosis Patients: Physiology, Systematic Review of Urodynamic Data, and Recommendations for Care.
Stoffel JT
Urol Clin North Am 2017 Aug;44(3):429-439. doi: 10.1016/j.ucl.2017.04.009. PMID: 28716323
Iatrogenic urological triggers of autonomic dysreflexia: a systematic review.
Liu N, Zhou M, Biering-Sørensen F, Krassioukov AV
Spinal Cord 2015 Jul;53(7):500-9. Epub 2015 Mar 24 doi: 10.1038/sc.2015.39. PMID: 25800696
An updated systematic review and statistical comparison of standardised mean outcomes for the use of botulinum toxin in the management of lower urinary tract disorders.
Mangera A, Apostolidis A, Andersson KE, Dasgupta P, Giannantoni A, Roehrborn C, Novara G, Chapple C
Eur Urol 2014 May;65(5):981-90. Epub 2013 Nov 1 doi: 10.1016/j.eururo.2013.10.033. PMID: 24239446
Contemporary management of lower urinary tract disease with botulinum toxin A: a systematic review of botox (onabotulinumtoxinA) and dysport (abobotulinumtoxinA).
Mangera A, Andersson KE, Apostolidis A, Chapple C, Dasgupta P, Giannantoni A, Gravas S, Madersbacher S
Eur Urol 2011 Oct;60(4):784-95. Epub 2011 Jul 13 doi: 10.1016/j.eururo.2011.07.001. PMID: 21782318
A review of non-invasive electro neuromodulation as an intervention for non-neurogenic bladder dysfunction in children.
Bower WF, Yeung CK
Neurourol Urodyn 2004;23(1):63-7. doi: 10.1002/nau.10171. PMID: 14694460

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