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Enterocutaneous fistula

MedGen UID:
137955
•Concept ID:
C0341318
•
Anatomical Abnormality
Synonyms: Enterocutaneous Fistula; Fistula, Enterocutaneous
SNOMED CT: Enteric cutaneous fistula (197247001); Enterocutaneous fistula (197247001)
 
HPO: HP:0033279

Definition

An abnormal connection (fistula) between the intra-abdominal intestinal tract and the skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnterocutaneous fistula

Conditions with this feature

Inflammatory bowel disease 25
MedGen UID:
393403
•Concept ID:
C2675508
•
Disease or Syndrome
Any inflammatory bowel disease in which the cause of the disease is a mutation in the IL10RB gene.
See: Condition Record
Inflammatory bowel disease 25

Professional guidelines

PubMed

Treatment of enterocutaneous fistula: a systematic review and meta-analysis.
Gefen R, Garoufalia Z, Zhou P, Watson K, Emile SH, Wexner SD
Tech Coloproctol 2022 Nov;26(11):863-874. Epub 2022 Aug 1 doi: 10.1007/s10151-022-02656-3. PMID: 35915291
Management of Enterocutaneous Fistula: A Review.
Ghimire P
JNMA J Nepal Med Assoc 2022 Jan 15;60(245):93-100. doi: 10.31729/jnma.5780. PMID: 35199684Free PMC Article
ASPEN-FELANPE Clinical Guidelines.
Kumpf VJ, de Aguilar-Nascimento JE, Diaz-Pizarro Graf JI, Hall AM, McKeever L, Steiger E, Winkler MF, Compher CW; FELANPE; American Society for Parenteral and Enteral Nutrition
JPEN J Parenter Enteral Nutr 2017 Jan;41(1):104-112. Epub 2016 Dec 5 doi: 10.1177/0148607116680792. PMID: 27913762

Recent clinical studies

Etiology

AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review.
Hashash JG, Elkins J, Lewis JD, Binion DG
Gastroenterology 2024 Mar;166(3):521-532. Epub 2024 Jan 23 doi: 10.1053/j.gastro.2023.11.303. PMID: 38276922
Treatment of enterocutaneous fistula: a systematic review and meta-analysis.
Gefen R, Garoufalia Z, Zhou P, Watson K, Emile SH, Wexner SD
Tech Coloproctol 2022 Nov;26(11):863-874. Epub 2022 Aug 1 doi: 10.1007/s10151-022-02656-3. PMID: 35915291
Surgical Critical Care: Gastrointestinal Complications.
Sheldon R, Eckert M
Surg Clin North Am 2017 Dec;97(6):1425-1447. doi: 10.1016/j.suc.2017.08.002. PMID: 29132517
ASPEN-FELANPE Clinical Guidelines.
Kumpf VJ, de Aguilar-Nascimento JE, Diaz-Pizarro Graf JI, Hall AM, McKeever L, Steiger E, Winkler MF, Compher CW; FELANPE; American Society for Parenteral and Enteral Nutrition
JPEN J Parenter Enteral Nutr 2017 Jan;41(1):104-112. Epub 2016 Dec 5 doi: 10.1177/0148607116680792. PMID: 27913762
A step-up approach or open necrosectomy for necrotizing pancreatitis.
van Santvoort HC, Besselink MG, Bakker OJ, Hofker HS, Boermeester MA, Dejong CH, van Goor H, Schaapherder AF, van Eijck CH, Bollen TL, van Ramshorst B, Nieuwenhuijs VB, Timmer R, Laméris JS, Kruyt PM, Manusama ER, van der Harst E, van der Schelling GP, Karsten T, Hesselink EJ, van Laarhoven CJ, Rosman C, Bosscha K, de Wit RJ, Houdijk AP, van Leeuwen MS, Buskens E, Gooszen HG; Dutch Pancreatitis Study Group
N Engl J Med 2010 Apr 22;362(16):1491-502. doi: 10.1056/NEJMoa0908821. PMID: 20410514

Diagnosis

AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review.
Hashash JG, Elkins J, Lewis JD, Binion DG
Gastroenterology 2024 Mar;166(3):521-532. Epub 2024 Jan 23 doi: 10.1053/j.gastro.2023.11.303. PMID: 38276922
Spontaneous Enterocutaneous Fistula.
Perrotti G, Myers RL, Sadri L, Mejia-Sierra L, Katsnelson J, Fassler SA, Shadis R
Am Surg 2023 Dec;89(12):6209-6211. Epub 2022 Jul 6 doi: 10.1177/00031348221114037. PMID: 35792835
Management of Enterocutaneous Fistula: A Review.
Ghimire P
JNMA J Nepal Med Assoc 2022 Jan 15;60(245):93-100. doi: 10.31729/jnma.5780. PMID: 35199684Free PMC Article
Evaluation and Management of Enterocutaneous Fistula.
Bhama AR
Dis Colon Rectum 2019 Aug;62(8):906-910. doi: 10.1097/DCR.0000000000001424. PMID: 31283590
Surgical Critical Care: Gastrointestinal Complications.
Sheldon R, Eckert M
Surg Clin North Am 2017 Dec;97(6):1425-1447. doi: 10.1016/j.suc.2017.08.002. PMID: 29132517

Therapy

Complications of preventive loop ileostomy versus colostomy: a meta-analysis, trial sequential analysis, and systematic review.
Ge Z, Zhao X, Liu Z, Yang G, Wu Q, Wang X, Zhang X, Cheng Z, Wang K
BMC Surg 2023 Aug 12;23(1):235. doi: 10.1186/s12893-023-02129-w. PMID: 37568176Free PMC Article
Spontaneous Enterocutaneous Fistula.
Perrotti G, Myers RL, Sadri L, Mejia-Sierra L, Katsnelson J, Fassler SA, Shadis R
Am Surg 2023 Dec;89(12):6209-6211. Epub 2022 Jul 6 doi: 10.1177/00031348221114037. PMID: 35792835
ASPEN-FELANPE Clinical Guidelines.
Kumpf VJ, de Aguilar-Nascimento JE, Diaz-Pizarro Graf JI, Hall AM, McKeever L, Steiger E, Winkler MF, Compher CW; FELANPE; American Society for Parenteral and Enteral Nutrition
JPEN J Parenter Enteral Nutr 2017 Jan;41(1):104-112. Epub 2016 Dec 5 doi: 10.1177/0148607116680792. PMID: 27913762
A step-up approach or open necrosectomy for necrotizing pancreatitis.
van Santvoort HC, Besselink MG, Bakker OJ, Hofker HS, Boermeester MA, Dejong CH, van Goor H, Schaapherder AF, van Eijck CH, Bollen TL, van Ramshorst B, Nieuwenhuijs VB, Timmer R, Laméris JS, Kruyt PM, Manusama ER, van der Harst E, van der Schelling GP, Karsten T, Hesselink EJ, van Laarhoven CJ, Rosman C, Bosscha K, de Wit RJ, Houdijk AP, van Leeuwen MS, Buskens E, Gooszen HG; Dutch Pancreatitis Study Group
N Engl J Med 2010 Apr 22;362(16):1491-502. doi: 10.1056/NEJMoa0908821. PMID: 20410514
Serious intra-abdominal infections.
Barie PS
Curr Opin Crit Care 2001 Aug;7(4):263-7. doi: 10.1097/00075198-200108000-00009. PMID: 11571424

Prognosis

Post-Operative Wound Infection by Multiple Zoonotic Organisms.
Albert M, Wright JP, Ocariz B
Am Surg 2023 Nov;89(11):4908-4909. Epub 2021 Aug 30 doi: 10.1177/00031348211041558. PMID: 34455863
Single Institution Outcome of Minimally Invasive Enterocutaneous Fistula Management Utilizing the Biodesign® Fistula Plug.
Kaufman C, Adkison G, Smith T, Jenkins L, Cizman Z
Cardiovasc Intervent Radiol 2022 Jun;45(6):846-851. Epub 2022 Mar 11 doi: 10.1007/s00270-022-03099-x. PMID: 35277730
Enterocutaneous fistula after emergency general surgery: Mortality, readmission, and financial burden.
Hatchimonji JS, Passman J, Kaufman EJ, Sharoky CE, Ma LW, Scantling D, Xiong R, Holena DN
J Trauma Acute Care Surg 2020 Jul;89(1):167-172. doi: 10.1097/TA.0000000000002673. PMID: 32176165Free PMC Article
Treatment of Enterocutaneous Fistulas, Then and Now.
Ortiz LA, Zhang B, McCarthy MW, Kaafarani HMA, Fagenholz P, King DR, De Moya M, Velmahos G, Yeh DD
Nutr Clin Pract 2017 Aug;32(4):508-515. Epub 2017 Mar 30 doi: 10.1177/0884533617701402. PMID: 28358595
Metabolic and nutritional support of the enterocutaneous fistula patient: a three-phase approach.
Polk TM, Schwab CW
World J Surg 2012 Mar;36(3):524-33. doi: 10.1007/s00268-011-1315-0. PMID: 22033622

Clinical prediction guides

AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review.
Hashash JG, Elkins J, Lewis JD, Binion DG
Gastroenterology 2024 Mar;166(3):521-532. Epub 2024 Jan 23 doi: 10.1053/j.gastro.2023.11.303. PMID: 38276922
Complications of preventive loop ileostomy versus colostomy: a meta-analysis, trial sequential analysis, and systematic review.
Ge Z, Zhao X, Liu Z, Yang G, Wu Q, Wang X, Zhang X, Cheng Z, Wang K
BMC Surg 2023 Aug 12;23(1):235. doi: 10.1186/s12893-023-02129-w. PMID: 37568176Free PMC Article
The optimal timing and intervention to reduce mortality for necrotizing pancreatitis: a systematic review and network meta-analysis.
Yang Y, Zhang Y, Wen S, Cui Y
World J Emerg Surg 2023 Jan 27;18(1):9. doi: 10.1186/s13017-023-00479-7. PMID: 36707836Free PMC Article
Single Institution Outcome of Minimally Invasive Enterocutaneous Fistula Management Utilizing the Biodesign® Fistula Plug.
Kaufman C, Adkison G, Smith T, Jenkins L, Cizman Z
Cardiovasc Intervent Radiol 2022 Jun;45(6):846-851. Epub 2022 Mar 11 doi: 10.1007/s00270-022-03099-x. PMID: 35277730
Metabolic and nutritional support of the enterocutaneous fistula patient: a three-phase approach.
Polk TM, Schwab CW
World J Surg 2012 Mar;36(3):524-33. doi: 10.1007/s00268-011-1315-0. PMID: 22033622

Recent systematic reviews

The optimal timing and intervention to reduce mortality for necrotizing pancreatitis: a systematic review and network meta-analysis.
Yang Y, Zhang Y, Wen S, Cui Y
World J Emerg Surg 2023 Jan 27;18(1):9. doi: 10.1186/s13017-023-00479-7. PMID: 36707836Free PMC Article
Treatment of enterocutaneous fistula: a systematic review and meta-analysis.
Gefen R, Garoufalia Z, Zhou P, Watson K, Emile SH, Wexner SD
Tech Coloproctol 2022 Nov;26(11):863-874. Epub 2022 Aug 1 doi: 10.1007/s10151-022-02656-3. PMID: 35915291
Systematic review: pharmacotherapy for high-output enterostomies or enteral fistulas.
de Vries FEE, Reeskamp LF, van Ruler O, van Arum I, Kuin W, Dijksta G, Haveman JW, Boermeester MA, Serlie MJ
Aliment Pharmacol Ther 2017 Aug;46(3):266-273. Epub 2017 Jun 14 doi: 10.1111/apt.14136. PMID: 28613003
ASPEN-FELANPE Clinical Guidelines.
Kumpf VJ, de Aguilar-Nascimento JE, Diaz-Pizarro Graf JI, Hall AM, McKeever L, Steiger E, Winkler MF, Compher CW; FELANPE; American Society for Parenteral and Enteral Nutrition
JPEN J Parenter Enteral Nutr 2017 Jan;41(1):104-112. Epub 2016 Dec 5 doi: 10.1177/0148607116680792. PMID: 27913762
Systematic review and meta-analysis of the role of somatostatin and its analogues in the treatment of enterocutaneous fistula.
Stevens P, Foulkes RE, Hartford-Beynon JS, Delicata RJ
Eur J Gastroenterol Hepatol 2011 Oct;23(10):912-22. doi: 10.1097/MEG.0b013e32834a345d. PMID: 21814141

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