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Cellular leiomyoma

MedGen UID:
83155
•Concept ID:
C0334477
•
Neoplastic Process
Synonyms: Cellular Leiomyoma; cellular leiomyoma; cellular leiomyoma (morphologic abnormality)
SNOMED CT: Cellular leiomyoma (90955001); Cellular leiomyoma (754555501000119102)
 
Monarch Initiative: MONDO:0003296

Definition

A morphologic variant of classic leiomyoma characterized by a dense cellular infiltrate composed of spindle or round cells with scant cytoplasm and a less obvious interlacing fascicle pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular leiomyoma

Professional guidelines

PubMed

The utility of MRI for the preoperative differential diagnosis of uterine sarcoma and leiomyoma: a single-center study.
Yazawa H, Yazawa R, Anjo K, Inazuki A, Kikuta M
Fukushima J Med Sci 2024 Oct 18;70(4):211-218. Epub 2024 Oct 4 doi: 10.5387/fms.23-00018. PMID: 39370272
IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis between endometrial stromal tumor and cellular leiomyoma.
Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086Free PMC Article
Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas.
Swanson AA, Howitt BE, Schoolmeester JK
Hum Pathol 2020 Sep;103:83-94. Epub 2020 Jul 17 doi: 10.1016/j.humpath.2020.06.008. PMID: 32687944

Recent clinical studies

Etiology

HISTOPATHOLOGICAL, PROLIFERATIVE, APOPTOTIC AND HORMONAL CHARACTERISTICS OF VARIOUS TYPES OF LEIOMYOMAS.
Kiknadze T, Tevdorashvili G, Muzashvili T, Gachechiladze M, Burkadze G
Georgian Med News 2021 Mar;(312):119-125. PMID: 33964839
Leiomyoma: Its Variants And Secondary Changes A Five-Year Study.
Naz S, Rehman A, Riyaz A, Jehangir F, Naeem S, Iqbal T
J Ayub Med Coll Abbottabad 2019 Apr-Jun;31(2):192-195. PMID: 31094115
Prevalence of cellular leiomyoma and partially cellular leiomyoma in postoperative samples - analysis of 384 cases.
Sikora-Szczęśniak DL
Ginekol Pol 2016;87(9):609-616. doi: 10.5603/GP.2016.0054. PMID: 27723066
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Histological and molecular analysis of cellular leiomyoma with sclerosis: linked to HMGA2 overexpression.
Griffin BB, Feng Y, Saini P, Lu X, Bulun S, Chakravarti D, Wei JJ
Histopathology 2022 Nov;81(5):587-599. Epub 2022 Aug 12 doi: 10.1111/his.14732. PMID: 35961656Free PMC Article
Variant type of leiomyomas: 13 years of experience in a single institution.
Bacanakgil BH, Ilhan G, Kaban I
Ginekol Pol 2022;93(6):444-449. Epub 2021 Jun 22 doi: 10.5603/GP.a2021.0125. PMID: 34155617
Leiomyoma: Its Variants And Secondary Changes A Five-Year Study.
Naz S, Rehman A, Riyaz A, Jehangir F, Naeem S, Iqbal T
J Ayub Med Coll Abbottabad 2019 Apr-Jun;31(2):192-195. PMID: 31094115
Practical issues related to uterine pathology: endometrial stromal tumors.
Nucci MR
Mod Pathol 2016 Jan;29 Suppl 1:S92-103. doi: 10.1038/modpathol.2015.140. PMID: 26715176
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

Therapy

Low-Grade Endometrial Stromal Sarcoma Diagnosed 8 Years After Hysterectomy With Morcellation.
Sanneh A, Murdock T, Wethington SL, Fader AN, Xing D, Beavis AL
Obstet Gynecol 2020 Aug;136(2):365-368. doi: 10.1097/AOG.0000000000003908. PMID: 32649495
Submyometrial vasopressin injection before microwave ablation of vascular-rich submucosal myomas: a preliminary case study.
Tsuda A, Kanaoka Y
Int J Hyperthermia 2019;36(1):739-743. doi: 10.1080/02656736.2019.1612102. PMID: 31385549
Transcervical microwave myolysis for uterine myomas assisted by transvaginal ultrasonic guidance.
Kanaoka Y, Yoshida C, Fukuda T, Kajitani K, Ishiko O
J Obstet Gynaecol Res 2009 Feb;35(1):145-51. doi: 10.1111/j.1447-0756.2008.00872.x. PMID: 19215562

Prognosis

The utility of MRI for the preoperative differential diagnosis of uterine sarcoma and leiomyoma: a single-center study.
Yazawa H, Yazawa R, Anjo K, Inazuki A, Kikuta M
Fukushima J Med Sci 2024 Oct 18;70(4):211-218. Epub 2024 Oct 4 doi: 10.5387/fms.23-00018. PMID: 39370272
IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis between endometrial stromal tumor and cellular leiomyoma.
Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086Free PMC Article
HISTOPATHOLOGICAL, PROLIFERATIVE, APOPTOTIC AND HORMONAL CHARACTERISTICS OF VARIOUS TYPES OF LEIOMYOMAS.
Kiknadze T, Tevdorashvili G, Muzashvili T, Gachechiladze M, Burkadze G
Georgian Med News 2021 Mar;(312):119-125. PMID: 33964839
The selected biomarker analysis in 5 types of uterine smooth muscle tumors.
Zhang Q, Kanis MJ, Ubago J, Liu D, Scholtens DM, Strohl AE, Lurain JR, Shahabi S, Kong B, Wei JJ
Hum Pathol 2018 Jun;76:17-27. Epub 2017 Dec 16 doi: 10.1016/j.humpath.2017.12.005. PMID: 29258902Free PMC Article
Gastrointestinal stromal tumors: recent advances in understanding of their biology.
Miettinen M, Sarlomo-Rikala M, Lasota J
Hum Pathol 1999 Oct;30(10):1213-20. doi: 10.1016/s0046-8177(99)90040-0. PMID: 10534170

Clinical prediction guides

IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis between endometrial stromal tumor and cellular leiomyoma.
Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086Free PMC Article
The selected biomarker analysis in 5 types of uterine smooth muscle tumors.
Zhang Q, Kanis MJ, Ubago J, Liu D, Scholtens DM, Strohl AE, Lurain JR, Shahabi S, Kong B, Wei JJ
Hum Pathol 2018 Jun;76:17-27. Epub 2017 Dec 16 doi: 10.1016/j.humpath.2017.12.005. PMID: 29258902Free PMC Article
Prevalence of cellular leiomyoma and partially cellular leiomyoma in postoperative samples - analysis of 384 cases.
Sikora-Szczęśniak DL
Ginekol Pol 2016;87(9):609-616. doi: 10.5603/GP.2016.0054. PMID: 27723066
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397
Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma.
Sanci M, Dikis C, Inan S, Turkoz E, Dicle N, Ispahi C
Acta Histochem 2011 May;113(3):317-25. Epub 2010 Jan 27 doi: 10.1016/j.acthis.2010.01.001. PMID: 20106509

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