U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hypoxemic respiratory failure

MedGen UID:
573602
Concept ID:
C0340194
Disease or Syndrome
Synonyms: Failure, Hypoxemic Respiratory; Hypoxemic Respiratory Failure; Hypoxemic Respiratory Failures; Respiratory Failure, Hypoxemic
SNOMED CT: Type I respiratory failure (233765002); Hypoxemic respiratory failure (10676831000119101); Respiratory failure without hypercapnia (233765002); Type 1 respiratory failure (233765002)

Definition

Respiratory failure due to a low level of oxygen in the blood without a high level of carbon dioxide. [from SNOMEDCT_US]

Professional guidelines

PubMed

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Grieco DL, Maggiore SM, Roca O, Spinelli E, Patel BK, Thille AW, Barbas CSV, de Acilu MG, Cutuli SL, Bongiovanni F, Amato M, Frat JP, Mauri T, Kress JP, Mancebo J, Antonelli M
Intensive Care Med 2021 Aug;47(8):851-866. Epub 2021 Jul 7 doi: 10.1007/s00134-021-06459-2. PMID: 34232336Free PMC Article
Kaku S, Nguyen CD, Htet NN, Tutera D, Barr J, Paintal HS, Kuschner WG
J Intensive Care Med 2020 Aug;35(8):723-737. Epub 2019 Jun 17 doi: 10.1177/0885066619855021. PMID: 31208266

Recent clinical studies

Etiology

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Grieco DL, Maggiore SM, Roca O, Spinelli E, Patel BK, Thille AW, Barbas CSV, de Acilu MG, Cutuli SL, Bongiovanni F, Amato M, Frat JP, Mauri T, Kress JP, Mancebo J, Antonelli M
Intensive Care Med 2021 Aug;47(8):851-866. Epub 2021 Jul 7 doi: 10.1007/s00134-021-06459-2. PMID: 34232336Free PMC Article
Kaku S, Nguyen CD, Htet NN, Tutera D, Barr J, Paintal HS, Kuschner WG
J Intensive Care Med 2020 Aug;35(8):723-737. Epub 2019 Jun 17 doi: 10.1177/0885066619855021. PMID: 31208266
Piraino T
Respir Care 2019 Jun;64(6):638-646. doi: 10.4187/respcare.06735. PMID: 31110033
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network
N Engl J Med 2015 Jun 4;372(23):2185-96. Epub 2015 May 17 doi: 10.1056/NEJMoa1503326. PMID: 25981908

Diagnosis

Chen L, Rackley CR
Crit Care Clin 2024 Apr;40(2):221-233. Epub 2023 Dec 26 doi: 10.1016/j.ccc.2023.12.001. PMID: 38432693
Franchineau G, Jonkman AH, Piquilloud L, Yoshida T, Costa E, Rozé H, Camporota L, Piraino T, Spinelli E, Combes A, Alcala GC, Amato M, Mauri T, Frerichs I, Brochard LJ, Schmidt M
Am J Respir Crit Care Med 2024 Mar 15;209(6):670-682. doi: 10.1164/rccm.202306-1118CI. PMID: 38127779
Villar J, Szakmany T, Grasselli G, Camporota L
Crit Care 2023 Oct 31;27(1):416. doi: 10.1186/s13054-023-04699-w. PMID: 37907946Free PMC Article
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Azoulay E, Russell L, Van de Louw A, Metaxa V, Bauer P, Povoa P, Montero JG, Loeches IM, Mehta S, Puxty K, Schellongowski P, Rello J, Mokart D, Lemiale V, Mirouse A; Nine-i Investigators
Intensive Care Med 2020 Feb;46(2):298-314. Epub 2020 Feb 7 doi: 10.1007/s00134-019-05906-5. PMID: 32034433Free PMC Article

Therapy

Rampon GL, Simpson SQ, Agrawal R
Chest 2023 Feb;163(2):332-340. Epub 2022 Sep 23 doi: 10.1016/j.chest.2022.09.020. PMID: 36162482
Sankaran D, Lakshminrusimha S
Semin Fetal Neonatal Med 2022 Aug;27(4):101381. Epub 2022 Aug 7 doi: 10.1016/j.siny.2022.101381. PMID: 35963740
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Piraino T
Respir Care 2019 Jun;64(6):638-646. doi: 10.4187/respcare.06735. PMID: 31110033
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network
N Engl J Med 2015 Jun 4;372(23):2185-96. Epub 2015 May 17 doi: 10.1056/NEJMoa1503326. PMID: 25981908

Prognosis

Villar J, Szakmany T, Grasselli G, Camporota L
Crit Care 2023 Oct 31;27(1):416. doi: 10.1186/s13054-023-04699-w. PMID: 37907946Free PMC Article
Grasselli G, Calfee CS, Camporota L, Poole D, Amato MBP, Antonelli M, Arabi YM, Baroncelli F, Beitler JR, Bellani G, Bellingan G, Blackwood B, Bos LDJ, Brochard L, Brodie D, Burns KEA, Combes A, D'Arrigo S, De Backer D, Demoule A, Einav S, Fan E, Ferguson ND, Frat JP, Gattinoni L, Guérin C, Herridge MS, Hodgson C, Hough CL, Jaber S, Juffermans NP, Karagiannidis C, Kesecioglu J, Kwizera A, Laffey JG, Mancebo J, Matthay MA, McAuley DF, Mercat A, Meyer NJ, Moss M, Munshi L, Myatra SN, Ng Gong M, Papazian L, Patel BK, Pellegrini M, Perner A, Pesenti A, Piquilloud L, Qiu H, Ranieri MV, Riviello E, Slutsky AS, Stapleton RD, Summers C, Thompson TB, Valente Barbas CS, Villar J, Ware LB, Weiss B, Zampieri FG, Azoulay E, Cecconi M; European Society of Intensive Care Medicine Taskforce on ARDS
Intensive Care Med 2023 Jul;49(7):727-759. Epub 2023 Jun 16 doi: 10.1007/s00134-023-07050-7. PMID: 37326646Free PMC Article
Perkins GD, Ji C, Connolly BA, Couper K, Lall R, Baillie JK, Bradley JM, Dark P, Dave C, De Soyza A, Dennis AV, Devrell A, Fairbairn S, Ghani H, Gorman EA, Green CA, Hart N, Hee SW, Kimbley Z, Madathil S, McGowan N, Messer B, Naisbitt J, Norman C, Parekh D, Parkin EM, Patel J, Regan SE, Ross C, Rostron AJ, Saim M, Simonds AK, Skilton E, Stallard N, Steiner M, Vancheeswaran R, Yeung J, McAuley DF; RECOVERY-RS Collaborators
JAMA 2022 Feb 8;327(6):546-558. doi: 10.1001/jama.2022.0028. PMID: 35072713Free PMC Article
Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, García-de-Acilu M, Frat JP, Masclans JR, Ricard JD
Am J Respir Crit Care Med 2019 Jun 1;199(11):1368-1376. doi: 10.1164/rccm.201803-0589OC. PMID: 30576221
Roca O, Messika J, Caralt B, García-de-Acilu M, Sztrymf B, Ricard JD, Masclans JR
J Crit Care 2016 Oct;35:200-5. Epub 2016 May 31 doi: 10.1016/j.jcrc.2016.05.022. PMID: 27481760

Clinical prediction guides

Tan D, Walline JH, Ling B, Xu Y, Sun J, Wang B, Shan X, Wang Y, Cao P, Zhu Q, Geng P, Xu J
Crit Care 2020 Aug 6;24(1):489. doi: 10.1186/s13054-020-03214-9. PMID: 32762701Free PMC Article
Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, García-de-Acilu M, Frat JP, Masclans JR, Ricard JD
Am J Respir Crit Care Med 2019 Jun 1;199(11):1368-1376. doi: 10.1164/rccm.201803-0589OC. PMID: 30576221
Storgaard LH, Hockey HU, Laursen BS, Weinreich UM
Int J Chron Obstruct Pulmon Dis 2018;13:1195-1205. Epub 2018 Apr 16 doi: 10.2147/COPD.S159666. PMID: 29713153Free PMC Article
Duan J, Han X, Bai L, Zhou L, Huang S
Intensive Care Med 2017 Feb;43(2):192-199. Epub 2016 Nov 3 doi: 10.1007/s00134-016-4601-3. PMID: 27812731
Roca O, Messika J, Caralt B, García-de-Acilu M, Sztrymf B, Ricard JD, Masclans JR
J Crit Care 2016 Oct;35:200-5. Epub 2016 May 31 doi: 10.1016/j.jcrc.2016.05.022. PMID: 27481760

Recent systematic reviews

Pitre T, Zeraatkar D, Kachkovski GV, Leung G, Shligold E, Dowhanik S, Angriman F, Ferreyro BL, Scales DC, Rochwerg B
Chest 2023 Oct;164(4):913-928. Epub 2023 Apr 20 doi: 10.1016/j.chest.2023.04.022. PMID: 37085046
Weatherald J, Parhar KKS, Al Duhailib Z, Chu DK, Granholm A, Solverson K, Lewis K, Møller MH, Alshahrani M, Belley-Cote E, Loroff N, Qian ET, Gatto CL, Rice TW, Niven D, Stelfox HT, Fiest K, Cook D, Arabi YM, Alhazzani W
BMJ 2022 Dec 7;379:e071966. doi: 10.1136/bmj-2022-071966. PMID: 36740866Free PMC Article
Dianti J, Tisminetzky M, Ferreyro BL, Englesakis M, Del Sorbo L, Sud S, Talmor D, Ball L, Meade M, Hodgson C, Beitler JR, Sahetya S, Nichol A, Fan E, Rochwerg B, Brochard L, Slutsky AS, Ferguson ND, Serpa Neto A, Adhikari NKJ, Angriman F, Goligher EC
Am J Respir Crit Care Med 2022 Jun 1;205(11):1300-1310. doi: 10.1164/rccm.202108-1972OC. PMID: 35180042
Ferreyro BL, Angriman F, Munshi L, Del Sorbo L, Ferguson ND, Rochwerg B, Ryu MJ, Saskin R, Wunsch H, da Costa BR, Scales DC
JAMA 2020 Jul 7;324(1):57-67. doi: 10.1001/jama.2020.9524. PMID: 32496521Free PMC Article
Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, Mekontso-Dessap A, Schreiber A, Azoulay E, Mercat A, Demoule A, Lemiale V, Pesenti A, Riviello ED, Mauri T, Mancebo J, Brochard L, Burns K
Intensive Care Med 2019 May;45(5):563-572. Epub 2019 Mar 19 doi: 10.1007/s00134-019-05590-5. PMID: 30888444

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...