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Hypoxemic respiratory failure

MedGen UID:
573602
•Concept ID:
C0340194
•
Disease or Syndrome
Synonyms: Failure, Hypoxemic Respiratory; Hypoxemic Respiratory Failure; Hypoxemic Respiratory Failures; Respiratory Failure, Hypoxemic
SNOMED CT: Type I respiratory failure (233765002); Hypoxemic respiratory failure (10676831000119101); Respiratory failure without hypercapnia (233765002); Type 1 respiratory failure (233765002)

Definition

Respiratory failure due to a low level of oxygen in the blood without a high level of carbon dioxide. [from SNOMEDCT_US]

Professional guidelines

PubMed

Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS.
Grieco DL, Maggiore SM, Roca O, Spinelli E, Patel BK, Thille AW, Barbas CSV, de Acilu MG, Cutuli SL, Bongiovanni F, Amato M, Frat JP, Mauri T, Kress JP, Mancebo J, Antonelli M
Intensive Care Med 2021 Aug;47(8):851-866. Epub 2021 Jul 7 doi: 10.1007/s00134-021-06459-2. PMID: 34232336Free PMC Article
Acute Respiratory Distress Syndrome: Etiology, Pathogenesis, and Summary on Management.
Kaku S, Nguyen CD, Htet NN, Tutera D, Barr J, Paintal HS, Kuschner WG
J Intensive Care Med 2020 Aug;35(8):723-737. Epub 2019 Jun 17 doi: 10.1177/0885066619855021. PMID: 31208266

Recent clinical studies

Etiology

Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS.
Grieco DL, Maggiore SM, Roca O, Spinelli E, Patel BK, Thille AW, Barbas CSV, de Acilu MG, Cutuli SL, Bongiovanni F, Amato M, Frat JP, Mauri T, Kress JP, Mancebo J, Antonelli M
Intensive Care Med 2021 Aug;47(8):851-866. Epub 2021 Jul 7 doi: 10.1007/s00134-021-06459-2. PMID: 34232336Free PMC Article
Acute Respiratory Distress Syndrome: Etiology, Pathogenesis, and Summary on Management.
Kaku S, Nguyen CD, Htet NN, Tutera D, Barr J, Paintal HS, Kuschner WG
J Intensive Care Med 2020 Aug;35(8):723-737. Epub 2019 Jun 17 doi: 10.1177/0885066619855021. PMID: 31208266
Noninvasive Respiratory Support in Acute Hypoxemic Respiratory Failure.
Piraino T
Respir Care 2019 Jun;64(6):638-646. doi: 10.4187/respcare.06735. PMID: 31110033
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network
N Engl J Med 2015 Jun 4;372(23):2185-96. Epub 2015 May 17 doi: 10.1056/NEJMoa1503326. PMID: 25981908

Diagnosis

Diagnosis and Epidemiology of Acute Respiratory Failure.
Chen L, Rackley CR
Crit Care Clin 2024 Apr;40(2):221-233. Epub 2023 Dec 26 doi: 10.1016/j.ccc.2023.12.001. PMID: 38432693
Electrical Impedance Tomography to Monitor Hypoxemic Respiratory Failure.
Franchineau G, Jonkman AH, Piquilloud L, Yoshida T, Costa E, Rozé H, Camporota L, Piraino T, Spinelli E, Combes A, Alcala GC, Amato M, Mauri T, Frerichs I, Brochard LJ, Schmidt M
Am J Respir Crit Care Med 2024 Mar 15;209(6):670-682. doi: 10.1164/rccm.202306-1118CI. PMID: 38127779
Redefining ARDS: a paradigm shift.
Villar J, Szakmany T, Grasselli G, Camporota L
Crit Care 2023 Oct 31;27(1):416. doi: 10.1186/s13054-023-04699-w. PMID: 37907946Free PMC Article
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Diagnosis of severe respiratory infections in immunocompromised patients.
Azoulay E, Russell L, Van de Louw A, Metaxa V, Bauer P, Povoa P, Montero JG, Loeches IM, Mehta S, Puxty K, Schellongowski P, Rello J, Mokart D, Lemiale V, Mirouse A; Nine-i Investigators
Intensive Care Med 2020 Feb;46(2):298-314. Epub 2020 Feb 7 doi: 10.1007/s00134-019-05906-5. PMID: 32034433Free PMC Article

Therapy

Prone Positioning for Acute Hypoxemic Respiratory Failure and ARDS: A Review.
Rampon GL, Simpson SQ, Agrawal R
Chest 2023 Feb;163(2):332-340. Epub 2022 Sep 23 doi: 10.1016/j.chest.2022.09.020. PMID: 36162482
Pulmonary hypertension in the newborn- etiology and pathogenesis.
Sankaran D, Lakshminrusimha S
Semin Fetal Neonatal Med 2022 Aug;27(4):101381. Epub 2022 Aug 7 doi: 10.1016/j.siny.2022.101381. PMID: 35963740
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Noninvasive Respiratory Support in Acute Hypoxemic Respiratory Failure.
Piraino T
Respir Care 2019 Jun;64(6):638-646. doi: 10.4187/respcare.06735. PMID: 31110033
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network
N Engl J Med 2015 Jun 4;372(23):2185-96. Epub 2015 May 17 doi: 10.1056/NEJMoa1503326. PMID: 25981908

Prognosis

Redefining ARDS: a paradigm shift.
Villar J, Szakmany T, Grasselli G, Camporota L
Crit Care 2023 Oct 31;27(1):416. doi: 10.1186/s13054-023-04699-w. PMID: 37907946Free PMC Article
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.
Grasselli G, Calfee CS, Camporota L, Poole D, Amato MBP, Antonelli M, Arabi YM, Baroncelli F, Beitler JR, Bellani G, Bellingan G, Blackwood B, Bos LDJ, Brochard L, Brodie D, Burns KEA, Combes A, D'Arrigo S, De Backer D, Demoule A, Einav S, Fan E, Ferguson ND, Frat JP, Gattinoni L, Guérin C, Herridge MS, Hodgson C, Hough CL, Jaber S, Juffermans NP, Karagiannidis C, Kesecioglu J, Kwizera A, Laffey JG, Mancebo J, Matthay MA, McAuley DF, Mercat A, Meyer NJ, Moss M, Munshi L, Myatra SN, Ng Gong M, Papazian L, Patel BK, Pellegrini M, Perner A, Pesenti A, Piquilloud L, Qiu H, Ranieri MV, Riviello E, Slutsky AS, Stapleton RD, Summers C, Thompson TB, Valente Barbas CS, Villar J, Ware LB, Weiss B, Zampieri FG, Azoulay E, Cecconi M; European Society of Intensive Care Medicine Taskforce on ARDS
Intensive Care Med 2023 Jul;49(7):727-759. Epub 2023 Jun 16 doi: 10.1007/s00134-023-07050-7. PMID: 37326646Free PMC Article
Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.
Perkins GD, Ji C, Connolly BA, Couper K, Lall R, Baillie JK, Bradley JM, Dark P, Dave C, De Soyza A, Dennis AV, Devrell A, Fairbairn S, Ghani H, Gorman EA, Green CA, Hart N, Hee SW, Kimbley Z, Madathil S, McGowan N, Messer B, Naisbitt J, Norman C, Parekh D, Parkin EM, Patel J, Regan SE, Ross C, Rostron AJ, Saim M, Simonds AK, Skilton E, Stallard N, Steiner M, Vancheeswaran R, Yeung J, McAuley DF; RECOVERY-RS Collaborators
JAMA 2022 Feb 8;327(6):546-558. doi: 10.1001/jama.2022.0028. PMID: 35072713Free PMC Article
An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy.
Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, García-de-Acilu M, Frat JP, Masclans JR, Ricard JD
Am J Respir Crit Care Med 2019 Jun 1;199(11):1368-1376. doi: 10.1164/rccm.201803-0589OC. PMID: 30576221
Predicting success of high-flow nasal cannula in pneumonia patients with hypoxemic respiratory failure: The utility of the ROX index.
Roca O, Messika J, Caralt B, García-de-Acilu M, Sztrymf B, Ricard JD, Masclans JR
J Crit Care 2016 Oct;35:200-5. Epub 2016 May 31 doi: 10.1016/j.jcrc.2016.05.022. PMID: 27481760

Clinical prediction guides

High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial.
Tan D, Walline JH, Ling B, Xu Y, Sun J, Wang B, Shan X, Wang Y, Cao P, Zhu Q, Geng P, Xu J
Crit Care 2020 Aug 6;24(1):489. doi: 10.1186/s13054-020-03214-9. PMID: 32762701Free PMC Article
An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy.
Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, García-de-Acilu M, Frat JP, Masclans JR, Ricard JD
Am J Respir Crit Care Med 2019 Jun 1;199(11):1368-1376. doi: 10.1164/rccm.201803-0589OC. PMID: 30576221
Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure.
Storgaard LH, Hockey HU, Laursen BS, Weinreich UM
Int J Chron Obstruct Pulmon Dis 2018;13:1195-1205. Epub 2018 Apr 16 doi: 10.2147/COPD.S159666. PMID: 29713153Free PMC Article
Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict noninvasive ventilation failure in hypoxemic patients.
Duan J, Han X, Bai L, Zhou L, Huang S
Intensive Care Med 2017 Feb;43(2):192-199. Epub 2016 Nov 3 doi: 10.1007/s00134-016-4601-3. PMID: 27812731
Predicting success of high-flow nasal cannula in pneumonia patients with hypoxemic respiratory failure: The utility of the ROX index.
Roca O, Messika J, Caralt B, García-de-Acilu M, Sztrymf B, Ricard JD, Masclans JR
J Crit Care 2016 Oct;35:200-5. Epub 2016 May 31 doi: 10.1016/j.jcrc.2016.05.022. PMID: 27481760

Recent systematic reviews

Noninvasive Oxygenation Strategies in Adult Patients With Acute Hypoxemic Respiratory Failure: A Systematic Review and Network Meta-Analysis.
Pitre T, Zeraatkar D, Kachkovski GV, Leung G, Shligold E, Dowhanik S, Angriman F, Ferreyro BL, Scales DC, Rochwerg B
Chest 2023 Oct;164(4):913-928. Epub 2023 Apr 20 doi: 10.1016/j.chest.2023.04.022. PMID: 37085046
Efficacy of awake prone positioning in patients with covid-19 related hypoxemic respiratory failure: systematic review and meta-analysis of randomized trials.
Weatherald J, Parhar KKS, Al Duhailib Z, Chu DK, Granholm A, Solverson K, Lewis K, Møller MH, Alshahrani M, Belley-Cote E, Loroff N, Qian ET, Gatto CL, Rice TW, Niven D, Stelfox HT, Fiest K, Cook D, Arabi YM, Alhazzani W
BMJ 2022 Dec 7;379:e071966. doi: 10.1136/bmj-2022-071966. PMID: 36740866Free PMC Article
Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis.
Dianti J, Tisminetzky M, Ferreyro BL, Englesakis M, Del Sorbo L, Sud S, Talmor D, Ball L, Meade M, Hodgson C, Beitler JR, Sahetya S, Nichol A, Fan E, Rochwerg B, Brochard L, Slutsky AS, Ferguson ND, Serpa Neto A, Adhikari NKJ, Angriman F, Goligher EC
Am J Respir Crit Care Med 2022 Jun 1;205(11):1300-1310. doi: 10.1164/rccm.202108-1972OC. PMID: 35180042
Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-analysis.
Ferreyro BL, Angriman F, Munshi L, Del Sorbo L, Ferguson ND, Rochwerg B, Ryu MJ, Saskin R, Wunsch H, da Costa BR, Scales DC
JAMA 2020 Jul 7;324(1):57-67. doi: 10.1001/jama.2020.9524. PMID: 32496521Free PMC Article
High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis.
Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, Mekontso-Dessap A, Schreiber A, Azoulay E, Mercat A, Demoule A, Lemiale V, Pesenti A, Riviello ED, Mauri T, Mancebo J, Brochard L, Burns K
Intensive Care Med 2019 May;45(5):563-572. Epub 2019 Mar 19 doi: 10.1007/s00134-019-05590-5. PMID: 30888444

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