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Sagittal sinus thrombosis

MedGen UID:
90927
•Concept ID:
C0338575
•
Disease or Syndrome
Synonyms: Sagittal Sinus Thromboses; Sagittal Sinus Thrombosis; Sinus Thromboses, Sagittal; Sinus Thrombosis, Sagittal; Thromboses, Sagittal Sinus; Thrombosis, Sagittal Sinus
SNOMED CT: Thrombosis of superior sagittal sinus (70607008); Thrombosis of superior longitudinal sinus (192760003); Sagittal sinus thrombosis (70607008); Cerebral venous thrombosis of sagittal sinus (70607008)
 
Monarch Initiative: MONDO:0002695

Definition

Formation or presence of a blood clot (thrombus) in the superior sagittal sinus or the inferior sagittal sinus. Sagittal sinus thrombosis can result from infections, hematological disorders, craniocerebral trauma; and neurosurgical procedures. Clinical features are primarily related to the increased intracranial pressure causing headache; nausea; and vomiting. Severe cases can evolve to seizures or coma. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSagittal sinus thrombosis

Professional guidelines

PubMed

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD
Cochrane Database Syst Rev 2018 Jul 9;7(7):CD011492. doi: 10.1002/14651858.CD011492.pub2. PMID: 29987845Free PMC Article
Thromboembolism after ovarian stimulation: successful management of a woman with superior sagittal sinus thrombosis after IVF and embryo transfer: case report.
Ou YC, Kao YL, Lai SL, Kung FT, Huang FJ, Chang SY, ChangChien CC
Hum Reprod 2003 Nov;18(11):2375-81. doi: 10.1093/humrep/deg470. PMID: 14585890
Fetal arachnoid cysts: their site, progress, prognosis and differential diagnosis.
Bannister CM, Russell SA, Rimmer S, Mowle DH
Eur J Pediatr Surg 1999 Dec;9 Suppl 1:27-8. doi: 10.1055/s-2008-1072308. PMID: 10661787

Recent clinical studies

Etiology

Seizures in cerebral venous thrombosis - A retrospective analysis of a tertiary centre cohort.
Dias L, Carvalho M
Clin Neurol Neurosurg 2023 Sep;232:107840. Epub 2023 Jun 22 doi: 10.1016/j.clineuro.2023.107840. PMID: 37421930
A study of hyperhomocysteinemia in cerebral venous sinus thrombosis.
Kalita J, Singh VK, Misra UK
Indian J Med Res 2020 Dec;152(6):584-594. doi: 10.4103/ijmr.IJMR_2125_18. PMID: 34145098Free PMC Article
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD
Cochrane Database Syst Rev 2018 Jul 9;7(7):CD011492. doi: 10.1002/14651858.CD011492.pub2. PMID: 29987845Free PMC Article
Neonatal stroke.
Rutherford MA, Ramenghi LA, Cowan FM
Arch Dis Child Fetal Neonatal Ed 2012 Sep;97(5):F377-84. doi: 10.1136/fetalneonatal-2010-196451. PMID: 22933099
Sagittal sinus compression is associated with neonatal cerebral sinovenous thrombosis.
Tan M, Deveber G, Shroff M, Moharir M, Pontigon AM, Widjaja E, Kirton A
Pediatrics 2011 Aug;128(2):e429-35. Epub 2011 Jul 11 doi: 10.1542/peds.2010-3896. PMID: 21746724

Diagnosis

Post cerebral venous thrombosis headache - Prevalence, mechanisms and risk factors.
Dias L, João Pinto M, Maia R, Albuquerque L, Carvalho M
J Clin Neurosci 2024 Jan;119:205-211. Epub 2023 Dec 22 doi: 10.1016/j.jocn.2023.12.005. PMID: 38141436
A Rare Presentation of Neurobrucellosis in a 6-Year-Old Pediatric Patient with Sagittal Sinus Thrombosis.
Turel O, Abdillah FK, Yozgat CY, Uzuner S, Duramaz BB, Dundar TT, Seyithanoglu MH, Yesilbas O, Kutlu NO
Neuropediatrics 2021 Feb;52(1):48-51. Epub 2020 Oct 5 doi: 10.1055/s-0040-1715482. PMID: 33017853
Cerebral venous thrombosis as a complication of neuropsychiatric systemic lupus erythematosus.
Nishida H, Wakida K, Sakurai T
Intern Med 2015;54(7):837-41. Epub 2015 Apr 1 doi: 10.2169/internalmedicine.54.3079. PMID: 25832953
Neonatal stroke.
Rutherford MA, Ramenghi LA, Cowan FM
Arch Dis Child Fetal Neonatal Ed 2012 Sep;97(5):F377-84. doi: 10.1136/fetalneonatal-2010-196451. PMID: 22933099
Pseudotumour cerebri-neurosurgical considerations.
Lundar T, Nornes H
Acta Neurochir Suppl (Wien) 1990;51:366-8. doi: 10.1007/978-3-7091-9115-6_123. PMID: 2089940

Therapy

Seizures in cerebral venous thrombosis - A retrospective analysis of a tertiary centre cohort.
Dias L, Carvalho M
Clin Neurol Neurosurg 2023 Sep;232:107840. Epub 2023 Jun 22 doi: 10.1016/j.clineuro.2023.107840. PMID: 37421930
Behçet's disease; A rare refractory patient with vena cava superior syndrome treated with infliximab: a case report and review of the literature.
Uyaroglu OA, Erden A, Kilic L, Peynircioğlu B, Karadag O, Kalyoncu U
Acta Clin Belg 2019 Oct;74(5):364-369. Epub 2018 Sep 17 doi: 10.1080/17843286.2018.1522020. PMID: 30220250
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD
Cochrane Database Syst Rev 2018 Jul 9;7(7):CD011492. doi: 10.1002/14651858.CD011492.pub2. PMID: 29987845Free PMC Article
Hereditary thrombophilia in cerebral venous thrombosis: a study from India.
Pai N, Ghosh K, Shetty S
Blood Coagul Fibrinolysis 2013 Jul;24(5):540-3. doi: 10.1097/MBC.0b013e32835fad1e. PMID: 23518830
Thrombolytic therapy in neurointensive care.
Jichici D, Frank JI
Crit Care Clin 1997 Jan;13(1):201-27. doi: 10.1016/s0749-0704(05)70302-x. PMID: 9012582

Prognosis

Risk factors for the development of secondary intracranial hypertension in acute cerebral venous thrombosis.
Schuchardt F, Demerath T, Lützen N, Elsheikh S, Lagrèze W, Reich M, Küchlin S, Urbach H, Meckel S, Harloff A
Neuroradiology 2023 Mar;65(3):463-477. Epub 2022 Nov 29 doi: 10.1007/s00234-022-03091-9. PMID: 36445465
Acute Seizures in Cerebral Venous Sinus Thrombosis: Risk Factors and Prognosis.
Gazioglu S, Yildirim A, Kokturk EG, Seker D, Altunayoglu Cakmak V, Velioglu SK
Neurologist 2020 Sep;25(5):126-130. doi: 10.1097/NRL.0000000000000288. PMID: 32925483
Cerebral Venous Sinus Thrombosis Score and its Correlation with Clinical and MRI Findings.
Kalita J, Singh VK, Jain N, Misra UK, Kumar S
J Stroke Cerebrovasc Dis 2019 Nov;28(11):104324. Epub 2019 Aug 15 doi: 10.1016/j.jstrokecerebrovasdis.2019.104324. PMID: 31422004
Sagittal sinus compression is associated with neonatal cerebral sinovenous thrombosis.
Tan M, Deveber G, Shroff M, Moharir M, Pontigon AM, Widjaja E, Kirton A
Pediatrics 2011 Aug;128(2):e429-35. Epub 2011 Jul 11 doi: 10.1542/peds.2010-3896. PMID: 21746724
Cerebral venous sinus thrombosis in children: a multicenter cohort from the United States.
Wasay M, Dai AI, Ansari M, Shaikh Z, Roach ES
J Child Neurol 2008 Jan;23(1):26-31. doi: 10.1177/0883073807307976. PMID: 18184940

Clinical prediction guides

Post cerebral venous thrombosis headache - Prevalence, mechanisms and risk factors.
Dias L, João Pinto M, Maia R, Albuquerque L, Carvalho M
J Clin Neurosci 2024 Jan;119:205-211. Epub 2023 Dec 22 doi: 10.1016/j.jocn.2023.12.005. PMID: 38141436
PHOTORECEPTOR DAMAGE IN TERSON SYNDROME.
Szeligowski T, Fu DJ, Fernandez-Ledo N, Birtel J, Aslam SA, Patel CK, Xue K, Charbel Issa P
Retina 2023 Sep 1;43(9):1557-1562. doi: 10.1097/IAE.0000000000003842. PMID: 37253246
Risk factors for the development of secondary intracranial hypertension in acute cerebral venous thrombosis.
Schuchardt F, Demerath T, Lützen N, Elsheikh S, Lagrèze W, Reich M, Küchlin S, Urbach H, Meckel S, Harloff A
Neuroradiology 2023 Mar;65(3):463-477. Epub 2022 Nov 29 doi: 10.1007/s00234-022-03091-9. PMID: 36445465
Cerebral Venous Sinus Thrombosis Score and its Correlation with Clinical and MRI Findings.
Kalita J, Singh VK, Jain N, Misra UK, Kumar S
J Stroke Cerebrovasc Dis 2019 Nov;28(11):104324. Epub 2019 Aug 15 doi: 10.1016/j.jstrokecerebrovasdis.2019.104324. PMID: 31422004
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD
Cochrane Database Syst Rev 2018 Jul 9;7(7):CD011492. doi: 10.1002/14651858.CD011492.pub2. PMID: 29987845Free PMC Article

Recent systematic reviews

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD
Cochrane Database Syst Rev 2018 Jul 9;7(7):CD011492. doi: 10.1002/14651858.CD011492.pub2. PMID: 29987845Free PMC Article

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