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Lower limb ischemia

MedGen UID:
573804
•Concept ID:
C0340565
•
Disease or Syndrome
Synonym: Ischemic leg
SNOMED CT: Lower limb ischemia (233961000); Ischemic leg (233961000)

Professional guidelines

PubMed

Lower Limb Ischemia as Acute Onset of Primary Aortic Occlusion: CTA Imaging and Management.
Lassandro G, Tamburrini S, Liguori C, Picchi SG, Pezzullo F, Ferrandino G, Spinetti F, Vigliotti G, Marano I, Scaglione M
Int J Environ Res Public Health 2023 Feb 22;20(5) doi: 10.3390/ijerph20053868. PMID: 36900878Free PMC Article
History of the diagnosis and treatment of critical limb ischemia and diabetic foot.
Argenteri A, de Donato G, Setacci F, Benevento D, Marone EM, Palasciano G, Setacci C
Semin Vasc Surg 2018 Jun-Dec;31(2-4):25-42. Epub 2019 Jan 26 doi: 10.1053/j.semvascsurg.2019.01.006. PMID: 30876639
Dapagliflozin for the treatment of type 1 diabetes mellitus.
Pafili K, Maltezos E, Papanas N
Expert Opin Investig Drugs 2017 Jul;26(7):873-881. Epub 2017 Jun 12 doi: 10.1080/13543784.2017.1339788. PMID: 28587531

Recent clinical studies

Etiology

Medial Sclerosis-Epidemiology and Clinical Significance.
Lanzer P, Ferraresi R
Dtsch Arztebl Int 2023 May 30;120(21):365-372. doi: 10.3238/arztebl.m2023.0066. PMID: 36978268Free PMC Article
Vasculitides in HIV Infection.
Vega LE, Espinoza LR
Curr Rheumatol Rep 2020 Aug 26;22(10):60. doi: 10.1007/s11926-020-00945-0. PMID: 32845496Free PMC Article
Thrombolysis in Acute Lower Limb Ischemia: Review of the Current Literature.
Theodoridis PG, Davos CH, Dodos I, Iatrou N, Potouridis A, Pappas GM, Staramos D, Antoniadis P, Argitis V, Dervisis K
Ann Vasc Surg 2018 Oct;52:255-262. Epub 2018 Jun 6 doi: 10.1016/j.avsg.2018.02.030. PMID: 29772326
Acute Limb Ischemia.
Gilliland C, Shah J, Martin JG, Miller MJ Jr
Tech Vasc Interv Radiol 2017 Dec;20(4):274-280. Epub 2017 Oct 12 doi: 10.1053/j.tvir.2017.10.008. PMID: 29224661
Follow-up and surveillance of vein grafts: when and how to intervene to prevent complications.
McBRIDE OM, Chalmers RT
J Cardiovasc Surg (Torino) 2017 Apr;58(2):284-292. Epub 2016 Dec 19 doi: 10.23736/S0021-9509.16.09839-6. PMID: 27998051

Diagnosis

Medial Sclerosis-Epidemiology and Clinical Significance.
Lanzer P, Ferraresi R
Dtsch Arztebl Int 2023 May 30;120(21):365-372. doi: 10.3238/arztebl.m2023.0066. PMID: 36978268Free PMC Article
Lower Limb Ischemia as Acute Onset of Primary Aortic Occlusion: CTA Imaging and Management.
Lassandro G, Tamburrini S, Liguori C, Picchi SG, Pezzullo F, Ferrandino G, Spinetti F, Vigliotti G, Marano I, Scaglione M
Int J Environ Res Public Health 2023 Feb 22;20(5) doi: 10.3390/ijerph20053868. PMID: 36900878Free PMC Article
History of the diagnosis and treatment of critical limb ischemia and diabetic foot.
Argenteri A, de Donato G, Setacci F, Benevento D, Marone EM, Palasciano G, Setacci C
Semin Vasc Surg 2018 Jun-Dec;31(2-4):25-42. Epub 2019 Jan 26 doi: 10.1053/j.semvascsurg.2019.01.006. PMID: 30876639
Thrombolysis in Acute Lower Limb Ischemia: Review of the Current Literature.
Theodoridis PG, Davos CH, Dodos I, Iatrou N, Potouridis A, Pappas GM, Staramos D, Antoniadis P, Argitis V, Dervisis K
Ann Vasc Surg 2018 Oct;52:255-262. Epub 2018 Jun 6 doi: 10.1016/j.avsg.2018.02.030. PMID: 29772326
Follow-up and surveillance of vein grafts: when and how to intervene to prevent complications.
McBRIDE OM, Chalmers RT
J Cardiovasc Surg (Torino) 2017 Apr;58(2):284-292. Epub 2016 Dec 19 doi: 10.23736/S0021-9509.16.09839-6. PMID: 27998051

Therapy

Cell therapy of critical limb ischemia-problems and prospects.
Osipova O, Saaya S, Karpenko A, Zakian S, Aboian E
Vasa 2019 Nov;48(6):461-471. Epub 2019 Apr 10 doi: 10.1024/0301-1526/a000787. PMID: 30969159
Thrombolysis in Acute Lower Limb Ischemia: Review of the Current Literature.
Theodoridis PG, Davos CH, Dodos I, Iatrou N, Potouridis A, Pappas GM, Staramos D, Antoniadis P, Argitis V, Dervisis K
Ann Vasc Surg 2018 Oct;52:255-262. Epub 2018 Jun 6 doi: 10.1016/j.avsg.2018.02.030. PMID: 29772326
Acute Limb Ischemia.
Gilliland C, Shah J, Martin JG, Miller MJ Jr
Tech Vasc Interv Radiol 2017 Dec;20(4):274-280. Epub 2017 Oct 12 doi: 10.1053/j.tvir.2017.10.008. PMID: 29224661
Dapagliflozin for the treatment of type 1 diabetes mellitus.
Pafili K, Maltezos E, Papanas N
Expert Opin Investig Drugs 2017 Jul;26(7):873-881. Epub 2017 Jun 12 doi: 10.1080/13543784.2017.1339788. PMID: 28587531
Fenestrated and Branched Aortic Grafts.
Rylski B, Czerny M, Südkamp M, Russe M, Siep M, Beyersdorf F
Dtsch Arztebl Int 2015 Nov 27;112(48):816-22. doi: 10.3238/arztebl.2015.0816. PMID: 26667980Free PMC Article

Prognosis

Acute leukemia presenting as acute lower limb ischemia.
Bontinis A, Bontinis V, Koutsoumpelis A, Perifanis V, Kaiafa G, Giannopoulos A, Ktenidis K
Vasa 2022 Jan;51(1):37-45. Epub 2021 Nov 19 doi: 10.1024/0301-1526/a000977. PMID: 34794339
History of the diagnosis and treatment of critical limb ischemia and diabetic foot.
Argenteri A, de Donato G, Setacci F, Benevento D, Marone EM, Palasciano G, Setacci C
Semin Vasc Surg 2018 Jun-Dec;31(2-4):25-42. Epub 2019 Jan 26 doi: 10.1053/j.semvascsurg.2019.01.006. PMID: 30876639
Follow-up and surveillance of vein grafts: when and how to intervene to prevent complications.
McBRIDE OM, Chalmers RT
J Cardiovasc Surg (Torino) 2017 Apr;58(2):284-292. Epub 2016 Dec 19 doi: 10.23736/S0021-9509.16.09839-6. PMID: 27998051
Fenestrated and Branched Aortic Grafts.
Rylski B, Czerny M, Südkamp M, Russe M, Siep M, Beyersdorf F
Dtsch Arztebl Int 2015 Nov 27;112(48):816-22. doi: 10.3238/arztebl.2015.0816. PMID: 26667980Free PMC Article
Chronic lower limb ischemia and advanced renal failure. Do we possess sufficient therapeutic knowledge?
Gacka M, Adamiec R
Int Angiol 2013 Aug;32(4):355-61. PMID: 23822937

Clinical prediction guides

Lipoprotein-associated phospholipase A2 predicts lower limb ischemia in hemodialysis subjects.
De Mauri A, Vidali M, Chiarinotti D, Dianzani U, Rolla R
Ther Apher Dial 2020 Oct;24(5):548-553. Epub 2020 Jan 21 doi: 10.1111/1744-9987.13465. PMID: 31863555
History of the diagnosis and treatment of critical limb ischemia and diabetic foot.
Argenteri A, de Donato G, Setacci F, Benevento D, Marone EM, Palasciano G, Setacci C
Semin Vasc Surg 2018 Jun-Dec;31(2-4):25-42. Epub 2019 Jan 26 doi: 10.1053/j.semvascsurg.2019.01.006. PMID: 30876639
Bypass Surgery With Heparin-Bonded Grafts for Chronic Lower Limb Ischemia.
McAnelly SL, Hajibandeh S, Hajibandeh S, Georgiadis GS, Antoniou SA, Madan M, Antoniou GA
Ann Vasc Surg 2017 Aug;43:328-346. Epub 2017 May 4 doi: 10.1016/j.avsg.2017.03.169. PMID: 28478165
Follow-up and surveillance of vein grafts: when and how to intervene to prevent complications.
McBRIDE OM, Chalmers RT
J Cardiovasc Surg (Torino) 2017 Apr;58(2):284-292. Epub 2016 Dec 19 doi: 10.23736/S0021-9509.16.09839-6. PMID: 27998051
Chronic lower limb ischemia and advanced renal failure. Do we possess sufficient therapeutic knowledge?
Gacka M, Adamiec R
Int Angiol 2013 Aug;32(4):355-61. PMID: 23822937

Recent systematic reviews

Strategies to reduce limb ischemia in peripheral venoarterial extracorporeal membrane oxygenation: A systematic review and Meta-analysis.
Marbach JA, Faugno AJ, Pacifici S, Chweich H, Marbach JK, Rabinowitz JB, Thayer KL, Di Santo P, Kapur NK
Int J Cardiol 2022 Aug 15;361:77-84. Epub 2022 May 9 doi: 10.1016/j.ijcard.2022.04.084. PMID: 35523371
Aortic Thrombosis following COVID-19: A Systematic Review.
Petrov A, De Glee Romera JP, Wilbring M, Alexiou K, Kappert U, Matschke KE, Tugtekin SM
Thorac Cardiovasc Surg 2022 Jun;70(4):323-332. Epub 2022 Feb 2 doi: 10.1055/s-0041-1740554. PMID: 35108736
The influence of patients' nutritional status on the prevalence, course and treatment outcomes of lower limb ischemia: an overview of current evidence.
Spychalska-Zwolińska M, Zwoliński T, Anaszewicz M, Budzyński J
Int Angiol 2018 Apr;37(2):100-111. Epub 2018 Jan 31 doi: 10.23736/S0392-9590.18.03916-0. PMID: 29385791
Direct Revascularization With the Angiosome Concept for Lower Limb Ischemia: A Systematic Review and Meta-Analysis.
Huang TY, Huang TS, Wang YC, Huang PF, Yu HC, Yeh CH
Medicine (Baltimore) 2015 Aug;94(34):e1427. doi: 10.1097/MD.0000000000001427. PMID: 26313796Free PMC Article
Meta-analysis of the prevalence, incidence and natural history of critical limb ischemia.
Biancari F
J Cardiovasc Surg (Torino) 2013 Dec;54(6):663-9. PMID: 24126504

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