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Bizarre leiomyoma

MedGen UID:
90789
•Concept ID:
C0334478
•
Neoplastic Process
Synonyms: Atypical Leiomyoma; Atypical leiomyoma; atypical leiomyoma; Bizarre Leiomyoma; bizarre leiomyoma; Pleomorphic Leiomyoma; Pleomorphic leiomyoma; pleomorphic leiomyoma; Symplastic leiomyoma
SNOMED CT: Pleomorphic leiomyoma (48897006); Atypical leiomyoma (48897006); Symplastic leiomyoma (48897006); Bizarre leiomyoma (48897006)
 
Monarch Initiative: MONDO:0003288

Definition

A morphologic variant of leiomyoma characterized by the presence of pleomorphic muscle cells with bizarre hyperchromatic nuclei and eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBizarre leiomyoma

Professional guidelines

PubMed

Potential diagnostic biomarkers: differential expression of LMP2/β1i and cyclin B1 in human uterine leiomyosarcoma.
Hayashi T, Horiuchi A, Sano K, Hiraoka N, Ichimura T, Sudo T, Ishiko O, Yaegashi N, Aburatani H, Konishi I
Tumori 2014 Jul-Aug;100(4):99e-106e. doi: 10.1700/1636.17918. PMID: 25296613

Recent clinical studies

Etiology

Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization.
Kainsbak J, Hansen ES, Dueholm M
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:130-7. Epub 2015 Jun 11 doi: 10.1016/j.ejogrb.2015.05.018. PMID: 26117442
Potential diagnostic biomarkers: differential expression of LMP2/β1i and cyclin B1 in human uterine leiomyosarcoma.
Hayashi T, Horiuchi A, Sano K, Hiraoka N, Ichimura T, Sudo T, Ishiko O, Yaegashi N, Aburatani H, Konishi I
Tumori 2014 Jul-Aug;100(4):99e-106e. doi: 10.1700/1636.17918. PMID: 25296613
Uterine leiomyomas with inclusion bodies: an immunohistochemical and ultrastructural analysis of 12 cases.
Dundr P, Povýsil C, Tvrdík D, Mára M
Pathol Res Pract 2007;203(3):145-51. Epub 2007 Feb 16 doi: 10.1016/j.prp.2006.12.008. PMID: 17306931
Mast cells in smooth muscle tumors of the uterus.
Orii A, Mori A, Zhai YL, Toki T, Nikaido T, Fujii S
Int J Gynecol Pathol 1998 Oct;17(4):336-42. doi: 10.1097/00004347-199810000-00007. PMID: 9785134
Bizarre leiomyomas of the uterus: a comprehensive pathologic study of 24 cases with long-term follow-up.
Downes KA, Hart WR
Am J Surg Pathol 1997 Nov;21(11):1261-70. doi: 10.1097/00000478-199711000-00001. PMID: 9351564

Diagnosis

MVP immunohistochemistry is a useful adjunct in distinguishing leiomyosarcoma from leiomyoma and leiomyoma with bizarre nuclei.
Lintel NJ, Luebker SA, Lele SM, Koepsell SA
Hum Pathol 2018 Mar;73:122-127. Epub 2018 Jan 4 doi: 10.1016/j.humpath.2017.12.020. PMID: 29307622
Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization.
Kainsbak J, Hansen ES, Dueholm M
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:130-7. Epub 2015 Jun 11 doi: 10.1016/j.ejogrb.2015.05.018. PMID: 26117442
Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors.
Chen L, Yang B
Int J Gynecol Pathol 2008 Jul;27(3):326-32. doi: 10.1097/PGP.0b013e31815ea7f5. PMID: 18580309
Uterine leiomyomas with inclusion bodies: an immunohistochemical and ultrastructural analysis of 12 cases.
Dundr P, Povýsil C, Tvrdík D, Mára M
Pathol Res Pract 2007;203(3):145-51. Epub 2007 Feb 16 doi: 10.1016/j.prp.2006.12.008. PMID: 17306931
Vulvar leiomyoma.
Neri A, Peled Y, Braslavski D
Acta Obstet Gynecol Scand 1993 Apr;72(3):221-2. doi: 10.3109/00016349309013377. PMID: 8385861

Therapy

Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization.
Kainsbak J, Hansen ES, Dueholm M
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:130-7. Epub 2015 Jun 11 doi: 10.1016/j.ejogrb.2015.05.018. PMID: 26117442

Prognosis

Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization.
Kainsbak J, Hansen ES, Dueholm M
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:130-7. Epub 2015 Jun 11 doi: 10.1016/j.ejogrb.2015.05.018. PMID: 26117442
Expression of steroid receptors, Ki-67, and p53 in uterine leiomyosarcomas.
Zhai YL, Kobayashi Y, Mori A, Orii A, Nikaido T, Konishi I, Fujii S
Int J Gynecol Pathol 1999 Jan;18(1):20-8. doi: 10.1097/00004347-199901000-00004. PMID: 9891238
Mast cells in smooth muscle tumors of the uterus.
Orii A, Mori A, Zhai YL, Toki T, Nikaido T, Fujii S
Int J Gynecol Pathol 1998 Oct;17(4):336-42. doi: 10.1097/00004347-199810000-00007. PMID: 9785134
Bizarre leiomyomas of the uterus: a comprehensive pathologic study of 24 cases with long-term follow-up.
Downes KA, Hart WR
Am J Surg Pathol 1997 Nov;21(11):1261-70. doi: 10.1097/00000478-199711000-00001. PMID: 9351564
Recurrence of a renal myogenic tumor presented as a duodenal ulcerated lesion.
Pontes JM, Leitão MC, Cabral JE, Portela F, Botelho J, Martins I, Freitas DS
Hepatogastroenterology 1995 Jul-Aug;42(4):356-9. PMID: 8586368

Clinical prediction guides

The First Described Case of Bizarre Leiomyoma of the Portal Vein.
Ferhatoglu MF
J Coll Physicians Surg Pak 2019 Dec;29(12):S123-S125. doi: 10.29271/jcpsp.2019.12.S123. PMID: 31779764
Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors.
Chen L, Yang B
Int J Gynecol Pathol 2008 Jul;27(3):326-32. doi: 10.1097/PGP.0b013e31815ea7f5. PMID: 18580309
Expression of steroid receptors, Ki-67, and p53 in uterine leiomyosarcomas.
Zhai YL, Kobayashi Y, Mori A, Orii A, Nikaido T, Konishi I, Fujii S
Int J Gynecol Pathol 1999 Jan;18(1):20-8. doi: 10.1097/00004347-199901000-00004. PMID: 9891238

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