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Disorder of macula due to diabetes mellitus

MedGen UID:
573172
•Concept ID:
C0339471
•
Disease or Syndrome
Synonyms: Diabetic maculopathy; Maculopathy due to diabetes mellitus; Maculopathy with diabetes mellitus
SNOMED CT: Diabetic maculopathy (232020009); Maculopathy due to diabetes mellitus (232020009); Maculopathy with diabetes mellitus (232020009); Disorder of macula due to diabetes mellitus (232020009)

Professional guidelines

PubMed

Current management of diabetic tractional retinal detachments.
Stewart MW, Browning DJ, Landers MB
Indian J Ophthalmol 2018 Dec;66(12):1751-1762. doi: 10.4103/ijo.IJO_1217_18. PMID: 30451175Free PMC Article
Management of Diabetic Macular Edema.
Moisseiev E, Loewenstein A
Ophthalmic Res 2017;58(1):15-17. Epub 2017 Mar 14 doi: 10.1159/000458535. PMID: 28288460
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.
Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ
Circulation 2016 Sep 6;134(10):752-72. Epub 2016 Jul 28 doi: 10.1161/CIRCULATIONAHA.116.021887. PMID: 27470878

Recent clinical studies

Etiology

Renal Protection with SGLT2 Inhibitors: Effects in Acute and Chronic Kidney Disease.
Bailey CJ, Day C, Bellary S
Curr Diab Rep 2022 Jan;22(1):39-52. Epub 2022 Feb 3 doi: 10.1007/s11892-021-01442-z. PMID: 35113333Free PMC Article
The tubular hypothesis of nephron filtration and diabetic kidney disease.
Vallon V, Thomson SC
Nat Rev Nephrol 2020 Jun;16(6):317-336. Epub 2020 Mar 9 doi: 10.1038/s41581-020-0256-y. PMID: 32152499Free PMC Article
Diabetic Macular Edema.
Bandello F, Battaglia Parodi M, Lanzetta P, Loewenstein A, Massin P, Menchini F, Veritti D
Dev Ophthalmol 2017;58:102-138. Epub 2017 Mar 28 doi: 10.1159/000455277. PMID: 28351052
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.
Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ
Circulation 2016 Sep 6;134(10):752-72. Epub 2016 Jul 28 doi: 10.1161/CIRCULATIONAHA.116.021887. PMID: 27470878
Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales.
Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT; Global Diabetic Retinopathy Project Group
Ophthalmology 2003 Sep;110(9):1677-82. doi: 10.1016/S0161-6420(03)00475-5. PMID: 13129861

Diagnosis

Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials.
Wykoff CC, Abreu F, Adamis AP, Basu K, Eichenbaum DA, Haskova Z, Lin H, Loewenstein A, Mohan S, Pearce IA, Sakamoto T, Schlottmann PG, Silverman D, Sun JK, Wells JA, Willis JR, Tadayoni R; YOSEMITE and RHINE Investigators
Lancet 2022 Feb 19;399(10326):741-755. Epub 2022 Jan 24 doi: 10.1016/S0140-6736(22)00018-6. PMID: 35085503
Mechanisms of macular edema: Beyond the surface.
Daruich A, Matet A, Moulin A, Kowalczuk L, Nicolas M, Sellam A, Rothschild PR, Omri S, Gélizé E, Jonet L, Delaunay K, De Kozak Y, Berdugo M, Zhao M, Crisanti P, Behar-Cohen F
Prog Retin Eye Res 2018 Mar;63:20-68. Epub 2017 Nov 7 doi: 10.1016/j.preteyeres.2017.10.006. PMID: 29126927
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.
Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ
Circulation 2016 Sep 6;134(10):752-72. Epub 2016 Jul 28 doi: 10.1161/CIRCULATIONAHA.116.021887. PMID: 27470878
Renal autoregulation in health and disease.
Carlström M, Wilcox CS, Arendshorst WJ
Physiol Rev 2015 Apr;95(2):405-511. doi: 10.1152/physrev.00042.2012. PMID: 25834230Free PMC Article
Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales.
Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT; Global Diabetic Retinopathy Project Group
Ophthalmology 2003 Sep;110(9):1677-82. doi: 10.1016/S0161-6420(03)00475-5. PMID: 13129861

Therapy

Current Treatments for Diabetic Macular Edema.
Tatsumi T
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119591. PMID: 37298544Free PMC Article
Renal Protection with SGLT2 Inhibitors: Effects in Acute and Chronic Kidney Disease.
Bailey CJ, Day C, Bellary S
Curr Diab Rep 2022 Jan;22(1):39-52. Epub 2022 Feb 3 doi: 10.1007/s11892-021-01442-z. PMID: 35113333Free PMC Article
Lutein Supplementation for Eye Diseases.
Li LH, Lee JC, Leung HH, Lam WC, Fu Z, Lo ACY
Nutrients 2020 Jun 9;12(6) doi: 10.3390/nu12061721. PMID: 32526861Free PMC Article
The tubular hypothesis of nephron filtration and diabetic kidney disease.
Vallon V, Thomson SC
Nat Rev Nephrol 2020 Jun;16(6):317-336. Epub 2020 Mar 9 doi: 10.1038/s41581-020-0256-y. PMID: 32152499Free PMC Article
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.
Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ
Circulation 2016 Sep 6;134(10):752-72. Epub 2016 Jul 28 doi: 10.1161/CIRCULATIONAHA.116.021887. PMID: 27470878

Prognosis

Microperimetry in Retinal Diseases.
Horie S, Corradetti G, Esmaeilkhanian H, Sadda SR, Cheung CMG, Ham Y, Chang A, Takahashi T, Ohno-Matsui K
Asia Pac J Ophthalmol (Phila) 2023 Mar-Apr 01;12(2):211-227. Epub 2023 Mar 24 doi: 10.1097/APO.0000000000000597. PMID: 36971707
Diabetic macular ischaemia- a new therapeutic target?
Cheung CMG, Fawzi A, Teo KY, Fukuyama H, Sen S, Tsai WS, Sivaprasad S
Prog Retin Eye Res 2022 Jul;89:101033. Epub 2021 Dec 11 doi: 10.1016/j.preteyeres.2021.101033. PMID: 34902545Free PMC Article
The tubular hypothesis of nephron filtration and diabetic kidney disease.
Vallon V, Thomson SC
Nat Rev Nephrol 2020 Jun;16(6):317-336. Epub 2020 Mar 9 doi: 10.1038/s41581-020-0256-y. PMID: 32152499Free PMC Article
Mechanisms of macular edema: Beyond the surface.
Daruich A, Matet A, Moulin A, Kowalczuk L, Nicolas M, Sellam A, Rothschild PR, Omri S, Gélizé E, Jonet L, Delaunay K, De Kozak Y, Berdugo M, Zhao M, Crisanti P, Behar-Cohen F
Prog Retin Eye Res 2018 Mar;63:20-68. Epub 2017 Nov 7 doi: 10.1016/j.preteyeres.2017.10.006. PMID: 29126927
Diabetic Macular Edema.
Bandello F, Battaglia Parodi M, Lanzetta P, Loewenstein A, Massin P, Menchini F, Veritti D
Dev Ophthalmol 2017;58:102-138. Epub 2017 Mar 28 doi: 10.1159/000455277. PMID: 28351052

Clinical prediction guides

Microperimetry in Retinal Diseases.
Horie S, Corradetti G, Esmaeilkhanian H, Sadda SR, Cheung CMG, Ham Y, Chang A, Takahashi T, Ohno-Matsui K
Asia Pac J Ophthalmol (Phila) 2023 Mar-Apr 01;12(2):211-227. Epub 2023 Mar 24 doi: 10.1097/APO.0000000000000597. PMID: 36971707
Renal Protection with SGLT2 Inhibitors: Effects in Acute and Chronic Kidney Disease.
Bailey CJ, Day C, Bellary S
Curr Diab Rep 2022 Jan;22(1):39-52. Epub 2022 Feb 3 doi: 10.1007/s11892-021-01442-z. PMID: 35113333Free PMC Article
The tubular hypothesis of nephron filtration and diabetic kidney disease.
Vallon V, Thomson SC
Nat Rev Nephrol 2020 Jun;16(6):317-336. Epub 2020 Mar 9 doi: 10.1038/s41581-020-0256-y. PMID: 32152499Free PMC Article
Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial.
Baker CW, Glassman AR, Beaulieu WT, Antoszyk AN, Browning DJ, Chalam KV, Grover S, Jampol LM, Jhaveri CD, Melia M, Stockdale CR, Martin DF, Sun JK; DRCR Retina Network
JAMA 2019 May 21;321(19):1880-1894. doi: 10.1001/jama.2019.5790. PMID: 31037289Free PMC Article
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.
Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ
Circulation 2016 Sep 6;134(10):752-72. Epub 2016 Jul 28 doi: 10.1161/CIRCULATIONAHA.116.021887. PMID: 27470878

Recent systematic reviews

Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography.
Komatsu H, Onoguchi G, Silverstein SM, Jerotic S, Sakuma A, Kanahara N, Kakuto Y, Ono T, Yabana T, Nakazawa T, Tomita H
Mol Psychiatry 2024 Feb;29(2):464-482. Epub 2023 Dec 11 doi: 10.1038/s41380-023-02340-4. PMID: 38081943Free PMC Article
Anti-vascular endothelial growth factors in combination with vitrectomy for complications of proliferative diabetic retinopathy.
Dervenis P, Dervenis N, Smith JM, Steel DH
Cochrane Database Syst Rev 2023 May 31;5(5):CD008214. doi: 10.1002/14651858.CD008214.pub4. PMID: 37260074Free PMC Article
A Systematic Review of Carotenoids in the Management of Diabetic Retinopathy.
Lem DW, Gierhart DL, Davey PG
Nutrients 2021 Jul 16;13(7) doi: 10.3390/nu13072441. PMID: 34371951Free PMC Article
Adherence of patients with diabetic macular oedema to intravitreal injections: A systematic review.
Rose MA, Vukicevic M, Koklanis K
Clin Exp Ophthalmol 2020 Dec;48(9):1286-1298. Epub 2020 Nov 2 doi: 10.1111/ceo.13845. PMID: 32829485
Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy.
Virgili G, Menchini F, Casazza G, Hogg R, Das RR, Wang X, Michelessi M
Cochrane Database Syst Rev 2015 Jan 7;1(1):CD008081. doi: 10.1002/14651858.CD008081.pub3. PMID: 25564068Free PMC Article

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